PCIDB

KCF-S cluster No. 3672 (3 metabolites)

Corresponding Phytochemical cluster No. 67

Plant Species

Cumulative plant class count

class name count
rosids 4

Cumulative family count

class name count
Euphorbiaceae 4

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Phloroglucinols 1

metabolites link (1)

br08003 Category KEGG ID KNApSAcK ID
Phloroglucinols C10721 C00002708

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00002708 External link 512 Rottlerin
CHEMBL34241
CHEMBL1330502
C085746
122 / 69 / 82 53 / 4
C00007160 External link 512 3,4-Dihydroxyrottlerin
C00007161 External link 512 4-Hydroxyrottlerin

Human Protein / Gene in interactions

122 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002708 1 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00002708 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00002708 7 / 37
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00002708 0 / 0
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek C00002708 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002708 4 / 1
Q99700 Ataxin-2 Unclassified protein C00002708 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002708 2 / 0
Q15759 Mitogen-activated protein kinase 11 p38 C00002708 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002708 0 / 0
P06746 DNA polymerase beta Enzyme C00002708 0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00002708 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00002708 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00002708 0 / 0
P17252 Protein kinase C alpha type Alpha C00002708 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002708 0 / 0
Q05655 Protein kinase C delta type Delta C00002708 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002708 0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00002708 0 / 0
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily C00002708 0 / 0
P27448 MAP/microtubule affinity-regulating kinase 3 CAMK serine/threonine protein kinase MARK subfamily C00002708 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002708 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002708 11 / 10
Q05513 Protein kinase C zeta type Iota C00002708 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00002708 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002708 0 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 C00002708 0 / 0
Q9UQB9 Aurora kinase C Aur C00002708 1 / 1
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily C00002708 0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily C00002708 0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK C00002708 0 / 0
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK C00002708 0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk C00002708 0 / 0
P54132 Bloom syndrome protein Enzyme C00002708 1 / 2
P11473 Vitamin D3 receptor NR1I1 C00002708 2 / 3
Q15746 Myosin light chain kinase, smooth muscle Mlck C00002708 1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily C00002708 0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt C00002708 2 / 2
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00002708 0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00002708 0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn C00002708 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00002708 0 / 0
P17538 Chymotrypsinogen B S1A C00002708 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00002708 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002708 0 / 0
Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 META serine/threonine protein kinase subfamily C00002708 0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily C00002708 0 / 0
Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 Enzyme C00002708 0 / 0
Q96SB4 SRSF protein kinase 1 Srpk C00002708 0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 C00002708 0 / 0
O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 CMGC dual-specificity kinase DYRK2 C00002708 0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily C00002708 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002708 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002708 0 / 0
O75496 Geminin Unclassified protein C00002708 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00002708 0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb C00002708 0 / 0
O15264 Mitogen-activated protein kinase 13 p38 C00002708 0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk C00002708 0 / 1
P51955 Serine/threonine-protein kinase Nek2 Nek C00002708 0 / 0
Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 META serine/threonine protein kinase subfamily C00002708 0 / 0
Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 CAMK serine/threonine protein kinase MNK subfamily C00002708 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00002708 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00002708 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002708 0 / 0
P61586 Transforming protein RhoA Unclassified protein C00002708 0 / 0
P48730 Casein kinase I isoform delta Ck1 C00002708 1 / 0
Q96GD4 Aurora kinase B Aur C00002708 0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00002708 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002708 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002708 0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk C00002708 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002708 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002708 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002708 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00002708 5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002708 0 / 0
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily C00002708 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00002708 0 / 0
O75116 Rho-associated protein kinase 2 Rock C00002708 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002708 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002708 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00002708 4 / 1
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk C00002708 0 / 0
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00002708 0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb C00002708 2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002708 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002708 0 / 1
Q9HC98 Serine/threonine-protein kinase Nek6 Nek C00002708 0 / 0
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK C00002708 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002708 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00002708 1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002708 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002708 4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein C00002708 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002708 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002708 0 / 1
O96017 Serine/threonine-protein kinase Chk2 Rad53 C00002708 4 / 1
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 C00002708 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00002708 0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 C00002708 1 / 0
P53778 Mitogen-activated protein kinase 12 p38 C00002708 0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily C00002708 0 / 0
Q8TD08 Mitogen-activated protein kinase 15 Mapk C00002708 0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim C00002708 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002708 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002708 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002708 0 / 0
P40225 Thrombopoietin Unclassified protein C00002708 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002708 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002708 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002708 1 / 0
O00255 Menin Unclassified protein C00002708 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002708 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00002708 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002708 1 / 4
P20248 Cyclin-A2 Other cytosolic protein C00002708 0 / 0
P78396 Cyclin-A1 Other cytosolic protein C00002708 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00002708 0 / 0
P68400 Casein kinase II subunit alpha Ck2 C00002708 0 / 0
P19784 Casein kinase II subunit alpha' Ck2 C00002708 0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family C00002708 0 / 0

53 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
25 ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) C00002708
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002708
578 BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 BCL2-antagonist/killer 1 C00002708
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00002708
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002708
839 CASP6, MCH2 caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) C00002708
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002708
896 CCND3 cyclin D3 C00002708
952 CD38, T10 CD38 molecule (EC:3.2.2.5) C00002708
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00002708
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00002708
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002708
1050 CEBPA, C/EBP-alpha, CEBP CCAAT/enhancer binding protein (C/EBP), alpha C00002708
1277 COL1A1, OI4 collagen, type I, alpha 1 C00002708
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002708
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00002708
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00002708
1977 EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F eukaryotic translation initiation factor 4E C00002708
1978 EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I eukaryotic translation initiation factor 4E binding protein 1 C00002708
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00002708
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00002708
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00002708
3190 HNRNPK, CSBP, HNRPK, TUNP heterogeneous nuclear ribonucleoprotein K C00002708
3309 HSPA5, BIP, GRP78, MIF2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) C00002708
3440 IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2 interferon, alpha 2 C00002708
3558 IL2, IL-2, TCGF, lymphokine interleukin 2 C00002708
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002708
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00002708
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00002708
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002708
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00002708
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002708
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00002708
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00002708
4282 MIF, GIF, GLIF, MMIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) C00002708
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002708
2475 MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) C00002708
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00002708
4922 NTS, NMN-125, NN, NT, NT/N, NTS1 neurotensin C00002708
5337 PLD1 phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) C00002708
5359 PLSCR1, MMTRA1B phospholipid scramblase 1 C00002708
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002708
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC:2.7.10.2 2.7.11.13) C00002708
5588 PRKCQ, PRKCT, nPKC-theta protein kinase C, theta (EC:2.7.11.13) C00002708
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002708
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00002708
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002708
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00002708
412 STS, ARSC, ARSC1, ASC, ES, SSDD, XLI steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) C00002708
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00002708
7039 TGFA, TFGA transforming growth factor, alpha C00002708
8795 TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 tumor necrosis factor receptor superfamily, member 10b C00002708
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00002708

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (69)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer O96017
P31749
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P18054
P31749
#615109 Cowden syndrome 6; cws6 P31749
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300844 Mental retardation, x-linked 19; mrx19 P51812
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#259500 Osteogenic sarcoma O96017
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#176807 Prostate cancer O96017
#176920 Proteus syndrome P31749
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (82)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00881 Li-Fraumeni syndrome O96017 (related)
P04637 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P31751 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P31751 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P51812 (related)
Q99714 (related)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H01282 Spermatogenic failure Q9UQB9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00002708
D010051 Ovarian Neoplasms C00002708
D013736 Testicular Neoplasms C00002708
D015431 Weight Loss C00002708