phytochemical cluster No. 67 (27 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 26 |
| Euphyllophyta | 7 |
Cumulative family count
| class name | count |
|---|---|
| Euphorbiaceae | 13 |
| Cannabaceae | 6 |
| Dryopteridaceae | 4 |
| Myrtaceae | 3 |
| Hypericaceae | 3 |
| Polypodiaceae | 2 |
| Athyriaceae | 1 |
| Rosaceae | 1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Phloroglucinols | 7 |
metabolites link (7)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Phloroglucinols | C20207 | C00000293 |
| Phloroglucinols | C10672 | C00002690 |
| Phloroglucinols | C10673 | C00002691 |
| Phloroglucinols | C10695 | C00002697 |
| Phloroglucinols | C10704 | C00002700 |
| Phloroglucinols | C10706 | C00002701 |
| Phloroglucinols | C10721 | C00002708 |
Metabolite list (27)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
figure |
|---|---|---|---|---|---|---|---|
|
C00003016
|
Lupulone A
|
CHEMBL480268
|
No. 798 |
|
|||
|
C00002408
|
Isobutyrylmallotochromene
|
CHEMBL470674
|
No. 798 |
|
|||
|
C00002418
|
Mallotochromene
|
CHEMBL521361
|
C070197
|
No. 798 |
|
||
|
C00033159
|
Aspidin
|
C010302
|
No. 798 |
|
|||
|
C00002430
|
Mallotophilippen B
|
No. 798 |
|
||||
|
C00002434
|
Mallotophenone
|
CHEMBL504060
|
No. 798 |
|
|||
|
C00033158
|
Elaphopilosin B
|
CHEMBL552516
|
No. 798 |
|
|||
|
C00024155
|
Elaphopilosin A
/ (-)-Elaphopilosin A |
CHEMBL550641
|
No. 798 |
|
|||
|
C00024154
|
Humulone
|
No. 798 |
|
||||
|
C00002700
|
Robustaol A
|
No. 798 |
|
||||
|
C00002702
|
Adlupulone
|
No. 798 |
|
||||
|
C00002701
|
Psi-rhodomyrtoxin
|
No. 1763 |
|
||||
|
C00035518
|
Drumnondin A
|
No. 1763 |
|
||||
|
C00035519
|
Uliginosin B
|
No. 1763 |
|
||||
|
C00042708
|
4-Hydroxyrottlerin
|
No. 1763 |
|
||||
|
C00035567
|
3,4-Dihydroxyrottlerin
|
No. 1763 |
|
||||
|
C00002697
|
Isomallotolerin
|
C064421
|
No. 1763 |
|
|||
|
C00047442
|
Grandinol
|
CHEMBL225347
|
1 / 2 / 3 | No. 2268 |
|
||
|
C00002690
|
Alpoha-kosin
|
C069975
|
No. 2268 |
|
|||
|
C00002425
|
Mallotophilippen A
|
No. 2268 |
|
||||
|
C00043098
|
Rottlerin
|
CHEMBL34241
CHEMBL1330502 |
C085746
|
122 / 69 / 82 | 53 / 4 | No. 2268 |
|
|
C00047443
|
Aspidinol
|
CHEMBL214690
|
1 / 0 / 0 | No. 2268 |
|
||
|
C00007161
|
Cohumulone
|
C442487
|
No. 3672 |
|
|||
|
C00007160
|
Adhumulone
|
No. 3672 |
|
||||
|
C00002708
|
Lupulone
|
CHEMBL480267
|
C008299
|
No. 3672 |
|
||
|
C00000293
|
Butyrylmallotochromene
|
CHEMBL471480
|
No. 4087 |
|
|||
|
C00002691
|
Isomallotochromanol
|
CHEMBL523152
|
C064422
|
No. 7614 |
|
Human Protein / Gene in interactions
124 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002708 | 1 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00002708 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002708 | 7 / 37 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | C00002708 | 0 / 0 |
| Q8TDX7 | Serine/threonine-protein kinase Nek7 | Nek | C00002708 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002708 | 4 / 1 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002708 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002708 | 2 / 0 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | C00002708 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002708 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002708 | 0 / 0 |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | Pdk1 | C00002708 | 0 / 0 |
| P41240 | Tyrosine-protein kinase CSK | Csk | C00002708 | 0 / 0 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | C00002708 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002708 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002708 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00002708 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002708 | 0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | C00002708 | 0 / 0 |
| Q8IWQ3 | Serine/threonine-protein kinase BRSK2 | CAMK serine/threonine protein kinase BRSK subfamily | C00002708 | 0 / 0 |
| P27448 | MAP/microtubule affinity-regulating kinase 3 | CAMK serine/threonine protein kinase MARK subfamily | C00002708 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002708 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002708 | 11 / 10 |
| Q05513 | Protein kinase C zeta type | Iota | C00002708 | 0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00002708 | 0 / 0 |
| P49327 | Fatty acid synthase | Transferase | C00002691 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002708 | 0 / 1 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00002708 | 0 / 0 |
| Q9UQB9 | Aurora kinase C | Aur | C00002708 | 1 / 1 |
| Q9HBH9 | MAP kinase-interacting serine/threonine-protein kinase 2 | CAMK serine/threonine protein kinase MNK subfamily | C00002708 | 0 / 0 |
| Q9NQU5 | Serine/threonine-protein kinase PAK 6 | STE serine/threonine protein kinase PAKB subfamily | C00002708 | 0 / 0 |
| Q16644 | MAP kinase-activated protein kinase 3 | CAMK serine/threonine protein kinase MAPKAPK | C00002708 | 0 / 0 |
| Q9H422 | Homeodomain-interacting protein kinase 3 | CMGC dual-specificity kinase HIPK | C00002708 | 0 / 0 |
| Q14680 | Maternal embryonic leucine zipper kinase | Melk | C00002708 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00002708 | 1 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002708 | 2 / 3 |
| Q15746 | Myosin light chain kinase, smooth muscle | Mlck | C00002708 | 1 / 1 |
| Q13188 | Serine/threonine-protein kinase 3 | STE serine/threonine protein kinase MST subfamily | C00002708 | 0 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | C00002708 | 2 / 2 |
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | C00002708 | 0 / 0 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | C00002708 | 0 / 0 |
| Q16513 | Serine/threonine-protein kinase N2 | Pkn | C00002708 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00002708 | 0 / 0 |
| P17538 | Chymotrypsinogen B | S1A | C00002708 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002708 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002708 | 0 / 0 |
| Q8N5S9 | Calcium/calmodulin-dependent protein kinase kinase 1 | META serine/threonine protein kinase subfamily | C00002708 | 0 / 0 |
| Q9P286 | Serine/threonine-protein kinase PAK 7 | STE serine/threonine protein kinase PAKB subfamily | C00002708 | 0 / 0 |
| Q8IXJ6 | NAD-dependent protein deacetylase sirtuin-2 | Enzyme | C00002708 | 0 / 0 |
| Q96SB4 | SRSF protein kinase 1 | Srpk | C00002708 | 0 / 0 |
| Q92630 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | CMGC dual-specificity kinase DYRK2 | C00002708 | 0 / 0 |
| O43781 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 | CMGC dual-specificity kinase DYRK2 | C00002708 | 0 / 0 |
| O96013 | Serine/threonine-protein kinase PAK 4 | STE serine/threonine protein kinase PAKB subfamily | C00002708 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002708 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002708 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002708 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00002708 | 0 / 0 |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | Rskb | C00002708 | 0 / 0 |
| O15264 | Mitogen-activated protein kinase 13 | p38 | C00002708 | 0 / 0 |
| P53779 | Mitogen-activated protein kinase 10 | Jnk | C00002708 | 0 / 1 |
| P51955 | Serine/threonine-protein kinase Nek2 | Nek | C00002708 | 0 / 0 |
| Q96RR4 | Calcium/calmodulin-dependent protein kinase kinase 2 | META serine/threonine protein kinase subfamily | C00002708 | 0 / 0 |
| Q9BUB5 | MAP kinase-interacting serine/threonine-protein kinase 1 | CAMK serine/threonine protein kinase MNK subfamily | C00002708 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002708 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002708 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002708 | 0 / 0 |
| P61586 | Transforming protein RhoA | Unclassified protein | C00002708 | 0 / 0 |
| P48730 | Casein kinase I isoform delta | Ck1 | C00002708 | 1 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00002708 | 0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00002708 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002708 | 2 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00000293 | 2 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002708 | 0 / 0 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00002708 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002708 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002708 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002708 | 2 / 2 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00002708 | 5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002708 | 0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00002708 | 0 / 0 |
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | C00002708 | 0 / 0 |
| O75116 | Rho-associated protein kinase 2 | Rock | C00002708 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00002708 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002708 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00002708 | 4 / 1 |
| Q15118 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial | Pdhk | C00002708 | 0 / 0 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00002708 | 0 / 0 |
| P51812 | Ribosomal protein S6 kinase alpha-3 | Rskb | C00002708 | 2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002708 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002708 | 0 / 1 |
| Q9HC98 | Serine/threonine-protein kinase Nek6 | Nek | C00002708 | 0 / 0 |
| Q9H2X6 | Homeodomain-interacting protein kinase 2 | CMGC dual-specificity kinase HIPK | C00002708 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002708 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00002708 | 1 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002708 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002708 | 4 / 3 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00002708 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002708 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002708 | 0 / 1 |
| O96017 | Serine/threonine-protein kinase Chk2 | Rad53 | C00002708 | 4 / 1 |
| Q14012 | Calcium/calmodulin-dependent protein kinase type 1 | Camk1 | C00002708 | 0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00002708 | 0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | C00002708 | 1 / 0 |
| P53778 | Mitogen-activated protein kinase 12 | p38 | C00002708 | 0 / 0 |
| O00418 | Eukaryotic elongation factor 2 kinase | Atypical serine/threonine protein kinase alpha subfamily | C00002708 | 0 / 0 |
| Q8TD08 | Mitogen-activated protein kinase 15 | Mapk | C00002708 | 0 / 0 |
| Q86V86 | Serine/threonine-protein kinase pim-3 | Pim | C00002708 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002708 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002708 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002708 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00002708 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002708 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002708 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002708 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00002708 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002708 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002708 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002708 | 1 / 4 |
| P20248 | Cyclin-A2 | Other cytosolic protein | C00002708 | 0 / 0 |
| P78396 | Cyclin-A1 | Other cytosolic protein | C00002708 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00002708 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00002708 | 0 / 0 |
| P19784 | Casein kinase II subunit alpha' | Ck2 | C00002708 | 0 / 0 |
| P67870 | Casein kinase II subunit beta | REG serine/threonine protein kinase family | C00002708 | 0 / 0 |
53 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 25 | ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl | c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) |
C00002708
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00002708
|
| 578 | BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 | BCL2-antagonist/killer 1 |
C00002708
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00002708
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002708
|
| 839 | CASP6, MCH2 | caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) |
C00002708
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002708
|
| 896 | CCND3 | cyclin D3 |
C00002708
|
| 952 | CD38, T10 | CD38 molecule (EC:3.2.2.5) |
C00002708
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00002708
|
| 1021 | CDK6, PLSTIRE | cyclin-dependent kinase 6 (EC:2.7.11.22) |
C00002708
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002708
|
| 1050 | CEBPA, C/EBP-alpha, CEBP | CCAAT/enhancer binding protein (C/EBP), alpha |
C00002708
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00002708
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002708
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00002708
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00002708
|
| 1977 | EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F | eukaryotic translation initiation factor 4E |
C00002708
|
| 1978 | EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I | eukaryotic translation initiation factor 4E binding protein 1 |
C00002708
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00002708
|
| 9518 | GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB | growth differentiation factor 15 |
C00002708
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00002708
|
| 3190 | HNRNPK, CSBP, HNRPK, TUNP | heterogeneous nuclear ribonucleoprotein K |
C00002708
|
| 3309 | HSPA5, BIP, GRP78, MIF2 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
C00002708
|
| 3440 | IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2 | interferon, alpha 2 |
C00002708
|
| 3558 | IL2, IL-2, TCGF, lymphokine | interleukin 2 |
C00002708
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002708
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00002708
|
| 5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00002708
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002708
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00002708
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002708
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00002708
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002708
|
| 4282 | MIF, GIF, GLIF, MMIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) |
C00002708
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002708
|
| 2475 | MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 | mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) |
C00002708
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00002708
|
| 4922 | NTS, NMN-125, NN, NT, NT/N, NTS1 | neurotensin |
C00002708
|
| 5337 | PLD1 | phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) |
C00002708
|
| 5359 | PLSCR1, MMTRA1B | phospholipid scramblase 1 |
C00002708
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002708
|
| 5580 | PRKCD, MAY1, PKCD, nPKC-delta | protein kinase C, delta (EC:2.7.10.2 2.7.11.13) |
C00002708
|
| 5588 | PRKCQ, PRKCT, nPKC-theta | protein kinase C, theta (EC:2.7.11.13) |
C00002708
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002708
|
| 5894 | RAF1, CRAF, NS5, Raf-1, c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) |
C00002708
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00002708
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00002708
|
| 412 | STS, ARSC, ARSC1, ASC, ES, SSDD, XLI | steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) |
C00002708
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00002708
|
| 7039 | TGFA, TFGA | transforming growth factor, alpha |
C00002708
|
| 8795 | TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 | tumor necrosis factor receptor superfamily, member 10b |
C00002708
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00002708
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (71)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #615224 | Advanced sleep phase syndrome, familial, 2; fasps2 |
P48730
|
| #613780 | Aortic aneurysm, familial thoracic 7; aat7 |
Q15746
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
O96017
P31749 |
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #303600 | Coffin-lowry syndrome; cls |
P51812
|
| #114500 | Colorectal cancer; crc |
P18054
P31749 |
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #609265 | Li-fraumeni syndrome 2; lfs2 |
O96017
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300844 | Mental retardation, x-linked 19; mrx19 |
P51812
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #259500 | Osteogenic sarcoma |
O96017
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #176807 | Prostate cancer |
O96017
|
| #176920 | Proteus syndrome |
P31749
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #243060 | Spermatogenic failure 5; spgf5 |
Q9UQB9
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (82)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00881 | Li-Fraumeni syndrome |
O96017
(related)
P04637 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P31751 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
P08581 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P31751 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
P08581 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00480 | Non-syndromic X-linked mental retardation |
P51812
(related)
Q99714 (related) |
| H00574 | Coffin-Lowry syndrome (CLS) |
P51812
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
P53779
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
Q15746
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H01282 | Spermatogenic failure |
Q9UQB9
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|