Lithospermum erythrorhizon
Species
KNApSAcK Entry
| Organism name | Lithospermum erythrorhizon |
|---|---|
| Genus | Lithospermum |
| Family | Boraginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Lithospermum erythrorhizon |
|---|---|
| Linked NCBI taxonomy ID | 34254 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Boraginaceae |
|---|---|
| ID | 21571 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (28)
| Species | Activity |
|---|---|
| Lithospermum erythrorhizon Siebold & Zucc. | Analgesic |
| Lithospermum erythrorhizon Siebold & Zucc. | Anti-HIV |
| Lithospermum erythrorhizon Siebold & Zucc. | Antiangiogenic |
| Lithospermum erythrorhizon Siebold & Zucc. | Antibacterial |
| Lithospermum erythrorhizon Siebold & Zucc. | Anticancer |
| Lithospermum erythrorhizon Siebold & Zucc. | Antigonadotropic |
| Lithospermum erythrorhizon Siebold & Zucc. | Antihyperthyroid |
| Lithospermum erythrorhizon Siebold & Zucc. | Antiinflammatory |
| Lithospermum erythrorhizon Siebold & Zucc. | Antimutagenic |
| Lithospermum erythrorhizon Siebold & Zucc. | Antioxidant |
| Lithospermum erythrorhizon Siebold & Zucc. | Antipyretic |
| Lithospermum erythrorhizon Siebold & Zucc. | Antisarcomic |
| Lithospermum erythrorhizon Siebold & Zucc. | Antiseptic |
| Lithospermum erythrorhizon Siebold & Zucc. | Antithyroid |
| Lithospermum erythrorhizon Siebold & Zucc. | Antitumor |
| Lithospermum erythrorhizon Siebold & Zucc. | Antiviral |
| Lithospermum erythrorhizon Siebold & Zucc. | Apoptotic |
| Lithospermum erythrorhizon Siebold & Zucc. | Candidicide |
| Lithospermum erythrorhizon Siebold & Zucc. | Circulostimulant |
| Lithospermum erythrorhizon Siebold & Zucc. | Depurtive |
| Lithospermum erythrorhizon Siebold & Zucc. | Detoxicant |
| Lithospermum erythrorhizon Siebold & Zucc. | Diuretic |
| Lithospermum erythrorhizon Siebold & Zucc. | Fungicide |
| Lithospermum erythrorhizon Siebold & Zucc. | Granulant |
| Lithospermum erythrorhizon Siebold & Zucc. | Hypoglycemic |
| Lithospermum erythrorhizon Siebold & Zucc. | Immunomodulator |
| Lithospermum erythrorhizon Siebold & Zucc. | Lactobacillacide |
| Lithospermum erythrorhizon Siebold & Zucc. | Laxative |
Metabolite list (12)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000856
|
4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid |
CHEMBL441343
|
C038193
|
21 / 7 / 16 | 2 / 1 | No. 817 | No. 81 |
|
|
C00031982
|
Salvianolic acid B
/ Lithospermic acid B |
CHEMBL1615434
|
C111702
|
No. 1276 |
|
|||
|
C00030757
|
Methyl linoleate
/ Methyl 9Z,12Z-octadecadienoate |
C005575
|
No. 1785 |
|
||||
|
C00030760
|
Methyl oleate
/ Oleic acid methyl ester / Methyl (Z)-9-octadecenoate |
CHEMBL465725
|
C005576
|
2 / 6 / 5 | No. 1785 |
|
||
|
C00000859
|
Shikonin
|
CHEMBL9470
CHEMBL29285 CHEMBL28457 |
16 / 14 / 12 | No. 2968 | No. 80 |
|
||
|
C00000846
|
Geranyl diphosphate
/ Geranyl pyrophosphate |
CHEMBL41342
|
C015234
|
1 / 0 / 0 | 2 / 0 | No. 3475 | No. 34 |
|
|
C00000852
|
m-Geranyl-p-hydroxybenzoic acid
/ 3-Geranyl-4-hydroxybenzoic acid |
CHEMBL482787
|
No. 4238 |
|
||||
|
C00029462
|
2-Methylpropanoic acid
|
CHEMBL108778
|
C020380
|
No. 4580 |
|
|||
|
C00029461
|
2-Methylbutanoic acid
|
CHEMBL1160012
CHEMBL1162482 CHEMBL1162483 |
2 / 1 / 2 | No. 4580 |
|
|||
|
C00029460
|
2-Methyl-2-butenoic acid
|
CHEMBL55941
CHEMBL52416 |
C009489
|
No. 5138 |
|
|||
|
C00001189
|
Isovaleric acid
/ 3-Methylbutanoic acid |
CHEMBL568737
|
C008216
|
4 / 0 | No. 5262 |
|
||
|
C00040156
|
Rhizonone
|
No. 7318 |
|
Human Protein / Gene in interactions
41 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000859 C00030760 | 3 / 1 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000856 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000859 | 4 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000856 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000856 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000856 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000856 | 0 / 0 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00000859 | 0 / 0 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00000856 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000856 | 1 / 2 |
| Q9UQ49 | Sialidase-3 | Enzyme | C00000856 | 0 / 0 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00000856 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000856 | 1 / 8 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00000859 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000859 | 2 / 3 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000856 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000856 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000859 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000856 | 1 / 2 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000859 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000859 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000856 | 0 / 0 |
| O75908 | Sterol O-acyltransferase 2 | Enzyme | C00000859 | 0 / 0 |
| P14324 | Farnesyl pyrophosphate synthase | Transferase | C00000846 | 0 / 0 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00000856 | 1 / 1 |
| Q7Z4W1 | L-xylulose reductase | Enzyme | C00029461 | 0 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000856 | 0 / 1 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000856 | 0 / 0 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00000856 | 1 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000859 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000859 | 4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000856 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00030760 | 3 / 4 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000856 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000856 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000859 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000859 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000859 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000859 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000859 | 1 / 4 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00029461 | 1 / 1 |
8 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00001189
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00001189
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00001189
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00001189
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00000846
|
| 5906 | RAP1A, KREV-1, KREV1, RAP1, SMGP21 | RAP1A, member of RAS oncogene family |
C00000846
|
| 3952 | LEP, LEPD, OB, OBS | leptin |
C00000856
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000856
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (25)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #211980 | Lung cancer |
P00533
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (33)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
|
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
|
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H01065 | Pentosuria |
Q7Z4W1
(related)
|