Rhodobacter sphaeroides

• Index
• Plant Species
• Metabolite list (20)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Rhodobacter sphaeroides
Genus	Rhodobacter
Family	Rhodobacteraceae
Kingdom

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Rhodobacter sphaeroides
Linked NCBI taxonomy ID	1063
Linked level	species

Family

Family in NCBI taxonomy	Rhodobacteraceae
ID	31989

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Bacteria
ID	2

Plant class

Plant class
ID

Metabolite list (20)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00000923	Demethylspheroidene					No. 97	No. 59
C00000924	Demethylspheroidenone					No. 97	No. 59
C00000906	7,8,11,12-Tetrahydrolycopene					No. 97	No. 59
C00000927	Chloroxanthin / Hydroxyneurosporene					No. 97	No. 59
C00000930	Spheroidene		C005637			No. 97	No. 59
C00000928	Methoxyneurosporene / 3,4-Dihydrospheroidene					No. 97	No. 59
C00000914	Spheroidenone		C104880			No. 97	No. 59
C00000912	Neurosporene		C008604			No. 97	No. 59
C00000913	Phytofluene					No. 97	No. 59
C00000911	Lycopene / all-trans-Lycopene	CHEMBL501174 CHEMBL1984187	C015329	6 / 13 / 13	84 / 13	No. 97	No. 59
C00022901	3',4',7',8'-Tetrahydrospirilloxanthin / 3,4-Didehydro-1,1',2,2',7',8'-hexahydro-1,1'-dimethoxy-psi,psi-carotene					No. 402
C00022902	Hydroxyspheroidene / 3,4-Didehydro-1,1',2,2',7',8'-hexahydro-1'-hydroxy-1-methoxy-psi,psi-carotene		C005638			No. 402
C00023064	2,2'-Dioxospirilloxanthin / 2,2'-Diketospirilloxanthin / 3,3',4,4'-Tetradehydro-1,1',2,2'-tetrahydro-1,1'-dimethoxy-2,2'-dioxo-psi,psi-carotene					No. 402
C00000905	Phytoene / 15-cis-Phytoene / 15,15'-cis-Phytoene	CHEMBL1988265				No. 2614	No. 59
C00000846	Geranyl diphosphate / Geranyl pyrophosphate	CHEMBL41342	C015234	1 / 0 / 0	2 / 0	No. 3475	No. 34
C00000908	GGPP / Geranylgeranyl diphosphate / Geranylgeranyl pyrophosphate	CHEMBL1160059 CHEMBL1160061 CHEMBL1229266	C002963	3 / 0 / 0	34 / 0	No. 4178	No. 38
C00000907	FPP / Farnesyl pyrophosphate	CHEMBL69330 CHEMBL1160056 CHEMBL1160060	C004808	5 / 0 / 0	11 / 1	No. 4178	No. 38
C00007284	Copro'gen / Coproporphyrinogen III	CHEMBL1231891	C028026	1 / 1 / 1	1 / 0	No. 5144
C00007378	5-Aminolevulinic acid	CHEMBL18851 CHEMBL601	D000622	7 / 2 / 2	12 / 24	No. 6649
C00000910	Isopentenyl phosphate	CHEMBL342070				No. 8436

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P53609	Geranylgeranyl transferase type-1 subunit beta	Enzyme	C00000907 C00000908	0 / 0
P49354	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Enzyme	C00000907 C00000908	0 / 0
P49356	Protein farnesyltransferase subunit beta	Enzyme	C00000907 C00000908	0 / 0
O75496	Geminin	Unclassified protein	C00000911 C00007378	0 / 0
P36551	Coproporphyrinogen-III oxidase, mitochondrial	Enzyme	C00007284	1 / 1
O95749	Geranylgeranyl pyrophosphate synthase	Enzyme	C00000907	0 / 0
P24046	Gamma-aminobutyric acid receptor subunit rho-1	GABA-A rho	C00007378	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000911	2 / 3
P02545	Prelamin-A/C	Unclassified protein	C00000911	11 / 10
Q16348	Solute carrier family 15 member 2	Unclassified protein	C00007378	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000911	0 / 0
P14324	Farnesyl pyrophosphate synthase	Transferase	C00000846	0 / 0
P13716	Delta-aminolevulinic acid dehydratase	Enzyme	C00007378	1 / 1
P12955	Xaa-Pro dipeptidase	M24B	C00007378	1 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00000911	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000911	0 / 0
P46059	Solute carrier family 15 member 1	Dipeptide	C00007378	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00007378	0 / 0
P37268	Squalene synthase	Enzyme	C00000907	0 / 0

