Cicer arietinum
Species
KNApSAcK Entry
| Organism name | Cicer arietinum |
|---|---|
| Genus | Cicer |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cicer arietinum |
|---|---|
| Linked NCBI taxonomy ID | 3827 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (43)
| Species | Activity |
|---|---|
| Cicer arietinum L. | Anthelminthic |
| Cicer arietinum L. | Anti-Spina Bifida |
| Cicer arietinum L. | Antianemic |
| Cicer arietinum L. | Antiartherogenic |
| Cicer arietinum L. | Antibilious |
| Cicer arietinum L. | Anticervisotic |
| Cicer arietinum L. | Anticheilitic |
| Cicer arietinum L. | Anticoronary |
| Cicer arietinum L. | Antidementic |
| Cicer arietinum L. | Antidepressant |
| Cicer arietinum L. | Antigingivitic |
| Cicer arietinum L. | Antigout |
| Cicer arietinum L. | Antiinfertility |
| Cicer arietinum L. | Antileukemic |
| Cicer arietinum L. | Antimetaplastic |
| Cicer arietinum L. | Antimyelotoxic |
| Cicer arietinum L. | Antineuropathic |
| Cicer arietinum L. | Antiperiodontotic |
| Cicer arietinum L. | Antiplaque |
| Cicer arietinum L. | Antipolyp |
| Cicer arietinum L. | Antipsychotic |
| Cicer arietinum L. | Antipyretic |
| Cicer arietinum L. | Antistomatitic |
| Cicer arietinum L. | Antistress |
| Cicer arietinum L. | Aphrodisiac |
| Cicer arietinum L. | Astringent |
| Cicer arietinum L. | Cardioprotective |
| Cicer arietinum L. | Diuretic |
| Cicer arietinum L. | Estrogenic |
| Cicer arietinum L. | Fungicide |
| Cicer arietinum L. | Hemopoietic |
| Cicer arietinum L. | Hypocholesterolemic |
| Cicer arietinum L. | Hypolipidemic |
| Cicer arietinum L. | Immunostimulant |
| Cicer arietinum L. | Lactagogue |
| Cicer arietinum L. | Laxative |
| Cicer arietinum L. | Lipolytic |
| Cicer arietinum L. | Soporific |
| Cicer arietinum L. | Stimulant |
| Cicer arietinum L. | Stomachic |
| Cicer arietinum L. | Tonic |
| Cicer arietinum L. | Uricosuric |
| Cicer arietinum L. | Xanthine-Oxidase-Inhibitor |
Metabolite list (28)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005161
|
Kaempferol 3-apiosyl-(1->2)-glucoside
|
No. 1 | No. 15 |
|
||||
|
C00010112
|
Sissotrin
/ Astroside / Biochanin A 7-O-glucoside |
CHEMBL557296
CHEMBL1405026 |
7 / 12 / 38 | No. 2 | No. 15 |
|
||
|
C00010083
|
Formononetin 7-O-(6''-malonylglucoside)
/ Formononetin 7-O-glucoside-6''-malonate / Formononetin 7-O-beta-D-glucoside-6''-O-malonate |
No. 2 | No. 15 |
|
||||
|
C00002553
|
Ononin
/ Formononetin 7-O-glucoside |
CHEMBL465980
|
11 / 14 / 40 | No. 2 | No. 15 |
|
||
|
C00004635
|
Isorhamnetin
/ 3'-O-Methylquercetin / 3,4',5,7-Tetrahydroxy-3'-methoxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL379064
|
C047368
|
12 / 10 / 13 | 10 / 0 | No. 3 | No. 15 |
|
|
C00002563
|
Pratensein
/ 5,7,3'-Trihydroxy-4'-methoxyisoflavone |
CHEMBL252904
|
No. 3 | No. 15 |
|
|||
|
C00002510
|
Olmelin
/ Pratensol / Biochanin A / Genistein 4'-methyl ether / 5,7-Dihydroxy-4'-methoxyisoflavone |
CHEMBL131921
|
C004541
|
51 / 65 / 83 | 64 / 2 | No. 3 | No. 15 |
|
|
C00002525
|
Formononetin
/ 7-Hydroxy-4'-methoxyisoflavone |
CHEMBL242341
|
C007768
|
24 / 36 / 58 | 13 / 0 | No. 3 | No. 15 |
|
|
C00003553
|
Soyasaponin I
|
CHEMBL511016
|
C056684
|
2 / 1 | No. 9 | No. 51 |
|
|
|
C00000977
|
Liquiritigenin
|
CHEMBL252642
CHEMBL271939 |
C083152
|
5 / 4 / 4 | 1 / 1 | No. 25 | No. 14 |
|
|
C00002509
|
Betavulgarin
/ 2'-Hydroxy-5-methoxy-6,7-methylenedioxyisoflavone |
No. 27 | No. 15 |
|
||||
|
C00007185
|
Neoisoliquiritin
/ Neoisoliquiritigenin |
No. 36 | No. 13 |
|
||||
|
C00000964
|
Garbanzol
|
CHEMBL254051
|
No. 42 | No. 14 |
|
|||
|
C00009757
|
9-O-Methylcoumestrol
/ 4'-O-Methylcoumestrol / 3-Hydroxy-9-methoxycoumestan |
No. 54 | No. 17 |
|
||||
|
C00002546
|
Inermin
/ Maackiain / (-)-Maackiain / Demethylpterocarpin / 3-Hydroxy-8,9-methylenedioxypterocarpan |
CHEMBL334918
CHEMBL239047 CHEMBL445279 |
3 / 2 / 3 | No. 66 | No. 15 |
|
||
|
C00004540
|
Resokaempferol
|
CHEMBL242383
|
19 / 22 / 55 | No. 76 | No. 15 |
|
||
|
C00002535
|
Homoferreirin
|
No. 106 | No. 14 |
|
||||
|
C00009760
|
Medicagol
/ 3-Hydroxy-8,9-methylenedioxycoumestan / 7-Hydroxy-11,12-methylenedioxycoumestan |
CHEMBL99941
|
1 / 0 / 0 | No. 473 |
|
|||
|
C00000615
|
Caffeic acid
|
CHEMBL145
CHEMBL1320034 |
68 / 64 / 63 | No. 904 | No. 6 |
|
||
|
C00001200
|
Pyruvic acid
|
CHEMBL1162144
|
D019289
|
5 / 2 / 2 | 10 / 4 | No. 2782 |
|
|
|
C00000091
|
trans-Zeatin
|
CHEMBL525239
|
D015026
|
2 / 3 / 2 | 0 / 1 | No. 2879 |
|
|
|
C00000093
|
Dihydrozeatin
|
No. 2879 |
|
|||||
|
C00001555
|
Trigonelline
|
CHEMBL350675
|
C009560
|
3 / 1 / 0 | No. 3681 | No. 1 |
|
|
|
C00001183
|
Fumaric acid
|
CHEMBL503160
CHEMBL539648 |
C032005
|
17 / 14 / 46 | 0 / 1 | No. 3766 |
|
|
|
C00001508
|
5-Ribosyluracil
|
CHEMBL603512
|
D011560
|
1 / 1 / 1 | No. 3929 |
|
||
|
C00001490
|
Adenine
|
CHEMBL226345
|
D000225
|
52 / 44 / 38 | 1 / 6 | No. 6151 |
|
|
|
C00001198
|
Oxalic acid
|
CHEMBL146755
|
D019815
|
2 / 0 / 0 | 1 / 6 | No. 7540 |
|
|
|
C00001186
|
Glyoxylic acid
|
CHEMBL1162545
|
C031150
|
1 / 0 / 0 | 0 / 1 | No. 7855 |
|
Human Protein / Gene in interactions
172 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001183 C00002510 C00002525 C00002553 C00004540 C00010112 | 7 / 37 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000615 C00002510 C00002525 C00002546 C00004540 | 0 / 1 |
| O00255 | Menin | Unclassified protein | C00000615 C00002510 C00002525 C00004540 C00004635 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000615 C00002510 C00002525 C00004540 C00004635 | 1 / 2 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001183 C00001490 C00002525 C00002553 C00010112 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000615 C00001183 C00002510 C00004540 C00004635 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000615 C00002510 C00002525 C00004540 | 1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000615 C00002510 C00002525 C00004540 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000615 C00002510 C00002525 C00004540 | 4 / 3 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000615 C00002510 C00002525 C00004540 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001183 C00002510 C00002553 C00010112 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000615 C00002510 C00002525 C00004540 | 0 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000615 C00002510 C00002525 C00004540 | 2 / 2 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002510 C00002525 C00002553 C00010112 | 4 / 2 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000615 C00001490 C00002510 C00004540 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000615 C00002510 C00002525 C00004540 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000615 C00002510 C00002525 C00004540 | 3 / 3 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002510 C00002553 C00010112 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000615 C00001490 C00004635 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000615 C00001490 C00002510 | 1 / 8 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00002510 C00002553 C00010112 | 1 / 1 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00001490 C00002510 C00004540 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000615 C00001490 C00004635 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000091 C00000615 C00001183 | 3 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000615 C00001490 C00002510 | 11 / 10 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000615 C00000977 C00001490 | 2 / 2 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000615 C00001183 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001490 C00002510 | 1 / 1 |
| Q9C0B1 | Alpha-ketoglutarate-dependent dioxygenase FTO | Unclassified protein | C00001183 C00001200 | 1 / 2 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000615 C00002525 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002510 C00002553 | 1 / 1 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00002510 C00002553 | 0 / 0 |
| O15427 | Monocarboxylate transporter 4 | Unclassified protein | C00001186 C00001200 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000091 C00002510 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000615 C00004635 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000615 C00001183 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00002510 C00002525 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000615 C00000977 | 0 / 0 |
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00002525 C00002546 | 1 / 1 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000615 C00001183 | 0 / 0 |
| P31639 | Sodium/glucose cotransporter 2 | Glucose | C00002525 C00002546 | 1 / 1 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | C00000615 C00001490 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000615 C00002510 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000615 C00001183 | 1 / 2 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002510 C00002553 | 1 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00000615 C00002510 | 1 / 1 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00002525 C00004635 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002510 C00002525 | 4 / 1 |
| P08253 | 72 kDa type IV collagenase | M10A | C00000615 C00001490 | 1 / 3 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000615 C00004635 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00000977 C00002510 | 2 / 2 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00002510 C00002525 | 0 / 0 |
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00000615 C00001183 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001183 C00001555 | 0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00000977 C00002510 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00000615 C00001490 | 0 / 1 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002510 C00010112 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000615 C00001183 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00000615 C00002553 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001183 C00002510 | 0 / 0 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00000615 C00001183 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000615 C00002510 | 0 / 0 |
| P05412 | Transcription factor AP-1 | Transcription Factor | C00000977 | 0 / 0 |
| O43353 | Receptor-interacting serine/threonine-protein kinase 2 | Ripk | C00001490 | 0 / 0 |
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00001490 | 1 / 3 |
| P42330 | Aldo-keto reductase family 1 member C3 | Enzyme | C00000615 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000615 | 0 / 0 |
| P07332 | Tyrosine-protein kinase Fes/Fps | Fer | C00001490 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00004635 | 0 / 0 |
| P16152 | Carbonyl reductase [NADPH] 1 | Enzyme | C00002510 | 0 / 0 |
| Q13464 | Rho-associated protein kinase 1 | Rock | C00001490 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000615 | 2 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000615 | 0 / 3 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002510 | 0 / 1 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | C00001490 | 0 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | C00001490 | 2 / 2 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00001490 | 0 / 0 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00001490 | 0 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002510 | 1 / 2 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000615 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000615 | 0 / 0 |
| Q99683 | Mitogen-activated protein kinase kinase kinase 5 | Ste11 | C00001490 | 0 / 0 |
| P15056 | Serine/threonine-protein kinase B-raf | Raf | C00001490 | 6 / 3 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000615 | 3 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00001183 | 1 / 2 |
| P04792 | Heat shock protein beta-1 | Unclassified protein | C00004635 | 2 / 1 |
| O75828 | Carbonyl reductase [NADPH] 3 | Enzyme | C00002510 | 0 / 0 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00001490 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002510 | 0 / 1 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001490 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00000615 | 4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002525 | 5 / 3 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001490 | 5 / 9 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00004635 | 4 / 4 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00001198 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00000615 | 1 / 1 |
| P04745 | Alpha-amylase 1 | Enzyme | C00004635 | 0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00001490 | 0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00001490 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002510 | 2 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00000615 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00000615 | 0 / 0 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00001490 | 0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00001490 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000615 | 0 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00002510 | 1 / 0 |
| Q16798 | NADP-dependent malic enzyme, mitochondrial | Enzyme | C00001183 | 0 / 0 |
| Q13177 | Serine/threonine-protein kinase PAK 2 | STE serine/threonine protein kinase PAKA subfamily | C00001490 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00002510 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00002510 | 1 / 1 |
| Q04828 | Aldo-keto reductase family 1 member C1 | Enzyme | C00000615 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00001198 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000615 | 0 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000615 | 5 / 2 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00000615 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000615 | 0 / 0 |
| Q08881 | Tyrosine-protein kinase ITK/TSK | Tec | C00001490 | 1 / 1 |
| O00329 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Enzyme | C00001490 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000615 | 3 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00002510 | 6 / 4 |
| P55210 | Caspase-7 | C14 | C00004540 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00001490 | 4 / 1 |
| Q15118 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial | Pdhk | C00001490 | 0 / 0 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00001490 | 0 / 0 |
| P17516 | Aldo-keto reductase family 1 member C4 | Enzyme | C00000615 | 1 / 0 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | C00002510 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000615 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002553 | 0 / 0 |
| P52895 | Aldo-keto reductase family 1 member C2 | Enzyme | C00000615 | 1 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000615 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00001555 | 0 / 0 |
| O14965 | Aurora kinase A | Aur | C00001490 | 0 / 0 |
