Cucumis sativus
Species
KNApSAcK Entry
| Organism name | Cucumis sativus |
|---|---|
| Genus | Cucumis |
| Family | Cucurbitaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cucumis sativus |
|---|---|
| Linked NCBI taxonomy ID | 3659 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Cucurbitaceae |
|---|---|
| ID | 3650 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (32)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006229
|
Vicenin 2
/ Apigenin 6,8-di-C-glucoside |
CHEMBL1442950
|
6 / 14 / 8 | No. 1 | No. 15 |
|
||
|
C00006224
|
Saponarin
|
C457771
|
No. 1 | No. 15 |
|
|||
|
C00006223
|
Meloside A
/ Isovitexin 2''-O-glucoside |
No. 1 | No. 15 |
|
||||
|
C00014107
|
Isoscoparin 4'-O-glucoside
|
No. 1 | No. 15 |
|
||||
|
C00037790
|
Saponarin 4'-O-glucoside
/ (-)-Saponarin 4'-O-glucoside |
No. 5 | No. 15 |
|
||||
|
C00014081
|
Isovitexin 2''-O-(6'''-(E)-p-coumaroyl)glucoside 4'-O-glucoside
|
No. 7 | No. 15 |
|
||||
|
C00006334
|
Isoscoparin 2''-(6-(E)-p-coumaroylglucoside)
|
No. 7 | No. 15 |
|
||||
|
C00014080
|
Isovitexin 2''-O-(6'''-(E)-p-coumaroyl)glucoside
|
No. 7 | No. 15 |
|
||||
|
C00014082
|
Isovitexin 2''-O-(6'''-feruloyl)glucoside
|
No. 7 | No. 15 |
|
||||
|
C00014083
|
Isovitexin 2''-O-(6'''-(E)-feruloyl)glucoside 4'-O-glucoside
|
No. 7 | No. 15 |
|
||||
|
C00001059
|
Isovitexin
/ Saponaretin / Homovitexin / 6-C-beta-D-Glucopyranosylapigenin / 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL465360
CHEMBL1601394 |
C049772
|
28 / 20 / 19 | No. 22 | No. 15 |
|
|
|
C00001110
|
Vitexin
/ Apigenin 8-C-glucoside / 8-D-Glucosyl-4',5,7-trihydroxyflavone / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL487417
CHEMBL1332209 CHEMBL1357921 |
16 / 4 / 8 | No. 22 | No. 15 |
|
||
|
C00001078
|
Lutexin
/ Orientin / Luteolin 8-C-beta-D-glucopyranoside / 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone |
CHEMBL520866
CHEMBL1468796 |
C065886
|
20 / 15 / 14 | No. 22 | No. 15 |
|
|
|
C00014014
|
Cucumerin B
|
No. 30 | No. 15 |
|
||||
|
C00004172
|
Echinacin
/ (-)-Echinacin / Apigenin 7-O-p-coumaroylglucoside / Apigenin 7-(6''-p-coumarylglucoside) / Apigenin 7-O-(6''-O-p-coumaroylglucoside) |
C084441
|
No. 30 | No. 15 |
|
|||
|
C00014015
|
Cucumerin A
/ 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[1-(4-hydroxyphenyl)ethyl]-4H-1-benzopyran-4-one |
No. 30 | No. 15 |
|
||||
|
C00000005
|
GA5
/ Gibberellin A5 |
No. 40 | No. 41 |
|
||||
|
C00000034
|
GA34
/ Gibberellin A34 |
No. 40 | No. 41 |
|
||||
|
C00000008
|
GA8
/ Gibberellin A8 |
No. 40 | No. 41 |
|
||||
|
C00000004
|
GA4
/ Gibberellin A4 |
No. 40 | No. 41 |
|
||||
|
C00000003
|
GA3
/ Gibberellin A3 |
CHEMBL513241
CHEMBL566653 CHEMBL1232952 CHEMBL1476967 CHEMBL1487394 |
C007842
|
10 / 18 / 17 | No. 40 | No. 41 |
|
|
|
C00000020
|
GA20
/ Gibberellin A20 |
No. 40 | No. 41 |
|
||||
|
C00000001
|
GA1
/ Gibberellin A1 |
C422660
|
No. 40 | No. 41 |
|
|||
|
C00003684
|
Cucurbitacin C
|
CHEMBL449220
CHEMBL1355541 |
12 / 9 / 9 | No. 220 | No. 11 |
|
||
|
C00001162
|
Galactinol
|
No. 423 | No. 73 |
|
||||
|
C00001434
|
Tryptamine
/ beta-(3-Indolyl)ethylamine |
CHEMBL6640
|
C030820
|
20 / 5 / 7 | 6 / 2 | No. 710 | No. 4 |
|
|
C00000109
|
Indole-3-acetaldehyde
|
C001655
|
No. 710 | No. 4 |
|
|||
|
C00000114
|
Tryptophol
/ Indole-3-ethanol |
CHEMBL226545
|
C005949
|
2 / 4 / 2 | No. 710 | No. 4 |
|
|
|
C00000152
|
p-Coumaric acid
|
CHEMBL66879
CHEMBL2336752 |
C032171
|
23 / 13 / 18 | 6 / 1 | No. 904 | No. 6 |
|
|
C00001151
|
Sucrose
/ (+)-Sucrose |
CHEMBL253582
CHEMBL1976550 |
D013395
|
1 / 0 / 0 | 4 / 10 | No. 3949 |
|
|
|
C00007452
|
Sucrose 6-phosphate
|
C535046
|
No. 3949 |
|
||||
|
C00001317
|
Nona-2,6-dienal
|
No. 5928 |
|
Human Protein / Gene in interactions
83 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001059 C00001078 C00001110 C00006229 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000003 C00001110 C00001434 C00003684 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001059 C00001078 C00001110 C00003684 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001059 C00001434 C00003684 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000003 C00001110 C00001434 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001059 C00001078 C00001434 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001059 C00001078 C00001110 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000003 C00001110 C00001434 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000003 C00001110 C00001434 | 1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001059 C00001434 C00003684 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001059 C00001078 C00006229 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000003 C00001110 C00001434 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001059 C00001078 C00003684 | 1 / 2 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001059 C00001078 C00001110 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001059 C00001078 C00001110 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001059 C00001078 C00001110 | 1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001059 C00001078 C00006229 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001059 C00001078 C00001434 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000003 C00001110 C00001434 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001059 C00001078 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001059 C00001110 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001059 C00001110 | 1 / 4 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001059 C00001110 | 0 / 1 |
| O00255 | Menin | Unclassified protein | C00001059 C00001078 | 2 / 5 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001059 C00003684 | 1 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001059 C00001078 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001078 C00006229 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001059 C00001078 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001078 C00003684 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00001059 C00001078 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001059 C00006229 | 7 / 3 |
| P15121 | Aldose reductase | Enzyme | C00000152 C00001110 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000003 C00003684 | 2 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000003 | 3 / 4 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001059 | 0 / 0 |
| P42330 | Aldo-keto reductase family 1 member C3 | Enzyme | C00000152 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001078 | 3 / 1 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00003684 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000114 | 4 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001434 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000152 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000114 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000152 | 1 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000003 | 11 / 10 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000152 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000152 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000003 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00000152 | 4 / 2 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001434 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000152 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000152 | 0 / 1 |
| Q04828 | Aldo-keto reductase family 1 member C1 | Enzyme | C00000152 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00003684 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00006229 | 6 / 4 |
| P03372 | Estrogen receptor | NR3A1 | C00000152 | 1 / 1 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001434 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001434 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001434 | 0 / 0 |
| P30989 | Neurotensin receptor type 1 | Neurotensin receptor | C00001059 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001059 | 2 / 2 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000152 | 3 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000152 | 0 / 3 |
| P52895 | Aldo-keto reductase family 1 member C2 | Enzyme | C00000152 | 1 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001434 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00000152 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001078 | 4 / 3 |
| P02768 | Serum albumin | Secreted protein | C00001151 | 0 / 0 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00000152 | 0 / 0 |
| P28221 | 5-hydroxytryptamine receptor 1D | Serotonin receptor | C00001434 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000152 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000152 | 1 / 1 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000152 | 0 / 0 |
| P17516 | Aldo-keto reductase family 1 member C4 | Enzyme | C00000152 | 1 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001059 | 0 / 0 |
| P43235 | Cathepsin K | C1A | C00001434 | 1 / 2 |
| P05164 | Myeloperoxidase | Enzyme | C00001434 | 1 / 2 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000152 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003684 | 2 / 3 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000152 | 1 / 8 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000152 | 1 / 2 |
| P28222 | 5-hydroxytryptamine receptor 1B | Serotonin receptor | C00001434 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001059 | 2 / 1 |
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00003684 | 1 / 2 |
16 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00001434
|
| 3356 | HTR2A, 5-HT2A, HTR2 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
C00001434
|
| 6530 | SLC6A2, NAT1, NET, NET1, SLC6A5 | solute carrier family 6 (neurotransmitter transporter), member 2 |
C00001434
|
| 6531 | SLC6A3, DAT, DAT1, PKDYS | solute carrier family 6 (neurotransmitter transporter), member 3 |
C00001434
|
| 6532 | SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT | solute carrier family 6 (neurotransmitter transporter), member 4 |
C00001434
|
| 134864 | TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 | trace amine associated receptor 1 |
C00001434
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000152
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00000152
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00000152
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00000152
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000152
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00000152
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001151
|
| 55630 | SLC39A4, AEZ, AWMS2, ZIP4 | solute carrier family 39 (zinc transporter), member 4 |
C00001151
|
| 80834 | TAS1R2, GPR71, T1R2, TR2 | taste receptor, type 1, member 2 |
C00001151
|
| 83756 | TAS1R3, T1R3 | taste receptor, type 1, member 3 |
C00001151
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (74)
| OMIM | preferred title | UniProt |
|---|---|---|
| #614279 | 46,xy sex reversal 8; srxy8 |
P17516
P52895 |
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 |
Q06710
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P00533
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #254600 | Myeloperoxidase deficiency; mpod |
P05164
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #265800 | Pycnodysostosis |
P43235
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (73)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
|
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
|
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00101 | Other phagocyte defects |
P05164
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P05164
(marker)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00273 | Pycnodysostosis |
P43235
(related)
|
| H00425 | Lysosomal cysteine protease deficiencies |
P43235
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00032 | Thyroid cancer |
Q06710
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
Q06710
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
13 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D012640 | Seizures |
C00001434
|
| D014202 | Tremor |
C00001434
|
| D008545 | Melanoma |
C00000152
|
| D019969 | Amphetamine-Related Disorders |
C00001151
|
| D018149 | Glucose Intolerance |
C00001151
|
| D006461 | Hemolysis |
C00001151
|
| D006946 | Hyperinsulinism |
C00001151
|
| D006948 | Hyperkinesis |
C00001151
|
| D006973 | Hypertension |
C00001151
|
| D007333 | Insulin Resistance |
C00001151
|
| D009401 | Nephrosis |
C00001151
|
| C541083 | Non-alcoholic Fatty Liver Disease |
C00001151
|
| D019966 | Substance-Related Disorders |
C00001151
|