Species

KNApSAcK Entry

Organism name Gibberella fujikuroi
Genus Gibberella
Family Nectriaceae
Kingdom Fungi

NCBI taxonomy

Entry

Linked NCBI taxonomy name Fusarium fujikuroi
Linked NCBI taxonomy ID 5127
Linked level species

Family

Family in NCBI taxonomy Nectriaceae
ID 110618

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (42)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000001 External link 512 GA1
/ Gibberellin A1
C422660
No. 40 No. 41
C00000003 External link 512 GA3
/ Gibberellin A3
CHEMBL513241
CHEMBL566653
CHEMBL1232952
CHEMBL1476967
CHEMBL1487394
C007842
10 / 18 / 17 No. 40 No. 41
C00000004 External link 512 GA4
/ Gibberellin A4
No. 40 No. 41
C00000009 External link 512 GA9
/ Gibberellin A9
No. 40 No. 41
C00000011 External link 512 GA11
/ Gibberellin A11
No. 40 No. 41
C00007332 External link 512 GA120
/ Gibberellin A120
No. 40 No. 41
C00000015 External link 512 GA15
/ Gibberellin A15
No. 40 No. 41
C00000016 External link 512 GA16
/ Gibberellin A16
No. 40 No. 41
C00000020 External link 512 GA20
/ Gibberellin A20
No. 40 No. 41
C00000866 External link 512 2,3-DehydroGA9
No. 40 No. 41
C00000214 External link 512 GA10
/ Gibberellin A10
No. 40 No. 41
C00000098 External link 512 GA2
/ Gibberellin A2
No. 40 No. 41
C00000037 External link 512 GA37
/ Gibberellin A37
No. 40 No. 41
C00000040 External link 512 GA40
/ Gibberellin A40
No. 40 No. 41
C00000056 External link 512 GA56
/ Gibberellin A56
No. 40 No. 41
C00000057 External link 512 GA57
/ Gibberellin A57
No. 40 No. 41
C00000047 External link 512 GA47
/ Gibberellin A47
No. 40 No. 41
C00000054 External link 512 GA54
/ Gibberellin A54
No. 40 No. 41
C00000055 External link 512 GA55
/ Gibberellin A55
No. 40 No. 41
C00000078 External link 512 GA78
/ Gibberellin A78
No. 40 No. 41
C00003652 External link 512 Ergosterol
/ Ergosta-5,7,22-trien-3beta-ol
CHEMBL222608
CHEMBL1232562
CHEMBL1512075
CHEMBL1741735
CHEMBL1965225
D004875
12 / 14 / 11 No. 111 No. 11
C00023764 External link 512 Ergosta-5,7,22,24(28)-tetraen-3beta-ol
No. 111 No. 11
C00007253 External link 512 ent-Kaurene
/ ent-Kaur-16-ene
/ (-)-ent-Kaur-16-ene
CHEMBL454740
No. 159 No. 41
C00000042 External link 512 GA42
/ Gibberellin A42
No. 187 No. 41
C00000036 External link 512 GA36
/ Gibberellin A36
No. 187 No. 41
C00000024 External link 512 GA24
/ Gibberellin A24
C120176
No. 187 No. 41
C00000041 External link 512 GA41
/ Gibberellin A41
No. 187 No. 41
C00000025 External link 512 GA25
/ Gibberellin A25
No. 187 No. 41
C00000013 External link 512 GA13
/ Gibberellin A13
No. 187 No. 41
C00003657 External link 512 Lanosterol
/ Lanosta-8,24-dien-3beta-ol
CHEMBL225111
CHEMBL465181
CHEMBL1397369
D007810
10 / 17 / 17 1 / 0 No. 218 No. 51
C00000218 External link 512 Jasmonic acid
/ trans-Jasmonic acid
/ 3-Oxo-2-(2Z-pentenyl)cyclotentylacetic acid
CHEMBL445499
CHEMBL449572
C011006
4 / 1 / 0 No. 707 No. 70
C00023761 External link 512 Ergosta-5,7,9(11),22-tetraenol
/ (+)-Ergosta-5,7,9(11),22-tetraenol
/ Ergosta-5,7,9(11),22-tetraen-3beta-ol
C010905
No. 768
C00007333 External link 512 7beta,18-dihydroxykaurenolide
No. 999 No. 41
C00000886 External link 512 Gibberellin A12 aldehyde
C048463
No. 1235 No. 41
C00000881 External link 512 Cunabic acid
/ ent-Kaurenoic acid
/ ent-Kaur-16-en-19-oic acid
CHEMBL523791
CHEMBL480983
CHEMBL1076299
CHEMBL1968150
C051436
1 / 0 / 0 No. 1235 No. 41
C00007331 External link 512 Gibberellin A14-aldehyde
No. 1235 No. 41
C00011527 External link 512 Cyclonerodiol
C000539
No. 2642
C00049242 External link 512 O-Demethylanhydrofusarubin
No. 4024
C00000908 External link 512 GGPP
/ Geranylgeranyl diphosphate
/ Geranylgeranyl pyrophosphate
CHEMBL1160059
CHEMBL1160061
CHEMBL1229266
C002963
3 / 0 / 0 34 / 0 No. 4178 No. 38
C00000880 External link 512 ent-CPP
/ ent-Copalyl diphosphate
No. 4186 No. 46
C00049240 External link 512 Norbikaverin
No. 5475 No. 65
C00002798 External link 512 Bikaverin
CHEMBL373432
C000269
No. 5475 No. 65

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000003 C00003652 C00003657 0 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00003652 C00003657 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000003 C00003652 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000003 C00003652 1 / 1
P02545 Prelamin-A/C Unclassified protein C00000003 C00003657 11 / 10
P10636 Microtubule-associated protein tau Unclassified protein C00003652 C00003657 4 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000003 C00003652 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00003652 C00003657 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00003652 C00003657 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003652 C00003657 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000003 C00003652 0 / 0
O75496 Geminin Unclassified protein C00000003 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000003 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000003 2 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000218 0 / 0
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000218 0 / 0
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 C00003657 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003657 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000218 1 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000218 1 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00003652 5 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000881 0 / 0
P10275 Androgen receptor NR3C4 C00000003 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003657 0 / 0
P31939 Bifunctional purine biosynthesis protein PURH Enzyme C00003652 1 / 1
P49356 Protein farnesyltransferase subunit beta Enzyme C00000908 0 / 0
P49354 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Enzyme C00000908 0 / 0
P53609 Geranylgeranyl transferase type-1 subunit beta Enzyme C00000908 0 / 0

35 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000908
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000908
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00000908
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000908
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000908
1277 COL1A1, OI4 collagen, type I, alpha 1 C00000908
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00000908
1490 CTGF, CCN2, HCS24, IGFBP8, NOV2 connective tissue growth factor C00000908
2152 F3, CD142, TF, TFA coagulation factor III (thromboplastin, tissue factor) C00000908
9453 GGPS1, GGPPS, GGPPS1 geranylgeranyl diphosphate synthase 1 (EC:2.5.1.1 2.5.1.10 2.5.1.29) C00000908
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00000908
3265 HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 Harvey rat sarcoma viral oncogene homolog C00000908
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000908
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00000908
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000908
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00000908
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000908
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000908
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000908
4312 MMP1, CLG, CLGN matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) C00000908
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00000908
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000908
8013 NR4A3, CHN, CSMF, MINOR, NOR1, TEC nuclear receptor subfamily 4, group A, member 3 C00000908
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00000908
5155 PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis platelet-derived growth factor beta polypeptide C00000908
5444 PON1, ESA, MVCD5, PON paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) C00000908
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00000908
56729 RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1 resistin C00000908
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00000908
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00000908
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00000908
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000908
8743 TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL tumor necrosis factor (ligand) superfamily, member 10 C00000908
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00000908
1593 CYP27A1, CP27, CTX, CYP27 cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) C00003657

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (31)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#608688 Aicar transformylase/imp cyclohydrolase deficiency P31939
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (25)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00966 AICA-ribosiduria P31939 (related)
H01171 Poor drug metabolism (PM) P33261 (related)