KCF-S cluster No. 29 (115 metabolites)

Corresponding Phytochemical cluster No. 19

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (115)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	120
asterids	40
Euphyllophyta	28
eudicotyledons	15
Liliopsida	14
Magnoliophyta	13
Spermatophyta	12

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Cumulative family count (Top 20)

class name	count
Fabaceae	24
Theaceae	23
Dryopteridaceae	14
Rosaceae	13
Vitaceae	13
Anacardiaceae	12
Polygonaceae	9
Pinaceae	9
Lauraceae	9
Salicaceae	9
Rubiaceae	9
Gleicheniaceae	8
Hippocastanaceae	7
Rhizophoraceae	7
Myrtaceae	7
Betulaceae	6
Cistaceae	6
Poaceae	5
Dioscoreaceae	5
Myricaceae	4

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Proanthocyanidins	5

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Proanthocyanidins	C09972	C00001010
Proanthocyanidins	C10223	C00002919
Proanthocyanidins	C10225	C00002921
Proanthocyanidins	C10233	C00002929
Proanthocyanidins	C10239	C00002936

Metabolite list (115)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001010	Theasinensin A	CHEMBL349197 CHEMBL1394337		16 / 16 / 21
C00002919	Epigallocatechin-(4beta->8)-epicatechin-3-O-gallate
C00002921	ent-Fisetinidol-(4beta->8)-catechin-(6->4beta)-ent-fisetinidol
C00002929	Kandelin A1 / Cinchonain-1a-(4beta->8)-catechin	CHEMBL491581
C00002936	Robinetinidol-(4alpha->8)-catechin-(6->4alpoha)-robinetinidol
C00008914	Catechin-(6'->8)-catechin-(4alpha->8)-catechin
C00008916	Theasinensin B	CHEMBL159548 CHEMBL1325390		15 / 23 / 26
C00008918	Theasinensin F	CHEMBL159692
C00008927	Mesquitol-(5->6)-catechin-(8->5)-mesquitol
C00008930	Assamicain A	CHEMBL348910 CHEMBL350009
C00008931	Assamicain C
C00008960	8,12-Bis(2,4-dihydroxyphenyl)-6,10-bis(3,4-dihydroxyphenyl)-7,11-dihydroxy-7,8,11,12-tetrahydro-6H,10H-dipyrano[2,3-f:2',3'-h]catechin
C00009051	Cassiaflavan-(4beta->8)-epiafzelechin-(4beta->8)-epiafzelechin
C00009054	Prodistenidin C1
C00009063	[Epiafzelechin-(4beta->8)]2-epiafzelechin
C00009064	[Epiafzelechin-(4beta->8)]2-4'-O-methyl-epigallocatechin
C00009065	[3,5,7,4'-Tetrahydroxyflavan-(4->8)]2-3,4,5,7,4'-pentahydroxyflavan
C00009083	[Catechin-(4alpha->6)]2-epicatechin
C00009084	[Epicatechin-(4beta->6)]2-epicatechin
C00009085	Catechin-(4alpha->6)-epicatechin-(4beta->8)-epicatechin	CHEMBL592228		2 / 3 / 4
C00009086	Epicatechin-(4beta->6)-epicatechin-(4beta->8)-catechin	CHEMBL592228		2 / 3 / 4
C00009087	Epicatechin-(4beta->6)-epicatechin-(4beta->8)-epicatechin	CHEMBL592228		2 / 3 / 4
C00009088	Catechin-(4alpha->8)-catechin-(4alpha->6)-catechin	CHEMBL592329		2 / 3 / 4
C00009089	Arecatannin B1	CHEMBL592329		2 / 3 / 4
C00009090	Epicatechin-(4beta->8)-epicatechin-(4beta->6)-epicatechin	CHEMBL592329		2 / 3 / 4
C00009091	Procyanidin C2	CHEMBL290632		13 / 5 / 6
C00009092	[Catechin-(4alpha->8)]2-epicatechin	CHEMBL290632		13 / 5 / 6
C00009093	Catechin-(4alpha->8)-epicatechin-(4beta->8)-catechin	CHEMBL290632		13 / 5 / 6
C00009094	Catechin-(4alpha->8)-epicatechin-(4beta->8)-epicatechin	CHEMBL290632		13 / 5 / 6
C00009095	Procyanidin C4	CHEMBL290632		13 / 5 / 6
C00009096	Epicatechin-(4beta->8)-catechin-(4alpha->8)-epicatechin	CHEMBL290632		13 / 5 / 6
C00009097	Arecatamnin A1 / [Epicatechin-(4beta->8)]2-catechin	CHEMBL290632		13 / 5 / 6
C00009098	Procyanidin C1 / [Epicatechin-(4beta->8)]2-epicatechin	CHEMBL290632		13 / 5 / 6
C00009099	Catechin-(4alpha->8)-gallocatechin-(4alpha->8)-catechin
C00009100	Catechin-(4alpha->8)-gallocatechin-(4alpha->8)-gallocatechin
C00009119	Gallocatechin-(4alpha->8)-catechin-(4alpha->8)-catechin
C00009120	[Gallocatechin-(4alpha->8)]2-catechin
C00009121	[Gallocatechin-(4alpha->8)]2-gallocatechin
C00009133	Guibourtinidol-(4alpha->10)-[7,8-dihydro-8-(2,4-dihydroxyphenyl)-6-(3,4-dihydroxyphenyl)-7-hydroxy-6H-pyrano[2,3-f]catechin
C00009150	Fisetinidol-(4alpha->8)-catechin-(6->4alpha)-fisetinidol
C00009151	Fisetinidol-(4beta->8)-catechin-(6->4alpha)-fisetinidol
C00009152	ent-Fisetinidol-(4alpha->8)-catechin-(6->4alpha)-ent-fisetinidol
C00009153	ent-Fisetinidol-(4beta->8)-catechin-(6->4alpha)-ent-fisetinidol
C00009154	Fisetinidol-(4beta->6)-fisetinidol-(4alpha->6)-fisetinidol-4alpha-ol
C00009165	Fisetinidol-(4alpha->8)-[7,8-dihydro-8-(2,4-dihydroxyphenyl)-7-hydroxy-6-(4-hydroxyphenyl)-6H-pyrano[2,3-f]catechin]
C00009166	Fisetinidol-(4alpha->8)-[7,8-dihydro-8-(2,4-dihydroxyphenyl)-6-(3,4-dihydroxyphenyl)-7-hydroxy-6H-pyrano[2,3-f]catechin]
C00009171	Robinetinidol-(4beta->8)-catechin-(6->4beta)-robinetinidol
C00009172	Robinetinidol-(4alpha->8)-gallocatechin-(6->4alpha)-robinetinidol
C00009173	Dolabriproanthocyanidin
C00009181	Robinetinidol-(4alpha->8)-[7,8-dihydro-8-(2,4-dihydroxyphenyl)-7-hydroxy-6-(3,4,5-trihydroxyphenyl)-6H-pyrano[2,3-f]catechin]
C00009186	Cinchonanin IIa / Cinchonain-1a-(4beta->8)-epicatechin	CHEMBL491581
C00009205	3-O-Galloylepiafzelechin-(4beta->6)-epigallocatechin-3-O-gallate
C00009206	3-O-Galloylepicatechin-(4beta->6)-catechin
C00009207	3-O-Galloylepicatechin-(4beta->6)-epicatechin-3-O-gallate
C00009208	3-O-Galloylepicatechin-(4beta->8)-epicatechin
C00009209	3-O-Galloylcatechin-(4alpha->8)-catechin
C00009210	Catechin-(4alpha->8)-epicatechin-3-O-gallate
C00009211	3-O-Galloylepicatechin-(4beta->8)-catechin
C00009212	Epicatechin-(4beta->8)-epicatechin-3-O-gallate
C00009213	3-O-Galloylepicatechin-(4beta->8)-epicatechin-3-O-gallate	CHEMBL39504		11 / 2 / 2
C00009214	3-O-Galloyl-ent-epicatechin-(4alpha->8)-ent-epicatechin
C00009215	ent-Epicatechin-(4alpha->8)-ent-epicatechin-3-O-gallate
C00009216	3-O-Galloyl-ent-epicatechin-(4alpha->8)-ent-epicatechin-3-O-gallate	CHEMBL39504		11 / 2 / 2
C00009217	3-O-Galloylepicatechin-(4beta->6)-epigallocatechin-3-O-gallate
C00009218	Catechin-(4alpha->8)-epigallocatechin-3-O-gallate
C00009219	3-O-Galloylepicatechin-(4beta->8)-epigallocatechin-3-O-gallate
C00009230	3-O-Galloylepigallocatechin-(4beta->6)-epicatechin-3-O-gallate
C00009231	3-O-Galloylepigallocatechin-(4beta->8)-catechin
C00009232	3-O-Galloylepigallocatechin-(4beta->8)-epicatechin-3-O-gallate
C00009233	3-O-Galloylepigallocatechin-(4beta->6)-gallocatechin
C00009234	Epigallocatechin-(4beta->6)-epigallocatechin-3-O-gallate
C00009236	3-O-Galloylepigallocatechin-(4beta->8)-gallocatechin
C00009237	Gallocatechin-(4alpha->8)-epigallocatechin-3-O-gallate	CHEMBL348912 CHEMBL161077
