Species

KNApSAcK Entry

Organism name Piper hispidum
Genus Piper
Family Piperaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Piper hispidum
Linked NCBI taxonomy ID 130401
Linked level species

Family

Family in NCBI taxonomy Piperaceae
ID 16739

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00008158 External link 512 5,7,8-Trimethoxyflavanone
No. 25 No. 14
C00008155 External link 512 8-Hydroxy-5,7-dimethoxyflavanone
CHEMBL1350188
21 / 16 / 18 No. 25 No. 14
C00008150 External link 512 6-Hydroxy-5,7-dimethoxyflavanone
No. 25 No. 14
C00006961 External link 512 2',3'-Dihydroxy-4',6'-dimethoxychalcone
CHEMBL1446527
13 / 17 / 11 No. 79
C00006963 External link 512 2'-Hydroxy-3',4',6'-trimethoxychalcone
No. 79
C00006935 External link 512 Cardamomin
CHEMBL378104
13 / 18 / 14 No. 92 No. 13
C00006934 External link 512 Pinostrobin chalcone
/ 2',6'-Dihydroxy-4'-methoxychalcone
CHEMBL317221
CHEMBL1705800
3 / 1 / 2 No. 92 No. 13

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75164 Lysine-specific demethylase 4A Enzyme C00006935 C00006961 C00008155 0 / 0
O75496 Geminin Unclassified protein C00006935 C00006961 C00008155 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00006935 C00006961 C00008155 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00006935 C00006961 C00008155 4 / 3
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00006935 C00006961 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00006934 C00008155 0 / 0
O00255 Menin Unclassified protein C00006935 C00008155 2 / 5
P11473 Vitamin D3 receptor NR1I1 C00006961 C00008155 2 / 3
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00006935 C00006961 1 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00006935 C00008155 1 / 2
Q99700 Ataxin-2 Unclassified protein C00006935 C00006961 1 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00006935 C00006961 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00006961 C00008155 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00006935 C00006961 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00008155 3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00008155 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00008155 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00008155 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00006934 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00006935 2 / 0
P39748 Flap endonuclease 1 Enzyme C00008155 0 / 0
Q15056 Eukaryotic translation initiation factor 4H Unclassified protein C00008155 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00006934 0 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00008155 1 / 1
P11940 Polyadenylate-binding protein 1 Unclassified protein C00008155 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00006961 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00008155 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00008155 0 / 0
P22001 Potassium voltage-gated channel subfamily A member 3 KCNA, Kv1.x (Shaker) C00006935 0 / 0
P06746 DNA polymerase beta Enzyme C00008155 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00008155 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00006961 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114500 Colorectal cancer; crc P84022
Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (24)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00213 Hypophosphatasia P05186 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)