Pseudomonas putida
Species
KNApSAcK Entry
| Organism name | Pseudomonas putida |
|---|---|
| Genus | Pseudomonas |
| Family | Pseudomonadaceae |
| Kingdom | Bacteria |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Pseudomonas putida |
|---|---|
| Linked NCBI taxonomy ID | 303 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Pseudomonadaceae |
|---|---|
| ID | 135621 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Bacteria |
|---|---|
| ID | 2 |
Plant class
| Plant class | |
|---|---|
| ID |
Metabolite list (18)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00007490
|
Muconic acid
/ cis,cis-Muconic acid |
C005939
|
5 / 3 |
|
||||
|
C00002728
|
Coniferaldehyde
/ Coniferyl aldehyde / 4-Hydroxy-3-methoxycinnamaldehyde |
CHEMBL242529
CHEMBL1956165 |
C075384
|
1 / 1 / 1 | No. 310 | No. 6 |
|
|
|
C00007259
|
Acetyl-CoA
|
D000105
|
4 / 0 | No. 461 | No. 6 |
|
||
|
C00007264
|
Feruloyl-CoA
|
No. 461 | No. 6 |
|
||||
|
C00000856
|
4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid |
CHEMBL441343
|
C038193
|
21 / 7 / 16 | 2 / 1 | No. 817 | No. 81 |
|
|
C00002668
|
Protocatechuic acid
/ 3,4-Dihydroxybenzoic acid |
CHEMBL37537
|
C009091
|
33 / 19 / 19 | 2 / 0 | No. 817 | No. 81 |
|
|
C00007309
|
Homogentisate
/ Homogentisic acid |
D006713
|
No. 1584 |
|
||||
|
C00000770
|
2-Oxoadipic acid
/ alpha-Ketoadipate / alpha-Ketoadipic acid |
C001918
|
No. 2414 |
|
||||
|
C00007599
|
4-Fumarylacetoacetic acid
|
CHEMBL1743220
|
C105171
|
1 / 0 / 0 | No. 2946 |
|
||
|
C00007508
|
2-Octenedioic acid
/ 4-Maleyl-acetoacetic acid |
CHEMBL1743220
|
1 / 0 / 0 | No. 2946 |
|
|||
|
C00001397
|
L-Tyrosine
|
CHEMBL925
CHEMBL108615 CHEMBL1076637 |
17 / 9 / 14 | No. 3303 |
|
|||
|
C00001183
|
Fumaric acid
|
CHEMBL503160
CHEMBL539648 |
C032005
|
17 / 14 / 46 | 0 / 1 | No. 3766 |
|
|
|
C00007512
|
4-Hydroxyphenylpyruvate
/ p-Hydroxyphenylpyruvic acid |
CHEMBL607712
|
1 / 1 / 0 | No. 5246 |
|
|||
|
C00007489
|
3-Oxoadipate enol-lactone
|
No. 5901 |
|
|||||
|
C00007499
|
cis,cis-3-Carboxymuconic acid
|
No. 6127 |
|
|||||
|
C00007458
|
Acetoacetic acid
|
CHEMBL2074691
|
C016635
|
1 / 0 / 0 | 3 / 0 | No. 7323 |
|
|
|
C00001186
|
Glyoxylic acid
|
CHEMBL1162545
|
C031150
|
1 / 0 / 0 | 0 / 1 | No. 7855 |
|
|
|
C00028410
|
Isopyoverdin
|
No. 8685 |
|
Human Protein / Gene in interactions
67 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P00918 | Carbonic anhydrase 2 | Lyase | C00000856 C00001183 C00001397 C00002668 | 1 / 2 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000856 C00001183 C00001397 C00002668 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000856 C00001183 C00001397 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000856 C00001397 C00002668 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000856 C00001397 C00002668 | 1 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000856 C00001397 C00002668 | 0 / 1 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000856 C00001397 C00002668 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000856 C00001397 C00002668 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000856 C00001397 C00002668 | 1 / 2 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000856 C00001183 C00001397 | 0 / 0 |
| O43708 | Maleylacetoacetate isomerase | Enzyme | C00007508 C00007599 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000856 C00001397 | 0 / 0 |
| O15427 | Monocarboxylate transporter 4 | Unclassified protein | C00001186 C00007458 | 0 / 0 |
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00001183 C00002668 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00001183 C00002668 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002668 | 0 / 0 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00000856 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001183 | 3 / 2 |
| P02768 | Serum albumin | Secreted protein | C00002668 | 0 / 0 |
| Q9UQ49 | Sialidase-3 | Enzyme | C00000856 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002668 | 2 / 2 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00000856 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000856 | 1 / 8 |
| P22894 | Neutrophil collagenase | M10A | C00002668 | 0 / 0 |
| P14174 | Macrophage migration inhibitory factor | Enzyme | C00007512 | 1 / 0 |
| P05164 | Myeloperoxidase | Enzyme | C00001397 | 1 / 2 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001183 | 7 / 37 |
| P16581 | E-selectin | Adhesion | C00002668 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002668 | 1 / 1 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00001183 | 0 / 0 |
| P41240 | Tyrosine-protein kinase CSK | Csk | C00001397 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000856 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002668 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002668 | 0 / 0 |
| P07711 | Cathepsin L1 | C1A | C00002668 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002668 | 0 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002668 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00001183 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001183 | 0 / 0 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00000856 | 1 / 1 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002668 | 3 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00002668 | 1 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001183 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000856 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002668 | 1 / 1 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002668 | 0 / 0 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00000856 | 1 / 1 |
| P14151 | L-selectin | Adhesion | C00002668 | 0 / 0 |
| P16109 | P-selectin | Adhesion | C00002668 | 1 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002728 | 1 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001183 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001183 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002668 | 4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000856 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001183 | 0 / 0 |
| Q16798 | NADP-dependent malic enzyme, mitochondrial | Enzyme | C00001183 | 0 / 0 |
| P08254 | Stromelysin-1 | M10A | C00002668 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001397 | 2 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002668 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001397 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001397 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002668 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002668 | 1 / 4 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000856 | 0 / 0 |
| Q05BR4 | SLC16A10 protein | Unclassified protein | C00001397 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002668 | 0 / 0 |
| Q9C0B1 | Alpha-ketoglutarate-dependent dioxygenase FTO | Unclassified protein | C00001183 | 1 / 2 |
15 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00007259
C00007490
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00007458
|
| 2944 | GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 | glutathione S-transferase mu 1 (EC:2.5.1.18) |
C00007490
|
| 2952 | GSTT1 | glutathione S-transferase theta 1 (EC:2.5.1.18) |
C00007490
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00007490
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00002668
|
| 2023 | ENO1, ENO1L1, MPB1, NNE, PPH | enolase 1, (alpha) (EC:4.2.1.11) |
C00002668
|
| 2052 | EPHX1, EPHX, EPOX, HYL1, MEH | epoxide hydrolase 1, microsomal (xenobiotic) (EC:3.3.2.9) |
C00007490
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00007458
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00007458
|
| 3952 | LEP, LEPD, OB, OBS | leptin |
C00000856
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000856
|
| 9 | NAT1, AAC1, MNAT, NAT-1, NATI | N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) |
C00007259
|
| 10 | NAT2, AAC2, NAT-2, PNAT | N-acetyltransferase 2 (arylamine N-acetyltransferase) (EC:2.3.1.5) |
C00007259
|
| 6799 | SULT1A2, HAST4, P-PST, ST1A2, STP2, TSPST2 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 (EC:2.8.2.1) |
C00007259
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (42)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #612938 | Growth retardation, developmental delay, coarse facies, and early death; gdfd |
Q9C0B1
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P00533
P04637 |
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #254600 | Myeloperoxidase deficiency; mpod |
P05164
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604302 | Rheumatoid arthritis, systemic juvenile |
P14174
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P16109
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (68)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04637 (related) P08253 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P08253 (related) P14780 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00101 | Other phagocyte defects |
P05164
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P05164
(marker)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00409 | Type II diabetes mellitus |
Q9C0B1
(related)
|
| H00926 | Growth retardation, developmental delay, coarse facies, and early death |
Q9C0B1
(related)
|
| H00236 | Congenital polycythemia |
Q9GZT9
(related)
|
Diseases related to CTD interactions
6 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D048629 | Micronuclei, Chromosome-Defective |
C00007490
|
| D009784 | Occupational Diseases |
C00007490
|
| D011041 | Poisoning |
C00007490
|
| D007669 | Kidney Calculi |
C00001186
|
| D002471 | Cell Transformation, Neoplastic |
C00001183
|
| D012220 | Rhinitis |
C00000856
|