id | C00000769 |
---|---|
Name | alpha-Oxoglutaric acid / alpha-Ketoglutaric acid |
CAS RN | 328-50-7 |
Standard InChI | InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10) |
Standard InChI (Main Layer) | InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10) |
Phytochemical cluster | |
---|---|
KCF-S cluster | No. 2414 |
By standard InChI | CHEMBL1686 |
---|---|
By standard InChI Main Layer | CHEMBL1686 |
By LinkDB | C00026 |
---|
By CAS RN | C029743 |
---|
class name | count |
---|---|
asterids | 1 |
rosids | 1 |
Liliopsida | 1 |
family name | count |
---|---|
Methanococcaceae | 1 |
Sapotaceae | 1 |
Brassicaceae | 1 |
Poaceae | 1 |
KNApSAcK organism | *ID | *family | *plant class | *kingdom |
---|---|---|---|---|
Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
Hordeum vulgare | 4513 | Poaceae | Liliopsida | Viridiplantae |
Methanococcus voltae | 2188 | Methanococcaceae | Archaea | |
Sebertia acuminata | 280718 | Sapotaceae | asterids | Viridiplantae |
accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|---|
Q9H6Z9 | Egl nine homolog 3 | Enzyme | CHEMBL1686 |
CHEMBL1243626
(1)
|
0 / 0 |
Q9Y694 | Solute carrier family 22 member 7 | Unclassified protein | CHEMBL1686 |
CHEMBL2077536
(1)
CHEMBL2075465
(1)
|
0 / 0 |
P08183 | Multidrug resistance protein 1 | drug | CHEMBL1686 |
CHEMBL2077338
(1)
|
1 / 0 |
Q9GZT9 | Egl nine homolog 1 | Enzyme | CHEMBL1686 |
CHEMBL1047005
(1)
CHEMBL1047006
(1)
CHEMBL1047007 (1) CHEMBL1047008 (1) CHEMBL1047009 (1) CHEMBL1047010 (1) CHEMBL1243625 (1) CHEMBL2318594 (1) CHEMBL2318595 (1) |
1 / 1 |
P13674 | Prolyl 4-hydroxylase subunit alpha-1 | Enzyme | CHEMBL1686 |
CHEMBL1243628
(1)
|
0 / 0 |
Q96KS0 | Egl nine homolog 2 | Enzyme | CHEMBL1686 |
CHEMBL1243624
(1)
|
0 / 0 |
Q9NWT6 | Hypoxia-inducible factor 1-alpha inhibitor | Enzyme | CHEMBL1686 |
CHEMBL1243627
(1)
|
0 / 0 |
Q8TCC7 | Solute carrier family 22 member 8 | Antiporter | CHEMBL1686 |
CHEMBL2077090
(1)
|
0 / 0 |
Q4U2R8 | Solute carrier family 22 member 6 | Antiporter | CHEMBL1686 |
CHEMBL2076900
(1)
CHEMBL2077164
(1)
CHEMBL2077170 (1) CHEMBL2077864 (1) |
0 / 0 |
P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL1686 |
CHEMBL1613808
(1)
|
0 / 0 |
Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL1686 |
CHEMBL2114890
(1)
|
0 / 0 |
P10275 | Androgen receptor | NR3C4 | CHEMBL1686 |
CHEMBL1794560
(1)
|
3 / 4 |
O76082 | Solute carrier family 22 member 5 | Unclassified protein | CHEMBL1686 |
CHEMBL2078097
(1)
|
1 / 2 |
compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
---|---|---|---|---|---|---|---|
C029743 | 8424 |
BBOX1
BBH BBOX G-BBH gamma-BBH |
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 (EC:1.14.11.1) | alpha-ketoglutaric acid inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] |
decreases reaction
/ increases chemical synthesis |
protein |
21439360
|
C029743 | 8424 |
BBOX1
BBH BBOX G-BBH gamma-BBH |
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 (EC:1.14.11.1) | alpha-ketoglutaric acid inhibits the reaction [Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] |
decreases reaction
/ increases chemical synthesis |
protein |
21439360
|
C029743 | 8424 |
BBOX1
BBH BBOX G-BBH gamma-BBH |
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 (EC:1.14.11.1) | [BBOX1 protein co-treated with alpha-ketoglutaric acid] results in increased metabolism of gamma-butyrobetaine |
affects cotreatment
/ increases metabolic processing |
protein |
21439360
|
C029743 | 728294 |
D2HGDH
D2HGD |
D-2-hydroxyglutarate dehydrogenase (EC:1.1.99.-) | D2HGDH protein results in increased chemical synthesis of alpha-ketoglutaric acid |
increases chemical synthesis
|
protein |
15609246
|
C029743 | 3091 |
HIF1A
HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein] |
affects binding
/ affects cotreatment / increases reaction |
protein |
19263519
|
C029743 | 3091 |
HIF1A
HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]] |
affects binding
/ affects cotreatment / decreases reaction / increases reaction |
protein |
19263519
|
C029743 | 8290 |
HIST3H3
H3.4 H3/g H3FT H3t |
histone cluster 3, H3 | [[Iron co-treated with alpha-ketoglutaric acid] results in increased activity of KDM3A protein] which results in decreased methylation of HIST3H3 protein |
affects cotreatment
/ decreases methylation / increases activity |
protein |
16603237
|
C029743 | 55818 |
KDM3A
JHDM2A JHMD2A JMJD1 JMJD1A TSGA |
lysine (K)-specific demethylase 3A | [[Iron co-treated with alpha-ketoglutaric acid] results in increased activity of KDM3A protein] which results in decreased methylation of HIST3H3 protein |
affects cotreatment
/ decreases methylation / increases activity |
protein |
16603237
|
C029743 | 54681 |
P4HTM
EGLN4 HIFPH4 P4H-TM PH-4 PH4 PHD4 |
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | [alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] results in increased activity of P4HTM protein |
affects cotreatment
/ increases activity |
protein |
19263519
|
C029743 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | alpha-ketoglutaric acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] |
affects transport
/ decreases reaction |
protein |
12472777
|
C029743 | 9356 |
SLC22A6
HOAT1 OAT1 PAHT ROAT1 |
solute carrier family 22 (organic anion transporter), member 6 | alpha-ketoglutaric acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]] |
affects cotreatment
/ decreases reaction / increases response to substance |
protein |
12606766
|
C029743 | 7428 |
VHL
HRCA1 RCA1 VHL1 pVHL |
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein] |
affects binding
/ affects cotreatment / increases reaction |
protein |
19263519
|
C029743 | 7428 |
VHL
HRCA1 RCA1 VHL1 pVHL |
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with alpha-ketoglutaric acid co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]] |
affects binding
/ affects cotreatment / decreases reaction / increases reaction |
protein |
19263519
|
OMIM | preferred title | UniProt |
---|---|---|
#300068 | Androgen insensitivity syndrome; ais |
P10275
|
#312300 | Androgen insensitivity, partial; pais |
P10275
|
#212140 | Carnitine deficiency, systemic primary; cdsp |
O76082
|
#609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
#612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
#313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
KEGG | disease name | UniProt |
---|---|---|
H00286 | Crohn's disease |
O76082
(related)
|
H00525 | Disorders of fatty-acid oxidation |
O76082
(related)
|
H00024 | Prostate cancer |
P10275
(related)
|
H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
H00236 | Congenital polycythemia |
Q9GZT9
(related)
|