Polytrichum commune
Species
KNApSAcK Entry
| Organism name | Polytrichum commune |
|---|---|
| Genus | Polytrichum |
| Family | Polytrichaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Polytrichum commune |
|---|---|
| Linked NCBI taxonomy ID | 3213 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Polytrichaceae |
|---|---|
| ID | 3211 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Embryophyta |
|---|---|
| ID | 3193 |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00029585
|
Ikshusterol
/ 7alpha-Hydroxysitosterol / Stigmast-5-ene-3beta,7alpha-diol / (-)-Stigmast-5-ene-3beta,7alpha-diol |
CHEMBL455367
|
C011486
|
No. 53 | No. 11 |
|
||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00003652
|
Ergosterol
/ Ergosta-5,7,22-trien-3beta-ol |
CHEMBL222608
CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225 |
D004875
|
12 / 14 / 11 | No. 111 | No. 11 |
|
|
|
C00047677
|
5-Hydroxy-6-methoxy-7-O-beta-D-glucosylcoumarin
|
No. 491 | No. 25 |
|
||||
|
C00000856
|
4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid |
CHEMBL441343
|
C038193
|
21 / 7 / 16 | 2 / 1 | No. 817 | No. 81 |
|
|
C00002682
|
Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid |
CHEMBL120568
|
D014641
|
5 / 3 / 3 | 5 / 0 | No. 1073 |
|
|
|
C00047705
|
alpha-D-Furanallulose
|
CHEMBL604608
|
1 / 0 / 0 | No. 2228 |
|
|||
|
C00001151
|
Sucrose
/ (+)-Sucrose |
CHEMBL253582
CHEMBL1976550 |
D013395
|
1 / 0 / 0 | 4 / 10 | No. 3949 |
|
|
|
C00047817
|
Communin B
|
No. 5561 |
|
|||||
|
C00047816
|
Communin A
/ (-)-Communin A |
No. 5561 |
|
|||||
|
C00047994
|
Methyl indoline-6-carboxylate
|
No. 6658 |
|
Human Protein / Gene in interactions
50 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003652 C00003672 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003652 C00003672 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003652 C00003672 | 1 / 1 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00000856 C00002682 | 1 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00002682 C00003672 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003652 C00003672 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003652 C00003672 | 0 / 1 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000856 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000856 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00000856 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000856 | 1 / 2 |
| P02768 | Serum albumin | Secreted protein | C00001151 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| Q9UQ49 | Sialidase-3 | Enzyme | C00000856 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000856 | 0 / 0 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00000856 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000856 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003652 | 2 / 3 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000856 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000856 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003652 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000856 | 1 / 2 |
| P42858 | Huntingtin | Unclassified protein | C00002682 | 1 / 1 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000856 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002682 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000856 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003652 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00000856 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000856 | 0 / 1 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000856 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003652 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000856 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| P10323 | Acrosin | S1A | C00047705 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002682 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003652 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003652 | 4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000856 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000856 | 0 / 0 |
| P31939 | Bifunctional purine biosynthesis protein PURH | Enzyme | C00003652 | 1 / 1 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000856 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
11 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3952 | LEP, LEPD, OB, OBS | leptin |
C00000856
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000856
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001151
|
| 55630 | SLC39A4, AEZ, AWMS2, ZIP4 | solute carrier family 39 (zinc transporter), member 4 |
C00001151
|
| 80834 | TAS1R2, GPR71, T1R2, TR2 | taste receptor, type 1, member 2 |
C00001151
|
| 83756 | TAS1R3, T1R3 | taste receptor, type 1, member 3 |
C00001151
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002682
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002682
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002682
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002682
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002682
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (39)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608688 | Aicar transformylase/imp cyclohydrolase deficiency |
P31939
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #143500 | Gilbert syndrome |
P22309
|
| #143100 | Huntington disease; hd |
P42858
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #211980 | Lung cancer |
P00533
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (37)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
|
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
|
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00966 | AICA-ribosiduria |
P31939
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
11 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D012220 | Rhinitis |
C00000856
|
| D019969 | Amphetamine-Related Disorders |
C00001151
|
| D018149 | Glucose Intolerance |
C00001151
|
| D006461 | Hemolysis |
C00001151
|
| D006946 | Hyperinsulinism |
C00001151
|
| D006948 | Hyperkinesis |
C00001151
|
| D006973 | Hypertension |
C00001151
|
| D007333 | Insulin Resistance |
C00001151
|
| D009401 | Nephrosis |
C00001151
|
| C541083 | Non-alcoholic Fatty Liver Disease |
C00001151
|
| D019966 | Substance-Related Disorders |
C00001151
|