Species

KNApSAcK Entry

Organism name Pueraria thunbergiana
Genus Pueraria
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pueraria
Linked NCBI taxonomy ID 3892
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00039554 External link 512 Kakkalide
CHEMBL264409
C108698
No. 1 No. 15
C00010115 External link 512 Kakkanin
/ Biochanin A 7-O-xylosyl-(1->6)-glucoside
No. 1 No. 15
C00019124 External link 512 5,7,4'-Trihydroxy-6-methoxyisoflavone 7-O-beta-D-xylopyranosyl-(1->6)-O-beta-D-glucopyranoside
No. 1 No. 15
C00019123 External link 512 7,4'-Dihydroxy-6-methoxyisoflavone 7-O-beta-D-xylopyranosyl-(1->6)-O-beta-D-glucopyranoside
No. 1 No. 15
C00010089 External link 512 Glycitin
/ Glycitein 7-O-glucoside
CHEMBL1574061
3 / 4 / 1 No. 2 No. 15
C00010125 External link 512 Kakkalidone
/ Irisolidone 7-O-glucoside
/ Irisolidone 7-O-beta-D-glucoside
No. 2 No. 15
C00002576 External link 512 Shekanin
/ Shekkanin
/ Tectoridin
/ Tectorigenin 7-O-glucoside
CHEMBL520214
C120040
0 / 2 No. 2 No. 15
C00002540 External link 512 Irisolidone
/ 4'-O-Methyltectorigenin
/ 5,7-Dihydroxy-6,4'-dimethoxyisoflavone
CHEMBL265945
1 / 0 / 0 No. 3 No. 15
C00009392 External link 512 Glycitein
/ 7,4'-Dihydroxy-6-methoxyisoflavone
CHEMBL513024
C086566
2 / 2 / 2 40 / 4 No. 3 No. 15
C00006094 External link 512 Puerarin
/ Kakonein
CHEMBL486386
CHEMBL1319403
CHEMBL1334785
C033607
8 / 7 / 7 56 / 12 No. 22 No. 15
C00009380 External link 512 Daidzein
/ 7,4'-Dihydroxyisoflavone
CHEMBL8145
C004742
60 / 68 / 76 113 / 12 No. 71 No. 15
C00009684 External link 512 Tuberosin
/ (+)-Tuberosine
No. 325 No. 15
C00002532 External link 512 (-)-Glycinol
/ 3,6a,9-Trihydroxypterocarpan
C042061
No. 396 No. 15
C00010061 External link 512 Puerarol
/ 3,9-Dihydroxy-2-geranylcoumestan
No. 436 No. 17

Human Protein / Gene in interactions

62 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P03372 Estrogen receptor NR3A1 C00006094 C00009380 C00009392 1 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00006094 C00009380 C00010089 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00006094 C00009380 2 / 2
Q16637 Survival motor neuron protein Unclassified protein C00009380 C00010089 4 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00009380 C00010089 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00006094 C00009380 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00006094 C00009380 3 / 3
O75496 Geminin Unclassified protein C00006094 C00009380 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00006094 C00009380 1 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00009380 C00009392 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00009380 0 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00009380 0 / 0
P02545 Prelamin-A/C Unclassified protein C00009380 11 / 10
P49798 Regulator of G-protein signaling 4 Unclassified protein C00009380 2 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00009380 3 / 1
P05091 Aldehyde dehydrogenase, mitochondrial Oxidoreductase C00009380 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00009380 0 / 1
P54132 Bloom syndrome protein Enzyme C00009380 1 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00009380 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00009380 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00009380 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00009380 0 / 0
Q99700 Ataxin-2 Unclassified protein C00009380 1 / 1
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00009380 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00009380 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00009380 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00009380 0 / 1
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00009380 1 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00009380 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00009380 0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00009380 2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00009380 5 / 3
P04745 Alpha-amylase 1 Enzyme C00009380 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00009380 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00009380 1 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00009380 2 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00009380 1 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00009380 1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00009380 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00009380 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00009380 7 / 37
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00009380 3 / 0
P35372 Mu-type opioid receptor Opioid receptor C00009380 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00009380 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00009380 1 / 1
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00009380 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00009380 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00006094 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00009380 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00009380 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00009380 0 / 0
P10275 Androgen receptor NR3C4 C00009380 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00009380 0 / 0
P05412 Transcription factor AP-1 Transcription Factor C00002540 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00009380 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00009380 0 / 0
P40225 Thrombopoietin Unclassified protein C00009380 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00009380 0 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00009380 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00009380 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00009380 1 / 1
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00009380 0 / 0

158 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00006094 C00009380 C00009392
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00006094 C00009380 C00009392
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00006094 C00009380 C00009392
81537 SGPP1, SPPase1 sphingosine-1-phosphate phosphatase 1 C00009380 C00009392
119 ADD2, ADDB adducin 2 (beta) C00009380 C00009392
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00006094 C00009380
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00006094 C00009380
7345 UCHL1, NDGOA, PARK5, PGP_9.5, PGP9.5, PGP95, Uch-L1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12) C00009380 C00009392
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00006094 C00009380
396 ARHGDIA, GDIA1, NPHS8, RHOGDI, RHOGDI-1 Rho GDP dissociation inhibitor (GDI) alpha C00009380 C00009392
23545 ATP6V0A2, A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS ATPase, H+ transporting, lysosomal V0 subunit a2 (EC:3.6.3.6) C00009380 C00009392
11177 BAZ1A, ACF1, WALp1, WCRF180, hACF1 bromodomain adjacent to zinc finger domain, 1A C00009380 C00009392
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00006094 C00009380
9537 TP53I11, PIG11 tumor protein p53 inducible protein 11 C00009380 C00009392
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00009380 C00009392
7130 TNFAIP6, TSG-6, TSG6 tumor necrosis factor, alpha-induced protein 6 C00009380 C00009392
6870 TACR3, HH11, NK-3R, NK3R, NKR, TAC3RL tachykinin receptor 3 C00009380 C00009392
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00006094 C00009380
890 CCNA2, CCN1, CCNA cyclin A2 C00009380 C00009392
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00009380 C00009392
6781 STC1, STC stanniocalcin 1 C00009380 C00009392
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00009380 C00009392
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00009380 C00009392
6558 SLC12A2, BSC, BSC2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 C00009380 C00009392
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00006094 C00009380
6197 RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1) C00009380 C00009392
5458 POU4F2, BRN3.2, BRN3B, Brn-3b POU class 4 homeobox 2 C00009380 C00009392
5411 PNN, DRS, DRSP, SDK3, memA pinin, desmosome associated protein C00009380 C00009392
5241 PGR, NR3C3, PR progesterone receptor C00006094 C00009380
64236 PDLIM2, MYSTIQUE, SLIM PDZ and LIM domain 2 (mystique) C00009380 C00009392
5111 PCNA proliferating cell nuclear antigen C00009380 C00009392
56944 OLFML3, HNOEL-iso, OLF44 olfactomedin-like 3 C00009380 C00009392
8204 NRIP1, RIP140 nuclear receptor interacting protein 1 C00009380 C00009392
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00006094 C00009380
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00006094 C00009380
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00009380 C00009392
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00006094 C00009380
1795 DOCK3, MOCA, PBP dedicator of cytokinesis 3 C00009380 C00009392
26251 KCNG2, KCNF2, KV6.2 potassium voltage-gated channel, subfamily G, member 2 C00009380 C00009392
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00009380 C00009392
26145 IRF2BP1 interferon regulatory factor 2 binding protein 1 C00009380 C00009392
7866 IFRD2, IFNRP, SKMc15, SM15 interferon-related developmental regulator 2 C00009380 C00009392
2041 EPHA1, EPH, EPHT, EPHT1 EPH receptor A1 (EC:2.7.10.1) C00009380 C00009392
83715 ESPN, DFNB36 espin C00009380 C00009392
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00009380 C00009392
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00006094 C00009380
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00006094 C00009380
56776 FMN2 formin 2 C00009380 C00009392
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00006094
2103 ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2 estrogen-related receptor beta C00009380
2101 ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1 estrogen-related receptor alpha C00009380
9687 GREB1 growth regulation by estrogen in breast cancer 1 C00009380
3284 HSD3B2, HSD3B, HSDB, SDR11E2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) C00009380
2027 ENO3, GSD13, MSE enolase 3 (beta, muscle) (EC:4.2.1.11) C00009380
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00009380
3487 IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4 insulin-like growth factor binding protein 4 C00009380
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00009380
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00009380
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00009380
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00009380
9166 EBAG9, EB9, PDAF estrogen receptor binding site associated, antigen, 9 C00009380
1846 DUSP4, HVH2, MKP-2, MKP2, TYP dual specificity phosphatase 4 (EC:3.1.3.16 3.1.3.48) C00009380
354 KLK3, APS, KLK2A1, PSA, hK3 kallikrein-related peptidase 3 (EC:3.4.21.77) C00009380
27074 LAMP3, CD208, DC_LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403 lysosomal-associated membrane protein 3 C00009380
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00009380
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00009380
4199 ME1, HUMNDME, MES malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) C00009380
4502 MT2A, MT2 metallothionein 2A C00009380
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00009380
10499 NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75 nuclear receptor coactivator 2 C00009380
4824 NKX3-1, BAPX2, NKX3, NKX3.1, NKX3A NK3 homeobox 1 C00009380
1589 CYP21A2, CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) C00009380
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00009380
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00009380
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00009380
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00009380
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00009380
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00009380
6387 CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B chemokine (C-X-C motif) ligand 12 C00009380
5174 PDZK1, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1 PDZ domain containing 1 C00009380
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00009380
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00009380
10957 PNRC1, B4-2, PNAS-145, PROL2, PRR2 proline-rich nuclear receptor coactivator 1 C00009380
9167 COX7A2L, COX7AR, COX7RP, EB1, SIG81 cytochrome c oxidase subunit VIIa polypeptide 2 like C00009380
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC:2.7.10.2 2.7.11.13) C00009380
11098 PRSS23, SIG13, SPUVE, ZSIG13 protease, serine, 23 C00009380
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00009380
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00009380
5932 RBBP8, COM1, CTIP, JWDS, RIM, SAE2, SCKL2 retinoblastoma binding protein 8 C00009380
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00009380
1152 CKB, B-CK, CKBB creatine kinase, brain (EC:2.7.3.2) C00009380
1103 CHAT, CHOACTASE, CMS1A, CMS1A2 choline O-acetyltransferase (EC:2.3.1.6) C00009380
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00009380
8140 SLC7A5, 4F2LC, CD98, D16S469E, E16, LAT1, MPE16, hLAT1 solute carrier family 7 (amino acid transporter light chain, L system), member 5 C00009380
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00009380
27347 STK39, DCHT, PASK, SPAK serine threonine kinase 39 (EC:2.7.11.1) C00009380
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00009380
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00009380
103993 C00009380
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00009380
7041 TGFB1I1, ARA55, HIC-5, HIC5, TSC-5 transforming growth factor beta 1 induced transcript 1 C00009380
672 BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53 breast cancer 1, early onset C00009380
632 BGLAP, BGP, OC, OCN bone gamma-carboxyglutamate (gla) protein C00009380
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00009380
7164 TPD52L1, D53, hD53 tumor protein D52-like 1 C00009380
251 ALPPL2, ALPG, ALPPL, GCAP alkaline phosphatase, placental-like 2 (EC:3.1.3.1) C00009380
249 ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) C00009380
196 AHR, bHLHe76 aryl hydrocarbon receptor C00009380
10057 ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 C00009380
10257 ABCC4, EST170205, MOAT-B, MOATB, MRP4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 C00009380
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00009380
7367 UGT2B17, BMND12, UDPGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 (EC:2.4.1.17) C00009380
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00009380
47 ACLY, ACL, ATPCL, CLATP ATP citrate lyase (EC:2.3.3.8) C00006094
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00006094
358 AQP1, AQP-CHIP, CHIP28, CO aquaporin 1 C00006094
360 AQP3, AQP-3, GIL aquaporin 3 (Gill blood group) C00006094
581 BAX, BCL2L4 BCL2-associated X protein C00006094
2104 ESRRG, ERR3, ERRgamma, NR3B3 estrogen-related receptor gamma C00009380
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00006094
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00006094
4512 COX1, COI, MTCO1, MT-CO1 cytochrome c oxidase subunit I C00006094
114757 CYGB, HGB, STAP cytoglobin C00006094
1830 DSG3, CDHF6, PVA desmoglein 3 C00006094
1950 EGF, HOMG4, URG epidermal growth factor C00006094
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00006094
2200 FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 fibrillin 1 C00006094
2201 FBN2, CCA, DA9 fibrillin 2 C00006094
2246 FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 fibroblast growth factor 1 (acidic) C00006094
3036 HAS1, HAS hyaluronan synthase 1 (EC:2.4.1.212) C00006094
3315 HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 heat shock 27kDa protein 1 C00006094
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00006094
3479 IGF1, IGF-I, IGF1A, IGFI insulin-like growth factor 1 (somatomedin C) C00006094
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00006094
9365 KL klotho (EC:3.2.1.31) C00006094
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00006094
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00006094
4157 MC1R, CMM5, MSH-R, SHEP2 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) C00006094
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00006094
8985 PLOD3, LH3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) C00006094
5371 PML, MYL, PP8675, RNF71, TRIM19 promyelocytic leukemia C00006094
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00006094
5731 PTGER1, EP1 prostaglandin E receptor 1 (subtype EP1), 42kDa C00006094
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00006094
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00006094
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00006094
6716 SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) C00006094
7015 TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT telomerase reverse transcriptase (EC:2.7.7.49) C00006094
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00006094
7178 TPT1, HRF, TCTP, p02, p23 tumor protein, translationally-controlled 1 C00006094
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00006094
7306 TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN tyrosinase-related protein 1 (EC:1.14.18.-) C00006094
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00006094
54578 UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) C00006094
4314 MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) C00009392
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00009392
6667 SP1 Sp1 transcription factor C00009392
7421 VDR, NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor C00009392

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (68)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#610251 Alcohol sensitivity, acute P05091
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#218800 Crigler-najjar syndrome, type i P22310
#606785 Crigler-najjar syndrome, type ii P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22310
#137800 Glioma susceptibility 1; glm1 P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989

KEGG DISEASE (76)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H01071 Acute alcohol sensitivity P05091 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

28 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006973 Hypertension C00009380
C00006094
D056486 Drug-Induced Liver Injury C00006094
C00002576
D002545 Brain Ischemia C00006094
D003924 Diabetes Mellitus, Type 2 C00009380
D004487 Edema C00009380
D016889 Endometrial Neoplasms C00009380
D007172 Erectile Dysfunction C00009380
D006965 Hyperplasia C00009380
D000230 Adenocarcinoma C00009380
D017254 Leukemic Infiltration C00009380
D008569 Memory Disorders C00009380
D014693 Ventricular Fibrillation C00009380
D019973 Alcohol-Related Disorders C00006094
D001161 Arteriosclerosis C00006094
D002318 Cardiovascular Diseases C00009380
D003920 Diabetes Mellitus C00006094
D003928 Diabetic Nephropathies C00006094
D000647 Amnesia C00009380
D006461 Hemolysis C00006094
D006949 Hyperlipidemias C00006094
D007249 Inflammation C00006094
D008103 Liver Cirrhosis C00006094
D017202 Myocardial Ischemia C00006094
D001254 Astrocytoma C00009392
D009361 Neoplasm Invasiveness C00009392
D019636 Neurodegenerative Diseases C00009392
D010243 Paralysis C00009392
D005234 Fatty Liver C00002576