Myroxylon peruiferum

• Index
• Plant Species
• Metabolite list (9)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Myroxylon peruiferum
Genus	Myroxylon
Family	Fabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Myroxylon peruiferum
Linked NCBI taxonomy ID	1231556
Linked level	species

Family

Family in NCBI taxonomy	Fabaceae
ID	3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (9)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00002579	Texasin / 6,7-Dihydroxy-4'-methoxyisoflavone	CHEMBL239028		3 / 2 / 0		No. 3	No. 15
C00002510	Olmelin / Pratensol / Biochanin A / Genistein 4'-methyl ether / 5,7-Dihydroxy-4'-methoxyisoflavone	CHEMBL131921	C004541	51 / 65 / 83	64 / 2	No. 3	No. 15
C00002507	Castanin / Afromosin / Afrormosin / 7-Hydroxy-6,4'-dimethoxyisoflavone	CHEMBL464404	C080240	7 / 14 / 39	1 / 0	No. 35	No. 15
C00009405	Cabreuvin / 7,3',4'-Trimethoxyisoflavone	CHEMBL273891		7 / 10 / 6		No. 35	No. 15
C00009414	2'-Hydroxy-7,3',4'-trimethoxyisoflavone					No. 35	No. 15
C00002547	(-)-Medicarpin / 3-Hydroxy-9-methoxypterocarpan	CHEMBL238845 CHEMBL413297	C047353	3 / 1 / 1		No. 66	No. 15
C00009625	4-Methoxyhomopterocarpin					No. 66	No. 15
C00004579	Fisetin / 3,3',4',7-Tetrahydroxyflavone / 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one	CHEMBL31574	C017875	53 / 51 / 73	37 / 2	No. 71	No. 15
C00009546	3'-Methoxyisosativanone					No. 106	No. 14

Human Protein / Gene in interactions

88 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002510 C00002547 C00009405	1 / 1
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002507 C00002510 C00009405	4 / 2
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00002510 C00002579 C00004579	2 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002510 C00004579 C00009405	4 / 3
P04637	Cellular tumor antigen p53	Transcription Factor	C00002507 C00002510 C00004579	7 / 37
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002507 C00002510 C00009405	0 / 0
O75496	Geminin	Unclassified protein	C00002507 C00002510 C00002547	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002507 C00002510 C00009405	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002510 C00004579	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002510 C00004579	0 / 1
P02545	Prelamin-A/C	Unclassified protein	C00002510 C00004579	11 / 10
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002579 C00004579	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002510 C00004579	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00002510 C00004579	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00002510 C00004579	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002510 C00004579	2 / 2
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00002510 C00004579	2 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002510 C00004579	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002510 C00004579	3 / 3
P28482	Mitogen-activated protein kinase 1	Erk	C00002510 C00004579	0 / 0
O00255	Menin	Unclassified protein	C00002510 C00004579	2 / 5
P04150	Glucocorticoid receptor	NR3C1	C00002510 C00004579	0 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002510 C00009405	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002510 C00004579	1 / 2
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00002579 C00004579	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002510 C00004579	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00002510 C00009405	1 / 1
P10275	Androgen receptor	NR3C4	C00002510 C00004579	3 / 4
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00002510	0 / 0
P16152	Carbonyl reductase [NADPH] 1	Enzyme	C00002510	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002507	2 / 2
P68871	Hemoglobin subunit beta	Secreted protein	C00004579	4 / 4
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00004579	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00004579	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00004579	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00002510	0 / 1
P40763	Signal transducer and activator of transcription 3	Transcription Factor	C00002510	1 / 2
P11387	DNA topoisomerase 1	Isomerase	C00004579	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002510	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00002510	1 / 8
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00002510	2 / 2
P06276	Cholinesterase	Hydrolase	C00004579	0 / 0
P04745	Alpha-amylase 1	Enzyme	C00004579	0 / 0
O75828	Carbonyl reductase [NADPH] 3	Enzyme	C00002510	0 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00004579	0 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00004579	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00004579	0 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00002510	1 / 1
P08183	Multidrug resistance protein 1	drug	C00002510	1 / 0
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00004579	1 / 0
P05091	Aldehyde dehydrogenase, mitochondrial	Oxidoreductase	C00002510	1 / 1
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00004579	0 / 0
P03372	Estrogen receptor	NR3A1	C00002510	1 / 1
P22303	Acetylcholinesterase	Hydrolase	C00004579	1 / 0
Q02880	DNA topoisomerase 2-beta	Isomerase	C00004579	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00004579	1 / 1
P55210	Caspase-7	C14	C00004579	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002510	1 / 1
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00002510	0 / 0
Q92793	CREB-binding protein	Enzyme	C00004579	1 / 1
Q15046	Lysine--tRNA ligase	Enzyme	C00004579	2 / 1
P29466	Caspase-1	C14	C00004579	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00004579	5 / 1
P04062	Glucosylceramidase	Enzyme	C00002510	6 / 4
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00004579	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002547	0 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00004579	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00004579	0 / 1
Q04760	Lactoylglutathione lyase	Enzyme	C00004579	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00004579	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002510	4 / 1
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00004579	3 / 0
P42224	Signal transducer and activator of transcription 1-alpha/beta	Unclassified protein	C00002510	3 / 3
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002507	1 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00002510	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00002510	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00004579	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00004579	0 / 0
P06493	Cyclin-dependent kinase 1	Cdc2	C00004579	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00004579	0 / 0
Q00653	Nuclear factor NF-kappa-B p100 subunit	Transcription Factor	C00002510	0 / 0
Q04206	Transcription factor p65	Transcription Factor	C00002510	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00002510	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00004579	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00004579	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00002510	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00002510	1 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002510	1 / 0

91 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00002507 C00002510
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00002510 C00004579
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002510 C00004579
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002510 C00004579
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002510 C00004579
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00002510 C00004579
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002510 C00004579
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00002510 C00004579
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002510 C00004579
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002510 C00004579
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002510 C00004579
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00004579
1152	CKB, B-CK, CKBB	creatine kinase, brain (EC:2.7.3.2)	C00002510
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002510
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002510
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00002510
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00002510
1594	CYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR	cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13)	C00002510
51071	DERA, DEOC	deoxyribose-phosphate aldolase (putative) (EC:4.1.2.4)	C00002510
1983	EIF5, EIF-5, EIF-5A	eukaryotic translation initiation factor 5	C00002510
59084	ENPP5	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	C00002510
2060	EPS15, AF-1P, AF1P, MLLT5	epidermal growth factor receptor pathway substrate 15	C00002510
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00002510
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00002510
2101	ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1	estrogen-related receptor alpha	C00002510
2103	ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2	estrogen-related receptor beta	C00002510
2104	ESRRG, ERR3, ERRgamma, NR3B3	estrogen-related receptor gamma	C00002510
2091	FBL, FIB, FLRN, RNU3IP1	fibrillarin	C00002510
2348	FOLR1, FBP, FOLR	folate receptor 1 (adult)	C00002510
2760	GM2A, GM2-AP, SAP-3	GM2 ganglioside activator	C00002510
2773	GNAI3, 87U6, ARCND1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	C00002510
2876	GPX1, GPXD, GSHPX1	glutathione peroxidase 1 (EC:1.11.1.9)	C00002510
9766		KIAA0247	C00002510
753	LDLRAD4, C18orf1	low density lipoprotein receptor class A domain containing 4	C00002510
56925	LXN, ECI, TCI	latexin	C00002510
4323	MMP14, MMP-14, MMP-X1, MT-MMP, MT-MMP_1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS	matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80)	C00002510
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002510
9577	BRE, BRCC4, BRCC45	brain and reproductive organ-expressed (TNFRSF1A modulator)	C00002510
4502	MT2A, MT2	metallothionein 2A	C00002510
4698	NDUFA5, B13, CI-13KD-B, CI-13kB, NUFM, UQOR13	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 (EC:1.6.5.3 1.6.99.3)	C00002510
4841	NONO, NMT55, NRB54, P54, P54NRB	non-POU domain containing, octamer-binding	C00002510
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002510
5204	PFDN5, MM-1, MM1, PFD5	prefoldin subunit 5	C00002510
5241	PGR, NR3C3, PR	progesterone receptor	C00002510
5329	PLAUR, CD87, U-PAR, UPAR, URKR	plasminogen activator, urokinase receptor	C00002510
10957	PNRC1, B4-2, PNAS-145, PROL2, PRR2	proline-rich nuclear receptor coactivator 1	C00002510
55684	RABL6, C9orf86, PARF, RBEL1, pp8875	RAB, member RAS oncogene family-like 6	C00002510
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002510
55183	RIF1	RAP1 interacting factor homolog (yeast)	C00002510
285367	RPUSD3	RNA pseudouridylate synthase domain containing 3	C00002510
6455	SH3GL1, CNSA1, EEN, SH3D2B, SH3P8	SH3-domain GRB2-like 1	C00002510
5250	SLC25A3, PHC, PTP	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	C00002510
6426	SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a	serine/arginine-rich splicing factor 1	C00002510
84222	TMEM191A, TMEM191AP	transmembrane protein 191A (pseudogene)	C00002510
27242	TNFRSF21, BM-018, CD358, DR6	tumor necrosis factor receptor superfamily, member 21	C00002510
203068	TUBB, M40, OK/SW-cl.56, TUBB1, TUBB5	tubulin, beta class I	C00002510
7322	UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH5B	ubiquitin-conjugating enzyme E2D 2 (EC:6.3.2.19)	C00002510
84159	ARID5B, DESRT, MRF-2, MRF2	AT rich interactive domain 5B (MRF1-like)	C00002510
501	ALDH7A1, ATQ1, EPD, PDE	aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31)	C00002510
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002510
375790	AGRN	agrin	C00002510
1244	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	C00002510
54663	WDR74	WD repeat domain 74	C00002510
80014	WWC2, BOMB	WW and C2 domain containing 2	C00002510
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00004579
578	BAK1, BAK, BAK-LIKE, BCL2L7, CDN1	BCL2-antagonist/killer 1	C00004579
637	BID, FP497	BH3 interacting domain death agonist	C00004579
1000	CDH2, CD325, CDHN, CDw325, NCAD	cadherin 2, type 1, N-cadherin (neuronal)	C00002510
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00004579
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00004579
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00004579
891	CCNB1, CCNB	cyclin B1	C00004579
958	CD40, Bp50, CDW40, TNFRSF5, p50	CD40 molecule, TNF receptor superfamily member 5	C00004579
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00004579
1734	DIO2, 5DII, D2, DIOII, SelY, TXDI2	deiodinase, iodothyronine, type II (EC:1.97.1.10)	C00004579
1786	DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT	DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37)	C00004579
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00004579
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00004579
3596	IL13, IL-13, P600	interleukin 13	C00004579
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00004579
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00004579
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00004579
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00004579
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00004579
354	KLK3, APS, KLK2A1, PSA, hK3	kallikrein-related peptidase 3 (EC:3.4.21.77)	C00004579
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00004579
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00004579
4773	NFATC2, NFAT1, NFATP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	C00004579
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00004579
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00004579
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00004579

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions