Species

KNApSAcK Entry

Organism name Pericopsis mooniana
Genus Pericopsis
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pericopsis mooniana
Linked NCBI taxonomy ID 53917
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002540 External link 512 Irisolidone
/ 4'-O-Methyltectorigenin
/ 5,7-Dihydroxy-6,4'-dimethoxyisoflavone
CHEMBL265945
1 / 0 / 0 No. 3 No. 15
C00002510 External link 512 Olmelin
/ Pratensol
/ Biochanin A
/ Genistein 4'-methyl ether
/ 5,7-Dihydroxy-4'-methoxyisoflavone
CHEMBL131921
C004541
51 / 65 / 83 64 / 2 No. 3 No. 15
C00000977 External link 512 Liquiritigenin
CHEMBL252642
CHEMBL271939
C083152
5 / 4 / 4 1 / 1 No. 25 No. 14
C00002507 External link 512 Castanin
/ Afromosin
/ Afrormosin
/ 7-Hydroxy-6,4'-dimethoxyisoflavone
CHEMBL464404
C080240
7 / 14 / 39 1 / 0 No. 35 No. 15
C00009380 External link 512 Daidzein
/ 7,4'-Dihydroxyisoflavone
CHEMBL8145
C004742
60 / 68 / 76 113 / 12 No. 71 No. 15
C00009533 External link 512 Dihydrodaidzein
/ 7,4'-Dihydroxyisoflavanone
No. 106 No. 14
C00002216 External link 512 Caulophylline
/ N-Methylcytisine
/ (-)-N-Methylcytisine
CHEMBL66191
CHEMBL1085045
C034245
No. 376 No. 3
C00009794 External link 512 Angolensin
CHEMBL1373918
5 / 7 / 11 No. 1331 No. 13

Human Protein / Gene in interactions

85 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00002507 C00002510 C00009380 7 / 37
P51151 Ras-related protein Rab-9A Unclassified protein C00002507 C00002510 C00009380 0 / 0
O75496 Geminin Unclassified protein C00002507 C00002510 C00009380 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00000977 C00002510 C00009380 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002507 C00002510 C00009380 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002510 C00009380 C00009794 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002510 C00009380 C00009794 4 / 3
P05091 Aldehyde dehydrogenase, mitochondrial Oxidoreductase C00002510 C00009380 1 / 1
O00255 Menin Unclassified protein C00002510 C00009794 2 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002510 C00009380 0 / 0
P05412 Transcription factor AP-1 Transcription Factor C00000977 C00002540 0 / 0
P10275 Androgen receptor NR3C4 C00002510 C00009380 3 / 4
Q16637 Survival motor neuron protein Unclassified protein C00002510 C00009380 4 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002510 C00009380 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002510 C00009380 1 / 0
P02545 Prelamin-A/C Unclassified protein C00002510 C00009380 11 / 10
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00002510 C00009380 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002510 C00009380 1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002510 C00009794 1 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002510 C00009380 0 / 0
P03372 Estrogen receptor NR3A1 C00002510 C00009380 1 / 1
Q92731 Estrogen receptor beta NR3A2 C00002510 C00009380 0 / 1
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00002510 C00009380 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00002510 C00009380 1 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002510 C00009380 1 / 8
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002510 C00009380 2 / 2
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00002510 C00009380 2 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002510 C00009380 3 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00002510 C00009380 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002510 C00009380 1 / 1
P04150 Glucocorticoid receptor NR3C1 C00002510 C00009380 0 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein C00002510 C00009380 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00002510 C00009380 0 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00002510 C00009380 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002507 C00002510 4 / 2
Q04206 Transcription factor p65 Transcription Factor C00000977 C00002510 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002510 C00009380 0 / 1
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002510 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002510 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00009380 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00009380 1 / 0
P16152 Carbonyl reductase [NADPH] 1 Enzyme C00002510 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00009794 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002510 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00002507 2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00009380 5 / 3
P04745 Alpha-amylase 1 Enzyme C00009380 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002510 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002510 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00009380 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00009380 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00009380 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00002510 1 / 1
P11387 DNA topoisomerase 1 Isomerase C00009380 0 / 0
P54132 Bloom syndrome protein Enzyme C00009380 1 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00009380 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00009380 0 / 0
O75828 Carbonyl reductase [NADPH] 3 Enzyme C00002510 0 / 0
P08183 Multidrug resistance protein 1 drug C00002510 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00009380 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00002510 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00009380 3 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00009380 1 / 1
P14780 Matrix metalloproteinase-9 M10A C00000977 2 / 2
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00009380 0 / 0
P04062 Glucosylceramidase Enzyme C00002510 6 / 4
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00009380 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00009380 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00009380 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00009380 2 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00009380 0 / 0
Q99700 Ataxin-2 Unclassified protein C00009380 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002510 0 / 0
P40225 Thrombopoietin Unclassified protein C00009380 1 / 1
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002510 3 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00009380 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00009380 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002507 1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00009380 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00009380 1 / 0
Q00653 Nuclear factor NF-kappa-B p100 subunit Transcription Factor C00002510 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000977 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00009380 3 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00009380 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002510 1 / 1

154 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00002507 C00002510 C00009380
1152 CKB, B-CK, CKBB creatine kinase, brain (EC:2.7.3.2) C00002510 C00009380
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002510 C00009380
196 AHR, bHLHe76 aryl hydrocarbon receptor C00002510 C00009380
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002510 C00009380
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002510 C00009380
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002510 C00009380
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00002510 C00009380
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00002510 C00009380
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002510 C00009380
10957 PNRC1, B4-2, PNAS-145, PROL2, PRR2 proline-rich nuclear receptor coactivator 1 C00002510 C00009380
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002510 C00009380
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002510 C00009380
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002510 C00009380
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002510 C00009380
5241 PGR, NR3C3, PR progesterone receptor C00002510 C00009380
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002510 C00009380
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00002510 C00009380
4502 MT2A, MT2 metallothionein 2A C00002510 C00009380
2104 ESRRG, ERR3, ERRgamma, NR3B3 estrogen-related receptor gamma C00002510 C00009380
2103 ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2 estrogen-related receptor beta C00002510 C00009380
2101 ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1 estrogen-related receptor alpha C00002510 C00009380
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00002510 C00009380
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00002510 C00009380
4199 ME1, HUMNDME, MES malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) C00009380
59084 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) C00002510
1983 EIF5, EIF-5, EIF-5A eukaryotic translation initiation factor 5 C00002510
2091 FBL, FIB, FLRN, RNU3IP1 fibrillarin C00002510
2348 FOLR1, FBP, FOLR folate receptor 1 (adult) C00002510
2760 GM2A, GM2-AP, SAP-3 GM2 ganglioside activator C00002510
2773 GNAI3, 87U6, ARCND1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 C00002510
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00002510
9766 KIAA0247 C00002510
753 LDLRAD4, C18orf1 low density lipoprotein receptor class A domain containing 4 C00002510
56925 LXN, ECI, TCI latexin C00002510
4323 MMP14, MMP-14, MMP-X1, MT-MMP, MT-MMP_1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS matrix metallopeptidase 14 (membrane-inserted) (EC:3.4.24.80) C00002510
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002510
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00002510
51071 DERA, DEOC deoxyribose-phosphate aldolase (putative) (EC:4.1.2.4) C00002510
4698 NDUFA5, B13, CI-13KD-B, CI-13kB, NUFM, UQOR13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 (EC:1.6.5.3 1.6.99.3) C00002510
4841 NONO, NMT55, NRB54, P54, P54NRB non-POU domain containing, octamer-binding C00002510
1594 CYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) C00002510
5204 PFDN5, MM-1, MM1, PFD5 prefoldin subunit 5 C00002510
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00002510
5329 PLAUR, CD87, U-PAR, UPAR, URKR plasminogen activator, urokinase receptor C00002510
1000 CDH2, CD325, CDHN, CDw325, NCAD cadherin 2, type 1, N-cadherin (neuronal) C00002510
55684 RABL6, C9orf86, PARF, RBEL1, pp8875 RAB, member RAS oncogene family-like 6 C00002510
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002510
55183 RIF1 RAP1 interacting factor homolog (yeast) C00002510
285367 RPUSD3 RNA pseudouridylate synthase domain containing 3 C00002510
6455 SH3GL1, CNSA1, EEN, SH3D2B, SH3P8 SH3-domain GRB2-like 1 C00002510
5250 SLC25A3, PHC, PTP solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 C00002510
6426 SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a serine/arginine-rich splicing factor 1 C00002510
84222 TMEM191A, TMEM191AP transmembrane protein 191A (pseudogene) C00002510
27242 TNFRSF21, BM-018, CD358, DR6 tumor necrosis factor receptor superfamily, member 21 C00002510
203068 TUBB, M40, OK/SW-cl.56, TUBB1, TUBB5 tubulin, beta class I C00002510
7322 UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH5B ubiquitin-conjugating enzyme E2D 2 (EC:6.3.2.19) C00002510
9577 BRE, BRCC4, BRCC45 brain and reproductive organ-expressed (TNFRSF1A modulator) C00002510
84159 ARID5B, DESRT, MRF-2, MRF2 AT rich interactive domain 5B (MRF1-like) C00002510
501 ALDH7A1, ATQ1, EPD, PDE aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31) C00002510
375790 AGRN agrin C00002510
1244 ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 C00002510
54663 WDR74 WD repeat domain 74 C00002510
80014 WWC2, BOMB WW and C2 domain containing 2 C00002510
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00009380
10257 ABCC4, EST170205, MOAT-B, MOATB, MRP4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 C00009380
10057 ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 C00009380
119 ADD2, ADDB adducin 2 (beta) C00009380
249 ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) C00009380
251 ALPPL2, ALPG, ALPPL, GCAP alkaline phosphatase, placental-like 2 (EC:3.1.3.1) C00009380
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00009380
396 ARHGDIA, GDIA1, NPHS8, RHOGDI, RHOGDI-1 Rho GDP dissociation inhibitor (GDI) alpha C00009380
23545 ATP6V0A2, A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS ATPase, H+ transporting, lysosomal V0 subunit a2 (EC:3.6.3.6) C00009380
11177 BAZ1A, ACF1, WALp1, WCRF180, hACF1 bromodomain adjacent to zinc finger domain, 1A C00009380
632 BGLAP, BGP, OC, OCN bone gamma-carboxyglutamate (gla) protein C00009380
672 BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53 breast cancer 1, early onset C00009380
103993 C00009380
890 CCNA2, CCN1, CCNA cyclin A2 C00009380
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00009380
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00009380
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00009380
1103 CHAT, CHOACTASE, CMS1A, CMS1A2 choline O-acetyltransferase (EC:2.3.1.6) C00009380
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00009380
9167 COX7A2L, COX7AR, COX7RP, EB1, SIG81 cytochrome c oxidase subunit VIIa polypeptide 2 like C00009380
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00009380
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00009380
6387 CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B chemokine (C-X-C motif) ligand 12 C00009380
1589 CYP21A2, CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) C00009380
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00009380
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00009380
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00009380
1795 DOCK3, MOCA, PBP dedicator of cytokinesis 3 C00009380
1846 DUSP4, HVH2, MKP-2, MKP2, TYP dual specificity phosphatase 4 (EC:3.1.3.16 3.1.3.48) C00009380
9166 EBAG9, EB9, PDAF estrogen receptor binding site associated, antigen, 9 C00009380
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00009380
2027 ENO3, GSD13, MSE enolase 3 (beta, muscle) (EC:4.2.1.11) C00009380
2041 EPHA1, EPH, EPHT, EPHT1 EPH receptor A1 (EC:2.7.10.1) C00009380
83715 ESPN, DFNB36 espin C00009380
56776 FMN2 formin 2 C00009380
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00009380
9687 GREB1 growth regulation by estrogen in breast cancer 1 C00009380
3284 HSD3B2, HSD3B, HSDB, SDR11E2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) C00009380
7866 IFRD2, IFNRP, SKMc15, SM15 interferon-related developmental regulator 2 C00009380
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00009380
3487 IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4 insulin-like growth factor binding protein 4 C00009380
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00009380
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00009380
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00009380
26145 IRF2BP1 interferon regulatory factor 2 binding protein 1 C00009380
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00009380
26251 KCNG2, KCNF2, KV6.2 potassium voltage-gated channel, subfamily G, member 2 C00009380
354 KLK3, APS, KLK2A1, PSA, hK3 kallikrein-related peptidase 3 (EC:3.4.21.77) C00009380
27074 LAMP3, CD208, DC_LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403 lysosomal-associated membrane protein 3 C00009380
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00009380
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00009380
2060 EPS15, AF-1P, AF1P, MLLT5 epidermal growth factor receptor pathway substrate 15 C00002510
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00009380
10499 NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75 nuclear receptor coactivator 2 C00009380
4824 NKX3-1, BAPX2, NKX3, NKX3.1, NKX3A NK3 homeobox 1 C00009380
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00009380
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00009380
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00009380
8204 NRIP1, RIP140 nuclear receptor interacting protein 1 C00009380
56944 OLFML3, HNOEL-iso, OLF44 olfactomedin-like 3 C00009380
5111 PCNA proliferating cell nuclear antigen C00009380
64236 PDLIM2, MYSTIQUE, SLIM PDZ and LIM domain 2 (mystique) C00009380
5174 PDZK1, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1 PDZ domain containing 1 C00009380
5411 PNN, DRS, DRSP, SDK3, memA pinin, desmosome associated protein C00009380
5458 POU4F2, BRN3.2, BRN3B, Brn-3b POU class 4 homeobox 2 C00009380
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC:2.7.10.2 2.7.11.13) C00009380
11098 PRSS23, SIG13, SPUVE, ZSIG13 protease, serine, 23 C00009380
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00009380
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00009380
5932 RBBP8, COM1, CTIP, JWDS, RIM, SAE2, SCKL2 retinoblastoma binding protein 8 C00009380
6197 RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1) C00009380
81537 SGPP1, SPPase1 sphingosine-1-phosphate phosphatase 1 C00009380
6558 SLC12A2, BSC, BSC2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 C00009380
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00009380
8140 SLC7A5, 4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1 solute carrier family 7 (amino acid transporter light chain, L system), member 5 C00009380
6781 STC1, STC stanniocalcin 1 C00009380
27347 STK39, DCHT, PASK, SPAK serine threonine kinase 39 (EC:2.7.11.1) C00009380
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00009380
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00009380
6870 TACR3, HH11, NK-3R, NK3R, NKR, TAC3RL tachykinin receptor 3 C00009380
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00009380
7041 TGFB1I1, ARA55, HIC-5, HIC5, TSC-5 transforming growth factor beta 1 induced transcript 1 C00009380
7130 TNFAIP6, TSG-6, TSG6 tumor necrosis factor, alpha-induced protein 6 C00009380
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00009380
9537 TP53I11, PIG11 tumor protein p53 inducible protein 11 C00009380
7164 TPD52L1, D53, hD53 tumor protein D52-like 1 C00009380
7345 UCHL1, NDGOA, PARK5, PGP_9.5, PGP9.5, PGP95, Uch-L1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12) C00009380
7367 UGT2B17, BMND12, UDPGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 (EC:2.4.1.17) C00009380
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00009380
1831 TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP TSC22 domain family, member 3 C00000977

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (93)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#610251 Alcohol sensitivity, acute P05091
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#209950 Atypical mycobacteriosis, familial P42224
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
#218800 Crigler-najjar syndrome, type i P22310
#606785 Crigler-najjar syndrome, type ii P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22310
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989

KEGG DISEASE (94)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H01071 Acute alcohol sensitivity P05091 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

15 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D005909 Glioblastoma C00002510
D011471 Prostatic Neoplasms C00002510
D000230 Adenocarcinoma C00009380
D000647 Amnesia C00009380
D002318 Cardiovascular Diseases C00009380
D003924 Diabetes Mellitus, Type 2 C00009380
D004487 Edema C00009380
D016889 Endometrial Neoplasms C00009380
D007172 Erectile Dysfunction C00009380
D006965 Hyperplasia C00009380
D006973 Hypertension C00009380
D017254 Leukemic Infiltration C00009380
D008569 Memory Disorders C00009380
D014693 Ventricular Fibrillation C00009380
D009120 Muscle Cramp C00000977