Pseudotsuga menziesii

• Index
• Plant Species
• Natural Activity
• Metabolite list (32)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Pseudotsuga menziesii
Genus	Pseudotsuga
Family	Pinaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Pseudotsuga menziesii
Linked NCBI taxonomy ID	3357
Linked level	species

Family

Family in NCBI taxonomy	Pinaceae
ID	3318

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Spermatophyta
ID	58024

Natural Activity

List (7)

Species	Activity
Pseudotsuga menziesii (Mirb.) Franco.	Antidote, cicuta
Pseudotsuga menziesii (Mirb.) Franco.	Antiseptic
Pseudotsuga menziesii (Mirb.) Franco.	Antitussive
Pseudotsuga menziesii (Mirb.) Franco.	Diuretic
Pseudotsuga menziesii (Mirb.) Franco.	Emetic
Pseudotsuga menziesii (Mirb.) Franco.	Laxative
Pseudotsuga menziesii (Mirb.) Franco.	Tonic

Metabolite list (32)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005386	Quercetin 3'-glucoside / 3,5,7,3',4'-Pentahydroxyflavone	CHEMBL1222354				No. 2	No. 15
C00008238	Poriolin					No. 12	No. 14
C00008711	Taxifolin 3'-glucoside					No. 12	No. 14
C00008351	5,7,3',4'-Tetrahydroxy-6-C-methylflavanone 7-O-glucosdie					No. 12	No. 14
C00008237	Poriol	CHEMBL484640		20 / 14 / 14		No. 25	No. 14
C00009098	Procyanidin C1 / [Epicatechin-(4beta->8)]2-epicatechin	CHEMBL290632		13 / 5 / 6		No. 29	No. 19
C00009097	Arecatamnin A1 / [Epicatechin-(4beta->8)]2-catechin	CHEMBL290632		13 / 5 / 6		No. 29	No. 19
C00009095	Procyanidin C4	CHEMBL290632		13 / 5 / 6		No. 29	No. 19
C00009087	Epicatechin-(4beta->6)-epicatechin-(4beta->8)-epicatechin	CHEMBL592228		2 / 3 / 4		No. 29	No. 19
C00000001	GA1 / Gibberellin A1		C422660			No. 40	No. 41
C00000004	GA4 / Gibberellin A4					No. 40	No. 41
C00000007	GA7 / Gibberellin A7					No. 40	No. 41
C00000003	GA3 / Gibberellin A3	CHEMBL513241 CHEMBL566653 CHEMBL1232952 CHEMBL1476967 CHEMBL1487394	C007842	10 / 18 / 17		No. 40	No. 41
C00000677	Distylin / Dihydroquercetin / (2R,3R)-Taxifolin	CHEMBL66 CHEMBL9249 CHEMBL337309 CHEMBL1492383	C003377	65 / 41 / 37	29 / 1	No. 42	No. 14
C00008991	Catechin-4beta-ol	CHEMBL123809 CHEMBL124022 CHEMBL126393				No. 52	No. 14
C00006532	[5',5']-Bisdihydroquercetin					No. 57	No. 18
C00009109	[Epicatechin-(4beta->8)]4-epicatechin	CHEMBL592373		2 / 3 / 4		No. 113	No. 19
C00009106	Arecatannin A2					No. 113	No. 19
C00009108	[Epicatechin-(4beta->8)]4-catechin	CHEMBL592373		2 / 3 / 4		No. 113	No. 19
C00009107	Cinnamtannin A1					No. 113	No. 19
C00000096	9-Ribosyl-trans-zeatin / Zeatin-9-beta-D-ribofuranoside					No. 989
C00000100	IAA / Indole-3-acetic acid	CHEMBL82411	C030737	3 / 0 / 0	2 / 1	No. 1432	No. 4
C00001141	Melezitose	CHEMBL386007	C005190			No. 1765
C00011902	Pseudotsugonal					No. 2790
C00000094	2iP / N6-(delta2-Isopentenyl)adenine	CHEMBL476189	C001478	5 / 2 / 3	18 / 0	No. 2879
C00000842	Bornyl acetate	CHEMBL1439452		4 / 1 / 4		No. 4140	No. 35
C00000101	IAA methyl ester / Methyl indole-3-acetate					No. 4225
C00011900	ar-Todomatuic acid / (+/-)-ar-Todomatuic acid / (R)-4-(1,5-Dimethyl-3-oxohexyl)benzoic acid					No. 5320
C00011901	ar-Pseudotsugonal / (R)-4-(1,5-Dimethyl-3-oxohexyl)-benzaldehyde					No. 5320
C00011898	Dihydropseudotsugonol					No. 5371
C00011899	Dihydropseudotsugonal					No. 5371
C00000676	Pseudotsuganol					No. 5439

