Humulus lupulus

• Index
• Plant Species
• Metabolite list (42)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Humulus lupulus
Genus	Humulus
Family	Cannabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Humulus lupulus
Linked NCBI taxonomy ID	3486
Linked level	species

Family

Family in NCBI taxonomy	Cannabaceae
ID	3481

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (42)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005167	Kaempferol 3-neohesperidoside	CHEMBL507493				No. 1	No. 15
C00005449	Quercetin 3-rhamnosyl-(1->2)-rhamnosyl-(1->6)-glucoside					No. 5	No. 15
C00005211	Kaempferol 3-rhamnosyl-(1->2)-rhamnosyl-(1->6)-glucoside					No. 5	No. 15
C00005456	Manghaslin / Quercetin 3-2G-rhamnosylrutinoside	CHEMBL444468				No. 5	No. 15
C00000997	6-Prenylnaringenin	CHEMBL1537093		14 / 16 / 16		No. 28	No. 14
C00008245	8-Prenylnaringenin / Sophoraflavanone B / (-)-8-Prenylnaringenin	CHEMBL376915 CHEMBL460647		10 / 8 / 4		No. 28	No. 14
C00006956	4,4'-Dihydroxy-2',6'-dimethoxychalcone	CHEMBL449907				No. 79
C00014476	Xanthohumol C / 6'',6''-Dimethylpyrano[2'',3'':4',3']-4,2'-dihydroxy-6'-methoxychalcone	CHEMBL479351				No. 130
C00007100	4'-O-Methylxanthohumol	CHEMBL466335				No. 133	No. 13
C00007099	Xanthohumol	CHEMBL253896		6 / 0 / 1		No. 133	No. 13
C00007081	Isoxanthohumol(Helichrysum)					No. 133	No. 13
C00014472	Xanthohumol D / 3'-(2-Hydroxy-3-methylbutyl-3-enyl)-4,2',4'-trihydroxy-6'-methoxychalcone	CHEMBL479500				No. 133	No. 13
C00014475	Xanthogalenol / 3'-Prenyl-4,2',6'-trihydroxy-4'-methoxychalcone	CHEMBL466334				No. 133	No. 13
C00035575	Desmethylxanthohumol	CHEMBL466143		1 / 4 / 1		No. 133	No. 13
C00003186	beta-Selinene		C087920			No. 151	No. 38
C00014474	Xanthohumol E / 3'-Prenyl-6'',6''-dimethylpyrano[2'',3'':6',5']-4,2',4'-trihydroxychalcone					No. 186
C00000019	GA19 / Gibberellin A19		C120175			No. 187	No. 41
C00014473	5'-Prenylxanthohumol / 3',5'-Diprenyl-4,2',4'-trihydroxy-6-methoxychalcone	CHEMBL471777				No. 190	No. 13
C00014471	3'-Geranylchalconaringenin / 3'-Geranyl-4,2',4',6'-tetrahydroxychalcone	CHEMBL480722				No. 190	No. 13
C00020051	alpha-Cadinene					No. 283	No. 39
C00014477	Isodehydrocycloxanthohumol hydrate / 6'',6''-Dimethyl-4'',5''-dihydropyrano[2'',3'':4',3']-4,2'-dihydroxy-6'-methoxychalcone	CHEMBL447053				No. 337
C00014478	Xanthohumol B / Dehydrocycloxanthohumol hydrate / 6'',6''-Dimethyl-5''-hydroxy-4'',5''-dihydropyrano[2'',3'':4',3']-4,2'-dihydroxy-6'-methoxychalcone	CHEMBL520430				No. 337
C00021230	Aromadendrene / (+)-Aromadendrene / (+)-Aromadendr-7(15)-ene	CHEMBL509805 CHEMBL596664				No. 640
C00000099	2-Methylthioribosylzeatin / trans-Methylthioribosylzeatin / 2-Methylthioribosyl-trans-zeatin					No. 989
C00000095	9-Ribosyl-cis-zeatin / 6-(4-Hydroxy-3-methyl-cis-2-butenylamino)-9-beta-D-ribofuranosylpurine					No. 989
C00000096	9-Ribosyl-trans-zeatin / Zeatin-9-beta-D-ribofuranoside					No. 989
C00014615	alpha,beta-Dihydroxanthohumol / 4,2',4'-Trihydroxy-6'-methoxy-3'-prenyldihydrochalcone	CHEMBL510279		14 / 8 / 4		No. 1291
C00003147	Humulene / alpha-Caryophyllene / (+/-)-alpha-Humulene	CHEMBL251280	C042686			No. 1421	No. 38
C00002709	Tricyclodehydroisohumulone					No. 1473
C00035519	Adlupulone					No. 1763	No. 67
C00035518	Adhumulone					No. 1763	No. 67
C00035567	Cohumulone		C442487			No. 1763	No. 67
C00002701	Lupulone	CHEMBL480267	C008299			No. 1763	No. 67
C00002697	Humulone					No. 1763	No. 67
C00020070	gamma-Calacorene					No. 1859
C00012708	Selina-3,7(11)-diene					No. 2008
C00000091	trans-Zeatin	CHEMBL525239	D015026	2 / 3 / 2	0 / 1	No. 2879
C00000094	2iP / N6-(delta2-Isopentenyl)adenine	CHEMBL476189	C001478	5 / 2 / 3	18 / 0	No. 2879
C00020084	alpha-Corocalene					No. 3629
C00012714	Selina-4(14),7(11)-diene / Eudesma-4(14),7(11)-diene / (4aR-trans)-Decahydro-4a-methyl-1-methylene-7-(1-methylethylidene)naphthalene					No. 4110
C00007239	Isopentenyl adenosine monophosphate					No. 4121
C00001189	Isovaleric acid / 3-Methylbutanoic acid	CHEMBL568737	C008216		4 / 0	No. 5262

