KCF-S cluster No. 491 (16 metabolites)

Corresponding Phytochemical cluster No. 25

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (16)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	33
rosids	31
Magnoliophyta	1
Spermatophyta	1
Embryophyta	1

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Cumulative family count (Top 20)

class name	count
Asteraceae	12
Fabaceae	11
Apiaceae	5
Oleaceae	4
Solanaceae	3
Hippocastanaceae	3
Moraceae	3
Rutaceae	3
Caprifoliaceae	2
Rosaceae	2
Brassicaceae	2
Thymelaeaceae	2
Cannabaceae	1
Aceraceae	1
Euphorbiaceae	1
Araliaceae	1
Apocynaceae	1
Malvaceae	1
Anacardiaceae	1
Gentianaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Coumarins	4

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Coumarins	C09206	C00002458
Coumarins	C09264	C00002472
Coumarins	C09266	C00002474
Coumarins	C01527	C00002500

Metabolite list (16)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002458	Cichoriin		C410941
C00002472	Esculin	CHEMBL359043 CHEMBL482581 CHEMBL1434042 CHEMBL1515174 CHEMBL1536019 CHEMBL1619714 CHEMBL1624854	D004929	22 / 18 / 24	0 / 1
C00002474	Fraxin	CHEMBL293864	C080614	11 / 3 / 5
C00002500	Scopolin	CHEMBL225024	C417572	7 / 3 / 4
C00019796	Bergaptol-O-beta-D-glucopyranoside		C067416
C00019835	(-)-2,3-Dihydro-9-O-beta-glucosyloxy-2-isopropenyl-7H-furo[3,2-g][1]benzopyran-7-one
C00019844	6,7-Dihydroxy-5-methoxycoumarin 6-beta-D-glucopyranoside
C00019957	5-Methoxy-8-O-beta-D-glucosyloxy-psoralen
C00030984	Phellodenol G
C00030985	Phellodenol H
C00032165	Skimmin / (-)-Skimmin	CHEMBL526377
C00037003	Daphnin	CHEMBL1879316		3 / 2 / 3
C00044063	Gerberinside / 4-Hydroxy-5-methylcoumarin 4-O-beta-D-glucopyranoside		C058371
C00047445	Euoniside / (+)-Euoniside
C00047500	Mandshurin
C00047677	5-Hydroxy-6-methoxy-7-O-beta-D-glucosylcoumarin

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O75496	Geminin	Unclassified protein	C00002472 C00002474 C00037003	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002472 C00002474	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00002474 C00002500	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00002474 C00002500	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00002474 C00002500	0 / 1
O43570	Carbonic anhydrase 12	Lyase	C00002474 C00002500	1 / 2
P00918	Carbonic anhydrase 2	Lyase	C00002474 C00002500	1 / 2
Q8N1Q1	Carbonic anhydrase 13	Lyase	C00002474 C00002500	0 / 0
P42226	Signal transducer and activator of transcription 6	Unclassified protein	C00002472	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002472	0 / 1
P11473	Vitamin D3 receptor	NR1I1	C00037003	2 / 3
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00002472	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002472	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002472	1 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002472	1 / 1
P04062	Glucosylceramidase	Enzyme	C00002472	6 / 4
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002472	0 / 3
P29466	Caspase-1	C14	C00002472	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00037003	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002472	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00002472	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002472	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002474	1 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002472	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002472	2 / 2
P22303	Acetylcholinesterase	Hydrolase	C00002500	1 / 0
P55210	Caspase-7	C14	C00002472	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002472	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002472	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00002474	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002472	0 / 0
O00255	Menin	Unclassified protein	C00002472	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002472	1 / 2
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002474	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions