Lupinus albus

• Index
• Plant Species
• Metabolite list (70)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Lupinus albus
Genus	Lupinus
Family	Fabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Lupinus albus
Linked NCBI taxonomy ID	3870
Linked level	species

Family

Family in NCBI taxonomy	Fabaceae
ID	3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (70)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00002528	Genistin / Genistoside / Genistein 7-O-glucoside / Genistein 7-O-beta-glucopyranoside	CHEMBL486625 CHEMBL1364260	C040641	15 / 32 / 53	6 / 2	No. 2	No. 15
C00010110	Genistein 7-O-glucoside-6''-malonate / Genistein 7-O-beta-D-glucoside 6''-O-malonate					No. 2	No. 15
C00019699	2'-Hydroxygenistein 7-O-glucoside / 5,7,2',4'-Tetrahydroxyisoflavone 7-O-glucoside					No. 2	No. 15
C00019704	2'-Hydroxygenistein 7-O-(6''-malonylglucoside) / 5,7,2',4'-Tetrahydroxyisoflavone 7-O-(6''-malonylglucoside)					No. 2	No. 15
C00019700	2'-Hydroxygenistein 4'-O-glucoside / 5,7,2',4'-Tetrahydroxyisoflavone 4'-O-glucoside					No. 2	No. 15
C00010105	Sophoricoside / Genistein 4'-O-glucoside	CHEMBL486626		3 / 0 / 0		No. 2	No. 15
C00010063	Lupinalbin A	CHEMBL312186		2 / 1 / 1		No. 3	No. 15
C00002510	Olmelin / Pratensol / Biochanin A / Genistein 4'-methyl ether / 5,7-Dihydroxy-4'-methoxyisoflavone	CHEMBL131921	C004541	51 / 65 / 83	64 / 2	No. 3	No. 15
C00010068	Lupinalbin F					No. 14	No. 15
C00009936	2'-Hydroxyisolupalbigenin / 5,7,2',4'-Tetrahydroxy-8,3'-diprenylisoflavone					No. 14	No. 15
C00009925	Lupinisol A					No. 14	No. 15
C00009926	Lupinisol B					No. 14	No. 15
C00009916	Lupinisol C					No. 14	No. 15
C00010066	Lupinalbin B					No. 15	No. 15
C00002542	Licoisoflavone A					No. 15	No. 15
C00002545	Luteone / Luteone(isoflavone)	CHEMBL549617				No. 15	No. 15
C00002586	Wighteone / Erythrinin B / 5,7,4'-Trihydroxy-6-prenylisoflavone	CHEMBL393222		2 / 1 / 1		No. 15	No. 15
C00020646	Lupisoflavone					No. 15	No. 15
C00010064	Lupinalbin D					No. 15	No. 15
C00020643	Lupinalbin G					No. 15	No. 15
C00009919	Angustone B / 5,7,2'-Trihydroxy-6-prenyl-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone					No. 18	No. 15
C00009915	Isochandalone / 5,7-Dihydroxy-6-prenyl-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone	CHEMBL460441				No. 18	No. 15
C00009929	Angustone C / 5,2',4'-Trihydroxy-3'-prenyl-6'',6''-dimethylpyrano[2'',3'':7,6]isoflavone					No. 18	No. 15
C00009934	Lupinisoflavone K					No. 18	No. 15
C00009930	Lupinisoflavone L					No. 18	No. 15
C00019719	Lupinol A / (2S,3S)-3,5,7,4'-Tetrahydroxy-6,3'-diprenylcoumaranochroman-5-one					No. 19	No. 14
C00019720	Lupinol B / (2S,3S)-5,7,4'-Trihydroxy-3-methoxy-6,3'-diprenylcoumaranochroman-4-one					No. 19	No. 14
C00009497	Licoisoflavone B	CHEMBL463741				No. 24	No. 15
C00009873	Isoderrone / 5,7-Dihydroxy-6'',6''-dimethylpyrano[2'',3'':4',3']isoflavone					No. 24	No. 15
C00009874	Sophoraisoflavone A / Allolicoisoflavone B					No. 24	No. 15
C00000004	GA4 / Gibberellin A4					No. 40	No. 41
C00000003	GA3 / Gibberellin A3	CHEMBL513241 CHEMBL566653 CHEMBL1232952 CHEMBL1476967 CHEMBL1487394	C007842	10 / 18 / 17		No. 40	No. 41
C00000082	GA82 / Gibberellin A82					No. 40	No. 41
C00000001	GA1 / Gibberellin A1		C422660			No. 40	No. 41
C00009917	Lupinisolone C					No. 47	No. 15
C00009920	Lupinisolone B					No. 47	No. 15
C00009921	Lupinisoflavone I					No. 47	No. 15
C00009932	Lupinisoflavone G					No. 47	No. 15
C00009933	Lupinisoflavone H					No. 47	No. 15
C00009931	Lupinisolone A					No. 47	No. 15
C00009918	Lupinisoflavone J					No. 47	No. 15
C00007692	17-Oxosparteine	CHEMBL509343	C035707			No. 85	No. 3
C00014703	Lupinalbisone A					No. 88
C00009832	Lupinisoflavone C					No. 139
C00009838	Lupinisoflavone B					No. 139
C00010065	Lupinalbin E					No. 139
C00009833	Lupinisoflavone D	CHEMBL263445				No. 139
C00010067	Lupinalbin C					No. 139
C00000043	GA43 / Gibberellin A43					No. 187	No. 41
C00000083	GA83 / Gibberellin A83					No. 187	No. 41
C00019703	Iicoisoflavone A 4'-O-glucoside / 5,7,2',4'-Tetrahydroxy-3'-prenylisoflavone 4'-O-glucoside					No. 371
C00019701	Iuteone 7-O-glucoside / 5,7,2',4'-Tetrahydroxy-6-prenylisoflavone 7-O-glucoside					No. 371
C00019702	Iicoisoflavone A 7-O-glucoside / 5,7,2',4'-Tetrahydroxy-3'-prenylisoflavone 7-O-glucoside					No. 371
C00002207	Anagyrine / (-)-Anagyrine	CHEMBL203399 CHEMBL509692 CHEMBL1324708 CHEMBL1454284	C012736	7 / 8 / 11		No. 384	No. 3
C00002228	Multiflorine / (-)-Multiflorine	CHEMBL517095				No. 424	No. 3
C00002219	5,6-Dehydrolupanine					No. 555	No. 3
C00000218	Jasmonic acid / trans-Jasmonic acid / 3-Oxo-2-(2Z-pentenyl)cyclotentylacetic acid	CHEMBL445499 CHEMBL449572	C011006	4 / 1 / 0		No. 707	No. 70
C00009837	Lupinisoflavone A	CHEMBL332078				No. 984
C00002208	Angustifoline	CHEMBL459206	C101930			No. 1023	No. 3
C00007730	Tetrahydrorhombifoline	CHEMBL460224				No. 1023	No. 3
C00007709	13alpha-(Cinnamoyloxy)-lupanine					No. 1268	No. 3
C00025362	13alpha-Cinnamoyloxylupanine					No. 1268	No. 3
C00009928	Lupinisoflavone N					No. 2264
C00009927	Lupinisoflavone M					No. 2264
C00020645	Lupinisoflavone F	CHEMBL122095				No. 2264
C00020644	Lupinisoflavone E					No. 2264
C00007774	Lusitanine					No. 2560	No. 1
C00007754	11,12-Seco-12,13-didehydromultiflorine		C058266			No. 5313	No. 3
C00002204	Albine	CHEMBL514884				No. 5313	No. 3
C00007697	17-Oxolupanine					No. 5494

Human Protein / Gene in interactions

62 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000003 C00002207 C00002510	1 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002207 C00002510 C00010105	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000003 C00002207 C00002510	1 / 1
P03372	Estrogen receptor	NR3A1	C00002510 C00002586 C00010063	1 / 1
Q92731	Estrogen receptor beta	NR3A2	C00002510 C00002586 C00010063	0 / 1
O75496	Geminin	Unclassified protein	C00000003 C00002510 C00002528	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002207 C00002510 C00010105	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000003 C00002510 C00002528	11 / 10
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00002510 C00002528	1 / 8
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002510 C00002528	1 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002207 C00002510	1 / 2
O00255	Menin	Unclassified protein	C00002207 C00002510	2 / 5
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000003 C00002510	0 / 1
P10275	Androgen receptor	NR3C4	C00000003 C00002510	3 / 4
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002510 C00010105	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000003 C00002510	0 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00002510 C00002528	7 / 37
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002510 C00002528	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00002510 C00002528	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002510 C00002528	2 / 2
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002207 C00002510	3 / 3
Q16637	Survival motor neuron protein	Unclassified protein	C00002510 C00002528	4 / 1
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002510 C00002528	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002510 C00002528	4 / 2
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00002510	2 / 0
P40763	Signal transducer and activator of transcription 3	Transcription Factor	C00002510	1 / 2
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002510	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000003	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002510	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00002510	0 / 1
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00002510	2 / 2
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00002510	2 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002510	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000003	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000003	2 / 0
P17516	Aldo-keto reductase family 1 member C4	Enzyme	C00000218	1 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00002510	1 / 1
Q04828	Aldo-keto reductase family 1 member C1	Enzyme	C00000218	0 / 0
P16152	Carbonyl reductase [NADPH] 1	Enzyme	C00002510	0 / 0
P42330	Aldo-keto reductase family 1 member C3	Enzyme	C00000218	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00002510	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002528	0 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00002510	0 / 0
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00002510	0 / 0
P04062	Glucosylceramidase	Enzyme	C00002510	6 / 4
P52895	Aldo-keto reductase family 1 member C2	Enzyme	C00000218	1 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00002528	1 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002510	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002528	0 / 0
O75828	Carbonyl reductase [NADPH] 3	Enzyme	C00002510	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00002510	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00002510	0 / 0
P42224	Signal transducer and activator of transcription 1-alpha/beta	Unclassified protein	C00002510	3 / 3
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002528	1 / 0
P08183	Multidrug resistance protein 1	drug	C00002510	1 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00002510	0 / 0
Q00653	Nuclear factor NF-kappa-B p100 subunit	Transcription Factor	C00002510	0 / 0
Q04206	Transcription factor p65	Transcription Factor	C00002510	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00002510	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00002510	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00002510	1 / 1
P05091	Aldehyde dehydrogenase, mitochondrial	Oxidoreductase	C00002510	1 / 1

69 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
4502	MT2A, MT2	metallothionein 2A	C00002510 C00002528
5250	SLC25A3, PHC, PTP	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	C00002510
375790	AGRN	agrin	C00002510
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002510
501	ALDH7A1, ATQ1, EPD, PDE	aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)	C00002510
84159	ARID5B, DESRT, MRF-2, MRF2	AT rich interactive domain 5B (MRF1-like)	C00002510
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002510
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002510
9577	BRE, BRCC4, BRCC45	brain and reproductive organ-expressed (TNFRSF1A modulator)	C00002510
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002510
1000	CDH2, CD325, CDHN, CDw325, NCAD	cadherin 2, type 1, N-cadherin (neuronal)	C00002510
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002510
1152	CKB, B-CK, CKBB	creatine kinase, brain (EC:2.7.3.2)	C00002510
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002510
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002510
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00002510
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00002510
1594	CYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR	cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13)	C00002510
51071	DERA, DEOC	deoxyribose-phosphate aldolase (putative) (EC:4.1.2.4)	C00002510
1983	EIF5, EIF-5, EIF-5A	eukaryotic translation initiation factor 5	C00002510
59084	ENPP5	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	C00002510
2060	EPS15, AF-1P, AF1P, MLLT5	epidermal growth factor receptor pathway substrate 15	C00002510
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00002510
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00002510
2101	ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1	estrogen-related receptor alpha	C00002510
2103	ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2	estrogen-related receptor beta	C00002510
2104	ESRRG, ERR3, ERRgamma, NR3B3	estrogen-related receptor gamma	C00002510
2091	FBL, FIB, FLRN, RNU3IP1	fibrillarin	C00002510
2348	FOLR1, FBP, FOLR	folate receptor 1 (adult)	C00002510
2760	GM2A, GM2-AP, SAP-3	GM2 ganglioside activator	C00002510
2773	GNAI3, 87U6, ARCND1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	C00002510
2876	GPX1, GPXD, GSHPX1	glutathione peroxidase 1 (EC:1.11.1.9)	C00002510
9766		KIAA0247	C00002510
753	LDLRAD4, C18orf1	low density lipoprotein receptor class A domain containing 4	C00002510
56925	LXN, ECI, TCI	latexin	C00002510
4323	MMP14, MMP-14, MMP-X1, MT-MMP, MT-MMP_1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS	matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80)	C00002510
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002510
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002510
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00002510
4698	NDUFA5, B13, CI-13KD-B, CI-13kB, NUFM, UQOR13	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 (EC:1.6.5.3 1.6.99.3)	C00002510
4841	NONO, NMT55, NRB54, P54, P54NRB	non-POU domain containing, octamer-binding	C00002510
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00002510
5204	PFDN5, MM-1, MM1, PFD5	prefoldin subunit 5	C00002510
5241	PGR, NR3C3, PR	progesterone receptor	C00002510
5329	PLAUR, CD87, U-PAR, UPAR, URKR	plasminogen activator, urokinase receptor	C00002510
10957	PNRC1, B4-2, PNAS-145, PROL2, PRR2	proline-rich nuclear receptor coactivator 1	C00002510
55684	RABL6, C9orf86, PARF, RBEL1, pp8875	RAB, member RAS oncogene family-like 6	C00002510
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002510
55183	RIF1	RAP1 interacting factor homolog (yeast)	C00002510
285367	RPUSD3	RNA pseudouridylate synthase domain containing 3	C00002510
6455	SH3GL1, CNSA1, EEN, SH3D2B, SH3P8	SH3-domain GRB2-like 1	C00002510
1244	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	C00002510
6426	SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a	serine/arginine-rich splicing factor 1	C00002510
84222	TMEM191A, TMEM191AP	transmembrane protein 191A (pseudogene)	C00002510
27242	TNFRSF21, BM-018, CD358, DR6	tumor necrosis factor receptor superfamily, member 21	C00002510
203068	TUBB, M40, OK/SW-cl.56, TUBB1, TUBB5	tubulin, beta class I	C00002510
7322	UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH5B	ubiquitin-conjugating enzyme E2D 2 (EC:6.3.2.19)	C00002510
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00002510
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002510
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002510
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002510
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00002510
54663	WDR74	WD repeat domain 74	C00002510
80014	WWC2, BOMB	WW and C2 domain containing 2	C00002510
2539	G6PD, G6PD1	glucose-6-phosphate dehydrogenase (EC:1.1.1.49)	C00002528
4489	MT1A, MT1, MT1S, MTC	metallothionein 1A	C00002528
4493	MT1E, MT1, MTD	metallothionein 1E	C00002528
4501	MT1X, MT-1l, MT1	metallothionein 1X	C00002528
7779	SLC30A1, ZNT1, ZRC1	solute carrier family 30 (zinc transporter), member 1	C00002528

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions