PCIDB

KNApSAcK Metabolite C00000907

Metabolite

KNApSAcK Entry

id C00000907
Name FPP / Farnesyl pyrophosphate
CAS RN 13058-04-3
Standard InChI InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
Standard InChI (Main Layer) InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)

Cluster

Phytochemical cluster No. 38
KCF-S cluster No. 4178

Link

ChEMBL

By standard InChI CHEMBL69330
By standard InChI Main Layer CHEMBL69330 CHEMBL1160056 CHEMBL1160060

KEGG

By LinkDB C00448

CTD

By CAS RN C004808

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P37268 Squalene synthase Enzyme CHEMBL69330 CHEMBL952871 (2)
0 / 0
O95749 Geranylgeranyl pyrophosphate synthase Enzyme CHEMBL69330 CHEMBL938428 (1)
0 / 0
P49356 Protein farnesyltransferase subunit beta Enzyme CHEMBL69330 CHEMBL1160056 CHEMBL1160060 CHEMBL678612 (1) CHEMBL681816 (2)
CHEMBL680107 (2) CHEMBL827231 (1)
CHEMBL829318 (1) CHEMBL828657 (1)
0 / 0
P49354 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Enzyme CHEMBL69330 CHEMBL1160056 CHEMBL1160060 CHEMBL678612 (1) CHEMBL681816 (2)
CHEMBL680107 (2) CHEMBL680223 (2)
CHEMBL827231 (1) CHEMBL829318 (1)
CHEMBL828657 (1)
0 / 0
P53609 Geranylgeranyl transferase type-1 subunit beta Enzyme CHEMBL1160056 CHEMBL1160060 CHEMBL680223 (2)
0 / 0

CTD interaction (15)

compound gene gene name gene description interaction interaction type form reference
pmid
C004808 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] decreases expression
/ decreases reaction
protein 17472962
C004808 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 18766339
C004808 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA] decreases expression
/ decreases reaction
mRNA 16005304
C004808 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate decreases abundance
/ decreases activity
protein 17208200
C004808 3265 HRAS
C-BAS/HAS
C-H-RAS
C-HA-RAS1
CTLO
H-RASIDX
HAMSV
HRAS1
K-RAS
N-RAS
RASH1
Harvey rat sarcoma viral oncogene homolog farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]] decreases reaction
/ increases activity
protein 18625914
C004808 3265 HRAS
C-BAS/HAS
C-H-RAS
C-HA-RAS1
CTLO
H-RASIDX
HAMSV
HRAS1
K-RAS
N-RAS
RASH1
Harvey rat sarcoma viral oncogene homolog farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]] decreases reaction
/ increases localization
protein 18625914
C004808 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10946302
C004808 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10946302
C004808 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10946302
C004808 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] decreases reaction
/ increases expression
mRNA 15690306
C004808 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] decreases reaction
/ increases expression
mRNA 14500290
C004808 5879 RAC1
Rac-1
TC-25
p21-Rac1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]] decreases reaction
/ increases activity
protein 18625914
C004808 5879 RAC1
Rac-1
TC-25
p21-Rac1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]] decreases reaction
/ increases localization
protein 18625914
C004808 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]] decreases activity
/ decreases reaction
protein 18625914
C004808 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10946302

Related Disease

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D010146 C004808 Pain marker/mechanism
21353389