PCIDB

Euphorbia supina Rafin

Species

KNApSAcK Entry

Organism name Euphorbia supina Rafin
Genus Euphorbia
Family Euphorbiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Euphorbiaceae
Linked NCBI taxonomy ID 3977
Linked level family

Family

Family in NCBI taxonomy Euphorbiaceae
ID 3977

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (16)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00031826 External link 512 Glutinol
/ D:B-Friedoolean-5-en-3beta-ol
/ (+)-D:B-Friedoolean-5-en-3beta-ol
CHEMBL452242
No. 13 No. 51
C00038249 External link 512 3beta-Hydroxymultiflor-8-en-7-one
No. 13 No. 51
C00001078 External link 512 Lutexin
/ Orientin
/ Luteolin 8-C-beta-D-glucopyranoside
/ 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone
CHEMBL520866
CHEMBL1468796
C065886
20 / 15 / 14 No. 22 No. 15
C00001110 External link 512 Vitexin
/ Apigenin 8-C-glucoside
/ 8-D-Glucosyl-4',5,7-trihydroxyflavone
/ 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL487417
CHEMBL1332209
CHEMBL1357921
16 / 4 / 8 No. 22 No. 15
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00040351 External link 512 Spirosupinanonediol
No. 101 No. 52
C00039840 External link 512 Neospirosupinanetrione
No. 101 No. 52
C00039173 External link 512 Espinenoxide
No. 198 No. 52
C00039172 External link 512 Espinendiol B
No. 198 No. 52
C00039171 External link 512 Espinendiol A
No. 198 No. 52
C00040408 External link 512 Supinenolone A
CHEMBL318711
2 / 0 / 0 No. 198 No. 52
C00040409 External link 512 Supinenolone B
CHEMBL97827
2 / 0 / 0 No. 198 No. 52
C00040410 External link 512 Supinenolone C
CHEMBL327252
2 / 0 / 0 No. 198 No. 52
C00040411 External link 512 Supinenolone D
No. 198 No. 52
C00040412 External link 512 Supinenolone E
No. 198 No. 52
C00040566 External link 512 trisnor-Isoespinenoxide
No. 198 No. 52

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11388 DNA topoisomerase 2-alpha Isomerase C00003749 C00040408 C00040409 C00040410 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00040408 C00040409 C00040410 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001078 C00001110 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001078 C00001110 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001078 C00001110 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001078 C00001110 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001078 C00001110 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001078 C00001110 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001110 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001078 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00003749 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001078 3 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001078 0 / 0
O75496 Geminin Unclassified protein C00001110 0 / 0
P15121 Aldose reductase Enzyme C00001110 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003749 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001110 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001110 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001110 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001110 0 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00001078 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00001078 0 / 0
P06746 DNA polymerase beta Enzyme C00001078 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001078 4 / 3
Q99700 Ataxin-2 Unclassified protein C00001078 1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001078 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001078 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001078 1 / 1
O00255 Menin Unclassified protein C00001078 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001078 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001110 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001110 1 / 4
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001078 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001110 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (20)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749