Species

KNApSAcK Entry

Organism name Artemisia glutinosa
Genus Artemisia
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Artemisia
Linked NCBI taxonomy ID 4219
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004634 External link 512 Rhamnetin
/ 7-Methoxyquercetin
/ 3,5,3',4'-Tetrahydroxy-7-methoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1- benzopyran-4-one
CHEMBL312163
C063423
20 / 27 / 27 No. 3 No. 15
C00000982 External link 512 Naringenin
/ (-)-Naringenin
CHEMBL9352
CHEMBL32571
C005273
57 / 46 / 40 35 / 10 No. 25 No. 14
C00008577 External link 512 Padmatin
No. 42 No. 14

Human Protein / Gene in interactions

70 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000982 C00004634 1 / 2
O00255 Menin Unclassified protein C00000982 C00004634 2 / 5
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000982 C00004634 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000982 C00004634 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000982 C00004634 3 / 3
P04745 Alpha-amylase 1 Enzyme C00000982 C00004634 0 / 0
P15121 Aldose reductase Enzyme C00000982 C00004634 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000982 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000982 0 / 3
P04062 Glucosylceramidase Enzyme C00000982 6 / 4
P45984 Mitogen-activated protein kinase 9 Jnk C00004634 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00004634 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000982 0 / 0
P62158 Calmodulin Unclassified protein C00000982 1 / 0
P02545 Prelamin-A/C Unclassified protein C00004634 11 / 10
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000982 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00004634 3 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00000982 0 / 0
P08183 Multidrug resistance protein 1 drug C00000982 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000982 0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00000982 0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein C00000982 0 / 2
O75828 Carbonyl reductase [NADPH] 3 Enzyme C00000982 0 / 0
P04792 Heat shock protein beta-1 Unclassified protein C00004634 2 / 1
P41145 Kappa-type opioid receptor Opioid receptor C00000982 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00004634 0 / 0
P04278 Sex hormone-binding globulin Secreted protein C00000982 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000982 1 / 1
P16152 Carbonyl reductase [NADPH] 1 Enzyme C00000982 0 / 0
O75496 Geminin Unclassified protein C00000982 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000982 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000982 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000982 0 / 1
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000982 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00000982 1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000982 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000982 0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00000982 2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00000982 5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00000982 4 / 4
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00000982 1 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00000982 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00004634 0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk C00004634 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000982 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000982 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00000982 2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00000982 1 / 1
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000982 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000982 0 / 0
P03372 Estrogen receptor NR3A1 C00000982 1 / 1
P22303 Acetylcholinesterase Hydrolase C00000982 1 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000982 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000982 1 / 1
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00000982 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000982 3 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000982 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00004634 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000982 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00004634 4 / 3
P10275 Androgen receptor NR3C4 C00000982 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00000982 0 / 0
Q04760 Lactoylglutathione lyase Enzyme C00000982 0 / 0
P49888 Estrogen sulfotransferase Enzyme C00000982 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00004634 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00004634 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00004634 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00000982 0 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00000982 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000982 1 / 0

35 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000982
10257 ABCC4, EST170205, MOAT-B, MOATB, MRP4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 C00000982
10057 ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 C00000982
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000982
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000982
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000982
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000982
249 ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) C00000982
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00000982
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000982
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000982
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000982
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000982
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000982
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000982
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000982
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000982
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000982
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000982
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000982
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000982
3757 KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 C00000982
5444 PON1, ESA, MVCD5, PON paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) C00000982
6566 SLC16A1, HHF7, MCT, MCT1 solute carrier family 16 (monocarboxylate transporter), member 1 C00000982
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00000982
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000982
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00000982
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000982
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000982
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000982
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000982
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000982
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000982
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000982
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000982

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (66)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#114500 Colorectal cancer; crc P18054
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#601665 Obesity P37231
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#614916 Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 P62158
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (54)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00018 Gastric cancer P24864 (related)
H00055 Laryngeal cancer P24864 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

10 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00000982
D001932 Brain Neoplasms C00000982
D009202 Cardiomyopathies C00000982
D056486 Drug-Induced Liver Injury C00000982
D064420 Drug-Related Side Effects and Adverse Reactions C00000982
D007674 Kidney Diseases C00000982
D008106 Liver Cirrhosis, Experimental C00000982
D008107 Liver Diseases C00000982
D009369 Neoplasms C00000982
D009374 Neoplasms, Experimental C00000982