PCIDB

KNApSAcK Metabolite C00006961

Metabolite

KNApSAcK Entry

id C00006961
Name 2',3'-Dihydroxy-4',6'-dimethoxychalcone
CAS RN 54299-64-8
Standard InChI InChI=1S/C17H16O5/c1-21-13-10-14(22-2)16(19)17(20)15(13)12(18)9-8-11-6-4-3-5-7-11/h3-10,19-20H,1-2H3/b9-8+
Standard InChI (Main Layer) InChI=1S/C17H16O5/c1-21-13-10-14(22-2)16(19)17(20)15(13)12(18)9-8-11-6-4-3-5-7-11/h3-10,19-20H,1-2H3

Cluster

Phytochemical cluster
KCF-S cluster No. 79

Link

ChEMBL

By standard InChI CHEMBL1446527
By standard InChI Main Layer CHEMBL1446527

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count
Magnoliophyta 1

Family

family name count
Piperaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Piper hispidum 130401 Piperaceae Magnoliophyta Viridiplantae

Human Protein / Gene in interaction

13 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1446527 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1446527 CHEMBL2114784 (1)
1 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL1446527 CHEMBL1794311 (1)
2 / 3
O75496 Geminin Unclassified protein CHEMBL1446527 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL1446527 CHEMBL2114817 (1)
7 / 3
Q9Y253 DNA polymerase eta Enzyme CHEMBL1446527 CHEMBL1794569 (1)
1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL1446527 CHEMBL1963863 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1446527 CHEMBL1794483 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL1446527 CHEMBL1614052 (1)
1 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1446527 CHEMBL1737991 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1446527 CHEMBL1614421 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1446527 CHEMBL2114908 (1)
0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL1446527 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#600274 Frontotemporal dementia; ftd P10636
#174800 Mccune-albright syndrome; mas P63092
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (11)

KEGG disease name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)