Human Protein / Gene in interactions

81 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P14780	Matrix metalloproteinase-9	M10A	C00000677 C00009087 C00009095 C00009097 C00009098 C00009108 C00009109	2 / 2
P08253	72 kDa type IV collagenase	M10A	C00000677 C00009087 C00009095 C00009097 C00009098 C00009108 C00009109	1 / 3
P05129	Protein kinase C gamma type	Alpha	C00000677 C00009095 C00009097 C00009098	1 / 1
Q05513	Protein kinase C zeta type	Iota	C00000677 C00009095 C00009097 C00009098	0 / 0
P24723	Protein kinase C eta type	Eta	C00000677 C00009095 C00009097 C00009098	1 / 0
P05771	Protein kinase C beta type	Alpha	C00000677 C00009095 C00009097 C00009098	0 / 0
P41743	Protein kinase C iota type	Iota	C00000677 C00009095 C00009097 C00009098	0 / 0
Q05655	Protein kinase C delta type	Delta	C00000677 C00009095 C00009097 C00009098	0 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00000677 C00009095 C00009097 C00009098	0 / 0
Q04759	Protein kinase C theta type	Delta	C00000677 C00009095 C00009097 C00009098	0 / 1
O94806	Serine/threonine-protein kinase D3	Pkd	C00000677 C00009095 C00009097 C00009098	0 / 0
Q02156	Protein kinase C epsilon type	Eta	C00000677 C00009095 C00009097 C00009098	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00000677 C00009095 C00009097 C00009098	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000003 C00000094 C00000677	1 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000003 C00000094 C00000677	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000003 C00000094 C00000677	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000003 C00000094 C00000677	0 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00000677 C00000842 C00008237	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000003 C00000094 C00000677	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000677 C00000842	1 / 4
O00255	Menin	Unclassified protein	C00000677 C00008237	2 / 5
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000677 C00008237	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000677 C00000842	0 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000677 C00008237	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00000677 C00008237	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000677 C00008237	1 / 2
P39748	Flap endonuclease 1	Enzyme	C00000677 C00008237	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000677 C00008237	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000677 C00008237	0 / 0
O75496	Geminin	Unclassified protein	C00000003 C00000677	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000677 C00008237	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000003 C00000677	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00000677 C00008237	1 / 1
P24298	Alanine aminotransferase 1	Enzyme	C00000677	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00008237	0 / 0
P03956	Interstitial collagenase	M10A	C00000677	0 / 1
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00000677	0 / 0
Q9HBH1	Peptide deformylase, mitochondrial	Enzyme	C00000100	0 / 0
P45452	Collagenase 3	M10A	C00000677	1 / 1
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00000677	2 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000677	0 / 0
P56817	Beta-secretase 1	A1A	C00000677	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000677	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000003	2 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000677	3 / 3
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00000677	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000677	2 / 2
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000677	5 / 2
P35372	Mu-type opioid receptor	Opioid receptor	C00000677	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000677	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000677	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000842	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000677	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00000677	1 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00008237	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000677	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000677	4 / 3
P10275	Androgen receptor	NR3C4	C00000003	3 / 4
P08254	Stromelysin-1	M10A	C00000677	1 / 0
P11473	Vitamin D3 receptor	NR1I1	C00008237	2 / 3
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00008237	7 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000677	0 / 0
Q9GZU7	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	Enzyme	C00008237	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000677	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00008237	1 / 0
P54132	Bloom syndrome protein	Enzyme	C00000677	1 / 2
P02768	Serum albumin	Secreted protein	C00000100	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000677	1 / 1
P02545	Prelamin-A/C	Unclassified protein	C00000003	11 / 10
P28907	ADP-ribosyl cyclase 1	Enzyme	C00000677	0 / 1
P39900	Macrophage metalloelastase	M10A	C00000677	0 / 0
Q16773	Kynurenine--oxoglutarate transaminase 1	Enzyme	C00000100	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000677	1 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00000677	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000677	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00000677	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000677	2 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00000677	4 / 1
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	Other cytosolic protein	C00008237	0 / 0
Q02410	Amyloid beta A4 precursor protein-binding family A member 1	Unclassified protein	C00008237	0 / 0
Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	N-TYPE	C00008237	0 / 0

48 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000094 C00000677
1630	DCC, CRC18, CRCR1, IGDCC1, MRMV1	deleted in colorectal carcinoma	C00000677
10681	GNB5, GB5	guanine nucleotide binding protein (G protein), beta 5	C00000094
182	JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1	jagged 1	C00000094
9818	NUPL1, PRO2463	nucleoporin like 1	C00000094
5142	PDE4B, DPDE4, PDE4B5, PDEIVB	phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17)	C00000094
8544	PIR	pirin (iron-binding nuclear protein) (EC:1.13.11.24)	C00000094
5366	PMAIP1, APR, NOXA	phorbol-12-myristate-13-acetate-induced protein 1	C00000094
9360	PPIG, CARS-Cyp, CYP, SCAF10, SRCyp	peptidylprolyl isomerase G (cyclophilin G) (EC:5.2.1.8)	C00000094
5782	PTPN12, PTP-PEST, PTPG1	protein tyrosine phosphatase, non-receptor type 12 (EC:3.1.3.48)	C00000094
5774	PTPN3, PTP-H1, PTPH1	protein tyrosine phosphatase, non-receptor type 3 (EC:3.1.3.48)	C00000094
6004	RGS16, A28-RGS14, A28-RGS14P, RGS-R	regulator of G-protein signaling 16	C00000094
6016	RIT1, NS8, RIBB, RIT, ROC1	Ras-like without CAAX 1	C00000094
6286	S100P, MIG9	S100 calcium binding protein P	C00000094
7029	TFDP2, DP2	transcription factor Dp-2 (E2F dimerization partner 2)	C00000094
7127	TNFAIP2, B94, EXOC3L3	tumor necrosis factor, alpha-induced protein 2	C00000094
440	ASNS, TS11	asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4)	C00000094
7431	VIM, CTRCT30	vimentin	C00000094
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00000677
335	APOA1	apolipoprotein A-I	C00000677
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00000677
8900	CCNA1	cyclin A1	C00000677
993	CDC25A, CDC25A2	cell division cycle 25A (EC:3.1.3.48)	C00000677
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00000677
694	BTG1	B-cell translocation gene 1, anti-proliferative	C00000094
1950	EGF, HOMG4, URG	epidermal growth factor	C00000677
8817	FGF18, FGF-18, ZFGF5	fibroblast growth factor 18	C00000677
2248	FGF3, HBGF-3, INT2	fibroblast growth factor 3	C00000677
2621	GAS6, AXLLG, AXSF	growth arrest-specific 6	C00000677
9518	GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB	growth differentiation factor 15	C00000677
2944	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	C00000677
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00000677
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00000677
3458	IFNG, IFG, IFI	interferon, gamma	C00000677
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00000677
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00000677
4547	MTTP, ABL, MTP	microsomal triglyceride transfer protein	C00000677
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00000677
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00000677
5155	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis	platelet-derived growth factor beta polypeptide	C00000677
5921	RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	C00000677
6772	STAT1, CANDF7, ISGF-3, STAT91	signal transducer and activator of transcription 1, 91kDa	C00000677
7187	TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1	TNF receptor-associated factor 3	C00000677
7498	XDH, XO, XOR	xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)	C00000677
7507	XPA, XP1, XPAC	xeroderma pigmentosum, complementation group A	C00000677
7518	XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	C00000677
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000100
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00000100

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions