Aristolochia elegans
Species
KNApSAcK Entry
| Organism name | Aristolochia elegans |
|---|---|
| Genus | Aristolochia |
| Family | Aristolochiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Aristolochia elegans |
|---|---|
| Linked NCBI taxonomy ID | 143780 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Aristolochiaceae |
|---|---|
| ID | 16727 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (45)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000587
|
(-)-Pinoresinol
|
CHEMBL267963
CHEMBL487611 CHEMBL460862 |
7 / 5 / 6 | No. 38 | No. 21 |
|
||
|
C00000640
|
(+)-Eudesmin
|
CHEMBL519099
CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879 |
C105875
|
2 / 0 / 0 | No. 38 | No. 21 |
|
|
|
C00045654
|
Aristelegin C
/ (-)-Aristelegin C |
No. 38 | No. 21 |
|
||||
|
C00045653
|
Aristelegin B
/ (-)-Aristelegin B |
No. 38 | No. 21 |
|
||||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00025935
|
Lysicamine
/ Oxonuciferine |
CHEMBL510090
|
C069090
|
No. 74 |
|
|||
|
C00027145
|
Isomoschatoline
|
No. 74 |
|
|||||
|
C00027612
|
(-)-Temuconine
|
No. 89 | No. 4 |
|
||||
|
C00027122
|
Aristolactam AIIIa
|
CHEMBL388956
|
5 / 1 / 3 | No. 125 |
|
|||
|
C00027141
|
Noraristolodione
/ Dioxodehydroasimilobine / 4,5-Dioxodehydroasimilobine |
CHEMBL390369
|
No. 125 |
|
||||
|
C00027121
|
Aristolactam AII
/ Aristololactam A II |
CHEMBL390368
|
No. 125 |
|
||||
|
C00027124
|
Aristolactam E
|
No. 125 |
|
|||||
|
C00001885
|
Escholin
/ Escholine / Thalictrin / Thalictrine / Magnoflorine / (+)-Magnoflorine |
CHEMBL235428
|
C001670
|
No. 286 | No. 4 |
|
||
|
C00001526
|
Aristolochic acid I
/ Aristolochic acid A |
CHEMBL93353
|
C000228
|
13 / 11 / 12 | 21 / 10 | No. 291 | No. 4 |
|
|
C00027125
|
Aristolochic acid D
/ Aristolochic acid IVa |
CHEMBL604748
|
3 / 0 / 0 | No. 291 | No. 4 |
|
||
|
C00027126
|
Aristolochic acid Ia methyl ester
|
No. 291 | No. 4 |
|
||||
|
C00025324
|
N-cis-Feruloyltyramine
/ cis-N-Feruloyltyramine |
CHEMBL206555
CHEMBL451720 |
1 / 4 / 2 | No. 499 |
|
|||
|
C00025334
|
trans-Feruloyltyramine
/ N-trans-Feruloyltyramine / trans-N-Feruloyltyramine |
CHEMBL206555
CHEMBL451720 |
1 / 4 / 2 | No. 499 |
|
|||
|
C00027156
|
N-trans-Cinnamoyltyramine
|
CHEMBL417389
|
No. 499 |
|
||||
|
C00045652
|
Aristelegin A
/ (-)-Aristelegin A |
No. 629 | No. 21 |
|
||||
|
C00002608
|
Hinokinin
/ Hinoquinin / (-)-Hinokinin / (-)-Hinoquinin |
CHEMBL180970
CHEMBL182073 CHEMBL242011 |
C475934
|
2 / 1 / 1 | No. 629 | No. 21 |
|
|
|
C00000856
|
4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid |
CHEMBL441343
|
C038193
|
21 / 7 / 16 | 2 / 1 | No. 817 | No. 81 |
|
|
C00047011
|
Aristophyll A
/ (-)-Aristophyll A |
No. 990 |
|
|||||
|
C00047012
|
Aristophyll B
|
No. 990 |
|
|||||
|
C00027123
|
Aristolactam Ia N-beta-glucoside
/ Aristolactam C N-beta-D-glucoside / Aristolactam-Ia-N-beta-D-glucoside / Aristolactam Ia N-beta-D-glucopyranoside |
No. 1580 |
|
|||||
|
C00045662
|
Aristogin E
|
No. 1989 |
|
|||||
|
C00047010
|
Aristogin C
|
No. 1989 |
|
|||||
|
C00045661
|
Aristogin D
|
No. 1989 |
|
|||||
|
C00045659
|
Aristogin A
|
No. 1989 |
|
|||||
|
C00045660
|
Aristogin B
|
No. 1989 |
|
|||||
|
C00045655
|
Aristelegone A
/ (+)-Aristelegone A |
No. 1995 |
|
|||||
|
C00045657
|
Aristelegone C
/ (-)-Aristelegone C |
No. 1995 |
|
|||||
|
C00030771
|
Methylparaben
/ p-Methoxycarbonylphenol |
CHEMBL325372
|
C015358
|
102 / 49 / 57 | 3 / 0 | No. 2169 |
|
|
|
C00027155
|
Northalifoline
|
No. 2199 |
|
|||||
|
C00027167
|
Thalifoline
|
CHEMBL1813177
|
No. 2199 |
|
||||
|
C00027136
|
Corydaldine
/ 3,4-Dihydro-6,7-dimethoxy-1(2H)-isoquinolone |
No. 2199 |
|
|||||
|
C00027151
|
N-Methylcorydaldine
/ N-Methyl-6,7-dimethoxytetrahydroisoquinol-1-one |
CHEMBL504722
|
5 / 3 / 7 | No. 2199 |
|
|||
|
C00045658
|
Aristelegone D
/ (-)-Aristelegone D |
No. 3605 |
|
|||||
|
C00045656
|
Aristelegone B
|
No. 3605 |
|
|||||
|
C00027128
|
Aristoquinoline A
/ (-)-Aristoquinoline A |
No. 3937 |
|
|||||
|
C00027130
|
Aristoquinoline C
/ (-)-Aristoquinoline C |
No. 3937 |
|
|||||
|
C00027129
|
Aristoquinoline B
/ (-)-Aristoquinoline B |
No. 3937 |
|
|||||
|
C00027127
|
Aristoloside
|
C104942
|
No. 5170 |
|
||||
|
C00036762
|
Aristolin
/ (-)-Aristolin |
No. 7447 |
|
|||||
|
C00027380
|
Iseluxine
/ Pericampylinone A |
No. 7680 |
|
Human Protein / Gene in interactions
149 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001526 C00002608 C00003672 C00030771 | 0 / 1 |
| O75496 | Geminin | Unclassified protein | C00001526 C00027125 C00027151 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00001526 C00027122 C00027125 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002608 C00003672 C00030771 | 1 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 C00025324 C00025334 | 4 / 2 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000856 C00030771 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001526 C00030771 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 C00030771 | 1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000587 C00030771 | 0 / 3 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 C00030771 | 1 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000856 C00030771 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 C00030771 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001526 C00027151 | 2 / 5 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001526 C00027151 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000856 C00030771 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000856 C00030771 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001526 C00027151 | 1 / 2 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000856 C00030771 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000856 C00030771 | 1 / 2 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000856 C00030771 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000856 C00030771 | 1 / 8 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 C00030771 | 0 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001526 C00030771 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000856 C00030771 | 1 / 2 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00030771 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00030771 | 1 / 1 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00000856 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001526 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00030771 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00030771 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00030771 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00030771 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00030771 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00030771 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00030771 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00030771 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00030771 | 0 / 0 |
| Q9UQ49 | Sialidase-3 | Enzyme | C00000856 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00030771 | 2 / 2 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00030771 | 0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00027122 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00030771 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000587 | 0 / 0 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00000856 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00030771 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00030771 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00030771 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00030771 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00030771 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00030771 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00030771 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000856 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00030771 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00030771 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00030771 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00030771 | 1 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00030771 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001526 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00030771 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00030771 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00027125 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000640 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000856 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000856 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00030771 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00030771 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00030771 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00030771 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00030771 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00030771 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00030771 | 0 / 1 |
| O14965 | Aurora kinase A | Aur | C00027122 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00030771 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00030771 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00030771 | 1 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00030771 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00030771 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00030771 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00030771 | 1 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00030771 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00030771 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00027151 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00030771 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00030771 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00030771 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00030771 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00030771 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00030771 | 2 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000587 | 5 / 3 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00000856 | 1 / 1 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00030771 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00030771 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00030771 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00030771 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00030771 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00030771 | 0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | C00027122 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00030771 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00030771 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00030771 