Aeonium spp.
Species
KNApSAcK Entry
| Organism name | Aeonium spp. |
|---|---|
| Genus | Aeonium |
| Family | Crassulaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Aeonium |
|---|---|
| Linked NCBI taxonomy ID | 22994 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Crassulaceae |
|---|---|
| ID | 3781 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (12)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001096
|
Santin
|
CHEMBL161957
|
C104803
|
9 / 7 / 5 | No. 3 | No. 15 |
|
|
|
C00004569
|
Jaranol
/ Kumatakenin / Kumatakillin / Kaempferol 3,7-O-dimethyl ether / 5,4'-Dihydroxy-3,7-dimethoxyflavone / 5-Hydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL349724
|
No. 3 | No. 15 |
|
|||
|
C00004570
|
Ermanin
/ Kaempferol 3,4'-di-O-methyl ether / 5,7-Dihydroxy-3,4'-dimethoxyflavone / 5,7-Dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL309061
|
C104804
|
2 / 1 / 1 | No. 3 | No. 15 |
|
|
|
C00004593
|
6-Methoxykaempferol
/ 3,5,7,4'-Tetrahydroxy-6-methoxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one |
CHEMBL462898
|
No. 3 | No. 15 |
|
|||
|
C00004596
|
6-Methoxykaempferol 3-methyl ether
/ 5,7,4'-Trihydroxy-3,6-dimethoxyflavone / 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL351607
|
C014868
|
No. 3 | No. 15 |
|
||
|
C00004603
|
Penduletin
/ 5,4'-Dihydroxy-3,6,7-trimethoxyflavone / 5-Hydroxy-2-(4-hydroxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one |
CHEMBL165509
|
3 / 3 / 0 | No. 3 | No. 15 |
|
||
|
C00004770
|
Myricetin 3,7,3'-trimethyl ether
/ 3,7,3'-Trimethoxy-5,4',5'-trihydroxyflavone / 2-(3,4-Dihydroxy-5-methoxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-1-benzopyran-4-one |
No. 3 | No. 15 |
|
||||
|
C00004634
|
Rhamnetin
/ 7-Methoxyquercetin / 3,5,3',4'-Tetrahydroxy-7-methoxyflavone / 2-(3,4-Dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1- benzopyran-4-one |
CHEMBL312163
|
C063423
|
20 / 27 / 27 | No. 3 | No. 15 |
|
|
|
C00004642
|
Rhamnazin
/ 7,3'-Di-O-methylquercetin / 3,4',5-Trihydroxy-3',7-dimethoxyflavone / 3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one |
CHEMBL457148
|
No. 3 | No. 15 |
|
|||
|
C00004694
|
Centaureidin
/ Desmethoxycentaureidine / Quercetagetin 3,4',6-trimethyl ether / 5,7,3'-Trihydroxy-3,6,4'-trimethoxyflavone / 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one |
CHEMBL77552
|
C083161
|
24 / 14 / 6 | No. 3 | No. 15 |
|
|
|
C00004607
|
Penduletin 4'-methyl ether
/ 5-Hydroxy-3,6,7,4'-tetramethoxyflavone / 6-Hydroxykaempferol-3,6,7,4'-tetramethyl ether / 5-Hydroxy-3,6,7-trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL521934
|
No. 8 | No. 15 |
|
|||
|
C00004777
|
Combretol
/ 5-Hydroxy-3,3',4',5',7-pentamethoxyflavone / 5-Hydroxy-3,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL518300
|
No. 8 | No. 15 |
|
Human Protein / Gene in interactions
51 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00004570 C00004634 | 0 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001096 C00004694 | 1 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001096 C00004694 | 1 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001096 C00004634 | 4 / 3 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001096 C00004694 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00004603 C00004634 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001096 C00004694 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00004570 | 1 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00004634 | 3 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00004603 | 1 / 0 |
| P04792 | Heat shock protein beta-1 | Unclassified protein | C00004634 | 2 / 1 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00004634 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00004694 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00004694 | 2 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00004634 | 11 / 10 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00004634 | 0 / 0 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | C00004634 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00004694 | 1 / 1 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00001096 | 0 / 0 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00004694 | 2 / 2 |
| P04745 | Alpha-amylase 1 | Enzyme | C00004634 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00004634 | 0 / 0 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00004634 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00004634 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00004603 | 2 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00001096 | 1 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00004634 | 0 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00001096 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00004634 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00004634 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00004634 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00004634 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001096 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00004634 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00004634 | 1 / 2 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00004694 | 0 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | C00004694 | 0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00004694 | 1 / 0 |
| P04350 | Tubulin beta-4A chain | Structural | C00004694 | 2 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00004694 | 0 / 0 |
| P07437 | Tubulin beta chain | Structural | C00004694 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00004694 | 1 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | C00004694 | 0 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | C00004694 | 2 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00004694 | 0 / 0 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00004694 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00004694 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00004694 | 0 / 0 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00004694 | 0 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00004694 | 0 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00004694 | 1 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (46)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #606595 | Charcot-marie-tooth disease, axonal, type 2f; cmt2f |
P04792
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #608634 | Neuronopathy, distal hereditary motor, type iib; hmn2b |
P04792
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (33)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00856 | Distal hereditary motor neuropathies (dHMN) |
P04792
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|