Fagara macrophylla

• Index
• Plant Species
• Metabolite list (6)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Fagara macrophylla
Genus	Fagara
Family	Rutaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Rutaceae
Linked NCBI taxonomy ID	23513
Linked level	family

Family

Family in NCBI taxonomy	Rutaceae
ID	23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (6)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00024230	1-Hydroxy-3-methoxy-N-methylacridone	CHEMBL1094824				No. 257	No. 7
C00000601	(+)-Sesamin	CHEMBL43469 CHEMBL252915 CHEMBL1572261 CHEMBL1591714 CHEMBL1708854 CHEMBL1904496 CHEMBL1968861	C054125	20 / 24 / 15	0 / 5	No. 621	No. 21
C00002742	Fagaramide	CHEMBL252709				No. 638
C00000856	4-Hydroxybenzoic acid / p-Hydroxybenzoic acid	CHEMBL441343	C038193	21 / 7 / 16	2 / 1	No. 817	No. 81
C00002498	Scoparone / 6,7-Dimethoxycoumarin / Aesculetin dimethyl ether	CHEMBL325864	C018145	4 / 2 / 2	6 / 0	No. 864	No. 25
C00024273	Xanthoxoline					No. 2197	No. 7

Human Protein / Gene in interactions

45 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000601	1 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00000601	4 / 1
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00000856	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00000856	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00000856	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00000856	0 / 0
P51649	Succinate-semialdehyde dehydrogenase, mitochondrial	Oxidoreductase	C00000856	1 / 1
P00918	Carbonic anhydrase 2	Lyase	C00000856	1 / 2
P05091	Aldehyde dehydrogenase, mitochondrial	Oxidoreductase	C00002498	1 / 1
Q9UQ49	Sialidase-3	Enzyme	C00000856	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000601	0 / 1
Q9HAW7	UDP-glucuronosyltransferase 1-7	Enzyme	C00000856	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000856	1 / 8
P11473	Vitamin D3 receptor	NR1I1	C00000601	2 / 3
P23280	Carbonic anhydrase 6	Lyase	C00000856	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00000601	0 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00000856	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00000856	1 / 2
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000601	2 / 0
O75496	Geminin	Unclassified protein	C00000601	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00000856	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00000856	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000601	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000601	7 / 3
P83916	Chromobox protein homolog 1	Unclassified protein	C00000601	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000601	0 / 0
P80404	4-aminobutyrate aminotransferase, mitochondrial	Transferase	C00000856	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00000601	0 / 0
P56817	Beta-secretase 1	A1A	C00002498	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00000856	0 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000601	2 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000601	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00000856	0 / 0
P51580	Thiopurine S-methyltransferase	Enzyme	C00000856	1 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000601	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000601	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00000601	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000601	4 / 3
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00000856	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000601	0 / 0
P07451	Carbonic anhydrase 3	Lyase	C00000856	0 / 0
P22748	Carbonic anhydrase 4	Lyase	C00000856	1 / 1
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00002498	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00002498	1 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000601	1 / 1

8 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002498
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002498
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002498
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002498
5966	REL, C-Rel	v-rel avian reticuloendotheliosis viral oncogene homolog	C00002498
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002498
3952	LEP, LEPD, OB, OBS	leptin	C00000856
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00000856

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions