KNApSAcK Metabolite C00002510
Metabolite
KNApSAcK Entry
| id | C00002510 |
|---|---|
| Name | Olmelin / Pratensol / Biochanin A / Genistein 4'-methyl ether / 5,7-Dihydroxy-4'-methoxyisoflavone |
| CAS RN | 491-80-5 |
| Standard InChI | InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3 |
| Standard InChI (Main Layer) | InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)12-8-21-14-7-10(17)6-13(18)15(14)16(12)19/h2-8,17-18H,1H3 |
Cluster
| Phytochemical cluster | No. 15 |
|---|---|
| KCF-S cluster | No. 3 |
Link
ChEMBL
| By standard InChI | CHEMBL131921 |
|---|---|
| By standard InChI Main Layer | CHEMBL131921 |
KEGG
| By LinkDB | C00814 |
|---|
CTD
| By CAS RN | C004541 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 63 |
| Magnoliophyta | 4 |
| Liliopsida | 1 |
| Spermatophyta | 1 |
Family
| family name | count |
|---|---|
| Fabaceae | 63 |
| Myristicaceae | 3 |
| Annonaceae | 1 |
| Poaceae | 1 |
| Podocarpaceae | 1 |
List (71)
* NCBI
Human Protein / Gene in interaction
51 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL131921 |
CHEMBL1614110
(1)
|
1 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | CHEMBL131921 |
CHEMBL957998
(1)
CHEMBL957999
(1)
|
0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | CHEMBL131921 |
CHEMBL2076027
(1)
CHEMBL2076037
(1)
CHEMBL2078146 (1) |
0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL131921 |
CHEMBL1613992
(1)
CHEMBL1613995
(1)
CHEMBL1738132 (1) |
7 / 44 |
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL131921 |
CHEMBL1613842
(2)
|
4 / 2 |
| P04062 | Glucosylceramidase | Enzyme | CHEMBL131921 |
CHEMBL1613818
(1)
|
6 / 4 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL131921 |
CHEMBL1614544
(1)
|
11 / 10 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | CHEMBL131921 |
CHEMBL641179
(1)
CHEMBL693590
(1)
CHEMBL693591 (1) CHEMBL693592 (1) CHEMBL693593 (1) |
1 / 1 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | CHEMBL131921 |
CHEMBL862675
(1)
CHEMBL862676
(1)
|
0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | CHEMBL131921 |
CHEMBL2077116
(1)
CHEMBL2075618
(1)
CHEMBL2077295 (1) CHEMBL2077297 (1) |
1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL131921 |
CHEMBL1614027
(1)
|
0 / 1 |
| O75828 | Carbonyl reductase [NADPH] 3 | Enzyme | CHEMBL131921 |
CHEMBL1004501
(1)
CHEMBL1004502
(1)
CHEMBL1004503 (1) |
0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL131921 |
CHEMBL941404
(1)
|
1 / 11 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL131921 |
CHEMBL1614458
(1)
|
0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL131921 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| P16152 | Carbonyl reductase [NADPH] 1 | Enzyme | CHEMBL131921 |
CHEMBL1004498
(1)
CHEMBL1004499
(1)
CHEMBL1004500 (1) CHEMBL1004504 (1) CHEMBL1004505 (2) |
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL131921 |
CHEMBL2114843
(2)
|
0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | CHEMBL131921 |
CHEMBL1613838
(1)
|
0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | CHEMBL131921 |
CHEMBL2114807
(1)
|
4 / 2 |
| Q92731 | Estrogen receptor beta | NR3A2 | CHEMBL131921 |
CHEMBL2026721
(1)
|
0 / 1 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | CHEMBL131921 |
CHEMBL1614094
(1)
|
1 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL131921 |
CHEMBL2114788
(1)
|
0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | CHEMBL131921 |
CHEMBL1963893
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL131921 |
CHEMBL1052488
(1)
CHEMBL1052489
(1)
|
0 / 1 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | CHEMBL131921 |
CHEMBL827396
(1)
CHEMBL877007
(1)
CHEMBL831140 (1) CHEMBL835255 (1) CHEMBL836231 (1) CHEMBL834977 (1) CHEMBL1105634 (1) CHEMBL2014374 (1) |
2 / 2 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | CHEMBL131921 |
CHEMBL1614252
(1)
|
2 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL131921 |
CHEMBL1613808
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL131921 |
CHEMBL1613910
(1)
|
3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | CHEMBL131921 |
CHEMBL2076829
(1)
CHEMBL2076843
(1)
|
2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | CHEMBL131921 |
CHEMBL1006005
(1)
|
1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL131921 |
CHEMBL1614038
(1)
|
2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | CHEMBL131921 |
CHEMBL1614342
(1)
|
1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL131921 |
CHEMBL1738588
(1)
CHEMBL1738317
(1)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL131921 |
CHEMBL2026720
(1)
|
1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL131921 |
CHEMBL1613777
(1)
|
1 / 1 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | CHEMBL131921 |
CHEMBL958788
(1)
CHEMBL958789
(1)
|
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL131921 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
|
0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL131921 |
CHEMBL1614211
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL131921 |
CHEMBL1614250
(2)
CHEMBL1614421
(3)
CHEMBL1614502 (3) |
4 / 3 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL131921 |
CHEMBL1052486
(1)
CHEMBL1052487
(1)
CHEMBL1052490 (1) |
3 / 4 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL131921 |
CHEMBL1613914
(2)
|
0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | CHEMBL131921 |
CHEMBL1613829
(1)
|
0 / 0 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | CHEMBL131921 |
CHEMBL1614373
(1)
|
3 / 3 |
| O00255 | Menin | Unclassified protein | CHEMBL131921 |
CHEMBL1614257
(3)
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL131921 |
CHEMBL1614257
(3)
CHEMBL1614531
(1)
|
1 / 3 |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | Transcription Factor | CHEMBL131921 |
CHEMBL1613870
(1)
|
0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | CHEMBL131921 |
CHEMBL1613870
(1)
|
0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | CHEMBL131921 |
CHEMBL1613870
(1)
|
0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | CHEMBL131921 |
CHEMBL879881
(1)
CHEMBL689869
(1)
CHEMBL689870 (1) CHEMBL689871 (1) CHEMBL731143 (1) |
0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | CHEMBL131921 |
CHEMBL879881
(1)
CHEMBL689869
(1)
CHEMBL689870 (1) CHEMBL689871 (1) CHEMBL731143 (1) |
1 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | CHEMBL131921 |
CHEMBL2354287
(1)
|
1 / 1 |
CTD interaction (93)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C004541 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | biochanin A results in decreased activity of ABCC1 protein |
decreases activity
|
protein |
15581599
|
| C004541 | 1244 |
ABCC2
ABC30 CMOAT DJS MRP2 cMRP |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | biochanin A inhibits the reaction [ABCC2 protein affects the export of ochratoxin A] |
affects export
/ decreases reaction |
protein |
15955639
|
| C004541 | 375790 |
AGRN
|
agrin | biochanin A results in decreased expression of AGRN mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
protein |
16903077
|
| C004541 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter] |
affects binding
/ increases reaction |
protein |
16903077
|
| C004541 | 501 |
ALDH7A1
ATQ1 EPD PDE |
aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31) | biochanin A results in decreased expression of ALDH7A1 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 84159 |
ARID5B
DESRT MRF-2 MRF2 |
AT rich interactive domain 5B (MRF1-like) | biochanin A results in increased expression of ARID5B mRNA |
increases expression
|
mRNA |
12111696
|
| C004541 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | biochanin A results in decreased expression of BCL2 protein |
decreases expression
|
protein |
12791511
|
| C004541 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | biochanin A results in decreased expression of BCL2L1 protein |
decreases expression
|
protein |
12791511
|
| C004541 | 9577 |
BRE
BRCC4 BRCC45 |
brain and reproductive organ-expressed (TNFRSF1A modulator) | biochanin A results in increased expression of BRE mRNA |
increases expression
|
mRNA |
12111696
|
| C004541 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | biochanin A results in increased activity of CASP3 protein |
increases activity
|
protein |
12791511
|
| C004541 | 1000 |
CDH2
CD325 CDHN CDw325 NCAD |
cadherin 2, type 1, N-cadherin (neuronal) | biochanin A results in decreased expression of CDH2 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | biochanin A results in decreased expression of CDKN1A protein |
decreases expression
|
protein |
12111696
|
| C004541 | 1152 |
CKB
B-CK CKBB |
creatine kinase, brain (EC:2.7.3.2) | biochanin A results in increased activity of CKB protein |
increases activity
|
protein |
16621514
|
| C004541 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | biochanin A binds to and results in decreased activity of CYP19A1 protein |
affects binding
/ decreases activity |
protein |
9435150
|
| C004541 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | biochanin A results in decreased activity of CYP19A1 protein |
decreases activity
|
protein |
16965912
|
| C004541 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | biochanin A results in decreased expression of CYP19A1 mRNA |
decreases expression
|
mRNA |
16965912
|
| C004541 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased activity of CYP19A1 protein |
affects cotreatment
/ decreases activity |
protein |
16965912
|
| C004541 | 1588 |
CYP19A1
ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased expression of CYP19A1 mRNA |
affects cotreatment
/ decreases expression |
mRNA |
16965912
|
| C004541 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
promoter |
16903077
|
| C004541 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1A1 protein] |
decreases reaction
/ increases activity |
protein |
16903077
|
| C004541 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | biochanin A inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
16903077
|
| C004541 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | biochanin A promotes the reaction [AHR protein binds to CYP1A1 promoter] |
affects binding
/ increases reaction |
promoter |
16903077
|
| C004541 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | biochanin A results in increased activity of CYP1A1 protein |
increases activity
|
protein |
16903077
|
| C004541 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | biochanin A results in increased expression of CYP1A1 mRNA |
increases expression
|
mRNA |
16903077
|
| C004541 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | CYP1A1 protein results in decreased methylation of biochanin A |
decreases methylation
|
protein |
15479032
|
| C004541 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | CYP1A1 protein results in increased hydroxylation of biochanin A |
increases hydroxylation
|
protein |
15479032
|
| C004541 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | CYP1A2 protein results in increased metabolism of biochanin A |
increases metabolic processing
|
protein |
12814970
|
| C004541 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | CYP1B1 protein results in decreased methylation of biochanin A |
decreases methylation
|
protein |
15479032
|
| C004541 | 1594 |
CYP27B1
CP2B CYP1 CYP1alpha CYP27B P450c1 PDDR VDD1 VDDR VDDRI VDR |
cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) | biochanin A affects the activity of CYP27B1 protein |
affects activity
|
protein |
17659868
|
| C004541 | 1594 |
CYP27B1
CP2B CYP1 CYP1alpha CYP27B P450c1 PDDR VDD1 VDDR VDDRI VDR |
cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) | biochanin A affects the expression of CYP27B1 mRNA |
affects expression
|
mRNA |
17659868
|
| C004541 | 1594 |
CYP27B1
CP2B CYP1 CYP1alpha CYP27B P450c1 PDDR VDD1 VDDR VDDRI VDR |
cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) | biochanin A analog affects the expression of CYP27B1 mRNA |
affects expression
|
mRNA |
17659868
|
| C004541 | 1594 |
CYP27B1
CP2B CYP1 CYP1alpha CYP27B P450c1 PDDR VDD1 VDDR VDDRI VDR |
cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) | biochanin A analog results in increased activity of CYP27B1 protein |
increases activity
|
protein |
15795327
|
| C004541 | 1594 |
CYP27B1
CP2B CYP1 CYP1alpha CYP27B P450c1 PDDR VDD1 VDDR VDDRI VDR |
cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) | biochanin A analog results in increased expression of CYP27B1 mRNA |
increases expression
|
mRNA |
15795327
|
| C004541 | 1594 |
CYP27B1
CP2B CYP1 CYP1alpha CYP27B P450c1 PDDR VDD1 VDDR VDDRI VDR |
cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) | biochanin A results in increased activity of CYP27B1 protein |
increases activity
|
protein |
15795327
|
| C004541 | 1594 |
CYP27B1
CP2B CYP1 CYP1alpha CYP27B P450c1 PDDR VDD1 VDDR VDDRI VDR |
cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) | biochanin A results in increased expression of CYP27B1 mRNA |
increases expression
|
mRNA |
15795327
|
| C004541 | 51071 |
DERA
DEOC |
deoxyribose-phosphate aldolase (putative) (EC:4.1.2.4) | biochanin A results in decreased expression of DERA mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 1983 |
EIF5
EIF-5 EIF-5A |
eukaryotic translation initiation factor 5 | biochanin A results in decreased expression of EIF5 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 59084 |
ENPP5
|
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | biochanin A results in decreased expression of ENPP5 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 2060 |
EPS15
AF-1P AF1P MLLT5 |
epidermal growth factor receptor pathway substrate 15 | biochanin A results in decreased expression of EPS15 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | biochanin A binds to and results in increased activity of ESR1 protein |
affects binding
/ increases activity |
protein |
9751507
16076101 |
| C004541 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | biochanin A binds to ESR1 protein |
affects binding
|
protein |
12598185
14579009 19913605 |
| C004541 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | biochanin A inhibits the reaction [Estradiol binds to ESR1 protein] |
