Genista tinctoria

• Index
• Plant Species
• Natural Activity
• Metabolite list (11)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Genista tinctoria
Genus	Genista
Family	Fabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Genista tinctoria
Linked NCBI taxonomy ID	49825
Linked level	species

Family

Family in NCBI taxonomy	Fabaceae
ID	3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Natural Activity

List (12)

Species	Activity
Genista tinctoria L.	Cardiotonic
Genista tinctoria L.	Depurative
Genista tinctoria L.	Diaphoretic
Genista tinctoria L.	Diuretic
Genista tinctoria L.	Emetic
Genista tinctoria L.	Hallucinogen
Genista tinctoria L.	Hemostat
Genista tinctoria L.	Laxative
Genista tinctoria L.	Litholytic
Genista tinctoria L.	Nephrotonic
Genista tinctoria L.	Teratogenic
Genista tinctoria L.	Uterotonic

Metabolite list (11)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00002528	Genistin / Genistoside / Genistein 7-O-glucoside / Genistein 7-O-beta-glucopyranoside	CHEMBL486625 CHEMBL1364260	C040641	15 / 32 / 53	6 / 2	No. 2	No. 15
C00002525	Formononetin / 7-Hydroxy-4'-methoxyisoflavone	CHEMBL242341	C007768	24 / 36 / 58	13 / 0	No. 3	No. 15
C00000674	Luteolin	CHEMBL151	D047311	99 / 91 / 95	76 / 6	No. 71	No. 15
C00007694	alpha-Isolupanine	CHEMBL459396 CHEMBL520093 CHEMBL2008918				No. 85	No. 3
C00002234	Rhombifoline / (-)-Rhombifoline	CHEMBL1397610	C119591			No. 376	No. 3
C00002239	Tinctorine / (-)-Tinctorine					No. 384	No. 3
C00002233	Retamine					No. 424	No. 3
C00002236	Spartein / (-)-Spartein	CHEMBL412873 CHEMBL44625 CHEMBL172633 CHEMBL1328708 CHEMBL1492771 CHEMBL1740920 CHEMBL1908847 CHEMBL2010478	D013034	93 / 50 / 48	1 / 2	No. 424	No. 3
C00002219	5,6-Dehydrolupanine					No. 555	No. 3
C00007730	Tetrahydrorhombifoline	CHEMBL460224				No. 1023	No. 3
C00002014	(+)-Ammodendrine / (+)-Spherocarpine	CHEMBL464776 CHEMBL464777	C068578			No. 2560	No. 1

Human Protein / Gene in interactions

185 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000674 C00002236 C00002525	1 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000674 C00002236 C00002525	0 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000674 C00002236 C00002525	1 / 2
P04637	Cellular tumor antigen p53	Transcription Factor	C00000674 C00002525 C00002528	7 / 37
O00255	Menin	Unclassified protein	C00000674 C00002236 C00002525	2 / 5
P02545	Prelamin-A/C	Unclassified protein	C00000674 C00002236 C00002528	11 / 10
Q16637	Survival motor neuron protein	Unclassified protein	C00000674 C00002525 C00002528	4 / 1
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00000674 C00002525 C00002528	4 / 2
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000674 C00002236 C00002525	0 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000674 C00002525 C00002528	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000674 C00002236 C00002525	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000674 C00002525 C00002528	2 / 2
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000674 C00002236	0 / 3
P10636	Microtubule-associated protein tau	Unclassified protein	C00000674 C00002525	4 / 3
P22303	Acetylcholinesterase	Hydrolase	C00000674 C00002236	1 / 0
P03372	Estrogen receptor	NR3A1	C00000674 C00002236	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000674 C00002528	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00000674 C00002236	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000674 C00002525	3 / 3
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000674 C00002236	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000674 C00002236	0 / 1
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00000674 C00002525	0 / 0
P03956	Interstitial collagenase	M10A	C00000674 C00002236	0 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000674 C00002528	0 / 0
O75496	Geminin	Unclassified protein	C00000674 C00002528	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000674 C00002236	2 / 2
P00352	Retinal dehydrogenase 1	Enzyme	C00000674 C00002525	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000674 C00002236	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00002236 C00002528	1 / 8
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000674 C00002525	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00000674 C00002528	1 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00000674 C00002525	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00000674 C00002525	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000674 C00002236	1 / 1
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00002236	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00002236	1 / 2
P25021	Histamine H2 receptor	Histamine receptor	C00002236	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00002236	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00002236	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00002236	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00002236	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00002236	0 / 0
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00000674	1 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00000674	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00000674	3 / 1
P08183	Multidrug resistance protein 1	drug	C00000674	1 / 0
P49327	Fatty acid synthase	Transferase	C00000674	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00002236	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00000674	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00002236	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00002236	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000674	1 / 1
Q00535	Cyclin-dependent kinase 5	Cdk5	C00000674	0 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00000674	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00000674	1 / 2
P51570	Galactokinase	Enzyme	C00000674	1 / 1
Q9HC97	G-protein coupled receptor 35	Kynurenic acid receptor	C00000674	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000674	3 / 2
O95271	Tankyrase-1	Enzyme	C00000674	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00000674	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00000674	0 / 0
P14416	D(2) dopamine receptor	Dopamine receptor	C00002236	2 / 0
P28907	ADP-ribosyl cyclase 1	Enzyme	C00000674	0 / 1
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00002236	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00002236	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00002236	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00002236	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00002236	0 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00000674	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00002236	1 / 1
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00000674	0 / 0
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00002236	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00002236	1 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000674	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00000674	1 / 1
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00002236	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000674	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00000674	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002236	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000674	2 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00002525	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002528	0 / 0
P39900	Macrophage metalloelastase	M10A	C00000674	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00002236	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00002236	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00002236	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00002236	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00002236	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00002236	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00002236	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00002236	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00002236	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00002236	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00002236	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00002236	0 / 0
P08311	Cathepsin G	S1A	C00002236	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00002236	1 / 0
P09874	Poly [ADP-ribose] polymerase 1	Enzyme	C00000674	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00002236	0 / 0
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00002236	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00000674	1 / 1
P17252	Protein kinase C alpha type	Alpha	C00002236	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000674	0 / 0
P29466	Caspase-1	C14	C00002236	0 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00002236	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00002236	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00000674	4 / 2
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00002236	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00002236	2 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002525	5 / 3
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00002236	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00002236	1 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00000674	4 / 4
P21452	Substance-K receptor	Neurokinin receptor	C00002236	0 / 0
P06276	Cholinesterase	Hydrolase	C00000674	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00002236	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00002236	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00002236	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00000674	1 / 1
P04745	Alpha-amylase 1	Enzyme	C00000674	0 / 0
P45452	Collagenase 3	M10A	C00000674	1 / 1
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00000674	2 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00002236	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002236	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00002236	2 / 1
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000674	1 / 1
P08253	72 kDa type IV collagenase	M10A	C00000674	1 / 3
P04062	Glucosylceramidase	Enzyme	C00000674	6 / 4
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00000674	2 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00002236	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00002528	1 / 1
P06746	DNA polymerase beta	Enzyme	C00000674	0 / 0
Q9H2K2	Tankyrase-2	Enzyme	C00000674	0 / 0
O14763	Tumor necrosis factor receptor superfamily member 10B	Unclassified protein	C00000674	1 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00002236	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00002236	0 / 0
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00002236	1 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00002236	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00002236	0 / 1
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00002236	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00002236	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00002236	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00002236	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00002236	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00002236	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000674	0 / 0
P08246	Neutrophil elastase	S1A	C00002236	2 / 1
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00002236	2 / 2
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00002236	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00000674	0 / 0
Q15046	Lysine--tRNA ligase	Enzyme	C00000674	2 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00000674	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000674	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00000674	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00002236	0 / 0
P10275	Androgen receptor	NR3C4	C00000674	3 / 4
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00002236	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00002236	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00002236	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00002525	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00002236	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00002236	1 / 1
Q99700	Ataxin-2	Unclassified protein	C00000674	1 / 1
Q04760	Lactoylglutathione lyase	Enzyme	C00000674	0 / 0
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00002236	0 / 0
P08254	Stromelysin-1	M10A	C00000674	1 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000674	0 / 0
Q9NPH5	NADPH oxidase 4	Enzyme	C00000674	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000674	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000674	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000674	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002528	1 / 0
P31639	Sodium/glucose cotransporter 2	Glucose	C00002525	1 / 1
P13866	Sodium/glucose cotransporter 1	Glucose	C00002525	1 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000674	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000674	1 / 4
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00000674	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00000674	0 / 0
P06493	Cyclin-dependent kinase 1	Cdc2	C00000674	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00000674	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00000674	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00000674	0 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00002525	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00000674	2 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002528	1 / 1