C00009238	Epigallocatechin-(4beta->8)-epigallocatechin-3-O-gallate	CHEMBL348912 CHEMBL161077
C00009239	3-O-Galloylepigallocatechin-(4beta->8)-epigallocatechin-3-O-gallate	CHEMBL422711
C00009240	Samarangenin A
C00009241	Samarangenin B
C00009242	Fisetinidol-(4alpha->8)-catechin-3-O-gallate
C00009243	Catechin-(4alpha->8)-catechin-3-O-(1-hydroxy-6-oxo-2-cyclohexene-1-carboxylate)
C00009245	Gallocatechin-(4alpha->8)-epigallocatechin-3-O-(4-hydroxybenzoate)
C00009246	Epigallocatechin-(4beta->8)-epigallocatechin 3-O-(4-hydroxybenzoate)
C00009262	Selligueain A	CHEMBL452122	C084699
C00009263	Epiafzelechin-(2beta->7,4beta->8)-epiafzelechin-(4beta->8)-epiafzelechin	CHEMBL452122
C00009264	Epiafzelechin-(2beta->7,4beta->8)-epiafzelechin-(4beta->8)-epicatechin
C00009265	Epiafzelechin-(2beta->7,4beta->8)-epicatechin-(4beta->8)-epicatechin
C00009266	Epiafzelechin-(2beta->7,4beta->8)-epiafzelechin-(4beta->8)-3'-deoxydryopteric acid
C00009267	Selligueain B
C00009268	Arachnitannin 1
C00009269	Epiafzelechin-(2beta->7,4beta->8)-epiafzelechin-(4beta->8)-dryopteric acid
C00009270	Arachnitannin 3
C00009283	Epicatechin-(2beta->7,4beta->8)-epiafzelechin-(4beta->8)-epiafzelechin
C00009284	Epicatechin-(2beta->7,4beta->8)-epiafzelechin-(4beta->8)-epicatechin
C00009285	Epicatechin-(2beta->7,4beta->8)-epiacatechin-(4beta->8)-epiafzelechin
C00009286	Pavetannin B3
C00009287	Pavetannin B4
C00009288	Pavetannin B6	CHEMBL540956 CHEMBL81478 CHEMBL445468 CHEMBL1213875 CHEMBL1213876		14 / 4 / 7
C00009289	Cinnamtannin D1	CHEMBL540956 CHEMBL81478 CHEMBL445468 CHEMBL1213875 CHEMBL1213876		14 / 4 / 7
C00009290	Epicatechin-(2beta->7,4beta->8)-epicatechin-(4alpha->8)-epicatechin	CHEMBL540956 CHEMBL81478 CHEMBL445468 CHEMBL1213875 CHEMBL1213876		14 / 4 / 7
C00009291	Cinnamtannin B1	CHEMBL540956 CHEMBL81478 CHEMBL445468 CHEMBL1213875 CHEMBL1213876		14 / 4 / 7
C00009292	Pavetannin B 1	CHEMBL540956 CHEMBL81478 CHEMBL445468 CHEMBL1213875 CHEMBL1213876		14 / 4 / 7
C00009293	Aesculitannin B	CHEMBL540956 CHEMBL81478 CHEMBL445468 CHEMBL1213875 CHEMBL1213876		14 / 4 / 7
C00009294	Epicatechin-(2beta->7,4beta->8)-epicatechin-(4beta->8)-epigallocatechin
C00009295	Epicatechin-(2beta->7,4beta->8)-epicatechin-(4beta->8)-dryopteric acid
C00009296	Arachnitannin 2
C00009297	Epicatechin-(4beta->6)-epicatechin-(2beta->7,4beta->8)-catechin	CHEMBL449509
C00009298	Epicatechin-(4alpha->8)-epicatechin-(2beta->7,4beta->8)-epicatechin	CHEMBL503368
C00009299	Epicatechin-(4beta->8)-epicatechin-(2beta->7,4beta->8)-catechin	CHEMBL503368
C00009300	Aesculitannin C	CHEMBL506298
C00009301	Pavetannin B 7	CHEMBL506298
C00009315	Epigallocatechin-(2beta->7,4beta->8)-epigallocatechin-3-O-gallate	CHEMBL350227
C00009355	Oolonghomobisflavan A	CHEMBL352057
C00009356	Oolonghomobisflavan B	CHEMBL354463
C00013282	Pavetannin B 5 / [6S-[6alpha,10alpha,11beta,12beta(2S*,3S*),14alpha,15S*]]-6,10-bis(3,4-Dihydroxyphenyl)-12-[2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,5,7-trihydroxy-2H-1-benzopyran-8-yl]-11,12-dihydro-6,14-methano-10H,14H-[1]benzopyrano[7,6-d][1,3]benzodioxocin-1,3,11,13,15-pentol
C00013283	Geranin D / (+)-Geranin D
C00037690	Procyanidin B5 3'-O-gallate / (+)-Procyanidin B5 3'-O-gallate

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q15139	Serine/threonine-protein kinase D1	Pkd	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 0
Q05513	Protein kinase C zeta type	Iota	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 0
P41743	Protein kinase C iota type	Iota	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 0
P24723	Protein kinase C eta type	Eta	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	1 / 0
Q04759	Protein kinase C theta type	Delta	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 1
P05771	Protein kinase C beta type	Alpha	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 0
P05129	Protein kinase C gamma type	Alpha	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	1 / 1
O94806	Serine/threonine-protein kinase D3	Pkd	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 0
Q02156	Protein kinase C epsilon type	Eta	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 0
Q05655	Protein kinase C delta type	Delta	C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098 C00009213 C00009216 C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00009085 C00009086 C00009087 C00009088 C00009089 C00009090 C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098	1 / 3
P14780	Matrix metalloproteinase-9	M10A	C00009085 C00009086 C00009087 C00009088 C00009089 C00009090 C00009091 C00009092 C00009093 C00009094 C00009095 C00009096 C00009097 C00009098	2 / 2
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 0
Q06187	Tyrosine-protein kinase BTK	Tec	C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	2 / 2
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00009288 C00009289 C00009290 C00009291 C00009292 C00009293	0 / 3
P10636	Microtubule-associated protein tau	Unclassified protein	C00001010 C00008916	4 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001010 C00008916	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00001010 C00008916	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001010 C00008916	1 / 1
O00255	Menin	Unclassified protein	C00001010 C00008916	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001010 C00008916	1 / 2
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001010 C00008916	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001010 C00008916	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00001010 C00008916	1 / 2
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001010 C00008916	3 / 3
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001010 C00008916	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001010 C00008916	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00001010 C00008916	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001010 C00008916	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00008916	11 / 10
P11473	Vitamin D3 receptor	NR1I1	C00001010	2 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00001010	2 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions