Species

KNApSAcK Entry

Organism name Lonchocarpus neuroscapha
Genus Lonchocarpus
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Lonchocarpus
Linked NCBI taxonomy ID 3925
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00007061 External link 512 Isobavachromene
/ 4-Hydroxylonchocarpin
CHEMBL362378
1 / 0 / 0 No. 130
C00007050 External link 512 Lonchocarpin
CHEMBL457644
1 / 2 / 0 No. 130
C00007067 External link 512 4-Hydroxycordoin
CHEMBL460400
1 / 0 / 0 No. 133 No. 13
C00007045 External link 512 Isocordoin
CHEMBL460618
No. 133 No. 13
C00007052 External link 512 Derricin
CHEMBL455982
No. 133 No. 13
C00007064 External link 512 4-Hydroxyderricin
CHEMBL458094
C068243
17 / 27 / 26 No. 133 No. 13
C00002381 External link 512 Corylifolinin
/ Isobavachalcone
/ 2',4,4'-Trihydroxy-3'-(3-methyl-2-butenyl)chalcone
CHEMBL253467
C468754
8 / 22 / 21 No. 133 No. 13
C00007053 External link 512 Derricidin
CHEMBL450771
2 / 1 / 1 No. 133 No. 13
C00008001 External link 512 Dihydrocordoin
No. 1291
C00007046 External link 512 2',4'-Dihydroxy-3'-(1,1-dimethyl-2-propenyl)chalcone
No. 3383

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00007050 C00007064 2 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002381 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00007053 0 / 0
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily C00002381 9 / 3
P02545 Prelamin-A/C Unclassified protein C00007064 11 / 10
P37840 Alpha-synuclein Unclassified protein C00007064 4 / 2
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00007053 1 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002381 1 / 8
P11926 Ornithine decarboxylase Lyase C00007061 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00007064 0 / 0
O75496 Geminin Unclassified protein C00007064 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00007064 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00007064 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00002381 2 / 2
Q99700 Ataxin-2 Unclassified protein C00007064 1 / 1
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00002381 1 / 0
Q96RI1 Bile acid receptor NR1H4 C00007067 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00002381 2 / 3
P11362 Fibroblast growth factor receptor 1 Fgfr C00002381 4 / 5
Q9UNA4 DNA polymerase iota Enzyme C00007064 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00007064 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00007064 4 / 3
P10721 Mast/stem cell growth factor receptor Kit Pdgfr C00002381 4 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00007064 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00007064 1 / 0
O00255 Menin Unclassified protein C00007064 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00007064 1 / 2
P01215 Glycoprotein hormones alpha chain Unclassified protein C00007064 0 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein C00007064 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (50)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#101200 Apert syndrome P21802
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#123500 Crouzon syndrome P21802
#127750 Dementia, lewy body; dlb P37840
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P10721
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#602089 Hemangioma, capillary infantile P35968
#114550 Hepatocellular carcinoma P08581
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#123150 Jackson-weiss syndrome; jws P21802
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
#601626 Leukemia, acute myeloid; aml P10721
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#166250 Osteoglophonic dysplasia; ogd P11362
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#101600 Pfeiffer syndrome P11362
P21802
#172700 Pick disease of brain P10636
#172800 Piebald trait; pbt P10721
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#275210 Restrictive dermopathy, lethal P02545
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#273300 Testicular germ cell tumor; tgct P10721
#190440 Trigonocephaly 1; trigno1 P11362

KEGG DISEASE (48)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
P08581 (related)
P21802 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00548 Brunner syndrome P21397 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)