90 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00000674 C00002525
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00000674 C00002525
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000674 C00002525
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00000674 C00002525
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00000674 C00002525
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00000674 C00002525
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00000674
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00002525
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002525
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002525
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002525
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002525
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00002525
2539	G6PD, G6PD1	glucose-6-phosphate dehydrogenase (EC:1.1.1.49)	C00002528
4489	MT1A, MT1, MT1S, MTC	metallothionein 1A	C00002528
4493	MT1E, MT1, MTD	metallothionein 1E	C00002528
4501	MT1X, MT-1l, MT1	metallothionein 1X	C00002528
4502	MT2A, MT2	metallothionein 2A	C00002528
7779	SLC30A1, ZNT1, ZRC1	solute carrier family 30 (zinc transporter), member 1	C00002528
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00002236
9429	ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1	ATP-binding cassette, sub-family G (WHITE), member 2	C00000674
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00000674
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000674
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00000674
581	BAX, BCL2L4	BCL2-associated X protein	C00000674
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00000674
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00000674
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00000674
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00000674
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00000674
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00000674
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00000674
847	CAT	catalase (EC:1.11.1.6)	C00000674
890	CCNA2, CCN1, CCNA	cyclin A2	C00000674
891	CCNB1, CCNB	cyclin B1	C00000674
958	CD40, Bp50, CDW40, TNFRSF5, p50	CD40 molecule, TNF receptor superfamily member 5	C00000674
972	CD74, DHLAG, HLADG, II, Ia-GAMMA	CD74 molecule, major histocompatibility complex, class II invariant chain	C00000674
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00000674
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00000674
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00000674
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00000674
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00000674
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00000674
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00000674
1577	CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3	cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1)	C00000674
1950	EGF, HOMG4, URG	epidermal growth factor	C00000674
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00000674
1958	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225	early growth response 1	C00000674
2203	FBP1, FBP	fructose-1,6-bisphosphatase 1 (EC:3.1.3.11)	C00000674
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00000674
2354	FOSB, AP-1, G0S3, GOS3, GOSB	FBJ murine osteosarcoma viral oncogene homolog B	C00000674
4616	GADD45B, GADD45BETA, MYD118	growth arrest and DNA-damage-inducible, beta	C00000674
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00000674
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00000674
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00000674
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00000674
3726	JUNB, AP-1	jun B proto-oncogene	C00000674
3727	JUND, AP-1	jun D proto-oncogene	C00000674
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00000674
5602	MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK	mitogen-activated protein kinase 10 (EC:2.7.11.24)	C00000674
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00000674
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00000674
5601	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	C00000674
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00000674
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00000674
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00000674
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00000674
2056	EPO, EP, MVCD2	erythropoietin	C00002525
9572	NR1D1, EAR1, THRA1, THRAL, ear-1, hRev	nuclear receptor subfamily 1, group D, member 1	C00000674
5347	PLK1, PLK, STPK13	polo-like kinase 1 (EC:2.7.11.21)	C00000674
8000	PSCA, PRO232	prostate stem cell antigen	C00000674
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00000674
5747	PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK	protein tyrosine kinase 2 (EC:2.7.10.2)	C00000674
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00000674
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00000674
2810	SFN, YWHAS	stratifin	C00000674
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00000674
29110	TBK1, NAK, T2K	TANK-binding kinase 1 (EC:2.7.11.1)	C00000674
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000674
7128	TNFAIP3, A20, OTUD7C, TNFA1P2	tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)	C00000674
8743	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL	tumor necrosis factor (ligand) superfamily, member 10	C00000674
9540	TP53I3, PIG3	tumor protein p53 inducible protein 3	C00000674
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00000674
7161	TP73, P73	tumor protein p73	C00000674
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00000674
10451	VAV3	vav 3 guanine nucleotide exchange factor	C00000674
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00000674
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00000674
8839	WISP2, CCN5, CT58, CTGF-L	WNT1 inducible signaling pathway protein 2	C00000674
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00000674

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