PCIDB

Saussurea muliensis

Species

KNApSAcK Entry

Organism name Saussurea muliensis
Genus Saussurea
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Saussurea muliensis
Linked NCBI taxonomy ID 254917
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00038247 External link 512 3beta,22alpha-Dihydroxyolean-12-en-30-oic acid
/ (+)-3beta,22alpha-Dihydroxyolean-12-en-30-oic acid
CHEMBL513961
CHEMBL458310
CHEMBL482783
CHEMBL520845
CHEMBL482586
No. 13 No. 51
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00028801 External link 512 Paprazine
/ N-p-Coumaroyl-tyramine
/ trans-N-(p-Coumaroyl)tyramine
CHEMBL64286
No. 499
C00000856 External link 512 4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid
CHEMBL441343
C038193
21 / 7 / 16 2 / 1 No. 817 No. 81

Human Protein / Gene in interactions

42 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00003672 C00023774 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000856 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000856 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000856 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000856 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000856 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00000856 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00000856 1 / 2
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
Q9UQ49 Sialidase-3 Enzyme C00000856 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00000856 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000856 1 / 8
P23280 Carbonic anhydrase 6 Lyase C00000856 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000856 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000856 1 / 2
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000856 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00000856 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000856 0 / 1
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000856 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P51580 Thiopurine S-methyltransferase Enzyme C00000856 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 0 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000856 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000856 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000856 1 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00023774 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0

3 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3952 LEP, LEPD, OB, OBS leptin C00000856
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000856
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613163 Gaba-transaminase deficiency P80404
#143860 Hyperchlorhidrosis, isolated O43570
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#211980 Lung cancer P00533
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#610460 Thiopurine s-methyltransferase deficiency P51580
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (28)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D012220 Rhinitis C00000856