Cichorium endivia
Species
KNApSAcK Entry
| Organism name | Cichorium endivia |
|---|---|
| Genus | Cichorium |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cichorium endivia |
|---|---|
| Linked NCBI taxonomy ID | 114280 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (37)
| Species | Activity |
|---|---|
| Cichorium endivia L. | Allergenic |
| Cichorium endivia L. | Anti-HIV-Integrase |
| Cichorium endivia L. | Antibious |
| Cichorium endivia L. | Antidiabetic |
| Cichorium endivia L. | Antidiarrheal |
| Cichorium endivia L. | Antiflu |
| Cichorium endivia L. | Antihyaluronidase |
| Cichorium endivia L. | Antiotitic |
| Cichorium endivia L. | Antipyretic |
| Cichorium endivia L. | Antiradicular |
| Cichorium endivia L. | Antistomatitic |
| Cichorium endivia L. | Antisunburn |
| Cichorium endivia L. | Antiviral |
| Cichorium endivia L. | Bacteristat |
| Cichorium endivia L. | Bifidogenic |
| Cichorium endivia L. | Bitter |
| Cichorium endivia L. | Carminative |
| Cichorium endivia L. | Chemopreventive(breast) |
| Cichorium endivia L. | Chemopreventive(colon) |
| Cichorium endivia L. | Choleretic |
| Cichorium endivia L. | Collagen-Sparing |
| Cichorium endivia L. | Demulcent |
| Cichorium endivia L. | Diuretic |
| Cichorium endivia L. | Expectorant |
| Cichorium endivia L. | Gastrostimulant |
| Cichorium endivia L. | Hypocholesterolemic |
| Cichorium endivia L. | Hypoglycemic |
| Cichorium endivia L. | Immunostimulant |
| Cichorium endivia L. | Laxative |
| Cichorium endivia L. | Lipolytic |
| Cichorium endivia L. | Phagoytotic |
| Cichorium endivia L. | Prebiotic |
| Cichorium endivia L. | Probiotigenic |
| Cichorium endivia L. | Resolvent |
| Cichorium endivia L. | Stimulant |
| Cichorium endivia L. | Sunscreen |
| Cichorium endivia L. | Tonic |
Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00032170
|
Sonchuside A
/ (+)-Sonchuside A |
No. 212 |
|
|||||
|
C00030504
|
Hypochoeroside A
/ (+)-Hypochoeroside A |
No. 212 |
|
|||||
|
C00029959
|
Cichorioside M
/ (+)-Cichorioside M |
No. 212 |
|
|||||
|
C00029955
|
Cichorioside I
/ (-)-Cichorioside I |
No. 212 |
|
|||||
|
C00020808
|
Crepidiaside B
|
No. 212 |
|
|||||
|
C00029954
|
Cichorioside H
|
No. 212 |
|
|||||
|
C00029949
|
Cichorioside B
/ (-)-Cichorioside B |
No. 212 |
|
|||||
|
C00029950
|
Cichorioside C
|
No. 212 |
|
|||||
|
C00029952
|
Cichorioside F
/ (-)-Cichorioside |
No. 212 |
|
|||||
|
C00029953
|
Cichorioside G
/ (-)-Cichorioside G |
No. 212 |
|
|||||
|
C00020807
|
Jacquinelin
|
CHEMBL448636
|
No. 298 | No. 38 |
|
|||
|
C00029376
|
11beta,13-Dihydrolactucin
|
No. 298 | No. 38 |
|
||||
|
C00029960
|
Cichorioside N
/ (+)-Cichorioside N |
No. 324 |
|
|||||
|
C00002723
|
Chicoric acid
|
CHEMBL29660
CHEMBL282731 CHEMBL63592 CHEMBL397730 |
C100435
|
14 / 17 / 50 | No. 518 | No. 6 |
|
|
|
C00003311
|
Lactucin
|
CHEMBL521177
|
No. 596 | No. 38 |
|
|||
|
C00003312
|
Lactupicrin
/ Lactucopicrin / (+)-Lactucopicrin |
No. 2969 | No. 38 |
|
||||
|
C00029958
|
Cichorioside L
|
No. 3478 |
|
|||||
|
C00029957
|
Cichorioside K
/ (+)-Cichorioside K |
No. 4929 |
|
|||||
|
C00029956
|
Cichorioside J
/ (-)-Cichorioside J |
No. 4929 |
|
|||||
|
C00029951
|
Cichorioside D
/ (-)-Cichorioside D |
No. 5871 |
|
Human Protein / Gene in interactions
14 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002723 | 7 / 37 |
| P10145 | Interleukin-8 | Secreted protein | C00002723 | 0 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002723 | 1 / 2 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002723 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002723 | 3 / 3 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002723 | 1 / 1 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00002723 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002723 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002723 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002723 | 0 / 1 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002723 | 3 / 3 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002723 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002723 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002723 | 1 / 4 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #133239 | Esophageal cancer |
P04637
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
KEGG DISEASE (50)
| KEGG | name | UniProt |
|---|---|---|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|