PCIDB

KNApSAcK Metabolite C00004634

Metabolite

KNApSAcK Entry

id C00004634
Name Rhamnetin / 7-Methoxyquercetin / 3,5,3',4'-Tetrahydroxy-7-methoxyflavone / 2-(3,4-Dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1- benzopyran-4-one
CAS RN 90-19-7
Standard InChI InChI=1S/C16H12O7/c1-22-8-5-11(19)13-12(6-8)23-16(15(21)14(13)20)7-2-3-9(17)10(18)4-7/h2-6,17-19,21H,1H3
Standard InChI (Main Layer) InChI=1S/C16H12O7/c1-22-8-5-11(19)13-12(6-8)23-16(15(21)14(13)20)7-2-3-9(17)10(18)4-7/h2-6,17-19,21H,1H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL312163
By standard InChI Main Layer CHEMBL312163

KEGG

By LinkDB C10176

CTD

By CAS RN C063423

Species

Summary

Plant class

class name count
asterids 16
rosids 8
eudicotyledons 5
Liliopsida 2

Family (Top 10)

family name count
Asteraceae 14
Moringaceae 2
Dilleniaceae 2
Viscaceae 2
Capparaceae 1
Salicaceae 1
Boraginaceae 1
Velloziaceae 1
Nothofagaceae 1
Lamiaceae 1

List (31)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia ixiophylla 1120458 Fabaceae rosids Viridiplantae
Aeonium spp. 22994 Crassulaceae eudicotyledons Viridiplantae
Anthemis altissima 99027 Asteraceae asterids Viridiplantae
Artemisia campestris ssp. glutinosa 4219 Asteraceae asterids Viridiplantae
Artemisia glutinosa 4219 Asteraceae asterids Viridiplantae
Baccharis pilularis 41487 Asteraceae asterids Viridiplantae
Capparis tweediana 13394 Capparaceae rosids Viridiplantae
Cassinia vauvilliersii 125672 Asteraceae asterids Viridiplantae
Centaurea collina L. 145490 Asteraceae asterids Viridiplantae
Chromolaena meridensis 13420 Asteraceae asterids Viridiplantae
Chromolaena odorata 103745 Asteraceae asterids Viridiplantae
Chrysothamnus nauseosus 71039 Asteraceae asterids Viridiplantae
Dillenia spp. 4377 Dilleniaceae eudicotyledons Viridiplantae
Erysimum carniolicum 65352 Brassicaceae rosids Viridiplantae
Flourensia thurifera 191157 Asteraceae asterids Viridiplantae
Heliotropium stenophyllum 248301 Boraginaceae asterids Viridiplantae
Madia elegans 4255 Asteraceae asterids Viridiplantae
Meehania urticifolia 672825 Lamiaceae asterids Viridiplantae
Moringa oleifera 3735 Moringaceae rosids Viridiplantae
Moringa pterygosperma 3735 Moringaceae rosids Viridiplantae
Nothofagus obliqua 28948 Nothofagaceae rosids Viridiplantae
Ozothamnus expansifolius 59438 Asteraceae asterids Viridiplantae
Ozothamnus scutellifolius 1284902 Asteraceae asterids Viridiplantae
Populus nigra 3691 Salicaceae rosids Viridiplantae
Pulicaria dysenterica 56535 Asteraceae asterids Viridiplantae
Rhamnus cathartica 3610 Rhamnaceae rosids Viridiplantae
Smilax riparia 299599 Smilacaceae Liliopsida Viridiplantae
Tetracera spp. 85284 Dilleniaceae eudicotyledons Viridiplantae
Vellozia streptophylla 16383 Velloziaceae Liliopsida Viridiplantae
Viscum album 3972 Viscaceae eudicotyledons Viridiplantae
Viscum cruciatum 104251 Viscaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P45984 Mitogen-activated protein kinase 9 Jnk CHEMBL312163 CHEMBL1798111 (1)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL312163 CHEMBL1798114 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL312163 CHEMBL1614544 (1)
11 / 10
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL312163 CHEMBL1613776 (2)
3 / 1
P04792 Heat shock protein beta-1 Unclassified protein CHEMBL312163 CHEMBL993710 (1)
2 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL312163 CHEMBL1613800 (1)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL312163 CHEMBL1942674 (1)
0 / 0
P04745 Alpha-amylase 1 Enzyme CHEMBL312163 CHEMBL964479 (2)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL312163 CHEMBL1798112 (1)
0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk CHEMBL312163 CHEMBL1798113 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL312163 CHEMBL1613910 (1)
3 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL312163 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL312163 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL312163 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL312163 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL312163 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL312163 CHEMBL1613829 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL312163 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL312163 CHEMBL1614257 (2) CHEMBL1614531 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL312163 CHEMBL1614257 (2) CHEMBL1614531 (2)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (27)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (27)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)