PCIDB

KNApSAcK Metabolite C00001200

Metabolite

KNApSAcK Entry

id C00001200
Name Pyruvic acid
CAS RN 127-17-3
Standard InChI InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
Standard InChI (Main Layer) InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)

Cluster

Phytochemical cluster
KCF-S cluster No. 2782

Link

ChEMBL

By standard InChI CHEMBL1162144
By standard InChI Main Layer CHEMBL1162144

KEGG

By LinkDB C00022

CTD

By CAS RN D019289

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O15427 Monocarboxylate transporter 4 Unclassified protein CHEMBL1162144 CHEMBL2076227 (1)
0 / 0
Q92959 Solute carrier organic anion transporter family member 2A1 Unclassified protein CHEMBL1162144 CHEMBL2078491 (1)
1 / 0
O60669 Monocarboxylate transporter 2 Unclassified protein CHEMBL1162144 CHEMBL2075342 (1)
0 / 0
Q05BR4 SLC16A10 protein Unclassified protein CHEMBL1162144 CHEMBL2076232 (1)
0 / 0
Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO Unclassified protein CHEMBL1162144 CHEMBL2344107 (1)
1 / 2

CTD interaction (20)

compound gene gene name gene description interaction interaction type form reference
pmid
D019289 31 ACACA
ACAC
ACACAD
ACC
ACC1
ACCA
acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14) [Pyruvic Acid co-treated with Glucose] results in increased phosphorylation of ACACA protein affects cotreatment
/ increases phosphorylation
protein 19071085
D019289 1487 CTBP1
BARS
C-terminal binding protein 1 Pyruvic Acid affects the localization of CTBP1 protein affects localization
protein 18184656
D019289 1487 CTBP1
BARS
C-terminal binding protein 1 Pyruvic Acid inhibits the reaction [CTBP1 protein binds to CTBP2 protein] affects binding
/ decreases reaction
protein 18184656
D019289 1487 CTBP1
BARS
C-terminal binding protein 1 Pyruvic Acid inhibits the reaction [CTBP1 protein binds to NR5A1 protein] affects binding
/ decreases reaction
protein 18184656
D019289 1487 CTBP1
BARS
C-terminal binding protein 1 Pyruvic Acid promotes the reaction [CTBP1 protein binds to CYP17A1 promoter] affects binding
/ increases reaction
protein 18184656
D019289 1488 CTBP2
C-terminal binding protein 2 Pyruvic Acid affects the localization of CTBP2 protein affects localization
protein 18184656
D019289 1488 CTBP2
C-terminal binding protein 2 Pyruvic Acid inhibits the reaction [CTBP1 protein binds to CTBP2 protein] affects binding
/ decreases reaction
protein 18184656
D019289 1488 CTBP2
C-terminal binding protein 2 Pyruvic Acid promotes the reaction [CTBP2 protein binds to CYP17A1 promoter] affects binding
/ increases reaction
protein 18184656
D019289 1586 CYP17A1
CPT7
CYP17
P450C17
S17AH
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) Pyruvic Acid promotes the reaction [CTBP1 protein binds to CYP17A1 promoter] affects binding
/ increases reaction
promoter 18184656
D019289 1586 CYP17A1
CPT7
CYP17
P450C17
S17AH
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) Pyruvic Acid promotes the reaction [CTBP2 protein binds to CYP17A1 promoter] affects binding
/ increases reaction
promoter 18184656
D019289 1586 CYP17A1
CPT7
CYP17
P450C17
S17AH
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) Pyruvic Acid promotes the reaction [NR5A1 protein binds to CYP17A1 promoter] affects binding
/ increases reaction
promoter 18184656
D019289 1586 CYP17A1
CPT7
CYP17
P450C17
S17AH
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) Pyruvic Acid results in increased expression of CYP17A1 mRNA increases expression
mRNA 18184656
D019289 14103 Pyruvic Acid inhibits the reaction [FASL protein results in increased chemical synthesis of Hydrogen Peroxide] decreases reaction
/ increases chemical synthesis
protein 17724027
D019289 2516 NR5A1
AD4BP
ELP
FTZ1
FTZF1
POF7
SF-1
SF1
SPGF8
SRXY3
nuclear receptor subfamily 5, group A, member 1 Pyruvic Acid inhibits the reaction [CTBP1 protein binds to NR5A1 protein] affects binding
/ decreases reaction
protein 18184656
D019289 2516 NR5A1
AD4BP
ELP
FTZ1
FTZF1
POF7
SF-1
SF1
SPGF8
SRXY3
nuclear receptor subfamily 5, group A, member 1 Pyruvic Acid promotes the reaction [NR5A1 protein binds to CYP17A1 promoter] affects binding
/ increases reaction
protein 18184656
D019289 10891 PPARGC1A
LEM6
PGC-1(alpha)
PGC-1v
PGC1
PGC1A
PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [Pyruvic Acid co-treated with Glucose] results in decreased acetylation of PPARGC1A protein affects cotreatment
/ decreases acetylation
protein 19071085
D019289 23411 SIRT1
SIR2L1
sirtuin 1 [Pyruvic Acid co-treated with Glucose] results in increased expression of and results in increased activity of SIRT1 protein affects cotreatment
/ increases activity
/ increases expression
protein 19071085
D019289 6566 SLC16A1
HHF7
MCT
MCT1
solute carrier family 16 (monocarboxylate transporter), member 1 Pyruvic Acid inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates] decreases reaction
/ increases uptake
protein 19023563
D019289 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Pyruvic Acid inhibits the reaction [SOD1 protein mutant form promotes the reaction [cupric chloride results in increased abundance of Peroxides]] decreases reaction
/ increases abundance
/ increases reaction
protein 15812313
D019289 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Pyruvic Acid inhibits the reaction [SOD1 protein mutant form results in increased susceptibility to cupric chloride] decreases reaction
/ increases response to substance
protein 15812313

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#612938 Growth retardation, developmental delay, coarse facies, and early death; gdfd Q9C0B1
#614441 Hypertrophic osteoarthropathy, primary, autosomal recessive, 2; phoar2 Q92959

KEGG DISEASE (2)

KEGG disease name UniProt
H00409 Type II diabetes mellitus Q9C0B1 (related)
H00926 Growth retardation, developmental delay, coarse facies, and early death Q9C0B1 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D006943 D019289 Hyperglycemia marker/mechanism
19819963
D028361 D019289 Mitochondrial Diseases therapeutic
8232219
D009135 D019289 Muscular Diseases marker/mechanism
8147937
D009336 D019289 Necrosis therapeutic
10486581