Picrorhiza kurrosa
Species
KNApSAcK Entry
| Organism name | Picrorhiza kurrosa |
|---|---|
| Genus | Picrorhiza |
| Family | Plantaginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Picrorhiza |
|---|---|
| Linked NCBI taxonomy ID | 195119 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Plantaginaceae |
|---|---|
| ID | 156152 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002668
|
Protocatechuic acid
/ 3,4-Dihydroxybenzoic acid |
CHEMBL37537
|
C009091
|
33 / 19 / 19 | 2 / 0 | No. 817 | No. 81 |
|
|
C00002682
|
Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid |
CHEMBL120568
|
D014641
|
5 / 3 / 3 | 5 / 0 | No. 1073 |
|
Human Protein / Gene in interactions
35 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P15121 | Aldose reductase | Enzyme | C00002668 C00002682 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002668 C00002682 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002668 C00002682 | 1 / 1 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002668 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002668 | 0 / 0 |
| P22894 | Neutrophil collagenase | M10A | C00002668 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002668 | 2 / 2 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002668 | 1 / 2 |
| P02768 | Serum albumin | Secreted protein | C00002668 | 0 / 0 |
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00002668 | 1 / 1 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002668 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002668 | 0 / 0 |
| P16581 | E-selectin | Adhesion | C00002668 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002668 | 1 / 2 |
| P42858 | Huntingtin | Unclassified protein | C00002682 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00002668 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002668 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002668 | 1 / 1 |
| P07711 | Cathepsin L1 | C1A | C00002668 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002668 | 0 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002668 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002668 | 0 / 1 |
| P08253 | 72 kDa type IV collagenase | M10A | C00002668 | 1 / 3 |
| P06746 | DNA polymerase beta | Enzyme | C00002668 | 0 / 0 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00002682 | 1 / 1 |
| P14151 | L-selectin | Adhesion | C00002668 | 0 / 0 |
| P16109 | P-selectin | Adhesion | C00002668 | 1 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002668 | 3 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002668 | 4 / 3 |
| P08254 | Stromelysin-1 | M10A | C00002668 | 1 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002668 | 1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002668 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002668 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002668 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002668 | 0 / 0 |
7 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00002668
|
| 2023 | ENO1, ENO1L1, MPB1, NNE, PPH | enolase 1, (alpha) (EC:4.2.1.11) |
C00002668
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002682
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002682
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002682
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002682
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002682
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (21)
| OMIM | preferred title | UniProt |
|---|---|---|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #143100 | Huntington disease; hd |
P42858
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #601367 | Stroke, ischemic |
P16109
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
KEGG DISEASE (21)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00236 | Congenital polycythemia |
Q9GZT9
(related)
|