PCIDB

KNApSAcK Metabolite C00002381

Metabolite

KNApSAcK Entry

id C00002381
Name Corylifolinin / Isobavachalcone / 2',4,4'-Trihydroxy-3'-(3-methyl-2-butenyl)chalcone
CAS RN 20784-50-3
Standard InChI InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+
Standard InChI (Main Layer) InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3

Cluster

Phytochemical cluster No. 13
KCF-S cluster No. 133

Link

ChEMBL

By standard InChI CHEMBL253467
By standard InChI Main Layer CHEMBL253467

KEGG

By LinkDB C08648

CTD

By CAS RN C468754

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily CHEMBL253467 CHEMBL986526 (1)
9 / 3
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL253467 CHEMBL986517 (1)
1 / 11
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL253467 CHEMBL949646 (1)
2 / 2
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL253467 CHEMBL986511 (1)
0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr CHEMBL253467 CHEMBL986515 (1)
1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL253467 CHEMBL986512 (1)
2 / 3
P11362 Fibroblast growth factor receptor 1 Fgfr CHEMBL253467 CHEMBL986513 (1)
4 / 5
P10721 Mast/stem cell growth factor receptor Kit Pdgfr CHEMBL253467 CHEMBL986519 (1)
4 / 4

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#101200 Apert syndrome P21802
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#123500 Crouzon syndrome P21802
#606764 Gastrointestinal stromal tumor; gist P10721
#602089 Hemangioma, capillary infantile P35968
#114550 Hepatocellular carcinoma P08581
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#123150 Jackson-weiss syndrome; jws P21802
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
#601626 Leukemia, acute myeloid; aml P10721
#211980 Lung cancer P00533
#166250 Osteoglophonic dysplasia; ogd P11362
#101600 Pfeiffer syndrome P11362
P21802
#172800 Piebald trait; pbt P10721
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#273300 Testicular germ cell tumor; tgct P10721
#190440 Trigonocephaly 1; trigno1 P11362

KEGG DISEASE (21)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
P08581 (related)
P21802 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)