KCF-S cluster No. 79 (54 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (54)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	28
asterids	24
rosids	20
Liliopsida	11
Euphyllophyta	9
eudicotyledons	5
Spermatophyta	2

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Cumulative family count (Top 20)

class name	count
Annonaceae	17
Asteraceae	11
Pteridaceae	9
Gesneriaceae	8
Fabaceae	7
Zingiberaceae	7
Rutaceae	5
Lauraceae	5
Piperaceae	5
Polygonaceae	5
Lamiaceae	3
Orchidaceae	2
Acanthaceae	2
Pinaceae	2
Combretaceae	2
Rosaceae	2
Salicaceae	1
Cannabaceae	1
Xanthorrhoeaceae	1
Myristicaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (54)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00006923	Glypallichalcone / 4-Hydroxy-2,4'-dimethoxychalcone		C079973
C00006929	Isoliquiritigenin 4,4'-dimethyl ether	CHEMBL229907		18 / 36 / 28
C00006936	Flavokawin B	CHEMBL104255		19 / 31 / 55
C00006937	Tepanone
C00006939	2,4-Dihydroxy-6,4'-dimethoxychalcone
C00006946	2',4'-Dihydroxy-3,4-dimethoxychalcone	CHEMBL573524		19 / 38 / 59
C00006950	Kukulkanin A		C061638
C00006955	Gymnogrammene
C00006956	4,4'-Dihydroxy-2',6'-dimethoxychalcone	CHEMBL449907
C00006957	Flavokawain C	CHEMBL251958
C00006958	Flavokawin A / 2'-Hydroxy-4,4',6'-trimethoxychalcone	CHEMBL243829		3 / 3 / 0
C00006959	Pashanone
C00006960	2',4'-Dihydroxy-3',6'-dimethoxychalcone
C00006961	2',3'-Dihydroxy-4',6'-dimethoxychalcone	CHEMBL1446527		13 / 17 / 11
C00006962	Helilandin B
C00006963	2'-Hydroxy-3',4',6'-trimethoxychalcone
C00006964	2',3',4',6'-Tetramethoxychalcone
C00006965	Cerasin	CHEMBL601679
C00006966	Cerasidin
C00006967	2',4'-Dihydroxy-2,3',6'-trimethoxychalcone
C00006971	Okanin 3,4,3',4'-tetramethyl ether	CHEMBL316850 CHEMBL1702432		11 / 8 / 9
C00006976	3,2'-Dihydroxy-4,4',6'-trimethoxychalcone	CHEMBL571087		15 / 19 / 52
C00006977	2'-Hydroxy-3,4,4',6'-tetramethoxychalcone	CHEMBL243830		3 / 3 / 0
C00006979	4,6'-Dihydroxy-2',3',4'-trimethoxychalcone	CHEMBL2208192
C00006980	4,2'-Dihydroxy-3',4',6'-trimethoxychalcone
C00006981	6'-Hydroxy-4,2',3',4'-tetramethoxychalcone	CHEMBL2208193		1 / 5 / 3
C00006982	Pedicin / 2',5'-Dihydroxy-3',4',6'-trimethoxychalcone	CHEMBL481972
C00006983	Isodidymocarpin	CHEMBL505666
C00006984	3'-Hydroxy-2',4',5',6'-tetramethoxychalcone
C00006985	Kanakugiol
C00006986	Pedicellin	CHEMBL1998453
C00006987	Rubone
C00006988	2'-Hydroxy-3,4,5,4',6'-pentamethoxychalcone	CHEMBL571877		1 / 2 / 0
C00006989	6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone	CHEMBL458376
C00006990	2',5'-Dihydroxy-4,3',4',6'-tetramethoxychalcone
C00014421	Heliannone A / 2',4-Dihydroxy-3',4'-dimethoxychalcone
C00014423	2'-Hydroxy-2,4',6'-trimethoxychalcone	CHEMBL258497		1 / 2 / 0
C00014424	2',4'-Dihydroxy-4,6'-dimethoxychalcone	CHEMBL494264
C00014425	3'-Bromo-6'-hydroxy-2',4,4'-trimethoxychalcone
C00014426	4'-Hydroxy-2',4,6'-trimethoxychalcone	CHEMBL1514861		2 / 3 / 4
C00014428	Crotaoprostrin / 2'-Hydroxy-3,4,5-methoxychalcone	CHEMBL521653		16 / 23 / 18
C00014430	2'-Hydroxy-2,3,4',6'-tetramethoxychalcone	CHEMBL1254091		1 / 5 / 5
C00014433	4,3'-Hydroxy-2',4',5',6'-methoxychalcone
C00014434	Hamilcone / 3,4,6'-Trihydroxy-2',3',4'-trimethoxychalcone	CHEMBL465364
C00014435	2'-Hydroxy-3',4',6',3,4-pentamethoxychalcone
C00014436	2,3,4,2',4',6'-Hexamethoxychalcone	CHEMBL595815
C00032628	2'-Hydroxy-3,4,3',4',6'-pentamethoxychalcone
C00036451	2',3'-Dihydroxy-4',6'-dimethoxychalcone	CHEMBL1446527		13 / 17 / 11
C00036493	2'-Hydroxy-4,4',6'-trimethoxychalcone	CHEMBL243829		3 / 3 / 0
C00037157	Flavokavin A / Flavokawain A	CHEMBL243829		3 / 3 / 0
C00044793	Guieranone A	CHEMBL477526
C00045544	2'-Hydroxy-4',6'-dimethoxychalcone	CHEMBL104255		19 / 31 / 55
C00048940	2'-Hydroxy-4',5',6'-trimethoxychalcone
C00048941	2'-Hydroxy-4',6'-dimethoxychalcone	CHEMBL104255		19 / 31 / 55

Human Protein / Gene in interactions

51 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00006929 C00006936 C00006946 C00006958 C00006977 C00006988 C00014423 C00036493 C00037157 C00045544 C00048941	2 / 0
P11473	Vitamin D3 receptor	NR1I1	C00006936 C00006946 C00006961 C00006971 C00006976 C00014426 C00014428 C00036451 C00045544 C00048941	2 / 3
P10636	Microtubule-associated protein tau	Unclassified protein	C00006929 C00006936 C00006946 C00006961 C00006976 C00014428 C00036451 C00045544 C00048941	4 / 3
O75496	Geminin	Unclassified protein	C00006929 C00006936 C00006961 C00006971 C00014428 C00036451 C00045544 C00048941	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00006936 C00006961 C00006971 C00014428 C00036451 C00045544 C00048941	0 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00006929 C00006946 C00006958 C00006977 C00036493 C00037157	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00006929 C00006936 C00006946 C00006976 C00045544 C00048941	1 / 2
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00006929 C00006936 C00006961 C00036451 C00045544 C00048941	7 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00006929 C00006936 C00006946 C00006976 C00045544 C00048941	0 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00006936 C00006961 C00014428 C00036451 C00045544 C00048941	0 / 0
P08183	Multidrug resistance protein 1	drug	C00006929 C00006946 C00006958 C00006977 C00036493 C00037157	1 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00006936 C00006946 C00014428 C00045544 C00048941	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00006929 C00006961 C00006971 C00014428 C00036451	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00006929 C00006936 C00014428 C00045544 C00048941	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00006936 C00006961 C00036451 C00045544 C00048941	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00006936 C00006971 C00014428 C00045544 C00048941	1 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00006929 C00006961 C00006971 C00014428 C00036451	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00006936 C00006946 C00006976 C00045544 C00048941	7 / 37
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00006936 C00014428 C00045544 C00048941	2 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00006936 C00006976 C00045544 C00048941	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00006946 C00006976 C00014428	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00006946 C00006976 C00014426	1 / 1
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00006936 C00045544 C00048941	1 / 4
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00006929 C00006961 C00036451	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00006961 C00014428 C00036451	0 / 0
O00255	Menin	Unclassified protein	C00006929 C00006946 C00006976	2 / 5
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00006936 C00045544 C00048941	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00006929 C00006946 C00006976	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00006936 C00045544 C00048941	3 / 3
Q16637	Survival motor neuron protein	Unclassified protein	C00006929 C00006946	4 / 1
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00006946 C00006981	5 / 3
P02545	Prelamin-A/C	Unclassified protein	C00006929 C00014428	11 / 10
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00006961 C00036451	1 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00006946 C00006976	2 / 2
Q9Y253	DNA polymerase eta	Enzyme	C00006961 C00036451	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00006946 C00006976	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00006946	2 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00006971	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00006971	4 / 2
P04062	Glucosylceramidase	Enzyme	C00006946	6 / 4
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00006929	1 / 1
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00006976	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00006929	2 / 2
O14746	Telomerase reverse transcriptase	Enzyme	C00014430	5 / 5
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00006976	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00014428	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00006971	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00014428	2 / 2
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00006976	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00006971	0 / 3
P14555	Phospholipase A2, membrane associated	Enzyme	C00006971	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions