KCF-S cluster No. 4178 (3 metabolites)
Corresponding Phytochemical cluster No. 38
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 3 |
| rosids | 2 |
| Spermatophyta | 1 |
Cumulative family count
| class name | count |
|---|---|
| Enterobacteriaceae | 7 |
| Rhodobacteraceae | 4 |
| Streptomycetaceae | 2 |
| Flavobacteriaceae | 2 |
| Myxococcaceae | 2 |
| Asteraceae | 2 |
| Brassicaceae | 2 |
| Nectriaceae | 1 |
| Taxaceae | 1 |
| Phaeosphaeriaceae | 1 |
| Solanaceae | 1 |
KEGG BRITE br08003
Categories (2)
| br08003 Category | # of metabolite |
|---|---|
| Farnesenes | 1 |
| Linear diterpenes | 1 |
metabolites link (3)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Farnesenes | C00448 | C00000907 |
| Linear diterpenes | C00353 | C00000908 |
| Farnesenes | C00448 | C00007268 |
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000907
|
FPP
/ Farnesyl pyrophosphate |
CHEMBL69330
CHEMBL1160056 CHEMBL1160060 |
C004808
|
5 / 0 / 0 | 11 / 1 |
|
|
C00000908
|
GGPP
/ Geranylgeranyl diphosphate / Geranylgeranyl pyrophosphate |
CHEMBL1160059
CHEMBL1160061 CHEMBL1229266 |
C002963
|
3 / 0 / 0 | 34 / 0 |
|
|
C00007268
|
Farnesyl diphosphate
/ trans,trans-Farnesyl diphosphate |
CHEMBL69330
CHEMBL1160056 CHEMBL1160060 |
5 / 0 / 0 |
|
Human Protein / Gene in interactions
5 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P53609 | Geranylgeranyl transferase type-1 subunit beta | Enzyme | C00000907 C00000908 C00007268 | 0 / 0 |
| P49354 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Enzyme | C00000907 C00000908 C00007268 | 0 / 0 |
| P49356 | Protein farnesyltransferase subunit beta | Enzyme | C00000907 C00000908 C00007268 | 0 / 0 |
| O95749 | Geranylgeranyl pyrophosphate synthase | Enzyme | C00000907 C00007268 | 0 / 0 |
| P37268 | Squalene synthase | Enzyme | C00000907 C00007268 | 0 / 0 |
35 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00000907
C00000908
|
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E |
C00000907
C00000908
|
| 387 | RHOA, ARH12, ARHA, RHO12, RHOH12 | ras homolog family member A |
C00000907
C00000908
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000907
C00000908
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00000907
C00000908
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00000907
C00000908
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00000907
C00000908
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00000907
C00000908
|
| 3265 | HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 | Harvey rat sarcoma viral oncogene homolog |
C00000907
C00000908
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00000907
C00000908
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00000908
|
| 2152 | F3, CD142, TF, TFA | coagulation factor III (thromboplastin, tissue factor) |
C00000908
|
| 1490 | CTGF, CCN2, HCS24, IGFBP8, NOV2 | connective tissue growth factor |
C00000908
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00000908
|
| 1401 | CRP, PTX1 | C-reactive protein, pentraxin-related |
C00000908
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00000908
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00000908
|
| 9453 | GGPS1, GGPPS, GGPPS1 | geranylgeranyl diphosphate synthase 1 (EC:2.5.1.1 2.5.1.10 2.5.1.29) |
C00000908
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00000908
|
| 4312 | MMP1, CLG, CLGN | matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) |
C00000908
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00000908
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00000908
|
| 8013 | NR4A3, CHN, CSMF, MINOR, NOR1, TEC | nuclear receptor subfamily 4, group A, member 3 |
C00000908
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00000908
|
| 5155 | PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis | platelet-derived growth factor beta polypeptide |
C00000908
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00000908
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00000908
|
| 56729 | RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1 | resistin |
C00000908
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000908
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000908
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00000908
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000908
|
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 |
C00000908
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00000908
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00000907
|