PCIDB

KNApSAcK Metabolite C00002708

Metabolite

KNApSAcK Entry

id C00002708
Name Rottlerin
CAS RN 82-08-6
Standard InChI InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
Standard InChI (Main Layer) InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3

Cluster

Phytochemical cluster No. 67
KCF-S cluster No. 3672

Link

ChEMBL

By standard InChI CHEMBL34241
By standard InChI Main Layer CHEMBL34241 CHEMBL1330502

KEGG

By LinkDB C10721

CTD

By CAS RN C085746

Species

Summary

Plant class

class name count
rosids 2

Family

family name count
Euphorbiaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Mallotus philippensis 316645 Euphorbiaceae rosids Viridiplantae
Rottlera tinctoria 3977 Euphorbiaceae rosids Viridiplantae

Human Protein / Gene in interaction

122 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1330502 CHEMBL1741321 (1)
1 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 CHEMBL34241 CHEMBL1060147 (1)
1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1330502 CHEMBL1613992 (1)
7 / 44
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim CHEMBL34241 CHEMBL1061149 (1)
0 / 0
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek CHEMBL34241 CHEMBL1052109 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL34241 CHEMBL1613842 (3)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL34241 CHEMBL1794367 (1) CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL34241 CHEMBL1794499 (2)
2 / 0
Q15759 Mitogen-activated protein kinase 11 p38 CHEMBL34241 CHEMBL1062016 (1) CHEMBL1247634 (1)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL34241 CHEMBL1062824 (1) CHEMBL1247633 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL34241 CHEMBL1614079 (1)
0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 CHEMBL34241 CHEMBL1061083 (1)
0 / 0
P41240 Tyrosine-protein kinase CSK Csk CHEMBL34241 CHEMBL1062002 (1)
0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk CHEMBL34241 CHEMBL1060121 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL34241 CHEMBL1063727 (1) CHEMBL1249530 (1)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL34241 CHEMBL1062009 (1)
0 / 0
Q05655 Protein kinase C delta type Delta CHEMBL34241 CHEMBL766321 (1) CHEMBL1249788 (1)
CHEMBL1931128 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL34241 CHEMBL1738600 (1)
0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 CHEMBL34241 CHEMBL1063732 (1) CHEMBL1249541 (1)
0 / 0
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily CHEMBL34241 CHEMBL1051366 (1)
0 / 0
P27448 MAP/microtubule affinity-regulating kinase 3 CAMK serine/threonine protein kinase MARK subfamily CHEMBL34241 CHEMBL1060203 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL1330502 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL34241 CHEMBL1614310 (1) CHEMBL1614544 (1)
11 / 10
Q05513 Protein kinase C zeta type Iota CHEMBL34241 CHEMBL1061095 (1)
0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL34241 CHEMBL1061910 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1330502 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 CHEMBL34241 CHEMBL1061107 (1) CHEMBL1249534 (1)
0 / 0
Q9UQB9 Aurora kinase C Aur CHEMBL34241 CHEMBL1061993 (1)
1 / 1
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily CHEMBL34241 CHEMBL1060207 (1)
0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily CHEMBL34241 CHEMBL1061082 (1)
0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK CHEMBL34241 CHEMBL1060201 (1)
0 / 0
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK CHEMBL34241 CHEMBL1063749 (1)
0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk CHEMBL34241 CHEMBL1063735 (1)
0 / 0
P54132 Bloom syndrome protein Enzyme CHEMBL34241 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
P11473 Vitamin D3 receptor NR1I1 CHEMBL34241 CHEMBL1330502 CHEMBL1794311 (5)
2 / 3
Q15746 Myosin light chain kinase, smooth muscle Mlck CHEMBL34241 CHEMBL1063674 (1)
1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily CHEMBL34241 CHEMBL1060149 (1)
0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt CHEMBL34241 CHEMBL1062855 (1)
2 / 2
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily CHEMBL34241 CHEMBL1061974 (1) CHEMBL1247639 (1)
0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase CHEMBL34241 CHEMBL1052097 (1)
0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn CHEMBL34241 CHEMBL1062022 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL34241 CHEMBL1060157 (1)
0 / 0
P17538 Chymotrypsinogen B S1A CHEMBL34241 CHEMBL661258 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL1330502 CHEMBL1613800 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL34241 CHEMBL1330502 CHEMBL1614458 (5)
0 / 0
Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 META serine/threonine protein kinase subfamily CHEMBL34241 CHEMBL1061949 (1)
0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily CHEMBL34241 CHEMBL1063810 (1)
0 / 0
Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 Enzyme CHEMBL34241 CHEMBL913334 (1)
0 / 0
Q96SB4 SRSF protein kinase 1 Srpk CHEMBL34241 CHEMBL1060224 (1)
0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 CHEMBL34241 CHEMBL1062007 (1)
0 / 0
O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 CMGC dual-specificity kinase DYRK2 CHEMBL34241 CHEMBL1062805 (1)
0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily CHEMBL34241 CHEMBL1061161 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL34241 CHEMBL1794486 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL34241 CHEMBL1330502 CHEMBL1738606 (4)
0 / 0
O75496 Geminin Unclassified protein CHEMBL34241 CHEMBL1613941 (1) CHEMBL1738636 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL34241 CHEMBL1052077 (1) CHEMBL1249535 (1)
0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb CHEMBL34241 CHEMBL1063777 (1)
0 / 0
O15264 Mitogen-activated protein kinase 13 p38 CHEMBL34241 CHEMBL1063768 (1) CHEMBL1247636 (1)
0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk CHEMBL34241 CHEMBL1062757 (1)
0 / 1
P51955 Serine/threonine-protein kinase Nek2 Nek CHEMBL34241 CHEMBL1061977 (1)
0 / 0
Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 META serine/threonine protein kinase subfamily CHEMBL34241 CHEMBL1061996 (1)
0 / 0
Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 CAMK serine/threonine protein kinase MNK subfamily CHEMBL34241 CHEMBL1061970 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL34241 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL34241 CHEMBL1738610 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL34241 CHEMBL1330502 CHEMBL1794467 (3) CHEMBL1794492 (1)
0 / 0
P61586 Transforming protein RhoA Unclassified protein CHEMBL34241 CHEMBL1931129 (1)
0 / 0
P48730 Casein kinase I isoform delta Ck1 CHEMBL34241 CHEMBL1061203 (1)
1 / 0
Q96GD4 Aurora kinase B Aur CHEMBL34241 CHEMBL1062890 (1)
0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK CHEMBL34241 CHEMBL1060141 (1) CHEMBL1247638 (1)
CHEMBL1249806 (1)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL1330502 CHEMBL1614252 (1)
2 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL34241 CHEMBL1060115 (1) CHEMBL1247631 (1)
0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk CHEMBL34241 CHEMBL1062814 (1) CHEMBL1247632 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1330502 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1330502 CHEMBL1613910 (1) CHEMBL1614227 (2)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL1330502 CHEMBL1614038 (1)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL34241 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL34241 CHEMBL1738675 (1)
0 / 0
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily CHEMBL34241 CHEMBL1061099 (1)
0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK CHEMBL34241 CHEMBL732638 (1) CHEMBL1063666 (1)
CHEMBL1247640 (1) CHEMBL1249805 (1)
0 / 0
O75116 Rho-associated protein kinase 2 Rock CHEMBL34241 CHEMBL1063774 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1330502 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1330502 CHEMBL1614240 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL34241 CHEMBL1061171 (1) CHEMBL1249532 (1)
4 / 1
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk CHEMBL34241 CHEMBL1249531 (1)
0 / 0
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily CHEMBL34241 CHEMBL1060221 (1) CHEMBL1249533 (1)
0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb CHEMBL34241 CHEMBL1052117 (1)
2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1330502 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1330502 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
Q9HC98 Serine/threonine-protein kinase Nek6 Nek CHEMBL34241 CHEMBL1052108 (1)
0 / 0
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK CHEMBL34241 CHEMBL1062014 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL34241 CHEMBL1794483 (2)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL34241 CHEMBL1614052 (1)
1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL34241 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL34241 CHEMBL1330502 CHEMBL1614250 (3) CHEMBL1614421 (5)
CHEMBL1614502 (5)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL34241 CHEMBL1738402 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL34241 CHEMBL1737980 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL34241 CHEMBL1249540 (1)
0 / 1
O96017 Serine/threonine-protein kinase Chk2 Rad53 CHEMBL34241 CHEMBL1052082 (1)
4 / 1
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 CHEMBL34241 CHEMBL1062799 (1)
0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL34241 CHEMBL1062780 (1)
0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 CHEMBL34241 CHEMBL1063743 (1)
1 / 0
P53778 Mitogen-activated protein kinase 12 p38 CHEMBL34241 CHEMBL1060154 (1) CHEMBL1247635 (1)
0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily CHEMBL34241 CHEMBL1052075 (1)
0 / 0
Q8TD08 Mitogen-activated protein kinase 15 Mapk CHEMBL34241 CHEMBL1052076 (1)
0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim CHEMBL34241 CHEMBL1051343 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL34241 CHEMBL1330502 CHEMBL1794536 (3)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL34241 CHEMBL1330502 CHEMBL1613914 (3)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL34241 CHEMBL1614330 (1) CHEMBL1613829 (4)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL1330502 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL34241 CHEMBL1738442 (4)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL34241 CHEMBL1330502 CHEMBL1614364 (4)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL34241 CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL34241 CHEMBL1330502 CHEMBL1614257 (3)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL34241 CHEMBL1330502 CHEMBL1614257 (3)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL34241 CHEMBL1330502 CHEMBL1613933 (3)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL34241 CHEMBL1330502 CHEMBL1613933 (3)
1 / 6
P20248 Cyclin-A2 Other cytosolic protein CHEMBL34241 CHEMBL1061199 (1)
0 / 0
P78396 Cyclin-A1 Other cytosolic protein CHEMBL34241 CHEMBL1061199 (1)
0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL34241 CHEMBL1061199 (1)
0 / 0
P68400 Casein kinase II subunit alpha Ck2 CHEMBL34241 CHEMBL1052072 (1)
0 / 0
P19784 Casein kinase II subunit alpha' Ck2 CHEMBL34241 CHEMBL1052072 (1)
0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family CHEMBL34241 CHEMBL1052072 (1)
0 / 0

CTD interaction (96)

compound gene gene name gene description interaction interaction type form reference
pmid
C085746 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] decreases activity
/ decreases reaction
/ increases expression
/ increases phosphorylation
protein 17030193
C085746 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C085746 578 BAK1
BAK
BAK-LIKE
BCL2L7
CDN1
BCL2-antagonist/killer 1 rottlerin inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein] decreases reaction
/ increases activity
protein 15917298
C085746 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] decreases reaction
/ increases expression
mRNA 14527959
C085746 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) rottlerin inhibits the reaction [NSC606985 results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 19662097
C085746 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 21362627
C085746 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) rottlerin results in increased activity of CASP3 protein increases activity
protein 22410117
C085746 839 CASP6
MCH2
caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein] decreases reaction
/ increases cleavage
protein 21362627
C085746 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 [sorafenib co-treated with rottlerin] results in decreased expression of CCND1 protein affects cotreatment
/ decreases expression
protein 16959960
C085746 896 CCND3
cyclin D3 [sorafenib co-treated with rottlerin] results in decreased expression of CCND3 protein affects cotreatment
/ decreases expression
protein 16959960
C085746 952 CD38
T10
CD38 molecule (EC:3.2.2.5) rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA] decreases reaction
/ increases expression
mRNA 21393419
C085746 952 CD38
T10
CD38 molecule (EC:3.2.2.5) rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 protein] decreases reaction
/ increases expression
protein 21393419
C085746 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) [sorafenib co-treated with rottlerin] results in decreased expression of CDK4 protein affects cotreatment
/ decreases expression
protein 16959960
C085746 1021 CDK6
PLSTIRE
cyclin-dependent kinase 6 (EC:2.7.11.22) [sorafenib co-treated with rottlerin] results in decreased expression of CDK6 protein affects cotreatment
/ decreases expression
protein 16959960
C085746 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 15976015
C085746 1050 CEBPA
C/EBP-alpha
CEBP
CCAAT/enhancer binding protein (C/EBP), alpha rottlerin inhibits the reaction [NSC606985 results in decreased expression of CEBPA protein] decreases expression
/ decreases reaction
protein 19662097
C085746 1050 CEBPA
C/EBP-alpha
CEBP
CCAAT/enhancer binding protein (C/EBP), alpha rottlerin inhibits the reaction [NSC606985 results in increased ubiquitination of CEBPA protein] decreases reaction
/ increases ubiquitination
protein 19662097
C085746 1277 COL1A1
OI4
collagen, type I, alpha 1 rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] decreases activity
/ decreases reaction
/ increases expression
/ increases phosphorylation
protein 17030193
C085746 1277 COL1A1
OI4
collagen, type I, alpha 1 rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA] decreases reaction
/ increases expression
mRNA 17030193
C085746 1277 COL1A1
OI4
collagen, type I, alpha 1 rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 protein] decreases reaction
/ increases expression
protein 17030193
C085746 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) rottlerin results in decreased activity of CYP19A1 protein decreases activity
protein 15955695
C085746 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA] decreases reaction
/ increases expression
mRNA 17171638
C085746 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 rottlerin results in increased expression of DDIT3 protein increases expression
protein 22410117
C085746 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) rottlerin inhibits the reaction [irinotecan metabolite results in increased phosphorylation of EGFR protein] decreases reaction
/ increases phosphorylation
protein 15723263
C085746 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) rottlerin inhibits the reaction [irinotecan results in increased phosphorylation of EGFR protein] decreases reaction
/ increases phosphorylation
protein 15723263
C085746 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C085746 1977 EIF4E
AUTS19
CBP
EIF4E1
EIF4EL1
EIF4F
eukaryotic translation initiation factor 4E rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] affects binding
/ increases reaction
protein 19771169
C085746 1978 EIF4EBP1
4E-BP1
4EBP1
BP-1
PHAS-I
eukaryotic translation initiation factor 4E binding protein 1 rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] decreases reaction
/ increases phosphorylation
protein 19771169
C085746 1978 EIF4EBP1
4E-BP1
4EBP1
BP-1
PHAS-I
eukaryotic translation initiation factor 4E binding protein 1 rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] affects binding
/ increases reaction
protein 19771169
C085746 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein] affects localization
/ decreases reaction
protein 20599481
C085746 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rottlerin results in increased expression of GDF15 protein] decreases reaction
/ increases expression
protein 22410117
C085746 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 GDF15 affects the susceptibility to rottlerin affects response to substance
22410117
C085746 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 rottlerin results in increased expression of GDF15 mRNA increases expression
mRNA 22410117
C085746 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 rottlerin results in increased expression of GDF15 protein increases expression
protein 22410117
C085746 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 SB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein] decreases reaction
/ increases expression
protein 22410117
C085746 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA] decreases reaction
/ increases expression
mRNA 21238556
C085746 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 protein] decreases reaction
/ increases expression
protein 21238556
C085746 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) rottlerin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA] decreases reaction
/ increases expression
mRNA 18048804
C085746 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] decreases reaction
/ increases expression
protein 18357586
C085746 3190 HNRNPK
CSBP
HNRPK
TUNP
heterogeneous nuclear ribonucleoprotein K rottlerin inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein] decreases expression
/ decreases reaction
protein 19747914
C085746 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) rottlerin results in increased expression of HSPA5 protein increases expression
protein 22410117
C085746 3440 IFNA2
IFN-alphaA
IFNA
IFNA2B
INFA2
interferon, alpha 2 rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 mRNA] decreases reaction
/ increases expression
protein 16260419
C085746 3440 IFNA2
IFN-alphaA
IFNA
IFNA2B
INFA2
interferon, alpha 2 rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 protein] decreases reaction
/ increases expression
protein 16260419
C085746 3440 IFNA2
IFN-alphaA
IFNA
IFNA2B
INFA2
interferon, alpha 2 rottlerin inhibits the reaction [IFNA2 protein results in increased phosphorylation of and results in increased activity of PRKCD protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16260419
C085746 3558 IL2
IL-2
TCGF
lymphokine
interleukin 2 rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] affects cotreatment
/ decreases reaction
/ increases expression
/ increases reaction
protein 16241859
C085746 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 rottlerin inhibits the reaction [Deferoxamine results in increased expression of IL8 protein] decreases reaction
/ increases expression
protein 17097691
C085746 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein] affects localization
/ decreases reaction
protein 20599481
C085746 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein] decreases reaction
/ increases activity
/ increases expression
protein 18628248
C085746 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of JUN protein] decreases reaction
/ increases expression
/ increases phosphorylation
protein 18628248
C085746 5604 MAP2K1
CFC3
MAPKK1
MEK1
MKK1
PRKMK1
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) rottlerin results in decreased phosphorylation of MAP2K1 protein decreases phosphorylation
protein 15949478
C085746 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17030193
C085746 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C085746 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 18628248
20599481
C085746 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK1 protein affects cotreatment
/ decreases phosphorylation
protein 16959960
C085746 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) rottlerin results in decreased phosphorylation of MAPK14 protein decreases phosphorylation
protein 15949478
C085746 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 17030193
C085746 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C085746 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 18628248
20599481
C085746 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK3 protein affects cotreatment
/ decreases phosphorylation
protein 16959960
C085746 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) rottlerin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases phosphorylation
protein 15917298
C085746 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases phosphorylation
protein 20599481
C085746 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein] decreases reaction
/ increases phosphorylation
protein 20599481
C085746 4282 MIF
GIF
GLIF
MMIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein] decreases reaction
/ increases expression
protein 16872482
C085746 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein] decreases reaction
/ increases expression
protein 16872482
C085746 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein] decreases reaction
/ increases activity
protein 20599481
C085746 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA] decreases reaction
/ increases expression
mRNA 20599481
C085746 2475 MTOR
FRAP
FRAP1
FRAP2
RAFT1
RAPT1
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] decreases reaction
/ increases phosphorylation
protein 19771169
C085746 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 rottlerin inhibits the reaction [Acrolein affects the localization of NFE2L2 protein] affects localization
/ decreases reaction
protein 18048804
C085746 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C085746 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C085746 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C085746 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C085746 5337 PLD1
phospholipase D1, phosphatidylcholine-specific (EC:3.1.4.4) rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 17640750
C085746 5359 PLSCR1
MMTRA1B
phospholipid scramblase 1 rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 mRNA] decreases reaction
/ increases expression
mRNA 16260419
C085746 5359 PLSCR1
MMTRA1B
phospholipid scramblase 1 rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 protein] decreases reaction
/ increases expression
protein 16260419
C085746 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] decreases activity
/ decreases reaction
/ increases expression
/ increases phosphorylation
protein 17030193
C085746 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein] decreases reaction
/ increases phosphorylation
protein 17171638
C085746 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) rottlerin inhibits the reaction [IFNA2 protein results in increased phosphorylation of and results in increased activity of PRKCD protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16260419
C085746 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) rottlerin inhibits the reaction [NSC606985 results in increased activity of and results in increased cleavage of PRKCD protein] decreases reaction
/ increases activity
/ increases cleavage
protein 19662097
C085746 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) rottlerin results in decreased activity of PRKCD protein decreases activity
protein 15949478
15955695
C085746 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]] decreases activity
/ decreases reaction
/ increases expression
/ increases reaction
protein 22643241
C085746 5588 PRKCQ
PRKCT
nPKC-theta
protein kinase C, theta (EC:2.7.11.13) rottlerin results in decreased activity of PRKCQ protein decreases activity
protein 15691325
C085746 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 17363696
C085746 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 17363696
C085746 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) rottlerin inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 19084589
C085746 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 17640750
C085746 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) rottlerin results in decreased phosphorylation of RAF1 protein decreases phosphorylation
protein 15949478
C085746 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 rottlerin results in decreased phosphorylation of RB1 protein decreases phosphorylation
protein 15949478
C085746 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 21705328
C085746 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein] decreases reaction
/ increases expression
protein 21705328
C085746 412 STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) rottlerin inhibits the reaction [Tretinoin results in increased activity of STS protein] decreases reaction
/ increases activity
protein 16178010
C085746 7031 TFF1
BCEI
D21S21
HP1.A
HPS2
pNR-2
pS2
trefoil factor 1 [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]] decreases activity
/ decreases reaction
/ increases expression
/ increases reaction
mRNA 22643241
C085746 7039 TGFA
TFGA
transforming growth factor, alpha rottlerin inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein] decreases reaction
/ increases secretion
protein 15723263
C085746 7039 TGFA
TFGA
transforming growth factor, alpha rottlerin inhibits the reaction [irinotecan results in increased secretion of TGFA protein] decreases reaction
/ increases secretion
protein 15723263
C085746 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased expression of TNFRSF10B] decreases reaction
/ increases expression
21362627
C085746 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A rottlerin inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol] decreases reaction
/ increases abundance
protein 14704231

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (69)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer O96017
P31749
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P18054
P31749
#615109 Cowden syndrome 6; cws6 P31749
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300844 Mental retardation, x-linked 19; mrx19 P51812
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#259500 Osteogenic sarcoma O96017
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#176807 Prostate cancer O96017
#176920 Proteus syndrome P31749
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (82)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00881 Li-Fraumeni syndrome O96017 (related)
P04637 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P31751 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P31751 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P51812 (related)
Q99714 (related)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H01282 Spermatogenic failure Q9UQB9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D058186 C085746 Acute Kidney Injury therapeutic
21633170
D010051 C085746 Ovarian Neoplasms therapeutic
21633170
D013736 C085746 Testicular Neoplasms therapeutic
21633170
D015431 C085746 Weight Loss therapeutic
21633170