Species

KNApSAcK Entry

Organism name Humulus lupulus
Genus Humulus
Family Cannabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Humulus lupulus
Linked NCBI taxonomy ID 3486
Linked level species

Family

Family in NCBI taxonomy Cannabaceae
ID 3481

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (42)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005167 External link 512 Kaempferol 3-neohesperidoside
CHEMBL507493
No. 1 No. 15
C00005449 External link 512 Quercetin 3-rhamnosyl-(1->2)-rhamnosyl-(1->6)-glucoside
No. 5 No. 15
C00005211 External link 512 Kaempferol 3-rhamnosyl-(1->2)-rhamnosyl-(1->6)-glucoside
No. 5 No. 15
C00005456 External link 512 Manghaslin
/ Quercetin 3-2G-rhamnosylrutinoside
CHEMBL444468
No. 5 No. 15
C00000997 External link 512 6-Prenylnaringenin
CHEMBL1537093
14 / 16 / 16 No. 28 No. 14
C00008245 External link 512 8-Prenylnaringenin
/ Sophoraflavanone B
/ (-)-8-Prenylnaringenin
CHEMBL376915
CHEMBL460647
10 / 8 / 4 No. 28 No. 14
C00006956 External link 512 4,4'-Dihydroxy-2',6'-dimethoxychalcone
CHEMBL449907
No. 79
C00014476 External link 512 Xanthohumol C
/ 6'',6''-Dimethylpyrano[2'',3'':4',3']-4,2'-dihydroxy-6'-methoxychalcone
CHEMBL479351
No. 130
C00007100 External link 512 4'-O-Methylxanthohumol
CHEMBL466335
No. 133 No. 13
C00007099 External link 512 Xanthohumol
CHEMBL253896
6 / 0 / 1 No. 133 No. 13
C00007081 External link 512 Isoxanthohumol(Helichrysum)
No. 133 No. 13
C00014472 External link 512 Xanthohumol D
/ 3'-(2-Hydroxy-3-methylbutyl-3-enyl)-4,2',4'-trihydroxy-6'-methoxychalcone
CHEMBL479500
No. 133 No. 13
C00014475 External link 512 Xanthogalenol
/ 3'-Prenyl-4,2',6'-trihydroxy-4'-methoxychalcone
CHEMBL466334
No. 133 No. 13
C00035575 External link 512 Desmethylxanthohumol
CHEMBL466143
1 / 4 / 1 No. 133 No. 13
C00003186 External link 512 beta-Selinene
C087920
No. 151 No. 38
C00014474 External link 512 Xanthohumol E
/ 3'-Prenyl-6'',6''-dimethylpyrano[2'',3'':6',5']-4,2',4'-trihydroxychalcone
No. 186
C00000019 External link 512 GA19
/ Gibberellin A19
C120175
No. 187 No. 41
C00014473 External link 512 5'-Prenylxanthohumol
/ 3',5'-Diprenyl-4,2',4'-trihydroxy-6-methoxychalcone
CHEMBL471777
No. 190 No. 13
C00014471 External link 512 3'-Geranylchalconaringenin
/ 3'-Geranyl-4,2',4',6'-tetrahydroxychalcone
CHEMBL480722
No. 190 No. 13
C00020051 External link 512 alpha-Cadinene
No. 283 No. 39
C00014477 External link 512 Isodehydrocycloxanthohumol hydrate
/ 6'',6''-Dimethyl-4'',5''-dihydropyrano[2'',3'':4',3']-4,2'-dihydroxy-6'-methoxychalcone
CHEMBL447053
No. 337
C00014478 External link 512 Xanthohumol B
/ Dehydrocycloxanthohumol hydrate
/ 6'',6''-Dimethyl-5''-hydroxy-4'',5''-dihydropyrano[2'',3'':4',3']-4,2'-dihydroxy-6'-methoxychalcone
CHEMBL520430
No. 337
C00021230 External link 512 Aromadendrene
/ (+)-Aromadendrene
/ (+)-Aromadendr-7(15)-ene
CHEMBL509805
CHEMBL596664
No. 640
C00000099 External link 512 2-Methylthioribosylzeatin
/ trans-Methylthioribosylzeatin
/ 2-Methylthioribosyl-trans-zeatin
No. 989
C00000095 External link 512 9-Ribosyl-cis-zeatin
/ 6-(4-Hydroxy-3-methyl-cis-2-butenylamino)-9-beta-D-ribofuranosylpurine
No. 989
C00000096 External link 512 9-Ribosyl-trans-zeatin
/ Zeatin-9-beta-D-ribofuranoside
No. 989
C00014615 External link 512 alpha,beta-Dihydroxanthohumol
/ 4,2',4'-Trihydroxy-6'-methoxy-3'-prenyldihydrochalcone
CHEMBL510279
14 / 8 / 4 No. 1291
C00003147 External link 512 Humulene
/ alpha-Caryophyllene
/ (+/-)-alpha-Humulene
CHEMBL251280
C042686
No. 1421 No. 38
C00002709 External link 512 Tricyclodehydroisohumulone
No. 1473
C00035519 External link 512 Adlupulone
No. 1763 No. 67
C00035518 External link 512 Adhumulone
No. 1763 No. 67
C00035567 External link 512 Cohumulone
C442487
No. 1763 No. 67
C00002701 External link 512 Lupulone
CHEMBL480267
C008299
No. 1763 No. 67
C00002697 External link 512 Humulone
No. 1763 No. 67
C00020070 External link 512 gamma-Calacorene
No. 1859
C00012708 External link 512 Selina-3,7(11)-diene
No. 2008
C00000091 External link 512 trans-Zeatin
CHEMBL525239
D015026
2 / 3 / 2 0 / 1 No. 2879
C00000094 External link 512 2iP
/ N6-(delta2-Isopentenyl)adenine
CHEMBL476189
C001478
5 / 2 / 3 18 / 0 No. 2879
C00020084 External link 512 alpha-Corocalene
No. 3629
C00012714 External link 512 Selina-4(14),7(11)-diene
/ Eudesma-4(14),7(11)-diene
/ (4aR-trans)-Decahydro-4a-methyl-1-methylene-7-(1-methylethylidene)naphthalene
No. 4110
C00007239 External link 512 Isopentenyl adenosine monophosphate
No. 4121
C00001189 External link 512 Isovaleric acid
/ 3-Methylbutanoic acid
CHEMBL568737
C008216
4 / 0 No. 5262

Human Protein / Gene in interactions

44 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000997 C00008245 C00014615 0 / 0
O75496 Geminin Unclassified protein C00000997 C00008245 C00014615 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000997 C00007099 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000997 C00014615 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000997 C00014615 4 / 3
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000997 C00014615 2 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00014615 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00008245 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00000997 1 / 4
Q96LD8 Sentrin-specific protease 8 Enzyme C00014615 0 / 0
P37840 Alpha-synuclein Unclassified protein C00008245 4 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00000091 3 / 2
P42574 Caspase-3 C14 C00014615 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000094 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000094 1 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00007099 0 / 0
Q9BQF6 Sentrin-specific protease 7 Enzyme C00014615 0 / 0
Q9GZR1 Sentrin-specific protease 6 Enzyme C00014615 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000997 0 / 0
P17252 Protein kinase C alpha type Alpha C00007099 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00007099 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00008245 0 / 1
Q04759 Protein kinase C theta type Delta C00007099 0 / 1
P04062 Glucosylceramidase Enzyme C00000997 6 / 4
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000997 1 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000094 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00008245 2 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00008245 0 / 0
P03372 Estrogen receptor NR3A1 C00008245 1 / 1
P31749 RAC-alpha serine/threonine-protein kinase Akt C00035575 4 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000094 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000094 0 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000997 1 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00007099 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000997 0 / 0
Q99700 Ataxin-2 Unclassified protein C00014615 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00014615 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000091 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00000997 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00000997 1 / 4
P35372 Mu-type opioid receptor Opioid receptor C00014615 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00014615 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00008245 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00008245 1 / 1

22 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
440 ASNS, TS11 asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) C00000094
694 BTG1 B-cell translocation gene 1, anti-proliferative C00000094
10681 GNB5, GB5 guanine nucleotide binding protein (G protein), beta 5 C00000094
182 JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1 jagged 1 C00000094
9818 NUPL1, PRO2463 nucleoporin like 1 C00000094
5142 PDE4B, DPDE4, PDE4B5, PDEIVB phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) C00000094
8544 PIR pirin (iron-binding nuclear protein) (EC:1.13.11.24) C00000094
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00000094
9360 PPIG, CARS-Cyp, CYP, SCAF10, SRCyp peptidylprolyl isomerase G (cyclophilin G) (EC:5.2.1.8) C00000094
5782 PTPN12, PTP-PEST, PTPG1 protein tyrosine phosphatase, non-receptor type 12 (EC:3.1.3.48) C00000094
5774 PTPN3, PTP-H1, PTPH1 protein tyrosine phosphatase, non-receptor type 3 (EC:3.1.3.48) C00000094
6004 RGS16, A28-RGS14, A28-RGS14P, RGS-R regulator of G-protein signaling 16 C00000094
6016 RIT1, NS8, RIBB, RIT, ROC1 Ras-like without CAAX 1 C00000094
6286 S100P, MIG9 S100 calcium binding protein P C00000094
7029 TFDP2, DP2 transcription factor Dp-2 (E2F dimerization partner 2) C00000094
7127 TNFAIP2, B94, EXOC3L3 tumor necrosis factor, alpha-induced protein 2 C00000094
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00000094
7431 VIM, CTRCT30 vimentin C00000094
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00001189
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00001189
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00001189
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00001189

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (33)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#208900 Ataxia-telangiectasia; at Q13315
#614490 Blood group, junior system; jr Q9UNQ0
#114480 Breast cancer P31749
#114500 Colorectal cancer; crc P31749
P84022
#615109 Cowden syndrome 6; cws6 P31749
#127750 Dementia, lewy body; dlb P37840
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#601665 Obesity P32245
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#176920 Proteus syndrome P31749
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (26)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00000091