Organism name | Humulus lupulus |
---|---|
Genus | Humulus |
Family | Cannabaceae |
Kingdom | Plantae |
Linked NCBI taxonomy name | Humulus lupulus |
---|---|
Linked NCBI taxonomy ID | 3486 |
Linked level | species |
Family in NCBI taxonomy | Cannabaceae |
---|---|
ID | 3481 |
Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
---|---|
ID | 33090 |
Plant class | rosids |
---|---|
ID | 71275 |
KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
---|---|---|---|---|---|---|---|---|
C00005167
![]() |
Kaempferol 3-neohesperidoside
|
CHEMBL507493
|
No. 1 | No. 15 |
![]() |
|||
C00005449
![]() |
Quercetin 3-rhamnosyl-(1->2)-rhamnosyl-(1->6)-glucoside
|
No. 5 | No. 15 |
![]() |
||||
C00005211
![]() |
Kaempferol 3-rhamnosyl-(1->2)-rhamnosyl-(1->6)-glucoside
|
No. 5 | No. 15 |
![]() |
||||
C00005456
![]() |
Manghaslin
/ Quercetin 3-2G-rhamnosylrutinoside |
CHEMBL444468
|
No. 5 | No. 15 |
![]() |
|||
C00000997
![]() |
6-Prenylnaringenin
|
CHEMBL1537093
|
14 / 16 / 16 | No. 28 | No. 14 |
![]() |
||
C00008245
![]() |
8-Prenylnaringenin
/ Sophoraflavanone B / (-)-8-Prenylnaringenin |
CHEMBL376915
CHEMBL460647 |
10 / 8 / 4 | No. 28 | No. 14 |
![]() |
||
C00006956
![]() |
4,4'-Dihydroxy-2',6'-dimethoxychalcone
|
CHEMBL449907
|
No. 79 |
![]() |
||||
C00014476
![]() |
Xanthohumol C
/ 6'',6''-Dimethylpyrano[2'',3'':4',3']-4,2'-dihydroxy-6'-methoxychalcone |
CHEMBL479351
|
No. 130 |
![]() |
||||
C00007100
![]() |
4'-O-Methylxanthohumol
|
CHEMBL466335
|
No. 133 | No. 13 |
![]() |
|||
C00007099
![]() |
Xanthohumol
|
CHEMBL253896
|
6 / 0 / 1 | No. 133 | No. 13 |
![]() |
||
C00007081
![]() |
Isoxanthohumol(Helichrysum)
|
No. 133 | No. 13 |
![]() |
||||
C00014472
![]() |
Xanthohumol D
/ 3'-(2-Hydroxy-3-methylbutyl-3-enyl)-4,2',4'-trihydroxy-6'-methoxychalcone |
CHEMBL479500
|
No. 133 | No. 13 |
![]() |
|||
C00014475
![]() |
Xanthogalenol
/ 3'-Prenyl-4,2',6'-trihydroxy-4'-methoxychalcone |
CHEMBL466334
|
No. 133 | No. 13 |
![]() |
|||
C00035575
![]() |
Desmethylxanthohumol
|
CHEMBL466143
|
1 / 4 / 1 | No. 133 | No. 13 |
![]() |
||
C00003186
![]() |
beta-Selinene
|
C087920
|
No. 151 | No. 38 |
![]() |
|||
C00014474
![]() |
Xanthohumol E
/ 3'-Prenyl-6'',6''-dimethylpyrano[2'',3'':6',5']-4,2',4'-trihydroxychalcone |
No. 186 |
![]() |
|||||
C00000019
![]() |
GA19
/ Gibberellin A19 |
C120175
|
No. 187 | No. 41 |
![]() |
|||
C00014473
![]() |
5'-Prenylxanthohumol
/ 3',5'-Diprenyl-4,2',4'-trihydroxy-6-methoxychalcone |
CHEMBL471777
|
No. 190 | No. 13 |
![]() |
|||
C00014471
![]() |
3'-Geranylchalconaringenin
/ 3'-Geranyl-4,2',4',6'-tetrahydroxychalcone |
CHEMBL480722
|
No. 190 | No. 13 |
![]() |
|||
C00020051
![]() |
alpha-Cadinene
|
No. 283 | No. 39 |
![]() |
||||
C00014477
![]() |
Isodehydrocycloxanthohumol hydrate
/ 6'',6''-Dimethyl-4'',5''-dihydropyrano[2'',3'':4',3']-4,2'-dihydroxy-6'-methoxychalcone |
CHEMBL447053
|
No. 337 |
![]() |
||||
C00014478
![]() |
Xanthohumol B
/ Dehydrocycloxanthohumol hydrate / 6'',6''-Dimethyl-5''-hydroxy-4'',5''-dihydropyrano[2'',3'':4',3']-4,2'-dihydroxy-6'-methoxychalcone |
CHEMBL520430
|
No. 337 |
![]() |
||||
C00021230
![]() |
Aromadendrene
/ (+)-Aromadendrene / (+)-Aromadendr-7(15)-ene |
CHEMBL509805
CHEMBL596664 |
No. 640 |
![]() |
||||
C00000099
![]() |
2-Methylthioribosylzeatin
/ trans-Methylthioribosylzeatin / 2-Methylthioribosyl-trans-zeatin |
No. 989 |
![]() |
|||||
C00000095
![]() |
9-Ribosyl-cis-zeatin
/ 6-(4-Hydroxy-3-methyl-cis-2-butenylamino)-9-beta-D-ribofuranosylpurine |
No. 989 |
![]() |
|||||
C00000096
![]() |
9-Ribosyl-trans-zeatin
/ Zeatin-9-beta-D-ribofuranoside |
No. 989 |
![]() |
|||||
C00014615
![]() |
alpha,beta-Dihydroxanthohumol
/ 4,2',4'-Trihydroxy-6'-methoxy-3'-prenyldihydrochalcone |
CHEMBL510279
|
14 / 8 / 4 | No. 1291 |
![]() |
|||
C00003147
![]() |
Humulene
/ alpha-Caryophyllene / (+/-)-alpha-Humulene |
CHEMBL251280
|
C042686
|
No. 1421 | No. 38 |
![]() |
||
C00002709
![]() |
Tricyclodehydroisohumulone
|
No. 1473 |
![]() |
|||||
C00035519
![]() |
Adlupulone
|
No. 1763 | No. 67 |
![]() |
||||
C00035518
![]() |
Adhumulone
|
No. 1763 | No. 67 |
![]() |
||||
C00035567
![]() |
Cohumulone
|
C442487
|
No. 1763 | No. 67 |
![]() |
|||
C00002701
![]() |
Lupulone
|
CHEMBL480267
|
C008299
|
No. 1763 | No. 67 |
![]() |
||
C00002697
![]() |
Humulone
|
No. 1763 | No. 67 |
![]() |
||||
C00020070
![]() |
gamma-Calacorene
|
No. 1859 |
![]() |
|||||
C00012708
![]() |
Selina-3,7(11)-diene
|
No. 2008 |
![]() |
|||||
C00000091
![]() |
trans-Zeatin
|
CHEMBL525239
|
D015026
|
2 / 3 / 2 | 0 / 1 | No. 2879 |
![]() |
|
C00000094
![]() |
2iP
/ N6-(delta2-Isopentenyl)adenine |
CHEMBL476189
|
C001478
|
5 / 2 / 3 | 18 / 0 | No. 2879 |
![]() |
|
C00020084
![]() |
alpha-Corocalene
|
No. 3629 |
![]() |
|||||
C00012714
![]() |
Selina-4(14),7(11)-diene
/ Eudesma-4(14),7(11)-diene / (4aR-trans)-Decahydro-4a-methyl-1-methylene-7-(1-methylethylidene)naphthalene |
No. 4110 |
![]() |
|||||
C00007239
![]() |
Isopentenyl adenosine monophosphate
|
No. 4121 |
![]() |
|||||
C00001189
![]() |
Isovaleric acid
/ 3-Methylbutanoic acid |
CHEMBL568737
|
C008216
|
4 / 0 | No. 5262 |
![]() |
accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|
P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000997 C00008245 C00014615 | 0 / 0 |
O75496 | Geminin | Unclassified protein | C00000997 C00008245 C00014615 | 0 / 0 |
P28482 | Mitogen-activated protein kinase 1 | Erk | C00000997 C00007099 | 0 / 0 |
O75164 | Lysine-specific demethylase 4A | Enzyme | C00000997 C00014615 | 0 / 0 |
P10636 | Microtubule-associated protein tau | Unclassified protein | C00000997 C00014615 | 4 / 3 |
P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000997 C00014615 | 2 / 0 |
P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00014615 | 1 / 0 |
Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00008245 | 0 / 0 |
Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00000997 | 1 / 4 |
Q96LD8 | Sentrin-specific protease 8 | Enzyme | C00014615 | 0 / 0 |
P37840 | Alpha-synuclein | Unclassified protein | C00008245 | 4 / 2 |
P16473 | Thyrotropin receptor | Glycohormone receptor | C00000091 | 3 / 2 |
P42574 | Caspase-3 | C14 | C00014615 | 0 / 0 |
P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000094 | 0 / 1 |
P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000094 | 1 / 0 |
P27361 | Mitogen-activated protein kinase 3 | Erk | C00007099 | 0 / 0 |
Q9BQF6 | Sentrin-specific protease 7 | Enzyme | C00014615 | 0 / 0 |
Q9GZR1 | Sentrin-specific protease 6 | Enzyme | C00014615 | 0 / 0 |
Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000997 | 0 / 0 |
P17252 | Protein kinase C alpha type | Alpha | C00007099 | 0 / 0 |
P45984 | Mitogen-activated protein kinase 9 | Jnk | C00007099 | 0 / 0 |
Q92731 | Estrogen receptor beta | NR3A2 | C00008245 | 0 / 1 |
Q04759 | Protein kinase C theta type | Delta | C00007099 | 0 / 1 |
P04062 | Glucosylceramidase | Enzyme | C00000997 | 6 / 4 |
Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000997 | 1 / 2 |
P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000094 | 0 / 0 |
Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00008245 | 2 / 0 |
O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00008245 | 0 / 0 |
P03372 | Estrogen receptor | NR3A1 | C00008245 | 1 / 1 |
P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00035575 | 4 / 1 |
P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000094 | 1 / 1 |
P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000094 | 0 / 1 |
Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000997 | 1 / 0 |
O15530 | 3-phosphoinositide-dependent protein kinase 1 | Pdk1 | C00007099 | 0 / 0 |
P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000997 | 0 / 0 |
Q99700 | Ataxin-2 | Unclassified protein | C00014615 | 1 / 1 |
Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00014615 | 0 / 0 |
P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000091 | 0 / 0 |
Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000997 | 0 / 1 |
Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000997 | 1 / 4 |
P35372 | Mu-type opioid receptor | Opioid receptor | C00014615 | 0 / 0 |
P41143 | Delta-type opioid receptor | Opioid receptor | C00014615 | 0 / 0 |
O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00008245 | 0 / 0 |
Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00008245 | 1 / 1 |
gene | gene name | gene description | KNApSAcK metabolite in interactions |
---|---|---|---|
440 | ASNS, TS11 | asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) |
C00000094
|
694 | BTG1 | B-cell translocation gene 1, anti-proliferative |
C00000094
|
10681 | GNB5, GB5 | guanine nucleotide binding protein (G protein), beta 5 |
C00000094
|
182 | JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1 | jagged 1 |
C00000094
|
9818 | NUPL1, PRO2463 | nucleoporin like 1 |
C00000094
|
5142 | PDE4B, DPDE4, PDE4B5, PDEIVB | phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) |
C00000094
|
8544 | PIR | pirin (iron-binding nuclear protein) (EC:1.13.11.24) |
C00000094
|
5366 | PMAIP1, APR, NOXA | phorbol-12-myristate-13-acetate-induced protein 1 |
C00000094
|
9360 | PPIG, CARS-Cyp, CYP, SCAF10, SRCyp | peptidylprolyl isomerase G (cyclophilin G) (EC:5.2.1.8) |
C00000094
|
5782 | PTPN12, PTP-PEST, PTPG1 | protein tyrosine phosphatase, non-receptor type 12 (EC:3.1.3.48) |
C00000094
|
5774 | PTPN3, PTP-H1, PTPH1 | protein tyrosine phosphatase, non-receptor type 3 (EC:3.1.3.48) |
C00000094
|
6004 | RGS16, A28-RGS14, A28-RGS14P, RGS-R | regulator of G-protein signaling 16 |
C00000094
|
6016 | RIT1, NS8, RIBB, RIT, ROC1 | Ras-like without CAAX 1 |
C00000094
|
6286 | S100P, MIG9 | S100 calcium binding protein P |
C00000094
|
7029 | TFDP2, DP2 | transcription factor Dp-2 (E2F dimerization partner 2) |
C00000094
|
7127 | TNFAIP2, B94, EXOC3L3 | tumor necrosis factor, alpha-induced protein 2 |
C00000094
|
7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000094
|
7431 | VIM, CTRCT30 | vimentin |
C00000094
|
54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00001189
|
54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00001189
|
54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00001189
|
54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00001189
|
OMIM | preferred title | UniProt |
---|---|---|
#612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
#608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
#208900 | Ataxia-telangiectasia; at |
Q13315
|
#614490 | Blood group, junior system; jr |
Q9UNQ0
|
#114480 | Breast cancer |
P31749
|
#114500 | Colorectal cancer; crc |
P31749
P84022 |
#615109 | Cowden syndrome 6; cws6 |
P31749
|
#127750 | Dementia, lewy body; dlb |
P37840
|
#609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
#608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
#615363 | Estrogen resistance; estrr |
P03372
|
#600274 | Frontotemporal dementia; ftd |
P10636
|
#608013 | Gaucher disease, perinatal lethal |
P04062
|
#230800 | Gaucher disease, type i |
P04062
|
#230900 | Gaucher disease, type ii |
P04062
|
#231000 | Gaucher disease, type iii |
P04062
|
#231005 | Gaucher disease, type iiic |
P04062
|
#605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
#603373 | Hyperthyroidism, familial gestational |
P16473
|
#609152 | Hyperthyroidism, nonautoimmune |
P16473
|
#275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
#613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
#601665 | Obesity |
P32245
|
#168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
#605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
#168600 | Parkinson disease, late-onset; pd |
P04062
P37840 |
#260540 | Parkinson-dementia syndrome |
P10636
|
#172700 | Pick disease of brain |
P10636
|
#601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
#176920 | Proteus syndrome |
P31749
|
#183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
#601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
#138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
KEGG | name | UniProt |
---|---|---|
H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
H00066 | Lewy body dementia (LBD) |
P04062
(related)
P37840 (related) |
H00126 | Gaucher disease |
P04062
(related)
|
H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
H00036 | Osteosarcoma |
P08684
(marker)
|
H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
H01205 | Coumarin resistance |
P11712
(related)
|
H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
H01269 | Congenital hyperthyroidism |
P16473
(related)
|
H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
H00057 | Parkinson's disease (PD) |
P37840
(related)
|
H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
H00408 | Type I diabetes mellitus |
Q04759
(related)
|
H00005 | Chronic lymphocytic leukemia (CLL) |
Q13315
(related)
|
H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
H00094 | DNA repair defects |
Q13315
(related)
|
H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|