affects binding
/ decreases reaction |
protein |
14579009
|
| C004541 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | biochanin A binds to and results in increased activity of ESR2 protein |
affects binding
/ increases activity |
protein |
9751507
16076101 |
| C004541 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | biochanin A binds to ESR2 protein |
affects binding
|
protein |
12224631
16566672 19913605 |
| C004541 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | biochanin A inhibits the reaction [Estradiol binds to ESR2 protein] |
affects binding
/ decreases reaction |
protein |
16566672
|
| C004541 | 2101 |
ESRRA
ERR1 ERRa ERRalpha ESRL1 NR3B1 |
estrogen-related receptor alpha | biochanin A binds to and results in increased activity of ESRRA protein |
affects binding
/ increases activity |
protein |
14638870
|
| C004541 | 2101 |
ESRRA
ERR1 ERRa ERRalpha ESRL1 NR3B1 |
estrogen-related receptor alpha | biochanin A binds to ESRRA protein mutant form |
affects binding
|
protein |
14638870
|
| C004541 | 2101 |
ESRRA
ERR1 ERRa ERRalpha ESRL1 NR3B1 |
estrogen-related receptor alpha | biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004541 | 2103 |
ESRRB
DFNB35 ERR2 ERRb ESRL2 NR3B2 |
estrogen-related receptor beta | biochanin A binds to and results in increased activity of ESRRB protein |
affects binding
/ increases activity |
protein |
14638870
|
| C004541 | 2103 |
ESRRB
DFNB35 ERR2 ERRb ESRL2 NR3B2 |
estrogen-related receptor beta | biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004541 | 2104 |
ESRRG
ERR3 ERRgamma NR3B3 |
estrogen-related receptor gamma | biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004541 | 2091 |
FBL
FIB FLRN RNU3IP1 |
fibrillarin | biochanin A results in increased expression of FBL mRNA |
increases expression
|
mRNA |
12111696
|
| C004541 | 2348 |
FOLR1
FBP FOLR |
folate receptor 1 (adult) | biochanin A results in decreased expression of FOLR1 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 2760 |
GM2A
GM2-AP SAP-3 |
GM2 ganglioside activator | biochanin A results in decreased expression of GM2A mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 2773 |
GNAI3
87U6 ARCND1 |
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | biochanin A results in decreased expression of GNAI3 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 2876 |
GPX1
GPXD GSHPX1 |
glutathione peroxidase 1 (EC:1.11.1.9) | biochanin A results in decreased expression of GPX1 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 9766 | KIAA0247 | biochanin A results in increased expression of KIAA0247 mRNA |
increases expression
|
mRNA |
12111696
|
|
| C004541 | 753 |
LDLRAD4
C18orf1 |
low density lipoprotein receptor class A domain containing 4 | biochanin A results in decreased expression of LDLRAD4 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 56925 |
LXN
ECI TCI |
latexin | biochanin A results in increased expression of LXN mRNA |
increases expression
|
mRNA |
12111696
|
| C004541 | 4323 |
MMP14
MMP-14 MMP-X1 MT-MMP MT-MMP_1 MT1-MMP MT1MMP MTMMP1 WNCHRS |
matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) | biochanin A results in decreased expression of MMP14 protein |
decreases expression
|
protein |
16598420
|
| C004541 | 4313 |
MMP2
CLG4 CLG4A MMP-II MONA TBE-1 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) | biochanin A results in decreased activity of MMP2 protein |
decreases activity
|
protein |
16598420
|
| C004541 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | biochanin A results in decreased activity of MMP9 protein |
decreases activity
|
protein |
16598420
|
| C004541 | 4502 |
MT2A
MT2 |
metallothionein 2A | biochanin A results in increased expression of MT2A mRNA |
increases expression
|
mRNA |
10656621
|
| C004541 | 4698 |
NDUFA5
B13 CI-13KD-B CI-13kB NUFM UQOR13 |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 (EC:1.6.5.3 1.6.99.3) | biochanin A results in decreased expression of NDUFA5 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 4841 |
NONO
NMT55 NRB54 P54 P54NRB |
non-POU domain containing, octamer-binding | biochanin A results in decreased expression of NONO mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | biochanin A results in increased cleavage of PARP1 protein |
increases cleavage
|
protein |
12791511
|
| C004541 | 5204 |
PFDN5
MM-1 MM1 PFD5 |
prefoldin subunit 5 | biochanin A results in decreased expression of PFDN5 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | biochanin A binds to PGR protein |
affects binding
|
protein |
14579009
|
| C004541 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | biochanin A inhibits the reaction [Progesterone binds to PGR protein] |
affects binding
/ decreases reaction |
protein |
14579009
|
| C004541 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | biochanin A results in increased expression of PGR mRNA |
increases expression
|
mRNA |
16076101
|
| C004541 | 5329 |
PLAUR
CD87 U-PAR UPAR URKR |
plasminogen activator, urokinase receptor | biochanin A results in decreased expression of PLAUR protein |
decreases expression
|
protein |
16598420
|
| C004541 | 10957 |
PNRC1
B4-2 PNAS-145 PROL2 PRR2 |
proline-rich nuclear receptor coactivator 1 | biochanin A promotes the reaction [ESRRA protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004541 | 10957 |
PNRC1
B4-2 PNAS-145 PROL2 PRR2 |
proline-rich nuclear receptor coactivator 1 | biochanin A promotes the reaction [ESRRB protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004541 | 10957 |
PNRC1
B4-2 PNAS-145 PROL2 PRR2 |
proline-rich nuclear receptor coactivator 1 | biochanin A promotes the reaction [ESRRG protein binds to PNRC1 protein] |
affects binding
/ increases reaction |
protein |
14638870
|
| C004541 | 55684 |
RABL6
C9orf86 PARF RBEL1 pp8875 |
RAB, member RAS oncogene family-like 6 | biochanin A results in decreased expression of RABL6 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | biochanin A results in decreased expression of RELA mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 55183 |
RIF1
|
RAP1 interacting factor homolog (yeast) | biochanin A results in decreased expression of RIF1 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 285367 |
RPUSD3
|
RNA pseudouridylate synthase domain containing 3 | biochanin A results in decreased expression of RPUSD3 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 6455 |
SH3GL1
CNSA1 EEN SH3D2B SH3P8 |
SH3-domain GRB2-like 1 | biochanin A results in increased expression of SH3GL1 mRNA |
increases expression
|
mRNA |
12111696
|
| C004541 | 5250 |
SLC25A3
PHC PTP |
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | biochanin A results in decreased expression of SLC25A3 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 6426 |
SRSF1
ASF SF2 SF2p33 SFRS1 SRp30a |
serine/arginine-rich splicing factor 1 | biochanin A results in decreased expression of SRSF1 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 84222 |
TMEM191A
TMEM191AP |
transmembrane protein 191A (pseudogene) | biochanin A results in decreased expression of TMEM191A mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 27242 |
TNFRSF21
BM-018 CD358 DR6 |
tumor necrosis factor receptor superfamily, member 21 | biochanin A results in decreased expression of TNFRSF21 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 203068 |
TUBB
M40 OK/SW-cl.56 TUBB1 TUBB5 |
tubulin, beta class I | biochanin A results in increased expression of TUBB mRNA |
increases expression
|
mRNA |
12111696
|
| C004541 | 7322 |
UBE2D2
E2(17)KB2 PUBC1 UBC4 UBC4/5 UBCH5B |
ubiquitin-conjugating enzyme E2D 2 (EC:6.3.2.19) | biochanin A results in decreased expression of UBE2D2 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | UGT1A1 protein results in increased glucuronidation of biochanin A |
increases glucuronidation
|
protein |
14557274
|
| C004541 | 54575 |
UGT1A10
UDPGT UGT-1J UGT1-10 UGT1.10 UGT1J |
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) | UGT1A10 protein results in increased glucuronidation of biochanin A |
increases glucuronidation
|
protein |
14557274
|
| C004541 | 54577 |
UGT1A7
UDPGT UDPGT_1-7 UGT-1G UGT1-07 UGT1.7 UGT1G |
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) | UGT1A7 protein results in increased glucuronidation of biochanin A |
increases glucuronidation
|
protein |
14557274
|
| C004541 | 54576 |
UGT1A8
UDPGT UDPGT_1-8 UGT-1H UGT1-08 UGT1.8 UGT1A8S UGT1H |
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) | UGT1A8 protein results in increased glucuronidation of biochanin A |
increases glucuronidation
|
protein |
14557274
|
| C004541 | 54600 |
UGT1A9
HLUGP4 LUGP4 UDPGT UDPGT_1-9 UGT-1I UGT1-09 UGT1-9 UGT1.9 UGT1AI UGT1I |
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) | UGT1A9 protein results in increased glucuronidation of biochanin A |
increases glucuronidation
|
protein |
14557274
|
| C004541 | 54663 |
WDR74
|
WD repeat domain 74 | biochanin A results in decreased expression of WDR74 mRNA |
decreases expression
|
mRNA |
12111696
|
| C004541 | 80014 |
WWC2
BOMB |
WW and C2 domain containing 2 | biochanin A results in decreased expression of WWC2 mRNA |
decreases expression
|
mRNA |
12111696
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (65)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P00533
P04637 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
KEGG DISEASE (83)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|