PCIDB

KNApSAcK Metabolite C00007378

Metabolite

KNApSAcK Entry

id C00007378
Name 5-Aminolevulinic acid
CAS RN 106-60-5
Standard InChI InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
Standard InChI (Main Layer) InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)

Cluster

Phytochemical cluster
KCF-S cluster No. 6649

Link

ChEMBL

By standard InChI CHEMBL601
By standard InChI Main Layer CHEMBL18851 CHEMBL601

KEGG

By LinkDB C00430

CTD

By CAS RN D000622

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL601 CHEMBL1738312 (1)
0 / 0
P46059 Solute carrier family 15 member 1 Dipeptide CHEMBL601 CHEMBL699705 (1) CHEMBL1743153 (1)
0 / 0
Q16348 Solute carrier family 15 member 2 Unclassified protein CHEMBL601 CHEMBL1743154 (1)
0 / 0
P24046 Gamma-aminobutyric acid receptor subunit rho-1 GABA-A rho CHEMBL601 CHEMBL964514 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL601 CHEMBL2114780 (1)
0 / 0
P13716 Delta-aminolevulinic acid dehydratase Enzyme CHEMBL18851 CHEMBL601 CHEMBL858204 (4) CHEMBL636778 (4)
CHEMBL636779 (3) CHEMBL636780 (3)
CHEMBL762431 (1)
1 / 1
P12955 Xaa-Pro dipeptidase M24B CHEMBL601 CHEMBL769531 (1)
1 / 1

CTD interaction (22)

compound gene gene name gene description interaction interaction type form reference
pmid
D000622 210 ALAD
ALADH
PBGS
aminolevulinate dehydratase (EC:4.2.1.24) ALAD protein results in increased metabolism of Aminolevulinic Acid increases metabolic processing
protein 8687997
D000622 581 BAX
BCL2L4
BCL2-associated X protein Aminolevulinic Acid analog results in increased expression of BAX mRNA increases expression
mRNA 20676910
D000622 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Aminolevulinic Acid analog results in decreased expression of BCL2 mRNA decreases expression
mRNA 20676910
D000622 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Aminolevulinic Acid analog results in increased activity of CASP3 protein increases activity
protein 11281435
17245620
D000622 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Aminolevulinic Acid analog results in increased activity of CASP8 protein increases activity
protein 21138480
D000622 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP8 protein] decreases reaction
/ increases activity
protein 21138480
D000622 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Aminolevulinic Acid analog results in increased activity of CASP9 protein increases activity
protein 17245620
21138480
D000622 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 21138480
D000622 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein] decreases reaction
/ increases phosphorylation
protein 21138480
D000622 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain Aminolevulinic Acid analog results in increased phosphorylation of FADD protein increases phosphorylation
protein 21138480
D000622 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein] decreases reaction
/ increases phosphorylation
protein 21138480
D000622 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain FADD mutant form inhibits the reaction [Aminolevulinic Acid analog results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
mutant form 21138480
D000622 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Aminolevulinic Acid affects the expression of MMP1 mRNA affects expression
mRNA 12542540
D000622 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Aminolevulinic Acid affects the expression of MMP1 protein affects expression
protein 12542540
D000622 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP1 protein] affects expression
/ decreases reaction
protein 12542540
D000622 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) Aminolevulinic Acid affects the expression of MMP3 mRNA affects expression
mRNA 12542540
D000622 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) Aminolevulinic Acid affects the expression of MMP3 protein affects expression
protein 12542540
D000622 4314 MMP3
CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP3 protein] affects expression
/ decreases reaction
protein 12542540
D000622 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Aminolevulinic Acid analog results in increased cleavage of PARP1 protein increases cleavage
protein 21138480
D000622 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) FADD mutant form inhibits the reaction [Aminolevulinic Acid analog results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 21138480
D000622 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Aminolevulinic Acid analog affects the localization of RELA protein affects localization
protein 21138480
D000622 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Aminolevulinic Acid analog results in increased expression of TP53 increases expression
17311614

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#612740 Porphyria, acute hepatic P13716
#170100 Prolidase deficiency P12955

KEGG DISEASE (2)

KEGG disease name UniProt
H01119 Prolidase deficiency (PD) P12955 (related)
H00202 Hepatic porphyria P13716 (related)

Diseases related to CTD interactions

24 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001259 D000622 Ataxia marker/mechanism
750224
D002389 D000622 Catatonia marker/mechanism
750224
D017454 D000622 Dermatitis, Photoallergic marker/mechanism
18798755
D004890 D000622 Erythema marker/mechanism
19785604
21083701
D007022 D000622 Hypotension marker/mechanism
11371878
D055623 D000622 Keratosis, Actinic therapeutic
17501954
D009182 D000622 Mycosis Fungoides therapeutic
11281435
D009336 D000622 Necrosis marker/mechanism
9328146
12095508
D009369 D000622 Neoplasms marker/mechanism
11078907
D009422 D000622 Nervous System Diseases marker/mechanism
6271380
15490483
D010146 D000622 Pain marker/mechanism
17100738
17501954
18158756
19785604
19925929
21083701
D017118 D000622 Porphyria, Acute Intermittent marker/mechanism
11078907
D011164 D000622 Porphyrias marker/mechanism
8937451
18665889
D011230 D000622 Precancerous Conditions marker/mechanism
11078907
D011565 D000622 Psoriasis therapeutic
11281435
D012640 D000622 Seizures marker/mechanism
750224
15532533
D012868 D000622 Skin Abnormalities marker/mechanism
15490483
D012871 D000622 Skin Diseases therapeutic
16230562
19925929
D013610 D000622 Tachycardia marker/mechanism
11371878
D000267 D000622 Tissue Adhesions therapeutic
12095508
D020176 D000622 Tyrosinemias marker/mechanism
18665889
D001749 D000622 Urinary Bladder Neoplasms therapeutic
9252197
10886096
11371878
14678389
D056650 D000622 Vulvodynia therapeutic
17847765
D014860 D000622 Warts therapeutic
17100738