Human Protein / Gene in interactions

44 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000997 C00008245 C00014615	0 / 0
O75496	Geminin	Unclassified protein	C00000997 C00008245 C00014615	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000997 C00007099	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00000997 C00014615	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000997 C00014615	4 / 3
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000997 C00014615	2 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00014615	1 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00008245	0 / 0
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00000997	1 / 4
Q96LD8	Sentrin-specific protease 8	Enzyme	C00014615	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00008245	4 / 2
P16473	Thyrotropin receptor	Glycohormone receptor	C00000091	3 / 2
P42574	Caspase-3	C14	C00014615	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000094	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000094	1 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00007099	0 / 0
Q9BQF6	Sentrin-specific protease 7	Enzyme	C00014615	0 / 0
Q9GZR1	Sentrin-specific protease 6	Enzyme	C00014615	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000997	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00007099	0 / 0
P45984	Mitogen-activated protein kinase 9	Jnk	C00007099	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00008245	0 / 1
Q04759	Protein kinase C theta type	Delta	C00007099	0 / 1
P04062	Glucosylceramidase	Enzyme	C00000997	6 / 4
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000997	1 / 2
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000094	0 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00008245	2 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00008245	0 / 0
P03372	Estrogen receptor	NR3A1	C00008245	1 / 1
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00035575	4 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000094	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000094	0 / 1
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00000997	1 / 0
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00007099	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000997	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00014615	1 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00014615	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000091	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000997	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000997	1 / 4
P35372	Mu-type opioid receptor	Opioid receptor	C00014615	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00014615	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00008245	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00008245	1 / 1

22 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
440	ASNS, TS11	asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4)	C00000094
694	BTG1	B-cell translocation gene 1, anti-proliferative	C00000094
10681	GNB5, GB5	guanine nucleotide binding protein (G protein), beta 5	C00000094
182	JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1	jagged 1	C00000094
9818	NUPL1, PRO2463	nucleoporin like 1	C00000094
5142	PDE4B, DPDE4, PDE4B5, PDEIVB	phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)	C00000094
8544	PIR	pirin (iron-binding nuclear protein) (EC:1.13.11.24)	C00000094
5366	PMAIP1, APR, NOXA	phorbol-12-myristate-13-acetate-induced protein 1	C00000094
9360	PPIG, CARS-Cyp, CYP, SCAF10, SRCyp	peptidylprolyl isomerase G (cyclophilin G) (EC:5.2.1.8)	C00000094
5782	PTPN12, PTP-PEST, PTPG1	protein tyrosine phosphatase, non-receptor type 12 (EC:3.1.3.48)	C00000094
5774	PTPN3, PTP-H1, PTPH1	protein tyrosine phosphatase, non-receptor type 3 (EC:3.1.3.48)	C00000094
6004	RGS16, A28-RGS14, A28-RGS14P, RGS-R	regulator of G-protein signaling 16	C00000094
6016	RIT1, NS8, RIBB, RIT, ROC1	Ras-like without CAAX 1	C00000094
6286	S100P, MIG9	S100 calcium binding protein P	C00000094
7029	TFDP2, DP2	transcription factor Dp-2 (E2F dimerization partner 2)	C00000094
7127	TNFAIP2, B94, EXOC3L3	tumor necrosis factor, alpha-induced protein 2	C00000094
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000094
7431	VIM, CTRCT30	vimentin	C00000094
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00001189
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00001189
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00001189
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00001189

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions