KNApSAcK Metabolite C00000908
Metabolite
KNApSAcK Entry
| id | C00000908 |
|---|---|
| Name | GGPP / Geranylgeranyl diphosphate / Geranylgeranyl pyrophosphate |
| CAS RN | 6699-20-3 |
| Standard InChI | InChI=1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+ |
| Standard InChI (Main Layer) | InChI=1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23) |
Cluster
| Phytochemical cluster | No. 38 |
|---|---|
| KCF-S cluster | No. 4178 |
Link
ChEMBL
| By standard InChI | CHEMBL1229266 |
|---|---|
| By standard InChI Main Layer | CHEMBL1160059 CHEMBL1160061 CHEMBL1229266 |
KEGG
| By LinkDB | C00353 |
|---|
CTD
| By CAS RN | C002963 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 2 |
| Spermatophyta | 1 |
| rosids | 1 |
Family (Top 10)
| family name | count |
|---|---|
| Enterobacteriaceae | 3 |
| Rhodobacteraceae | 2 |
| Myxococcaceae | 1 |
| Flavobacteriaceae | 1 |
| Nectriaceae | 1 |
| Solanaceae | 1 |
| Phaeosphaeriaceae | 1 |
| Streptomycetaceae | 1 |
| Taxaceae | 1 |
| Asteraceae | 1 |
List (14)
* NCBI
Human Protein / Gene in interaction
3 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P49356 | Protein farnesyltransferase subunit beta | Enzyme | CHEMBL1160059 CHEMBL1160061 |
CHEMBL681816
(2)
CHEMBL680107
(2)
|
0 / 0 |
| P49354 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Enzyme | CHEMBL1160059 CHEMBL1160061 |
CHEMBL681816
(2)
CHEMBL680107
(2)
CHEMBL682485 (2) |
0 / 0 |
| P53609 | Geranylgeranyl transferase type-1 subunit beta | Enzyme | CHEMBL1160059 CHEMBL1160061 |
CHEMBL682485
(2)
|
0 / 0 |
CTD interaction (69)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C002963 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of AKT1 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
18031796
|
| C002963 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of BCL2 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
18031796
|
| C002963 | 332 |
BIRC5
API4 EPR-1 |
baculoviral IAP repeat containing 5 | geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] |
decreases expression
/ decreases reaction |
protein |
17472962
|
| C002963 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | geranylgeranyl pyrophosphate inhibits the reaction [atorvastatin results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
16470222
|
| C002963 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | geranylgeranyl pyrophosphate inhibits the reaction [cerivastatin results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
16470222
|
| C002963 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein] |
decreases reaction
/ increases activity / increases cleavage |
protein |
18766339
|
| C002963 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
16470222
|
| C002963 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of CDKN1A protein] |
decreases reaction
/ increases expression |
protein |
18625202
|
| C002963 | 1277 |
COL1A1
OI4 |
collagen, type I, alpha 1 | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
16575855
|
| C002963 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]] |
decreases reaction
/ increases expression |
18023360
|
|
| C002963 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] |
decreases reaction
/ increases secretion |
18023360
|
|
| C002963 | 1490 |
CTGF
CCN2 HCS24 IGFBP8 NOV2 |
connective tissue growth factor | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CTGF mRNA]] |
decreases reaction
/ increases expression |
mRNA |
15298857
|
| C002963 | 2152 |
F3
CD142 TF TFA |
coagulation factor III (thromboplastin, tissue factor) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
18031796
|
| C002963 | 9453 |
GGPS1
GGPPS GGPPS1 |
geranylgeranyl diphosphate synthase 1 (EC:2.5.1.1 2.5.1.10 2.5.1.29) | geranylgeranyl pyrophosphate analog results in decreased activity of GGPS1 protein |
decreases activity
|
protein |
16787319
|
| C002963 | 3156 |
HMGCR
LDLCQ3 |
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) | [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate |
decreases abundance
/ decreases activity |
protein |
17208200
|
| C002963 | 3265 |
HRAS
C-BAS/HAS C-H-RAS C-HA-RAS1 CTLO H-RASIDX HAMSV HRAS1 K-RAS N-RAS RASH1 |
Harvey rat sarcoma viral oncogene homolog | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]] |
decreases reaction
/ increases activity |
protein |
18625914
|
| C002963 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] |
decreases reaction
/ increases expression / increases reaction |
protein |
10946302
|
| C002963 | 3552 |
IL1A
IL-1A IL1 IL1-ALPHA IL1F1 |
interleukin 1, alpha | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]] |
affects cotreatment
/ decreases reaction / increases expression |
15728660
|
|
| C002963 | 3552 |
IL1A
IL-1A IL1 IL1-ALPHA IL1F1 |
interleukin 1, alpha | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] |
affects cotreatment
/ decreases reaction / increases secretion |
15728660
|
|
| C002963 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]] |
decreases reaction
/ increases secretion |
protein |
17075836
|
| C002963 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] |
decreases reaction
/ increases expression / increases reaction |
protein |
10946302
|
| C002963 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
decreases reaction
/ increases expression / increases reaction |
protein |
10946302
|
| C002963 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]] |
decreases reaction
/ increases expression |
mRNA |
16511915
|
| C002963 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]] |
decreases reaction
/ increases secretion |
protein |
17075836
|
| C002963 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL8 mRNA]] |
decreases reaction
/ increases expression |
mRNA |
16511915
|
| C002963 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | geranylgeranyl pyrophosphate inhibits the reaction [atorvastatin results in decreased phosphorylation of MAPK1 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
16470222
|
| C002963 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]] |
decreases reaction
/ increases phosphorylation |
protein |
18625914
|
| C002963 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | geranylgeranyl pyrophosphate inhibits the reaction [atorvastatin results in decreased phosphorylation of MAPK3 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
16470222
|
| C002963 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]] |
decreases reaction
/ increases phosphorylation |
protein |
18625914
|
| C002963 | 4312 |
MMP1
CLG CLGN |
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1]] |
decreases reaction
/ increases expression |
18625914
|
|
| C002963 | 4312 |
MMP1
CLG CLGN |
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]] |
decreases reaction
/ increases secretion |
protein |
18625914
|
| C002963 | 4312 |
MMP1
CLG CLGN |
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
17303772
|
| C002963 | 4312 |
MMP1
CLG CLGN |
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein] |
decreases expression
/ decreases reaction |
protein |
17303772
|
| C002963 | 4312 |
MMP1
CLG CLGN |
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein] |
decreases reaction
/ decreases secretion |
protein |
17303772
|
| C002963 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]] |
affects cotreatment
/ decreases reaction / increases expression |
mRNA |
15728660
|
| C002963 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] |
affects cotreatment
/ decreases reaction / increases secretion |
protein |
15728660
|
| C002963 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]] |
decreases reaction
/ increases expression |
mRNA |
15728660
|
| C002963 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]] |
decreases reaction
/ increases secretion |
protein |
15728660
|
| C002963 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]] |
decreases reaction
/ increases degradation |
protein |
17075836
|
| C002963 | 8013 |
NR4A3
CHN CSMF MINOR NOR1 TEC |
nuclear receptor subfamily 4, group A, member 3 | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
16005304
|
| C002963 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] |
decreases reaction
/ increases cleavage / increases reaction |
protein |
21910007
|
| C002963 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] |
decreases reaction
/ increases cleavage / increases reaction |
protein |
21910007
|
| C002963 | 5155 |
PDGFB
IBGC5 PDGF-2 PDGF2 SIS SSV c-sis |
platelet-derived growth factor beta polypeptide | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]] |
affects cotreatment
/ decreases reaction / increases expression |
15728660
|
|
| C002963 | 5155 |
PDGFB
IBGC5 PDGF-2 PDGF2 SIS SSV c-sis |
platelet-derived growth factor beta polypeptide | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] |
affects cotreatment
/ decreases reaction / increases secretion |
15728660
|
|
| C002963 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
14500290
|
| C002963 | 5879 |
RAC1
Rac-1 TC-25 p21-Rac1 |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | geranylgeranyl pyrophosphate inhibits the reaction [atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]] |
decreases reaction
/ increases localization |
protein |
17279352
|
| C002963 | 5879 |
RAC1
Rac-1 TC-25 p21-Rac1 |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]] |
decreases reaction
/ increases activity |
protein |
18625914
|
| C002963 | 5879 |
RAC1
Rac-1 TC-25 p21-Rac1 |
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]] |
decreases reaction
/ increases localization |
protein |
18625914
|
| C002963 | 56729 |
RETN
ADSF FIZZ3 RETN1 RSTN XCP1 |
resistin | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]] |
decreases reaction
/ increases expression |
mRNA |
18023360
|
| C002963 | 56729 |
RETN
ADSF FIZZ3 RETN1 RSTN XCP1 |
resistin | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] |
decreases reaction
/ increases secretion |
protein |
18023360
|
| C002963 | 387 |
RHOA
ARH12 ARHA RHO12 RHOH12 |
ras homolog family member A | geranylgeranyl pyrophosphate inhibits the reaction [atorvastatin results in decreased activity of RHOA protein] |
decreases activity
/ decreases reaction |
protein |
16470222
|
| C002963 | 387 |
RHOA
ARH12 ARHA RHO12 RHOH12 |
ras homolog family member A | geranylgeranyl pyrophosphate inhibits the reaction [atorvastatin results in increased localization of RHOA protein] |
decreases reaction
/ increases localization |
protein |
16470222
|
| C002963 | 387 |
RHOA
ARH12 ARHA RHO12 RHOH12 |
ras homolog family member A | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RHOA protein] |
affects localization
/ decreases activity / decreases reaction |
protein |
18031796
|
| C002963 | 387 |
RHOA
ARH12 ARHA RHO12 RHOH12 |
ras homolog family member A | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]] |
decreases activity
/ decreases reaction |
protein |
18625914
|
| C002963 | 387 |
RHOA
ARH12 ARHA RHO12 RHOH12 |
ras homolog family member A | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]] |
decreases reaction
/ increases activity |
protein |
17075836
|
| C002963 | 387 |
RHOA
ARH12 ARHA RHO12 RHOH12 |
ras homolog family member A | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased activity of RHOA protein] |
decreases activity
/ decreases reaction |
protein |
16470222
|
| C002963 | 387 |
RHOA
ARH12 ARHA RHO12 RHOH12 |
ras homolog family member A | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased localization of RHOA protein] |
decreases reaction
/ increases localization |
protein |
16005304
16470222 |
| C002963 | 387 |
RHOA
ARH12 ARHA RHO12 RHOH12 |
ras homolog family member A | Simvastatin inhibits the reaction [geranylgeranyl pyrophosphate affects the localization of RHOA protein] |
affects localization
/ decreases reaction |
protein |
18625202
|
| C002963 | 6401 |
SELE
CD62E ELAM ELAM1 ESEL LECAM2 |
selectin E | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] |
decreases reaction
/ increases expression / increases reaction |
protein |
10946302
|
| C002963 | 7040 |
TGFB1
CED DPD1 LAP TGFB TGFbeta |
transforming growth factor, beta 1 | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CTGF mRNA]] |
decreases reaction
/ increases expression |
15298857
|
|
| C002963 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]] |
decreases reaction
/ increases activity |
17075836
|
|
| C002963 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]] |
decreases reaction
/ increases degradation |
17075836
|
|
| C002963 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]] |
decreases reaction
/ increases expression |
16511915
|
|
| C002963 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL8 mRNA]] |
decreases reaction
/ increases expression |
16511915
|
|
| C002963 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]] |
decreases reaction
/ increases secretion |
17075836
|
|
| C002963 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]] |
decreases reaction
/ increases secretion |
17075836
|
|
| C002963 | 8743 |
TNFSF10
APO2L Apo-2L CD253 TL2 TRAIL |
tumor necrosis factor (ligand) superfamily, member 10 | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] |
decreases reaction
/ increases cleavage / increases reaction |
protein |
21910007
|
| C002963 | 8743 |
TNFSF10
APO2L Apo-2L CD253 TL2 TRAIL |
tumor necrosis factor (ligand) superfamily, member 10 | geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] |
decreases reaction
/ increases cleavage / increases reaction |
protein |
21910007
|
| C002963 | 7422 |
VEGFA
MVCD1 VEGF VPF |
vascular endothelial growth factor A | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA] |
decreases reaction
/ increases expression |
mRNA |
18356691
|