KCF-S cluster No. 133 (40 metabolites)

Corresponding Phytochemical cluster No. 13

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (40)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	57
asterids	28

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Cumulative family count

class name	count
Fabaceae	41
Asteraceae	18
Apiaceae	10
Moraceae	9
Cannabaceae	6
Euphorbiaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Chalcones	3

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Chalcones	C08648	C00002381
Chalcones	C16417	C00007099
Chalcones	C16416	C00035575
Chalcones	C08648	C00036579

Metabolite list (40)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002381	Corylifolinin / Isobavachalcone / 2',4,4'-Trihydroxy-3'-(3-methyl-2-butenyl)chalcone	CHEMBL253467	C468754	8 / 22 / 21
C00007045	Isocordoin	CHEMBL460618
C00007052	Derricin	CHEMBL455982
C00007053	Derricidin	CHEMBL450771		2 / 1 / 1
C00007056	Licochalcone C	CHEMBL141207		1 / 0 / 0
C00007064	4-Hydroxyderricin	CHEMBL458094	C068243	17 / 27 / 26
C00007065	Xanthoangelol D	CHEMBL1711961		6 / 15 / 41
C00007066	Xanthoangelol E	CHEMBL1718454		10 / 21 / 44
C00007067	4-Hydroxycordoin	CHEMBL460400		1 / 0 / 0
C00007068	Broussochalcone B	CHEMBL464428		1 / 2 / 2
C00007070	Bavachalcone
C00007078	Desmethylisoxanthohumol	CHEMBL2203298
C00007081	Isoxanthohumol(Helichrysum)
C00007083	2',4'-Dihydroxy-6'-methoxy-3'-prenylchalcone
C00007085	Ovalichalcone
C00007086	2',6'-Dihydroxy-4'-prenyloxychalcone
C00007087	2'-Hydroxy-6'-methoxy-4'-prenyloxychalcone
C00007089	Licochalcone D	CHEMBL1644932
C00007091	Morachalcone A	CHEMBL465880		1 / 2 / 2
C00007095	Broussochalcone A	CHEMBL115452	C106525	2 / 2 / 2
C00007099	Xanthohumol	CHEMBL253896		6 / 0 / 1
C00007100	4'-O-Methylxanthohumol	CHEMBL466335
C00007101	4,2',6'-Trihydroxy-4'-prenyloxychalcone
C00007125	Xanthoangelol B	CHEMBL494082		13 / 11 / 5
C00007159	Xanthoangelol C
C00014450	Psorachalcone A	CHEMBL428420
C00014456	Licoagrochalcone A / 3-Prenyl-4,2',4'-trihydroxychalcone	CHEMBL229885		2 / 2 / 2
C00014460	Xanthoangelol F / 3'-Geranyl-2',4-dihydroxy-4'-methoxychalcone	CHEMBL1722838		8 / 6 / 6
C00014461	Xanthoangelol G / 3'-(3,7-Dimethyl-6-hydroxyocta-2,7-dienyl)-4,2'-dihydroxy-4'-methoxychalcone	CHEMBL1823414
C00014472	Xanthohumol D / 3'-(2-Hydroxy-3-methylbutyl-3-enyl)-4,2',4'-trihydroxy-6'-methoxychalcone	CHEMBL479500
C00014475	Xanthogalenol / 3'-Prenyl-4,2',6'-trihydroxy-4'-methoxychalcone	CHEMBL466334
C00014487	Licoagrochalcone C / 3-Prenyl-4,3',4'-trihydroxy-2-methoxychalcone
C00014491	Ramosismin / 3'-Prenyl-2,4,5,2',4'-pentahydroxychalcone
C00014492	3'-Prenyl-2',6',beta-trihydroxy-4'-methoxychalcone
C00033900	Helichrysone A
C00035575	Desmethylxanthohumol	CHEMBL466143		1 / 4 / 1
C00035796	5-Prenylbutein	CHEMBL253677
C00036579	4-Hydroxyisocordoin	CHEMBL253467		8 / 22 / 21
C00040675	Xanthokeismin A	CHEMBL503569
C00041964	Xanthoangelol J	CHEMBL491512

Human Protein / Gene in interactions

47 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00002381 C00007068 C00007091 C00007095 C00014456 C00036579	2 / 2
O75164	Lysine-specific demethylase 4A	Enzyme	C00007064 C00007065 C00007066 C00007125 C00014460	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00007064 C00007066 C00007125 C00014460	1 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00007064 C00007065 C00007125 C00014460	0 / 0
O75496	Geminin	Unclassified protein	C00007064 C00007065 C00007066 C00007125	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00007064 C00007066 C00007125 C00014460	2 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00007056 C00007095 C00014456	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00007064 C00007065 C00007125	1 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00007065 C00007066 C00007125	7 / 3
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00007064 C00007066 C00014460	1 / 0
P08581	Hepatocyte growth factor receptor	TK tyrosine-protein kinase MET subfamily	C00002381 C00036579	2 / 3
P04637	Cellular tumor antigen p53	Transcription Factor	C00007065 C00007066	7 / 37
Q9UNA4	DNA polymerase iota	Enzyme	C00007064 C00014460	0 / 0
P11362	Fibroblast growth factor receptor 1	Fgfr	C00002381 C00036579	4 / 5
P10721	Mast/stem cell growth factor receptor Kit	Pdgfr	C00002381 C00036579	4 / 3
P35968	Vascular endothelial growth factor receptor 2	Vegfr	C00002381 C00036579	1 / 0
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00002381 C00036579	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00007064 C00014460	0 / 3
P21802	Fibroblast growth factor receptor 2	TK tyrosine-protein kinase TLK subfamily	C00002381 C00036579	9 / 3
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00002381 C00036579	1 / 8
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00007066 C00014460	2 / 2
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00007064	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00007053	0 / 0
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00007099	0 / 0
Q9BQF6	Sentrin-specific protease 7	Enzyme	C00007125	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00007066	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00007064	0 / 0
Q9GZR1	Sentrin-specific protease 6	Enzyme	C00007125	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00007099	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00007099	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00007067	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00007053	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00007125	0 / 0
P42574	Caspase-3	C14	C00007125	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00035575	4 / 1
P37840	Alpha-synuclein	Unclassified protein	C00007064	4 / 2
Q96LD8	Sentrin-specific protease 8	Enzyme	C00007125	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00007064	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00007066	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00007064	11 / 10
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00007064	0 / 0
Q04759	Protein kinase C theta type	Delta	C00007099	0 / 1
O00255	Menin	Unclassified protein	C00007064	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00007064	1 / 2
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00007125	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00007099	0 / 0
P45984	Mitogen-activated protein kinase 9	Jnk	C00007099	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions