Metabolite

KNApSAcK Entry

id C00002528
Name Genistin / Genistoside / Genistein 7-O-glucoside / Genistein 7-O-beta-glucopyranoside
CAS RN 529-59-9
Standard InChI InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15?,18-,19+,20?,21-/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 2

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL486625 CHEMBL1364260

KEGG

By LinkDB C09126

CTD

By CAS RN C040641

Species

Summary

Plant class

class name count
rosids 30

Family

family name count
Fabaceae 29
Moraceae 1

List (30)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Adenocarpus complicatus 49788 Fabaceae rosids Viridiplantae
Baptisia bracteata 313912 Fabaceae rosids Viridiplantae
Baptisia cinerea 313913 Fabaceae rosids Viridiplantae
Baptisia lanceolata 49796 Fabaceae rosids Viridiplantae
Baptisia lecontei 49796 Fabaceae rosids Viridiplantae
Baptisia megacarpa 49796 Fabaceae rosids Viridiplantae
Baptisia nuttalliana 49796 Fabaceae rosids Viridiplantae
Cytisus baeticus 176349 Fabaceae rosids Viridiplantae
Cytisus eriocarpus 3833 Fabaceae rosids Viridiplantae
Ficus septica 100573 Moraceae rosids Viridiplantae
Genista aetnensis 49819 Fabaceae rosids Viridiplantae
Genista depressa 49818 Fabaceae rosids Viridiplantae
Genista ephedroides 123905 Fabaceae rosids Viridiplantae
Genista tinctoria 49825 Fabaceae rosids Viridiplantae
Genista tridentata 49810 Fabaceae rosids Viridiplantae
Glycine max 3847 Fabaceae rosids Viridiplantae
Lupinus albus 3870 Fabaceae rosids Viridiplantae
Lupinus hartwegii 61077 Fabaceae rosids Viridiplantae
Lupinus luteus 3873 Fabaceae rosids Viridiplantae
Medicago truncatula 3880 Fabaceae rosids Viridiplantae
Retama sphaerocarpa 49838 Fabaceae rosids Viridiplantae
Sophora japonica 3897 Fabaceae rosids Viridiplantae
Spartium junceum 49843 Fabaceae rosids Viridiplantae
Thermopsis lanceolata 114320 Fabaceae rosids Viridiplantae
Thermopsis macrophylla 114322 Fabaceae rosids Viridiplantae
Thermopsis mollis 49852 Fabaceae rosids Viridiplantae
Thermopsis rhombifolia 61122 Fabaceae rosids Viridiplantae
Thermopsis villosa 114325 Fabaceae rosids Viridiplantae
Ulex minor 183318 Fabaceae rosids Viridiplantae
Ulex nanus 3901 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

15 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1364260 CHEMBL1738132 (1)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1364260 CHEMBL1613842 (1)
4 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1364260 CHEMBL1738312 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL1364260 CHEMBL1614544 (1)
11 / 10
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL1364260 CHEMBL1614166 (1)
1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL486625 CHEMBL941404 (1)
1 / 11
O75496 Geminin Unclassified protein CHEMBL1364260 CHEMBL2114780 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL1364260 CHEMBL1613838 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL1364260 CHEMBL2114807 (1)
4 / 2
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL1364260 CHEMBL1614038 (1)
2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL1364260 CHEMBL1614342 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1364260 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1364260 CHEMBL1738184 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1364260 CHEMBL2354311 (1)
1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL1364260 CHEMBL2354287 (1)
1 / 1

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
C040641 2539 G6PD
G6PD1
glucose-6-phosphate dehydrogenase (EC:1.1.1.49) genistin analog results in increased expression of G6PD mRNA increases expression
mRNA 16719502
C040641 4489 MT1A
MT1
MT1S
MTC
metallothionein 1A genistin analog results in increased expression of MT1A mRNA increases expression
mRNA 16719502
C040641 4493 MT1E
MT1
MTD
metallothionein 1E genistin analog results in increased expression of MT1E mRNA increases expression
mRNA 16719502
C040641 4501 MT1X
MT-1l
MT1
metallothionein 1X genistin analog results in increased expression of MT1X mRNA increases expression
mRNA 16719502
C040641 4502 MT2A
MT2
metallothionein 2A genistin analog results in increased expression of MT2A mRNA increases expression
mRNA 16719502
C040641 7779 SLC30A1
ZNT1
ZRC1
solute carrier family 30 (zinc transporter), member 1 genistin analog results in increased expression of SLC30A1 mRNA increases expression
mRNA 16719502

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637

KEGG DISEASE (53)

KEGG disease name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D005831 C040641 Genital Diseases, Female marker/mechanism
20049207
D011471 C040641 Prostatic Neoplasms therapeutic
10965018