Stevia rebaudiana
Species
KNApSAcK Entry
| Organism name | Stevia rebaudiana |
|---|---|
| Genus | Stevia |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Stevia rebaudiana |
|---|---|
| Linked NCBI taxonomy ID | 55670 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (42)
| Species | Activity |
|---|---|
| Stevia rebaudiana (Bertoni) Bertoni | Antibacterial |
| Stevia rebaudiana (Bertoni) Bertoni | Anticariogenic |
| Stevia rebaudiana (Bertoni) Bertoni | Anticariogenic |
| Stevia rebaudiana (Bertoni) Bertoni | Antidiabetic |
| Stevia rebaudiana (Bertoni) Bertoni | Antidiabetic |
| Stevia rebaudiana (Bertoni) Bertoni | Antiedemic |
| Stevia rebaudiana (Bertoni) Bertoni | Antiedemic |
| Stevia rebaudiana (Bertoni) Bertoni | Antifertility |
| Stevia rebaudiana (Bertoni) Bertoni | Antifertility |
| Stevia rebaudiana (Bertoni) Bertoni | Antigluconeogenic |
| Stevia rebaudiana (Bertoni) Bertoni | Antigluconeogenic |
| Stevia rebaudiana (Bertoni) Bertoni | Antihyperglycemic |
| Stevia rebaudiana (Bertoni) Bertoni | Antihypertensive |
| Stevia rebaudiana (Bertoni) Bertoni | Antiinflammatory |
| Stevia rebaudiana (Bertoni) Bertoni | Antiinflammatory |
| Stevia rebaudiana (Bertoni) Bertoni | Antiseptic |
| Stevia rebaudiana (Bertoni) Bertoni | Antiseptic |
| Stevia rebaudiana (Bertoni) Bertoni | Antiumor-Promotor |
| Stevia rebaudiana (Bertoni) Bertoni | Bactericide |
| Stevia rebaudiana (Bertoni) Bertoni | Calcium Antagonist |
| Stevia rebaudiana (Bertoni) Bertoni | Calcium-Blocker |
| Stevia rebaudiana (Bertoni) Bertoni | Candidicide |
| Stevia rebaudiana (Bertoni) Bertoni | Chemopreventive |
| Stevia rebaudiana (Bertoni) Bertoni | Contraceptive |
| Stevia rebaudiana (Bertoni) Bertoni | Contraceptive |
| Stevia rebaudiana (Bertoni) Bertoni | Diuretic |
| Stevia rebaudiana (Bertoni) Bertoni | Diuretic |
| Stevia rebaudiana (Bertoni) Bertoni | Glucagonostatic |
| Stevia rebaudiana (Bertoni) Bertoni | Glutamate-Dehydrogenase-Inhibitor |
| Stevia rebaudiana (Bertoni) Bertoni | Hypoglycemic |
| Stevia rebaudiana (Bertoni) Bertoni | Hypoglycemic |
| Stevia rebaudiana (Bertoni) Bertoni | Hypotensive |
| Stevia rebaudiana (Bertoni) Bertoni | Hypotensive |
| Stevia rebaudiana (Bertoni) Bertoni | Insulinotropic |
| Stevia rebaudiana (Bertoni) Bertoni | Mutagenic |
| Stevia rebaudiana (Bertoni) Bertoni | NADH-Oxidase-Inhibitor |
| Stevia rebaudiana (Bertoni) Bertoni | Natriuretic |
| Stevia rebaudiana (Bertoni) Bertoni | Nephrotoxic |
| Stevia rebaudiana (Bertoni) Bertoni | Ornithine-Decarboxylase-Inhibitor |
| Stevia rebaudiana (Bertoni) Bertoni | Succinate-Oxygenase-Inhibitor |
| Stevia rebaudiana (Bertoni) Bertoni | Sweetener |
| Stevia rebaudiana (Bertoni) Bertoni | Vasodilator |
Metabolite list (35)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000020
|
GA20
/ Gibberellin A20 |
No. 40 | No. 41 |
|
||||
|
C00022376
|
Jhanol
|
No. 70 |
|
|||||
|
C00045083
|
Sterebin L
|
No. 511 |
|
|||||
|
C00045082
|
Sterebin K
/ (+)-Sterebin K |
No. 511 |
|
|||||
|
C00045081
|
Sterebin J
/ (+)-Sterebin J |
No. 511 |
|
|||||
|
C00045084
|
Sterebin M
|
No. 511 |
|
|||||
|
C00022736
|
Sterebin E
|
No. 511 |
|
|||||
|
C00023176
|
Austroinulin 6-O-acetate
|
No. 511 |
|
|||||
|
C00022748
|
Austroinulin
|
No. 511 |
|
|||||
|
C00022737
|
Sterebin F
|
No. 511 |
|
|||||
|
C00045080
|
Sterebin I
|
No. 511 |
|
|||||
|
C00045085
|
Sterebin N
|
No. 511 |
|
|||||
|
C00000107
|
IAN
/ Indole-3-acetonitrile |
CHEMBL1812654
|
C016516
|
No. 710 | No. 4 |
|
||
|
C00034697
|
Steviolmonoside
|
C044523
|
No. 791 |
|
||||
|
C00034696
|
Steviolbioside
/ (-)-Steviolbioside |
CHEMBL1205986
|
C074471
|
No. 791 |
|
|||
|
C00036203
|
Rebaudioside D
|
No. 1038 | No. 41 |
|
||||
|
C00003485
|
Stevioside
|
CHEMBL25147
CHEMBL444122 |
C012043
|
3 / 2 / 1 | 0 / 1 | No. 1038 | No. 41 |
|
|
C00037724
|
Rebaudioside C
/ (-)-Rebaudioside C |
No. 1038 | No. 41 |
|
||||
|
C00036114
|
Dulcoside A
|
No. 1038 | No. 41 |
|
||||
|
C00023175
|
Rebaudioside A
|
C025474
|
No. 1038 | No. 41 |
|
|||
|
C00036205
|
Rebaudioside F
/ (-)-Rebaudioside F |
No. 1038 | No. 41 |
|
||||
|
C00036204
|
Rebaudioside E
|
No. 1038 | No. 41 |
|
||||
|
C00034695
|
Steviol
/ (-)-Steviol |
CHEMBL463996
CHEMBL1331260 |
C012042
|
5 / 3 / 2 | No. 1235 | No. 41 |
|
|
|
C00034394
|
4-Diphosphocytidyl-2-C-methyl-D-erythritol
/ (+)-4-Diphosphocytidyl-2-C-methyl-D-erythritol |
No. 1823 |
|
|||||
|
C00023383
|
Sterebin B
|
No. 2584 |
|
|||||
|
C00023381
|
Sterebin D
|
No. 2584 |
|
|||||
|
C00023384
|
Sterebin C
|
No. 2584 |
|
|||||
|
C00023382
|
Sterebin A
|
No. 2584 |
|
|||||
|
C00001200
|
Pyruvic acid
|
CHEMBL1162144
|
D019289
|
5 / 2 / 2 | 10 / 4 | No. 2782 |
|
|
|
C00007294
|
Dimethylallyl diphosphate
|
CHEMBL343480
|
C043060
|
2 / 0 | No. 3297 |
|
||
|
C00007285
|
Glyceraldehyde 3-phosphate
|
CHEMBL1232918
|
1 / 1 / 0 | No. 3380 |
|
|||
|
C00000908
|
GGPP
/ Geranylgeranyl diphosphate / Geranylgeranyl pyrophosphate |
CHEMBL1160059
CHEMBL1160061 CHEMBL1229266 |
C002963
|
3 / 0 / 0 | 34 / 0 | No. 4178 | No. 38 |
|
|
C00000876
|
CPP
/ Copalyl diphosphate |
C090962
|
No. 4186 | No. 46 |
|
|||
|
C00007297
|
2-C-Methyl-D-erythritol 4-phosphate
|
CHEMBL1161493
|
No. 7419 |
|
||||
|
C00007295
|
2-C-Methyl-D-erythritol 2,4-cyclodiphosphate
|
No. 8945 |
|
Human Protein / Gene in interactions
15 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P04150 | Glucocorticoid receptor | NR3C1 | C00003485 C00034695 | 0 / 1 |
| Q92959 | Solute carrier organic anion transporter family member 2A1 | Unclassified protein | C00001200 C00007285 | 1 / 0 |
| P49354 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Enzyme | C00000908 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003485 | 2 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00034695 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00034695 | 0 / 0 |
| P49356 | Protein farnesyltransferase subunit beta | Enzyme | C00000908 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003485 | 0 / 0 |
| O15427 | Monocarboxylate transporter 4 | Unclassified protein | C00001200 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00034695 | 2 / 0 |
| O60669 | Monocarboxylate transporter 2 | Unclassified protein | C00001200 | 0 / 0 |
| Q05BR4 | SLC16A10 protein | Unclassified protein | C00001200 | 0 / 0 |
| P53609 | Geranylgeranyl transferase type-1 subunit beta | Enzyme | C00000908 | 0 / 0 |
| Q9C0B1 | Alpha-ketoglutarate-dependent dioxygenase FTO | Unclassified protein | C00001200 | 1 / 2 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00034695 | 1 / 1 |
46 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000908
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000908
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00000908
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000908
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00000908
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00000908
|
| 1401 | CRP, PTX1 | C-reactive protein, pentraxin-related |
C00000908
|
| 1490 | CTGF, CCN2, HCS24, IGFBP8, NOV2 | connective tissue growth factor |
C00000908
|
| 2152 | F3, CD142, TF, TFA | coagulation factor III (thromboplastin, tissue factor) |
C00000908
|
| 9453 | GGPS1, GGPPS, GGPPS1 | geranylgeranyl diphosphate synthase 1 (EC:2.5.1.1 2.5.1.10 2.5.1.29) |
C00000908
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00000908
|
| 3265 | HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 | Harvey rat sarcoma viral oncogene homolog |
C00000908
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00000908
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00000908
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00000908
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00000908
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00000908
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00000908
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00000908
|
| 4312 | MMP1, CLG, CLGN | matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) |
C00000908
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00000908
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00000908
|
| 8013 | NR4A3, CHN, CSMF, MINOR, NOR1, TEC | nuclear receptor subfamily 4, group A, member 3 |
C00000908
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00000908
|
| 5155 | PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis | platelet-derived growth factor beta polypeptide |
C00000908
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00000908
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00000908
|
| 56729 | RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1 | resistin |
C00000908
|
| 387 | RHOA, ARH12, ARHA, RHO12, RHOH12 | ras homolog family member A |
C00000908
|
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E |
C00000908
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00000908
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000908
|
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 |
C00000908
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00000908
|
| 3594 | IL12RB1, CD212, IL-12R-BETA1, IL12RB | interleukin 12 receptor, beta 1 |
C00007294
|
| 7133 | TNFRSF1B, CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR | tumor necrosis factor receptor superfamily, member 1B |
C00007294
|
| 31 | ACACA, ACAC, ACACAD, ACC, ACC1, ACCA | acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14) |
C00001200
|
| 1487 | CTBP1, BARS | C-terminal binding protein 1 |
C00001200
|
| 1488 | CTBP2 | C-terminal binding protein 2 |
C00001200
|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) |
C00001200
|
| 14103 |
C00001200
|
||
| 2516 | NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 | nuclear receptor subfamily 5, group A, member 1 |
C00001200
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001200
|
| 23411 | SIRT1, SIR2L1 | sirtuin 1 |
C00001200
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00001200
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00001200
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (7)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #612938 | Growth retardation, developmental delay, coarse facies, and early death; gdfd |
Q9C0B1
|
| #614441 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 2; phoar2 |
Q92959
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
KEGG DISEASE (4)
| KEGG | name | UniProt |
|---|---|---|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00409 | Type II diabetes mellitus |
Q9C0B1
(related)
|
| H00926 | Growth retardation, developmental delay, coarse facies, and early death |
Q9C0B1
(related)
|