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00030771 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00030771 | 2 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000587 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000856 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00030771 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00030771 | 2 / 2 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00030771 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00030771 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00030771 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00030771 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00030771 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00030771 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00030771 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00030771 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00030771 | 0 / 0 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00000856 | 1 / 1 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00030771 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000587 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00030771 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00030771 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00030771 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001526 | 4 / 3 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000856 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00030771 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00030771 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00030771 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00000587 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00030771 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00030771 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000856 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00030771 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00030771 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000856 | 1 / 1 |
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00027122 | 1 / 3 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000640 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00001526 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001526 | 4 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00030771 | 7 / 37 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00000587 | 0 / 0 |
25 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3952 | LEP, LEPD, OB, OBS | leptin |
C00000856
C00030771
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00001526
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001526
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00001526
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001526
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001526
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00001526
|
| 1965 | EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
C00001526
|
| 2034 | EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73 | endothelial PAS domain protein 1 |
C00001526
|
| 26585 | GREM1, CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2 | gremlin 1, DAN family BMP antagonist |
C00001526
|
| 3309 | HSPA5, BIP, GRP78, MIF2 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
C00001526
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00001526
|
| 655 | BMP7, OP-1 | bone morphogenetic protein 7 |
C00001526
|
| 55867 | SLC22A11, OAT4, hOAT4 | solute carrier family 22 (organic anion/urate transporter), member 11 |
C00001526
|
| 9356 | SLC22A6, HOAT1, OAT1, PAHT, ROAT1 | solute carrier family 22 (organic anion transporter), member 6 |
C00001526
|
| 9376 | SLC22A8, OAT3 | solute carrier family 22 (organic anion transporter), member 8 |
C00001526
|
| 4086 | SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1 | SMAD family member 1 |
C00001526
|
| 4090 | SMAD5, DWFC, JV5-1, MADH5 | SMAD family member 5 |
C00001526
|
| 4093 | SMAD9, MADH6, MADH9, PPH2, SMAD8, SMAD8A, SMAD8B | SMAD family member 9 |
C00001526
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00001526
|
| 7494 | XBP1, TREB5, XBP-1, XBP2 | X-box binding protein 1 |
C00001526
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00030771
|
| 59 | ACTA2, AAT6, ACTSA, MYMY5 | actin, alpha 2, smooth muscle, aorta |
C00001526
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00030771
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000856
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (84)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
P37231 |
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (80)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P11802 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P11802 (related) P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
11 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001284 | Atrophy |
C00001526
|
| D001449 | Balkan Nephropathy |
C00001526
|
| D018376 | Cardiovascular Abnormalities |
C00001526
|
| D007249 | Inflammation |
C00001526
|
| D007674 | Kidney Diseases |
C00001526
|
| D007680 | Kidney Neoplasms |
C00001526
|
| D007683 | Kidney Tubular Necrosis, Acute |
C00001526
|
| D009369 | Neoplasms |
C00001526
|
| D051437 | Renal Insufficiency |
C00001526
|
| D014571 | Urologic Neoplasms |
C00001526
|
| D012220 | Rhinitis |
C00000856
|