120 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3156	HMGCR, LDLCQ3	3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34)	C00000846 C00000907 C00000908
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00000907 C00000908 C00000911
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00000907 C00000908 C00000911
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00000907 C00000908 C00007378
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00000908 C00000911
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000911 C00007378
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00000911 C00007378
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00000907 C00000911
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000908 C00000911
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00000907 C00000908
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00000908 C00000911
3265	HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1	Harvey rat sarcoma viral oncogene homolog	C00000907 C00000908
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00000908 C00007378
387	RHOA, ARH12, ARHA, RHO12, RHOH12	ras homolog family member A	C00000907 C00000908
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00000907 C00000908
5879	RAC1, Rac-1, TC-25, p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	C00000907 C00000908
5444	PON1, ESA, MVCD5, PON	paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81)	C00000907 C00000908
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00000908 C00007378
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00000908 C00000911
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00000908 C00007378
5320	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2	phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4)	C00000911
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00000908
8013	NR4A3, CHN, CSMF, MINOR, NOR1, TEC	nuclear receptor subfamily 4, group A, member 3	C00000908
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00000908
5155	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis	platelet-derived growth factor beta polypeptide	C00000908
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00000908
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00000908
56729	RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1	resistin	C00000908
3552	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1	interleukin 1, alpha	C00000908
9453	GGPS1, GGPPS, GGPPS1	geranylgeranyl diphosphate synthase 1 (EC:2.5.1.1 2.5.1.10 2.5.1.29)	C00000908
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00000908
2152	F3, CD142, TF, TFA	coagulation factor III (thromboplastin, tissue factor)	C00000908
8743	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL	tumor necrosis factor (ligand) superfamily, member 10	C00000908
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00000908
1490	CTGF, CCN2, HCS24, IGFBP8, NOV2	connective tissue growth factor	C00000908
5906	RAP1A, KREV-1, KREV1, RAP1, SMGP21	RAP1A, member of RAS oncogene family	C00000846
118	ADD1, ADDA	adducin 1 (alpha)	C00000911
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00000911
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000911
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00000911
571	BACH1, BACH-1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	C00000911
8314	BAP1, HUCEP-13, UCHL2	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (EC:3.4.19.12)	C00000911
673	BRAF, B-RAF1, BRAF1, NS7, RAFB1	v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1)	C00000911
1401	CRP, PTX1	C-reactive protein, pentraxin-related	C00000908
847	CAT	catalase (EC:1.11.1.6)	C00000911
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00000911
898	CCNE1, CCNE	cyclin E1	C00000911
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00000911
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00000911
1020	CDK5, PSSALRE	cyclin-dependent kinase 5 (EC:2.7.11.22)	C00000911
1022	CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15	cyclin-dependent kinase 7 (EC:2.7.11.23 2.7.11.22)	C00000911
1025	CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK	cyclin-dependent kinase 9 (EC:2.7.11.23 2.7.11.22)	C00000911
1113	CHGA, CGA	chromogranin A (parathyroid secretory protein 1)	C00000911
1114	CHGB, SCG1	chromogranin B (secretogranin 1)	C00000911
23418	CRB1, LCA8, RP12	crumbs homolog 1 (Drosophila)	C00000911
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00000911
1643	DDB2, DDBB, UV-DDB2	damage-specific DNA binding protein 2, 48kDa	C00000911
1981	EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18	eukaryotic translation initiation factor 4 gamma, 1	C00000911
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00000911
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00000911
2176	FANCC, FA3, FAC, FACC	Fanconi anemia, complementation group C	C00000911
2188	FANCF, FAF	Fanconi anemia, complementation group F	C00000911
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00000911
2701	GJA4, CX37	gap junction protein, alpha 4, 37kDa	C00000911
2702	GJA5, ATFB11, CX40	gap junction protein, alpha 5, 40kDa	C00000911
2879	GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx	glutathione peroxidase 4 (EC:1.11.1.12)	C00000911
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00000911
3479	IGF1, IGF-I, IGF1A, IGFI	insulin-like growth factor 1 (somatomedin C)	C00000911
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00000911
3485	IGFBP2, IBP2, IGF-BP53	insulin-like growth factor binding protein 2, 36kDa	C00000911
3713	IVL	involucrin	C00000911
3716	JAK1, JAK1A, JAK1B, JTK3	Janus kinase 1 (EC:2.7.10.2)	C00000911
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00000911
3796	KIF2A, CDCBM3, HK2, KIF2	kinesin heavy chain member 2A	C00000911
3838	KPNA2, IPOA1, QIP2, RCH1, SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	C00000911
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00000911
3988	LIPA, CESD, LAL	lipase A, lysosomal acid, cholesterol esterase (EC:3.1.1.13)	C00000911
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00000911
5605	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2	mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)	C00000911
6416	MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1	mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)	C00000911
5608	MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3	mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)	C00000911
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00000911
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00000911
4247	MGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC:2.4.1.143)	C00000911
100507436	MICA, MIC-A, PERB11.1	MHC class I polypeptide-related sequence A	C00000911
4292	MLH1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1	mutL homolog 1	C00000911
4436	MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2	mutS homolog 2	C00000911
2956	MSH6, GTBP, GTMBP, HNPCC5, HSAP, p160	mutS homolog 6	C00000911
4842	NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS	nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)	C00000911
8021	NUP214, CAIN, CAN, D9S46E, N214, p250	nucleoporin 214kDa	C00000911
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00000908
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00000911
10111	RAD50, NBSLD, RAD502, hRad50	RAD50 homolog (S. cerevisiae)	C00000911
8045	RASSF7, C11orf13, HRAS1, HRC1	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	C00000911
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00000911
5962	RDX, DFNB24	radixin	C00000911
6195	RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1	ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1)	C00000911
6197	RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1)	C00000911
6241	RRM2, R2, RR2, RR2M	ribonucleotide reductase M2 (EC:1.17.4.1)	C00000911
6414	SEPP1, SELP, SeP	selenoprotein P, plasma, 1	C00000911
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00000911
8243	SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB	structural maintenance of chromosomes 1A	C00000911
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00000911
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00000911
7980	TFPI2, PP5, REF1, TFPI-2	tissue factor pathway inhibitor 2	C00000911
7039	TGFA, TFGA	transforming growth factor, alpha	C00000911
7097	TLR2, CD282, TIL4	toll-like receptor 2	C00000911
7099	TLR4, ARMD10, CD284, TLR-4, TOLL	toll-like receptor 4	C00000911
1277	COL1A1, OI4	collagen, type I, alpha 1	C00000908
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00000911
7415	VCP, ALS14, IBMPFD, IBMPFD1, TERA, p97	valosin containing protein (EC:3.6.4.6)	C00000911
7485	WRB, CHD5	tryptophan rich basic protein	C00000911
7697	ZNF138, pHZ-32	zinc finger protein 138	C00000911
1371	CPOX, CPO, CPX, HCP	coproporphyrinogen oxidase (EC:1.3.3.3)	C00007284
210	ALAD, ALADH, PBGS	aminolevulinate dehydratase (EC:4.2.1.24)	C00007378
581	BAX, BCL2L4	BCL2-associated X protein	C00007378
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00007378
8772	FADD, MORT1	Fas (TNFRSF6)-associated via death domain	C00007378
4314	MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1	matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17)	C00007378
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00007378

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions