PCIDB

Viscum album

Species

KNApSAcK Entry

Organism name Viscum album
Genus Viscum
Family Santalaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Viscum album
Linked NCBI taxonomy ID 3972
Linked level species

Family

Family in NCBI taxonomy Viscaceae
ID 1003255

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00004372 External link 512 Homoflavoyadorinin B
/ Luteolin 7,3'-dimethyl ether 4'-apiosyl-(1->2)-glucoside
/ 2-[4-[(2-O-D-Apio-beta-D-furanosyl-beta-D-glucopyranosyl)oxy]-3-methoxyphenyl]-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one
CHEMBL2332118
No. 1 No. 15
C00004371 External link 512 Luteolin 7,3'-dimethyl ether 4'-glucoside
No. 2 No. 15
C00005607 External link 512 Rhamnazin 3-glucoside
CHEMBL563399
No. 2 No. 15
C00004635 External link 512 Isorhamnetin
/ 3'-O-Methylquercetin
/ 3,4',5,7-Tetrahydroxy-3'-methoxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL379064
C047368
12 / 10 / 13 10 / 0 No. 3 No. 15
C00004570 External link 512 Ermanin
/ Kaempferol 3,4'-di-O-methyl ether
/ 5,7-Dihydroxy-3,4'-dimethoxyflavone
/ 5,7-Dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL309061
C104804
2 / 1 / 1 No. 3 No. 15
C00004634 External link 512 Rhamnetin
/ 7-Methoxyquercetin
/ 3,5,3',4'-Tetrahydroxy-7-methoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1- benzopyran-4-one
CHEMBL312163
C063423
20 / 27 / 27 No. 3 No. 15
C00004569 External link 512 Jaranol
/ Kumatakenin
/ Kumatakillin
/ Kaempferol 3,7-O-dimethyl ether
/ 5,4'-Dihydroxy-3,7-dimethoxyflavone
/ 5-Hydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL349724
No. 3 No. 15
C00004638 External link 512 Quercetin 3,7-dimethyl ether
/ 5,3',4'-Trihydroxy-3,7-dimethoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL164861
C065497
2 / 1 / 2 No. 3 No. 15
C00004646 External link 512 Pachypodol
/ Quercetin 3,3',7-trimethyl ether
/ 5,4'-Dihydroxy-3,7,3'-trimethoxyflavone
/ 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL165180
C008751
1 / 2 / 0 No. 3 No. 15
C00004639 External link 512 Quercetin 3,3'-dimethyl ether
/ 5,7,4'-Trihydroxy-3,3'-dimethoxyflavone
/ 5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-methoxy-4H-1-benzopyran-4-one
CHEMBL511363
C060385
No. 3 No. 15
C00005578 External link 512 Isorhamnetin 3-apiosyl-(1->6)-glucoside-7-rhamnoside
No. 5 No. 15
C00007888 External link 512 4,2'-Dihydroxy-4',6'-dimethoxychalcone 4-glucoside
No. 36 No. 13
C00007917 External link 512 4,2'-Dihydroxy-3,4',6'-trimethoxychalcone 4-glucoside
No. 36 No. 13
C00007889 External link 512 4,2'-Dihydroxy-4',6'-dimethoxychalcone 4-apiosyl-(1->2)-glucoside
No. 411
C00001435 External link 512 Tyramine
CHEMBL11608
D014439
23 / 11 / 6 6 / 9 No. 936 No. 6

Human Protein / Gene in interactions

49 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001435 C00004570 C00004634 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00004634 C00004635 0 / 0
O00255 Menin Unclassified protein C00004634 C00004635 2 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001435 C00004634 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00004634 C00004635 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00004634 C00004635 1 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001435 C00004570 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001435 C00004635 0 / 0
P04745 Alpha-amylase 1 Enzyme C00004634 C00004635 0 / 0
P04792 Heat shock protein beta-1 Unclassified protein C00004634 C00004635 2 / 1
P15121 Aldose reductase Enzyme C00004634 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00004635 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00004634 3 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001435 1 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00004635 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001435 0 / 1
O15245 Solute carrier family 22 member 1 Drug uniporter C00001435 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00001435 2 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00004634 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001435 0 / 0
P39748 Flap endonuclease 1 Enzyme C00004635 0 / 0
O75496 Geminin Unclassified protein C00001435 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001435 0 / 0
P46098 5-hydroxytryptamine receptor 3A NS C00001435 0 / 0
P02545 Prelamin-A/C Unclassified protein C00004634 11 / 10
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001435 0 / 0
P14679 Tyrosinase Oxidoreductase C00001435 4 / 2
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00004635 4 / 4
P27361 Mitogen-activated protein kinase 3 Erk C00004634 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00004634 0 / 0
P56817 Beta-secretase 1 A1A C00001435 0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk C00004634 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00004634 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00004634 3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00004646 2 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001435 1 / 1
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00001435 0 / 0
Q96RJ0 Trace amine-associated receptor 1 Trace amine receptor C00001435 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001435 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00004634 4 / 3
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00004635 0 / 0
P00747 Plasminogen S1A C00004638 1 / 2
P46063 ATP-dependent DNA helicase Q1 Enzyme C00004634 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001435 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00004634 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001435 2 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00004638 0 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein C00001435 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001435 0 / 0

16 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00004635
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00004635
196 AHR, bHLHe76 aryl hydrocarbon receptor C00004635
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00004635
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00004635
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00004635
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00004635
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00004635
4973 OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 oxidized low density lipoprotein (lectin-like) receptor 1 C00004635
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00004635
4128 MAOA, MAO-A monoamine oxidase A (EC:1.4.3.4) C00001435
6530 SLC6A2, NAT1, NET, NET1, SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 2 C00001435
6531 SLC6A3, DAT, DAT1, PKDYS solute carrier family 6 (neurotransmitter transporter), member 3 C00001435
6532 SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT solute carrier family 6 (neurotransmitter transporter), member 4 C00001435
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00001435
134864 TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 trace amine associated receptor 1 C00001435

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (46)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P14416
#614490 Blood group, junior system; jr Q9UNQ0
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#217090 Plasminogen deficiency, type i P00747
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989

KEGG DISEASE (39)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00223 Inherited thrombophilia P00747 (related)
H01206 Plasminogen deficiency P00747 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

9 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009202 Cardiomyopathies C00001435
D002543 Cerebral Hemorrhage C00001435
D002637 Chest Pain C00001435
D006973 Hypertension C00001435
D007022 Hypotension C00001435
D008881 Migraine Disorders C00001435
D015878 Mydriasis C00001435
D011041 Poisoning C00001435
D013610 Tachycardia C00001435