Species

KNApSAcK Entry

Organism name Bulbophyllum vaginatum
Genus Bulbophyllum
Family Orchidaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Bulbophyllum vaginatum
Linked NCBI taxonomy ID 1138424
Linked level species

Family

Family in NCBI taxonomy Orchidaceae
ID 4747

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002631 External link 512 (+)-Lirioresinol B
/ (+)-Syringaresinol
CHEMBL361362
CHEMBL402653
C042192
1 / 0 / 0 No. 38 No. 21
C00033580 External link 512 6-Methoxycoelonin
CHEMBL562498
No. 75 No. 28
C00030201 External link 512 Erianthridin
CHEMBL253982
No. 75 No. 28
C00015262 External link 512 Coelonin
/ 2,7-Dihydroxy-4-methoxy-9,10-dihydrophenanthrene
CHEMBL560627
No. 75 No. 28
C00015898 External link 512 Nudol
CHEMBL253983
No. 104 No. 27
C00040831 External link 512 4-Methoxyphenanthrene-2,3,6,7-tetrol
No. 104 No. 27
C00024153 External link 512 Fimbriol B
CHEMBL254188
No. 104 No. 27
C00040832 External link 512 4-Methoxyphenanthrene-2,3,7-triol
No. 104 No. 27
C00033847 External link 512 Flavanthrinin
CHEMBL447210
No. 104 No. 27
C00015523 External link 512 Tristin
/ 3,4',5-Trihydroxy-3'-methoxybibenzyl
/ 3'-Methoxy-3,4',5-trihydroxybibenzyl
CHEMBL471504
No. 242 No. 26
C00002668 External link 512 Protocatechuic acid
/ 3,4-Dihydroxybenzoic acid
CHEMBL37537
C009091
33 / 19 / 19 2 / 0 No. 817 No. 81
C00000152 External link 512 p-Coumaric acid
CHEMBL66879
CHEMBL2336752
C032171
23 / 13 / 18 6 / 1 No. 904 No. 6
C00043201 External link 512 4,4',6,6'-Tetramethoxy-[1,1'-biphenanthrene]-2,2',3,3',7,7'-hexol
No. 1207
C00040946 External link 512 Dihydroferulic acid
CHEMBL387842
No. 1852 No. 6

Human Protein / Gene in interactions

46 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000152 C00002668 3 / 0
P22748 Carbonic anhydrase 4 Lyase C00000152 C00002668 1 / 1
P03372 Estrogen receptor NR3A1 C00000152 C00002668 1 / 1
Q16790 Carbonic anhydrase 9 Lyase C00000152 C00002668 0 / 1
P00915 Carbonic anhydrase 1 Lyase C00000152 C00002668 0 / 0
P15121 Aldose reductase Enzyme C00000152 C00002668 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000152 C00002668 1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase C00000152 C00002668 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000152 C00002668 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000152 C00002668 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000152 C00002668 1 / 2
O75496 Geminin Unclassified protein C00002668 0 / 0
P22894 Neutrophil collagenase M10A C00002668 0 / 0
P02768 Serum albumin Secreted protein C00002668 0 / 0
Q9GZT9 Egl nine homolog 1 Enzyme C00002668 1 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000152 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00002631 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000152 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000152 0 / 0
P16581 E-selectin Adhesion C00002668 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002668 1 / 1
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000152 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000152 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002668 2 / 2
P06746 DNA polymerase beta Enzyme C00002668 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000152 1 / 0
P07711 Cathepsin L1 C1A C00002668 0 / 0
P03956 Interstitial collagenase M10A C00002668 0 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002668 0 / 0
P14679 Tyrosinase Oxidoreductase C00000152 4 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000152 0 / 3
P08253 72 kDa type IV collagenase M10A C00002668 1 / 3
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000152 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002668 0 / 0
P14151 L-selectin Adhesion C00002668 0 / 0
P16109 P-selectin Adhesion C00002668 1 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002668 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000152 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002668 4 / 3
P07451 Carbonic anhydrase 3 Lyase C00000152 0 / 0
P08254 Stromelysin-1 M10A C00002668 1 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000152 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002668 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00002668 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002668 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002668 0 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00002668
2023 ENO1, ENO1L1, MPB1, NNE, PPH enolase 1, (alpha) (EC:4.2.1.11) C00002668
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000152
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000152
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000152
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000152
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000152
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00000152

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#600807 Asthma, susceptibility to Q13093
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#143860 Hyperchlorhidrosis, isolated O43570
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#211980 Lung cancer P00533
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#600852 Retinitis pigmentosa 17; rp17 P22748
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#601367 Stroke, ischemic P16109
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (29)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00236 Congenital polycythemia Q9GZT9 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D008545 Melanoma C00000152