Cryptoderma citrinum
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003652
|
Ergosterol
/ Ergosta-5,7,22-trien-3beta-ol |
CHEMBL222608
CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225 |
D004875
|
12 / 14 / 11 | No. 111 | No. 11 |
|
|
|
C00023754
|
5,6-Dehydroergosterol
/ Ergosta-7,22-dien-3beta-ol / 24-Methylcholesta-7,22-dien-3beta-ol |
CHEMBL463973
CHEMBL560819 |
No. 111 | No. 11 |
|
|||
|
C00023752
|
Fungisterol
/ Ergost-7-en-3beta-ol / (24S)24-Methylcholest-7-en-3beta-ol |
No. 111 | No. 11 |
|
||||
|
C00003657
|
Lanosterol
/ Lanosta-8,24-dien-3beta-ol |
CHEMBL225111
CHEMBL465181 CHEMBL1397369 |
D007810
|
10 / 17 / 17 | 1 / 0 | No. 218 | No. 51 |
|
Human Protein / Gene in interactions
16 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11473 | Vitamin D3 receptor | NR1I1 | C00003652 C00003657 | 2 / 3 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003652 C00003657 | 4 / 3 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003652 C00003657 | 0 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003652 C00003657 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003652 C00003657 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003652 C00003657 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003652 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003652 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003652 | 1 / 0 |
| Q16850 | Lanosterol 14-alpha demethylase | Cytochrome P450 51A1 | C00003657 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003652 | 1 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003657 | 11 / 10 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003652 | 5 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003657 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003657 | 0 / 0 |
| P31939 | Bifunctional purine biosynthesis protein PURH | Enzyme | C00003652 | 1 / 1 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1593 | CYP27A1, CP27, CTX, CYP27 | cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) |
C00003657
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (25)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608688 | Aicar transformylase/imp cyclohydrolase deficiency |
P31939
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (21)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00966 | AICA-ribosiduria |
P31939
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|