id | C00002528 |
---|---|
Name | Genistin / Genistoside / Genistein 7-O-glucoside / Genistein 7-O-beta-glucopyranoside |
CAS RN | 529-59-9 |
Standard InChI | InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15?,18-,19+,20?,21-/m1/s1 |
Standard InChI (Main Layer) | InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2 |
Phytochemical cluster | No. 15 |
---|---|
KCF-S cluster | No. 2 |
By standard InChI | |
---|---|
By standard InChI Main Layer | CHEMBL486625 CHEMBL1364260 |
By LinkDB | C09126 |
---|
By CAS RN | C040641 |
---|
accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|---|
P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL1364260 |
CHEMBL1738132
(1)
|
7 / 44 |
Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL1364260 |
CHEMBL1613842
(1)
|
4 / 2 |
Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL1364260 |
CHEMBL1738312
(1)
|
0 / 0 |
P02545 | Prelamin-A/C | Unclassified protein | CHEMBL1364260 |
CHEMBL1614544
(1)
|
11 / 10 |
Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | CHEMBL1364260 |
CHEMBL1614166
(1)
|
1 / 0 |
P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL486625 |
CHEMBL941404
(1)
|
1 / 11 |
O75496 | Geminin | Unclassified protein | CHEMBL1364260 |
CHEMBL2114780
(1)
|
0 / 0 |
P51151 | Ras-related protein Rab-9A | Unclassified protein | CHEMBL1364260 |
CHEMBL1613838
(1)
|
0 / 0 |
P38398 | Breast cancer type 1 susceptibility protein | Enzyme | CHEMBL1364260 |
CHEMBL2114807
(1)
|
4 / 2 |
P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL1364260 |
CHEMBL1614038
(1)
|
2 / 2 |
O15118 | Niemann-Pick C1 protein | Unclassified protein | CHEMBL1364260 |
CHEMBL1614342
(1)
|
1 / 1 |
Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL1364260 |
CHEMBL1738588
(1)
CHEMBL1738317
(1)
|
0 / 0 |
Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL1364260 |
CHEMBL1738184
(1)
|
0 / 0 |
O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL1364260 |
CHEMBL2354311
(1)
|
1 / 0 |
Q13148 | TAR DNA-binding protein 43 | Unclassified protein | CHEMBL1364260 |
CHEMBL2354287
(1)
|
1 / 1 |
compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
---|---|---|---|---|---|---|---|
C040641 | 2539 |
G6PD
G6PD1 |
glucose-6-phosphate dehydrogenase (EC:1.1.1.49) | genistin analog results in increased expression of G6PD mRNA |
increases expression
|
mRNA |
16719502
|
C040641 | 4489 |
MT1A
MT1 MT1S MTC |
metallothionein 1A | genistin analog results in increased expression of MT1A mRNA |
increases expression
|
mRNA |
16719502
|
C040641 | 4493 |
MT1E
MT1 MTD |
metallothionein 1E | genistin analog results in increased expression of MT1E mRNA |
increases expression
|
mRNA |
16719502
|
C040641 | 4501 |
MT1X
MT-1l MT1 |
metallothionein 1X | genistin analog results in increased expression of MT1X mRNA |
increases expression
|
mRNA |
16719502
|
C040641 | 4502 |
MT2A
MT2 |
metallothionein 2A | genistin analog results in increased expression of MT2A mRNA |
increases expression
|
mRNA |
16719502
|
C040641 | 7779 |
SLC30A1
ZNT1 ZRC1 |
solute carrier family 30 (zinc transporter), member 1 | genistin analog results in increased expression of SLC30A1 mRNA |
increases expression
|
mRNA |
16719502
|
OMIM | preferred title | UniProt |
---|---|---|
#202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
#612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
#614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
#114480 | Breast cancer |
P38398
|
#604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
#115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
#212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
#605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
#119900 | Digital clubbing, isolated congenital |
P15428
|
#181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
#133239 | Esophageal cancer |
P04637
|
#137800 | Glioma susceptibility 1; glm1 |
O75874
|
#610140 | Heart-hand syndrome, slovenian type |
P02545
|
#176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
#259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
#151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
#151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
#211980 | Lung cancer |
P00533
P04637 |
#248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
#613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
#159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
#160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
#257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
#167000 | Ovarian cancer |
P38398
|
#614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
#260500 | Papilloma of choroid plexus; cpp |
P04637
|
#275210 | Restrictive dermopathy, lethal |
P02545
|
#253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
#253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
#253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
#271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
#275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
KEGG | disease name | UniProt |
---|---|---|
H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) |
H00018 | Gastric cancer |
P00533
(related)
P04637 (related) |
H00022 | Bladder cancer |
P00533
(related)
P04637 (related) |
H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
H00030 | Cervical cancer |
P00533
(related)
|
H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
H00663 | Restrictive dermopathy |
P02545
(related)
|
H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
H00006 | Hairy-cell leukemia |
P04637
(related)
|
H00008 | Burkitt lymphoma |
P04637
(related)
|
H00009 | Adult T-cell leukemia |
P04637
(related)
|
H00010 | Multiple myeloma |
P04637
(related)
|
H00013 | Small cell lung cancer |
P04637
(related)
|
H00014 | Non-small cell lung cancer |
P04637
(related)
|
H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
H00026 | Endometrial Cancer |
P04637
(related)
|
H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
H00029 | Vulvar cancer |
P04637
(related)
|
H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
H00032 | Thyroid cancer |
P04637
(related)
|
H00033 | Adrenal carcinoma |
P04637
(related)
|
H00036 | Osteosarcoma |
P04637
(related)
|
H00038 | Malignant melanoma |
P04637
(related)
|
H00039 | Basal cell carcinoma |
P04637
(related)
|
H00040 | Squamous cell carcinoma |
P04637
(related)
|
H00041 | Kaposi's sarcoma |
P04637
(related)
|
H00044 | Cancer of the anal canal |
P04637
(related)
|
H00046 | Cholangiocarcinoma |
P04637
(related)
|
H00047 | Gallbladder cancer |
P04637
(related)
|
H00048 | Hepatocellular carcinoma |
P04637
(related)
|
H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
H01007 | Choroid plexus papilloma |
P04637
(related)
|
H00021 | Renal cell carcinoma |
P04637
(marker)
|
H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |