KNApSAcK Metabolite C00006094
Metabolite
KNApSAcK Entry
| id | C00006094 |
|---|---|
| Name | Puerarin / Kakonein |
| CAS RN | 3681-99-0 |
| Standard InChI | InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14?,17-,18+,19?,21+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2 |
Cluster
| Phytochemical cluster | No. 15 |
|---|---|
| KCF-S cluster | No. 22 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL486386 CHEMBL1319403 CHEMBL1334785 |
KEGG
| By LinkDB | C17057 |
|---|
CTD
| By CAS RN | C033607 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 3 |
| Spermatophyta | 1 |
Family
| family name | count |
|---|---|
| Fabaceae | 3 |
| Cephalotaxaceae | 1 |
List (4)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Cephalotaxus koreana | 450880 | Cephalotaxaceae | Spermatophyta | Viridiplantae |
| Pueraria mirifica | 861244 | Fabaceae | rosids | Viridiplantae |
| Pueraria montana var. lobata | 3893 | Fabaceae | rosids | Viridiplantae |
| Pueraria thunbergiana | 3892 | Fabaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
8 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL1319403 |
CHEMBL1614458
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL1334785 |
CHEMBL2114843
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL1319403 |
CHEMBL1613910
(1)
|
3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL1319403 |
CHEMBL1614038
(1)
|
2 / 2 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL486386 |
CHEMBL999948
(1)
|
1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL1334785 |
CHEMBL1794483
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL1319403 |
CHEMBL1613914
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL1319403 |
CHEMBL1614364
(1)
|
1 / 1 |
CTD interaction (86)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C033607 | 47 |
ACLY
ACL ATPCL CLATP |
ATP citrate lyase (EC:2.3.3.8) | puerarin results in increased expression of ACLY mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of AKT1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21884717
|
| C033607 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | puerarin results in increased phosphorylation of AKT1 protein |
increases phosphorylation
|
protein |
21884717
|
| C033607 | 358 |
AQP1
AQP-CHIP CHIP28 CO |
aquaporin 1 | puerarin results in increased expression of AQP1 mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 360 |
AQP3
AQP-3 GIL |
aquaporin 3 (Gill blood group) | puerarin results in increased expression of AQP3 mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 367 |
AR
AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
androgen receptor | puerarin results in decreased expression of AR mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | puerarin results in increased expression of BAX protein |
increases expression
|
protein |
16055262
|
| C033607 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | arsenic trioxide promotes the reaction [puerarin results in decreased expression of BCL2 mRNA] |
decreases expression
/ increases reaction |
mRNA |
20416161
|
| C033607 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | puerarin results in decreased expression of BCL2 mRNA |
decreases expression
|
mRNA |
20416161
|
| C033607 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | puerarin results in decreased expression of BCL2 protein |
decreases expression
|
protein |
16055262
|
| C033607 | 332 |
BIRC5
API4 EPR-1 |
baculoviral IAP repeat containing 5 | arsenic trioxide promotes the reaction [puerarin results in decreased expression of BIRC5 mRNA] |
decreases expression
/ increases reaction |
mRNA |
20416161
|
| C033607 | 332 |
BIRC5
API4 EPR-1 |
baculoviral IAP repeat containing 5 | puerarin results in decreased expression of BIRC5 mRNA |
decreases expression
|
mRNA |
20416161
|
| C033607 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP3 protein] |
increases expression
/ increases reaction |
protein |
20416161
|
| C033607 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | puerarin results in increased activity of CASP3 protein |
increases activity
|
protein |
16055262
|
| C033607 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | puerarin results in increased expression of CASP3 protein |
increases expression
|
protein |
20416161
|
| C033607 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | arsenic trioxide promotes the reaction [puerarin results in increased expression of CASP8 protein] |
increases expression
/ increases reaction |
protein |
20416161
|
| C033607 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | puerarin results in increased expression of CASP8 protein |
increases expression
|
protein |
20416161
|
| C033607 | 999 |
CDH1
Arc-1 CD324 CDHE ECAD LCAM UVO |
cadherin 1, type 1, E-cadherin (epithelial) | puerarin results in increased expression of CDH1 mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 4512 |
COX1
COI MTCO1 MT-CO1 |
cytochrome c oxidase subunit I | puerarin results in increased expression of COX1 mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 114757 |
CYGB
HGB STAP |
cytoglobin | puerarin results in decreased expression of CYGB mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 1830 |
DSG3
CDHF6 PVA |
desmoglein 3 | puerarin results in decreased expression of DSG3 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 1950 |
EGF
HOMG4 URG |
epidermal growth factor | puerarin results in decreased expression of EGF mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | puerarin results in decreased activity of ESR2 protein |
decreases activity
|
protein |
18937077
|
| C033607 | 2100 |
ESR2
ER-BETA ESR-BETA ESRB ESTRB Erb NR3A2 |
estrogen receptor 2 (ER beta) | puerarin results in decreased expression of ESR2 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 356 |
FASLG
ALPS1B APT1LG1 APTL CD178 CD95-L CD95L FASL TNFSF6 |
Fas ligand (TNF superfamily, member 6) | arsenic trioxide promotes the reaction [puerarin results in increased expression of FASLG protein] |
increases expression
/ increases reaction |
protein |
20416161
|
| C033607 | 356 |
FASLG
ALPS1B APT1LG1 APTL CD178 CD95-L CD95L FASL TNFSF6 |
Fas ligand (TNF superfamily, member 6) | puerarin results in increased expression of FASLG protein |
increases expression
|
protein |
20416161
|
| C033607 | 2200 |
FBN1
ACMICD ECTOL1 FBN GPHYSD2 MASS MFS1 OCTD SGS SSKS WMS WMS2 |
fibrillin 1 | puerarin results in decreased expression of FBN1 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 2201 |
FBN2
CCA DA9 |
fibrillin 2 | puerarin results in decreased expression of FBN2 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 2246 |
FGF1
AFGF ECGF ECGF-beta ECGFA ECGFB FGF-1 FGF-alpha FGFA GLIO703 HBGF-1 HBGF1 |
fibroblast growth factor 1 (acidic) | puerarin results in increased expression of FGF1 mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | puerarin results in increased expression of FOS mRNA |
increases expression
|
mRNA |
17142977
|
| C033607 | 3036 |
HAS1
HAS |
hyaluronan synthase 1 (EC:2.4.1.212) | puerarin results in decreased expression of HAS1 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 3315 |
HSPB1
CMT2F HMN2B HS.76067 HSP27 HSP28 Hsp25 SRP27 |
heat shock 27kDa protein 1 | puerarin results in increased expression of HSPB1 mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21884717
|
| C033607 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
21884717
|
| C033607 | 3479 |
IGF1
IGF-I IGF1A IGFI |
insulin-like growth factor 1 (somatomedin C) | puerarin results in decreased expression of IGF1 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 3552 |
IL1A
IL-1A IL1 IL1-ALPHA IL1F1 |
interleukin 1, alpha | puerarin results in decreased expression of IL1A mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 9365 |
KL
|
klotho (EC:3.2.1.31) | puerarin results in decreased expression of KL mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | puerarin results in increased phosphorylation of MAPK1 protein |
increases phosphorylation
|
protein |
21884717
|
| C033607 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | puerarin results in increased phosphorylation of MAPK3 protein |
increases phosphorylation
|
protein |
21884717
|
| C033607 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | arsenic trioxide promotes the reaction [puerarin results in increased expression of MAPK8 protein] |
increases expression
/ increases reaction |
protein |
20416161
|
| C033607 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | puerarin results in increased expression of MAPK8 protein |
increases expression
|
protein |
20416161
|
| C033607 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | puerarin results in increased phosphorylation of MAPK8 protein |
increases phosphorylation
|
protein |
21884717
|
| C033607 | 5601 |
MAPK9
JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK |
mitogen-activated protein kinase 9 (EC:2.7.11.24) | puerarin results in increased phosphorylation of MAPK9 protein |
increases phosphorylation
|
protein |
21884717
|
| C033607 | 4157 |
MC1R
CMM5 MSH-R SHEP2 |
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | puerarin results in decreased expression of MC1R mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 4609 |
MYC
MRTL MYCC bHLHe39 c-Myc |
v-myc avian myelocytomatosis viral oncogene homolog | puerarin results in decreased expression of MYC protein |
decreases expression
|
protein |
16055262
|
| C033607 | 4843 |
NOS2
HEP-NOS INOS NOS NOS2A |
nitric oxide synthase 2, inducible (EC:1.14.13.39) | puerarin results in decreased expression of NOS2 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide] |
decreases reaction
/ increases abundance / increases phosphorylation |
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide] |
decreases reaction
/ increases abundance / increases phosphorylation |
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | fulvestrant inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | fulvestrant inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide] |
decreases reaction
/ increases abundance / increases phosphorylation |
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | puerarin results in increased activity of NOS3 protein |
increases activity
|
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | puerarin results in increased expression of NOS3 mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | puerarin results in increased phosphorylation of NOS3 protein |
increases phosphorylation
|
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | [puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide |
increases abundance
/ increases phosphorylation |
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | W 7 inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
21884717
|
| C033607 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | W 7 inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide] |
decreases reaction
/ increases abundance / increases phosphorylation |
protein |
21884717
|
| C033607 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | puerarin results in decreased expression of PGR mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | puerarin results in increased expression of PGR protein |
increases expression
|
protein |
17142977
|
| C033607 | 8985 |
PLOD3
LH3 |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) | puerarin results in increased expression of PLOD3 mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 5371 |
PML
MYL PP8675 RNF71 TRIM19 |
promyelocytic leukemia | arsenic trioxide promotes the reaction [puerarin results in decreased expression of PML mRNA alternative form] |
decreases expression
/ increases reaction |
mRNA |
20416161
|
| C033607 | 5371 |
PML
MYL PP8675 RNF71 TRIM19 |
promyelocytic leukemia | puerarin results in decreased expression of PML mRNA alternative form |
decreases expression
|
mRNA |
20416161
|
| C033607 | 5468 |
PPARG
CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma |
peroxisome proliferator-activated receptor gamma | puerarin results in decreased expression of PPARG mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 5731 |
PTGER1
EP1 |
prostaglandin E receptor 1 (subtype EP1), 42kDa | puerarin results in decreased expression of PTGER1 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 5914 |
RARA
NR1B1 RAR |
retinoic acid receptor, alpha | arsenic trioxide promotes the reaction [puerarin results in decreased expression of RARA mRNA alternative form] |
decreases expression
/ increases reaction |
mRNA |
20416161
|
| C033607 | 5914 |
RARA
NR1B1 RAR |
retinoic acid receptor, alpha | puerarin results in decreased expression of RARA mRNA alternative form |
decreases expression
|
mRNA |
20416161
|
| C033607 | 5914 |
RARA
NR1B1 RAR |
retinoic acid receptor, alpha | puerarin results in increased expression of RARA mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein] |
decreases reaction
/ increases expression |
protein |
21884717
|
| C033607 | 6649 |
SOD3
EC-SOD |
superoxide dismutase 3, extracellular (EC:1.15.1.1) | puerarin results in decreased expression of SOD3 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 6716 |
SRD5A2
|
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) | puerarin results in decreased expression of SRD5A2 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 7015 |
TERT
CMM9 DKCA2 DKCB4 EST2 PFBMFT1 TCS1 TP2 TRT hEST2 hTRT |
telomerase reverse transcriptase (EC:2.7.7.49) | puerarin results in decreased expression of TERT mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] |
decreases reaction
/ increases expression |
protein |
21884717
|
| C033607 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | puerarin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
21884717
|
| C033607 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | puerarin inhibits the reaction [TNF protein results in increased expression of RELA protein] |
decreases reaction
/ increases expression |
protein |
21884717
|
| C033607 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | puerarin results in decreased activity of TNF protein |
decreases activity
|
protein |
21884717
|
| C033607 | 7178 |
TPT1
HRF TCTP p02 p23 |
tumor protein, translationally-controlled 1 | puerarin results in increased expression of TPT1 mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 7295 |
TXN
TRDX TRX TRX1 |
thioredoxin | puerarin results in increased expression of TXN mRNA |
increases expression
|
mRNA |
20706672
|
| C033607 | 7306 |
TYRP1
CAS2 CATB GP75 OCA3 TRP TRP1 TYRP b-PROTEIN |
tyrosinase-related protein 1 (EC:1.14.18.-) | puerarin results in decreased expression of TYRP1 mRNA |
decreases expression
|
mRNA |
20706672
|
| C033607 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | UGT1A1 protein results in increased metabolism of puerarin |
increases metabolic processing
|
protein |
22648071
|
| C033607 | 54575 |
UGT1A10
UDPGT UGT-1J UGT1-10 UGT1.10 UGT1J |
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) | UGT1A10 protein results in increased metabolism of puerarin |
increases metabolic processing
|
protein |
22648071
|
| C033607 | 54659 |
UGT1A3
UDPGT UDPGT_1-3 UGT-1C UGT1-03 UGT1.3 UGT1C |
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) | UGT1A3 protein results in increased metabolism of puerarin |
increases metabolic processing
|
protein |
22648071
|
| C033607 | 54578 |
UGT1A6
GNT1 HLUGP HLUGP1 UDPGT UDPGT_1-6 UGT1 UGT1A6S UGT1F |
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) | UGT1A6 protein results in increased metabolism of puerarin |
increases metabolic processing
|
protein |
22648071
|
| C033607 | 54577 |
UGT1A7
UDPGT UDPGT_1-7 UGT-1G UGT1-07 UGT1.7 UGT1G |
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) | UGT1A7 protein results in increased metabolism of puerarin |
increases metabolic processing
|
protein |
22648071
|
| C033607 | 54576 |
UGT1A8
UDPGT UDPGT_1-8 UGT-1H UGT1-08 UGT1.8 UGT1A8S UGT1H |
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) | UGT1A8 protein results in increased metabolism of puerarin |
increases metabolic processing
|
protein |
22648071
|
| C033607 | 54600 |
UGT1A9
HLUGP4 LUGP4 UDPGT UDPGT_1-9 UGT-1I UGT1-09 UGT1-9 UGT1.9 UGT1AI UGT1I |
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) | UGT1A9 protein results in increased metabolism of puerarin |
increases metabolic processing
|
protein |
22648071
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (7)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (7)
| KEGG | disease name | UniProt |
|---|---|---|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
12 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D019973 | C033607 | Alcohol-Related Disorders |
therapeutic
|
17887948
|
|
| D001161 | C033607 | Arteriosclerosis |
therapeutic
|
22648071
|
|
| D002545 | C033607 | Brain Ischemia |
therapeutic
|
16041641
22648071 |
|
| D003920 | C033607 | Diabetes Mellitus |
therapeutic
|
22648071
|
|
| D003928 | C033607 | Diabetic Nephropathies |
therapeutic
|
18763636
19761151 |
|
| D056486 | C033607 | Drug-Induced Liver Injury |
therapeutic
|
22001170
|
|
| D006461 | C033607 | Hemolysis |
marker/mechanism
|
21453687
|
|
| D006949 | C033607 | Hyperlipidemias |
therapeutic
|
22001170
|
|
| D006973 | C033607 | Hypertension |
therapeutic
|
22648071
|
|
| D007249 | C033607 | Inflammation |
therapeutic
|
23146695
|
|
| D008103 | C033607 | Liver Cirrhosis |
therapeutic
|
16426832
23146695 |
|
| D017202 | C033607 | Myocardial Ischemia |
therapeutic
|
22648071
|