| Q15303 | Receptor tyrosine-protein kinase erbB-4 | TK tyrosine-protein kinase EGFR subfamily | C00001490 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002510 | 3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00002525 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000615 | 1 / 2 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000615 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001490 | 0 / 1 |
| P52333 | Tyrosine-protein kinase JAK3 | Jakb | C00001490 | 1 / 1 |
| P04049 | RAF proto-oncogene serine/threonine-protein kinase | Raf | C00001490 | 2 / 0 |
| P43405 | Tyrosine-protein kinase SYK | Syk | C00001490 | 0 / 0 |
| P06732 | Creatine kinase M-type | Enzyme | C00009760 | 0 / 0 |
| P08254 | Stromelysin-1 | M10A | C00001490 | 1 / 0 |
| P48736 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Enzyme | C00001490 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000615 | 1 / 1 |
| Q12794 | Hyaluronidase-1 | Enzyme | C00000615 | 1 / 2 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002525 | 0 / 0 |
| P24298 | Alanine aminotransferase 1 | Enzyme | C00000615 | 0 / 0 |
| P19971 | Thymidine phosphorylase | Enzyme | C00001508 | 1 / 1 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001490 | 0 / 0 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002510 | 3 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000615 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000615 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001555 | 1 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | C00002510 | 0 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00001490 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00004540 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00004540 | 1 / 4 |
| P17252 | Protein kinase C alpha type | Alpha | C00001490 | 0 / 0 |
| Q92959 | Solute carrier organic anion transporter family member 2A1 | Unclassified protein | C00001200 | 1 / 0 |
| O60669 | Monocarboxylate transporter 2 | Unclassified protein | C00001200 | 0 / 0 |
| Q05BR4 | SLC16A10 protein | Unclassified protein | C00001200 | 0 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | C00001490 | 0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00001490 | 0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | C00001490 | 0 / 0 |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | Transcription Factor | C00002510 | 0 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00000615 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00004540 | 0 / 0 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00000615 | 4 / 2 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | C00001490 | 0 / 0 |
| P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Enzyme | C00001490 | 9 / 1 |
| P22894 | Neutrophil collagenase | M10A | C00001490 | 0 / 0 |
85 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00002510
C00002525
C00004635
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00002510
C00002525
C00004635
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00002510
C00002525
C00004635
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00002510
C00002525
C00004635
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002510
C00002525
C00004635
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002510
C00002525
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002510
C00002525
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002510
C00002525
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00002510
C00004635
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002510
C00002525
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002525
C00004635
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002510
C00002525
|
| 80014 | WWC2, BOMB | WW and C2 domain containing 2 |
C00002510
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002510
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002510
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002510
|
| 1000 | CDH2, CD325, CDHN, CDw325, NCAD | cadherin 2, type 1, N-cadherin (neuronal) |
C00002510
|
| 1594 | CYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR | cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) |
C00002510
|
| 51071 | DERA, DEOC | deoxyribose-phosphate aldolase (putative) (EC:4.1.2.4) |
C00002510
|
| 1983 | EIF5, EIF-5, EIF-5A | eukaryotic translation initiation factor 5 |
C00002510
|
| 59084 | ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) |
C00002510
|
| 2060 | EPS15, AF-1P, AF1P, MLLT5 | epidermal growth factor receptor pathway substrate 15 |
C00002510
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002510
|
| 9577 | BRE, BRCC4, BRCC45 | brain and reproductive organ-expressed (TNFRSF1A modulator) |
C00002510
|
| 2101 | ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1 | estrogen-related receptor alpha |
C00002510
|
| 2103 | ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2 | estrogen-related receptor beta |
C00002510
|
| 2104 | ESRRG, ERR3, ERRgamma, NR3B3 | estrogen-related receptor gamma |
C00002510
|
| 2091 | FBL, FIB, FLRN, RNU3IP1 | fibrillarin |
C00002510
|
| 2348 | FOLR1, FBP, FOLR | folate receptor 1 (adult) |
C00002510
|
| 2760 | GM2A, GM2-AP, SAP-3 | GM2 ganglioside activator |
C00002510
|
| 2773 | GNAI3, 87U6, ARCND1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
C00002510
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00002510
|
| 9766 | KIAA0247 |
C00002510
|
|
| 753 | LDLRAD4, C18orf1 | low density lipoprotein receptor class A domain containing 4 |
C00002510
|
| 56925 | LXN, ECI, TCI | latexin |
C00002510
|
| 4323 | MMP14, MMP-14, MMP-X1, MT-MMP, MT-MMP_1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS | matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) |
C00002510
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002510
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00002510
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00002510
|
| 4698 | NDUFA5, B13, CI-13KD-B, CI-13kB, NUFM, UQOR13 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 (EC:1.6.5.3 1.6.99.3) |
C00002510
|
| 4841 | NONO, NMT55, NRB54, P54, P54NRB | non-POU domain containing, octamer-binding |
C00002510
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00002510
|
| 5204 | PFDN5, MM-1, MM1, PFD5 | prefoldin subunit 5 |
C00002510
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00002510
|
| 5329 | PLAUR, CD87, U-PAR, UPAR, URKR | plasminogen activator, urokinase receptor |
C00002510
|
| 10957 | PNRC1, B4-2, PNAS-145, PROL2, PRR2 | proline-rich nuclear receptor coactivator 1 |
C00002510
|
| 55684 | RABL6, C9orf86, PARF, RBEL1, pp8875 | RAB, member RAS oncogene family-like 6 |
C00002510
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002510
|
| 55183 | RIF1 | RAP1 interacting factor homolog (yeast) |
C00002510
|
| 285367 | RPUSD3 | RNA pseudouridylate synthase domain containing 3 |
C00002510
|
| 6455 | SH3GL1, CNSA1, EEN, SH3D2B, SH3P8 | SH3-domain GRB2-like 1 |
C00002510
|
| 5250 | SLC25A3, PHC, PTP | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 |
C00002510
|
| 6426 | SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a | serine/arginine-rich splicing factor 1 |
C00002510
|
| 84222 | TMEM191A, TMEM191AP | transmembrane protein 191A (pseudogene) |
C00002510
|
| 27242 | TNFRSF21, BM-018, CD358, DR6 | tumor necrosis factor receptor superfamily, member 21 |
C00002510
|
| 203068 | TUBB, M40, OK/SW-cl.56, TUBB1, TUBB5 | tubulin, beta class I |
C00002510
|
| 7322 | UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH5B | ubiquitin-conjugating enzyme E2D 2 (EC:6.3.2.19) |
C00002510
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00002510
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002510
|
| 84159 | ARID5B, DESRT, MRF-2, MRF2 | AT rich interactive domain 5B (MRF1-like) |
C00002510
|
| 501 | ALDH7A1, ATQ1, EPD, PDE | aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31) |
C00002510
|
| 375790 | AGRN | agrin |
C00002510
|
| 54663 | WDR74 | WD repeat domain 74 |
C00002510
|
| 1152 | CKB, B-CK, CKBB | creatine kinase, brain (EC:2.7.3.2) |
C00002510
|
| 1244 | ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
C00002510
|
| 2056 | EPO, EP, MVCD2 | erythropoietin |
C00002525
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00002525
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00004635
|
| 4973 | OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 | oxidized low density lipoprotein (lectin-like) receptor 1 |
C00004635
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00004635
|
| 5972 | REN, HNFJ2 | renin (EC:3.4.23.15) |
C00003553
|
| 6484 | ST3GAL4, CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (EC:2.4.99.4) |
C00003553
|
| 1831 | TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP | TSC22 domain family, member 3 |
C00000977
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001490
|
| 31 | ACACA, ACAC, ACACAD, ACC, ACC1, ACCA | acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14) |
C00001200
|
| 1487 | CTBP1, BARS | C-terminal binding protein 1 |
C00001200
|
| 1488 | CTBP2 | C-terminal binding protein 2 |
C00001200
|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) |
C00001200
|
| 14103 |
C00001200
|
||
| 2516 | NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3 | nuclear receptor subfamily 5, group A, member 1 |
C00001200
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001200
|
| 23411 | SIRT1, SIR2L1 | sirtuin 1 |
C00001200
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00001200
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00001200
|
| 26762 | HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1 | hepatitis A virus cellular receptor 1 |
C00001198
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (143)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #614279 | 46,xy sex reversal 8; srxy8 |
P17516
P52895 |
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P31749
P38398 P42336 |
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115150 | Cardiofaciocutaneous syndrome 1; cfc1 |
P15056
|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #606595 | Charcot-marie-tooth disease, axonal, type 2f; cmt2f |
P04792
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P15056
P18054 P31749 P42336 |
| #612918 | Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi |
P42336
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #615108 | Cowden syndrome 5; cws5 |
P42336
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 P37231 |
| #606824 | Glucose/galactose malabsorption; ggm |
P13866
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #612938 | Growth retardation, developmental delay, coarse facies, and early death; gdfd |
Q9C0B1
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #114550 | Hepatocellular carcinoma |
P42336
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #614441 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 2; phoar2 |
Q92959
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #182000 | Keratosis, seborrheic |
P42336
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #611554 | Leopard syndrome 2 |
P04049
|
| #613707 | Leopard syndrome 3 |
P15056
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 P15056 |
| #605027 | Lymphoma, non-hodgkin, familial |
P15056
|
| #613011 | Lymphoproliferative syndrome 1; lpfs1 |
Q08881
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #602501 | Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap |
P42336
|
| #603387 | Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph |
P42336
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #603041 | Mitochondrial dna depletion syndrome 1 (mngie type); mtdps1 |
P19971
|
| #601492 | Mucopolysaccharidosis, type ix; mps9 |
Q12794
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #608634 | Neuronopathy, distal hereditary motor, type iib; hmn2b |
P04792
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #611553 | Noonan syndrome 5; ns5 |
P04049
|
| #613706 | Noonan syndrome 7; ns7 |
P15056
|
| #601665 | Obesity |
P37231
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
P38398 P42336 |
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #176920 | Proteus syndrome |
P31749
|
| #233100 | Renal glucosuria; glys1 |
P31639
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #600802 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative |
P52333
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (123)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) P08253 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P31751 (related) P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) P31751 (related) P38398 (related) P42336 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) P38398 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
P08069 (related) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P08253 (related) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P15056 (related) P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) P15056 (related) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00856 | Distal hereditary motor neuropathies (dHMN) |
P04792
(related)
|
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
P11308 (related) |
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00523 | Noonan syndrome and related disorders |
P15056
(related)
Q02750 (related) Q06124 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00469 | Mitochondrial DNA depletion syndrome (MDS) |
P19971
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01126 | Familial renal glucosuria (FRG) |
P31639
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
Q9C0B1 (related) |
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
Q08881 (related) |
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P52333
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00133 | Mucopolysaccharidosis type IX (MPS9) |
Q12794
(related)
|
| H00421 | Mucopolysaccharidosis (MPS) |
Q12794
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00926 | Growth retardation, developmental delay, coarse facies, and early death |
Q9C0B1
(related)
|
| H00236 | Congenital polycythemia |
Q9GZT9
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
22 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D051437 | Renal Insufficiency |
C00001490
C00001198 |
| D005909 | Glioblastoma |
C00002510
|
| D007669 | Kidney Calculi |
C00001186
|
| D002471 | Cell Transformation, Neoplastic |
C00001183
|
| D003092 | Colitis |
C00003553
|
| D009120 | Muscle Cramp |
C00000977
|
| D000855 | Anorexia |
C00001490
|
| D002779 | Cholestasis |
C00001490
|
| D056486 | Drug-Induced Liver Injury |
C00001490
|
| D007565 | Jaundice |
C00001490
|
| D009325 | Nausea |
C00001490
|
| D011471 | Prostatic Neoplasms |
C00002510
|
| D000647 | Amnesia |
C00000091
|
| D006943 | Hyperglycemia |
C00001200
|
| D028361 | Mitochondrial Diseases |
C00001200
|
| D009135 | Muscular Diseases |
C00001200
|
| D009336 | Necrosis |
C00001200
|
| D058186 | Acute Kidney Injury |
C00001198
|
| D006959 | Hyperoxaluria |
C00001198
|
| D006960 | Hyperoxaluria, Primary |
C00001198
|
| D009397 | Nephrocalcinosis |
C00001198
|
| D053040 | Nephrolithiasis |
C00001198
|