Gossypium hirsutum
Species
KNApSAcK Entry
| Organism name | Gossypium hirsutum |
|---|---|
| Genus | Gossypium |
| Family | Malvaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Gossypium hirsutum |
|---|---|
| Linked NCBI taxonomy ID | 3635 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Malvaceae |
|---|---|
| ID | 3629 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (25)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005361
|
Sexangularetin 3-glucoside-7-rhamnoside
|
No. 1 | No. 15 |
|
||||
|
C00005386
|
Quercetin 3'-glucoside
/ 3,5,7,3',4'-Pentahydroxyflavone |
CHEMBL1222354
|
No. 2 | No. 15 |
|
|||
|
C00005382
|
Quercimeritrin
/ Quercetin 7-glucoside / Quercetin 7-O-beta-D-glucoside |
CHEMBL248726
|
C089996
|
No. 2 | No. 15 |
|
||
|
C00004636
|
Tamarixetin
/ 4'-O-Methylquercetin / 3,3',5,7-Tetrahydroxy-4'-methoxyflavone / 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL226034
|
5 / 6 / 5 | No. 3 | No. 15 |
|
||
|
C00004644
|
Dillenetin
/ 3',4'-Dimethoxyquercetin / 3,5,7-Trihydroxy-3',4'-dimethoxyflavone / 2-(3,4-Dimethoxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one |
CHEMBL2043330
|
No. 3 | No. 15 |
|
|||
|
C00004651
|
Quercetin 3,5,7,4'-tetramethyl ether
|
CHEMBL77553
|
No. 8 | No. 15 |
|
|||
|
C00004652
|
Quercetin 3,5,3',4'-tetramethyl ether
|
No. 8 | No. 15 |
|
||||
|
C00000003
|
GA3
/ Gibberellin A3 |
CHEMBL513241
CHEMBL566653 CHEMBL1232952 CHEMBL1476967 CHEMBL1487394 |
C007842
|
10 / 18 / 17 | No. 40 | No. 41 |
|
|
|
C00000004
|
GA4
/ Gibberellin A4 |
No. 40 | No. 41 |
|
||||
|
C00000013
|
GA13
/ Gibberellin A13 |
No. 187 | No. 41 |
|
||||
|
C00020170
|
Lacinilene A
|
No. 647 | No. 38 |
|
||||
|
C00000096
|
9-Ribosyl-trans-zeatin
/ Zeatin-9-beta-D-ribofuranoside |
No. 989 |
|
|||||
|
C00000134
|
(s)-(+)-Abscisic acid
/ 2,4-Pentadienoic acid |
CHEMBL288040
CHEMBL379808 CHEMBL1318134 CHEMBL1469719 CHEMBL1741460 CHEMBL1965138 |
D000040
|
10 / 9 / 10 | No. 1435 | No. 38 |
|
|
|
C00003486
|
Strigol
/ (+)-Strigol |
No. 1816 | No. 38 |
|
||||
|
C00000094
|
2iP
/ N6-(delta2-Isopentenyl)adenine |
CHEMBL476189
|
C001478
|
5 / 2 / 3 | 18 / 0 | No. 2879 |
|
|
|
C00000091
|
trans-Zeatin
|
CHEMBL525239
|
D015026
|
2 / 3 / 2 | 0 / 1 | No. 2879 |
|
|
|
C00003143
|
Hemigossypol
|
No. 2950 | No. 38 |
|
||||
|
C00020116
|
Lacinilene C
|
CHEMBL254803
|
C023021
|
No. 3777 | No. 38 |
|
||
|
C00003158
|
Lacinilene C 7-methyl ether
|
CHEMBL2206801
|
C029267
|
No. 3777 | No. 38 |
|
||
|
C00013227
|
Lacinilene D
/ Lacinilene B / 21,7-Dihydroxy-1-methyl-4-(1-methylethyl)-(1H)-naphthalenone |
No. 3777 | No. 38 |
|
||||
|
C00007452
|
Sucrose 6-phosphate
|
C535046
|
No. 3949 |
|
||||
|
C00001151
|
Sucrose
/ (+)-Sucrose |
CHEMBL253582
CHEMBL1976550 |
D013395
|
1 / 0 / 0 | 4 / 10 | No. 3949 |
|
|
|
C00001239
|
Sterculic acid
|
C003345
|
No. 4256 | No. 70 |
|
|||
|
C00011606
|
beta-Bisabolol
|
No. 4385 |
|
|||||
|
C00011650
|
Bisabolene oxide
|
No. 4675 |
|
Human Protein / Gene in interactions
20 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000003 C00000094 C00000134 C00004636 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000003 C00000094 C00000134 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000003 C00000094 C00000134 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000003 C00000094 C00000134 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000003 C00000094 C00000134 | 0 / 1 |
| P10275 | Androgen receptor | NR3C4 | C00000003 C00000134 | 3 / 4 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000091 C00000134 | 3 / 2 |
| P10145 | Interleukin-8 | Secreted protein | C00000134 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000003 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00000003 | 0 / 0 |
| P04792 | Heat shock protein beta-1 | Unclassified protein | C00004636 | 2 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000003 | 0 / 0 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00004636 | 4 / 4 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00004636 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000134 | 1 / 1 |
| P02768 | Serum albumin | Secreted protein | C00001151 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000003 | 11 / 10 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000134 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00004636 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000091 | 0 / 0 |
22 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 440 | ASNS, TS11 | asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) |
C00000094
|
| 694 | BTG1 | B-cell translocation gene 1, anti-proliferative |
C00000094
|
| 10681 | GNB5, GB5 | guanine nucleotide binding protein (G protein), beta 5 |
C00000094
|
| 182 | JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1 | jagged 1 |
C00000094
|
| 9818 | NUPL1, PRO2463 | nucleoporin like 1 |
C00000094
|
| 5142 | PDE4B, DPDE4, PDE4B5, PDEIVB | phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) |
C00000094
|
| 8544 | PIR | pirin (iron-binding nuclear protein) (EC:1.13.11.24) |
C00000094
|
| 5366 | PMAIP1, APR, NOXA | phorbol-12-myristate-13-acetate-induced protein 1 |
C00000094
|
| 9360 | PPIG, CARS-Cyp, CYP, SCAF10, SRCyp | peptidylprolyl isomerase G (cyclophilin G) (EC:5.2.1.8) |
C00000094
|
| 5782 | PTPN12, PTP-PEST, PTPG1 | protein tyrosine phosphatase, non-receptor type 12 (EC:3.1.3.48) |
C00000094
|
| 5774 | PTPN3, PTP-H1, PTPH1 | protein tyrosine phosphatase, non-receptor type 3 (EC:3.1.3.48) |
C00000094
|
| 6004 | RGS16, A28-RGS14, A28-RGS14P, RGS-R | regulator of G-protein signaling 16 |
C00000094
|
| 6016 | RIT1, NS8, RIBB, RIT, ROC1 | Ras-like without CAAX 1 |
C00000094
|
| 6286 | S100P, MIG9 | S100 calcium binding protein P |
C00000094
|
| 7029 | TFDP2, DP2 | transcription factor Dp-2 (E2F dimerization partner 2) |
C00000094
|
| 7127 | TNFAIP2, B94, EXOC3L3 | tumor necrosis factor, alpha-induced protein 2 |
C00000094
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000094
|
| 7431 | VIM, CTRCT30 | vimentin |
C00000094
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001151
|
| 55630 | SLC39A4, AEZ, AWMS2, ZIP4 | solute carrier family 39 (zinc transporter), member 4 |
C00001151
|
| 80834 | TAS1R2, GPR71, T1R2, TR2 | taste receptor, type 1, member 2 |
C00001151
|
| 83756 | TAS1R3, T1R3 | taste receptor, type 1, member 3 |
C00001151
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (28)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #606595 | Charcot-marie-tooth disease, axonal, type 2f; cmt2f |
P04792
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #608634 | Neuronopathy, distal hereditary motor, type iib; hmn2b |
P04792
|
| #604229 | Peters anomaly |
Q16678
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
KEGG DISEASE (25)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00856 | Distal hereditary motor neuropathies (dHMN) |
P04792
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
Diseases related to CTD interactions
11 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D019969 | Amphetamine-Related Disorders |
C00001151
|
| D018149 | Glucose Intolerance |
C00001151
|
| D006461 | Hemolysis |
C00001151
|
| D006946 | Hyperinsulinism |
C00001151
|
| D006948 | Hyperkinesis |
C00001151
|
| D006973 | Hypertension |
C00001151
|
| D007333 | Insulin Resistance |
C00001151
|
| D009401 | Nephrosis |
C00001151
|
| C541083 | Non-alcoholic Fatty Liver Disease |
C00001151
|
| D019966 | Substance-Related Disorders |
C00001151
|
| D000647 | Amnesia |
C00000091
|