Physarum polycephalum
Species
KNApSAcK Entry
| Organism name | Physarum polycephalum |
|---|---|
| Genus | Physarum |
| Family | Physaridae |
| Kingdom | Amoebozoa |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Physarum polycephalum |
|---|---|
| Linked NCBI taxonomy ID | 5791 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Physaraceae |
|---|---|
| ID | 1115744 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Eukaryota |
|---|---|
| ID | 2759 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (12)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003647
|
Campesterol
/ 24alpha-Methylcholesterol / (24R)24-Methylcholest-5-en-3beta-ol |
CHEMBL520535
CHEMBL485421 CHEMBL1836653 |
C021273
|
No. 53 | No. 11 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00003668
|
Poriferasterol
/ Stigmasta-5,22-dien-3beta-ol / (24S)24-Ethylcholesta-5,22-dien-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
5 / 0 / 0 | No. 53 | No. 11 |
|
||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023770
|
Sitosterol
/ Stigmasta-5,22-dien-3beta-ol / (24R)24-Ethylcholesta-5,22-dien-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023745
|
22-Dehydrocholesterol
/ cis-22-Dehydrocholesterol / Cholesta-5,22-dien-3beta-ol |
CHEMBL1836651
|
No. 53 | No. 11 |
|
|||
|
C00023769
|
Clionasterol
/ gamma-Sitosterol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023756
|
24-Epicampesterol
/ Ergost-5-en-3beta-ol / Dihydrobrassicasterol / 24S-Methyl cholesterol / 7,(24S)24-Methylcholest-5-en-3beta-ol |
CHEMBL520535
CHEMBL485421 CHEMBL1836653 |
No. 53 | No. 11 |
|
|||
|
C00007516
|
Ergostanol
/ Campestanol / (24S)24-Methylcholestan-3beta-ol |
C003535
|
No. 68 | No. 11 |
|
|||
|
C00003657
|
Lanosterol
/ Lanosta-8,24-dien-3beta-ol |
CHEMBL225111
CHEMBL465181 CHEMBL1397369 |
D007810
|
10 / 17 / 17 | 1 / 0 | No. 218 | No. 51 |
|
|
C00024795
|
Physarochrome A
|
No. 5760 |
|
|||||
|
C00028050
|
Chrysophysarin A
|
No. 8558 |
|
Human Protein / Gene in interactions
30 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P06746 | DNA polymerase beta | Enzyme | C00003668 C00003672 C00023769 C00023770 C00023774 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003657 C00003672 C00023769 C00023770 | 0 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 C00023769 C00023770 | 1 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 C00023769 C00023770 | 1 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 C00023769 C00023770 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 C00023769 C00023770 | 1 / 1 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 C00023769 C00023770 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 C00023769 C00023770 | 3 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 C00023769 C00023770 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 C00023769 C00023770 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 C00023769 C00023770 | 2 / 0 |
| P00734 | Prothrombin | S1A | C00003672 C00023769 C00023770 | 4 / 2 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 C00023769 C00023770 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 C00023769 C00023770 | 1 / 1 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 C00023769 C00023770 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 C00023769 C00023770 | 4 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 C00023769 C00023770 | 0 / 1 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00003668 C00023774 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00003668 C00023774 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003668 C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00003668 C00023774 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003657 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003657 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003657 | 2 / 3 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003657 | 4 / 3 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003657 | 0 / 0 |
| Q16850 | Lanosterol 14-alpha demethylase | Cytochrome P450 51A1 | C00003657 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003657 | 11 / 10 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003657 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003657 | 0 / 0 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1593 | CYP27A1, CP27, CTX, CYP27 | cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) |
C00003657
|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (36)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (28)
| KEGG | name | UniProt |
|---|---|---|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|