PCIDB

Chromolaena odorata

Species

KNApSAcK Entry

Organism name Chromolaena odorata
Genus Chromolaena
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Chromolaena odorata
Linked NCBI taxonomy ID 103745
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (40)

Species Activity
Chromolaena odorata (L.) R. M. King & H.Rob. Analgesic
Chromolaena odorata (L.) R. M. King & H.Rob. Analgesic
Chromolaena odorata (L.) R. M. King & H.Rob. Antiallergic
Chromolaena odorata (L.) R. M. King & H.Rob. Antiallergic
Chromolaena odorata (L.) R. M. King & H.Rob. Antibacterial
Chromolaena odorata (L.) R. M. King & H.Rob. Anticancer, lung
Chromolaena odorata (L.) R. M. King & H.Rob. Antiedemic
Chromolaena odorata (L.) R. M. King & H.Rob. Antifertility
Chromolaena odorata (L.) R. M. King & H.Rob. Antiinflammatory
Chromolaena odorata (L.) R. M. King & H.Rob. Antioxidant
Chromolaena odorata (L.) R. M. King & H.Rob. Antiradicular
Chromolaena odorata (L.) R. M. King & H.Rob. Antiseptic
Chromolaena odorata (L.) R. M. King & H.Rob. Antiseptic
Chromolaena odorata (L.) R. M. King & H.Rob. Antispasmodic
Chromolaena odorata (L.) R. M. King & H.Rob. Antitussive
Chromolaena odorata (L.) R. M. King & H.Rob. Bactericide
Chromolaena odorata (L.) R. M. King & H.Rob. Cathartic
Chromolaena odorata (L.) R. M. King & H.Rob. Cytotoxic
Chromolaena odorata (L.) R. M. King & H.Rob. Decongestant
Chromolaena odorata (L.) R. M. King & H.Rob. Digestive
Chromolaena odorata (L.) R. M. King & H.Rob. Edemic
Chromolaena odorata (L.) R. M. King & H.Rob. Emetic
Chromolaena odorata (L.) R. M. King & H.Rob. Emmenagogue
Chromolaena odorata (L.) R. M. King & H.Rob. Emmenagogue
Chromolaena odorata (L.) R. M. King & H.Rob. Fungicide
Chromolaena odorata (L.) R. M. King & H.Rob. Hemostat
Chromolaena odorata (L.) R. M. King & H.Rob. Hepatoprotective
Chromolaena odorata (L.) R. M. King & H.Rob. Herbicide
Chromolaena odorata (L.) R. M. King & H.Rob. Insecticide
Chromolaena odorata (L.) R. M. King & H.Rob. Mercury-Binder
Chromolaena odorata (L.) R. M. King & H.Rob. Molluscacide
Chromolaena odorata (L.) R. M. King & H.Rob. PAF-Inhibitor
Chromolaena odorata (L.) R. M. King & H.Rob. Piscicide
Chromolaena odorata (L.) R. M. King & H.Rob. Piscicide
Chromolaena odorata (L.) R. M. King & H.Rob. Spasmogenic
Chromolaena odorata (L.) R. M. King & H.Rob. Stomachic
Chromolaena odorata (L.) R. M. King & H.Rob. Stomachic
Chromolaena odorata (L.) R. M. King & H.Rob. Tonic
Chromolaena odorata (L.) R. M. King & H.Rob. Tonic
Chromolaena odorata (L.) R. M. King & H.Rob. Vulnerary

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00004690 External link 512 Laciniatin
/ 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
No. 3 No. 15
C00004634 External link 512 Rhamnetin
/ 7-Methoxyquercetin
/ 3,5,3',4'-Tetrahydroxy-7-methoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1- benzopyran-4-one
CHEMBL312163
C063423
20 / 27 / 27 No. 3 No. 15
C00004636 External link 512 Tamarixetin
/ 4'-O-Methylquercetin
/ 3,3',5,7-Tetrahydroxy-4'-methoxyflavone
/ 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL226034
5 / 6 / 5 No. 3 No. 15
C00004643 External link 512 Ombuin
/ 4',7-Dimethylquercetin
/ 3,5,3'-Trihydroxy-7,4'-dimethoxyflavone
/ 3,5-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL75589
1 / 1 / 1 No. 3 No. 15
C00004644 External link 512 Dillenetin
/ 3',4'-Dimethoxyquercetin
/ 3,5,7-Trihydroxy-3',4'-dimethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
CHEMBL2043330
No. 3 No. 15
C00004649 External link 512 Quercetin 7,3',4'-trimethyl ether
/ 3,5-Dihydroxy-7,3',4'-trimethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1-benzopyran-4-one
CHEMBL1689343
1 / 2 / 0 No. 3 No. 15
C00003841 External link 512 Tetramethylscutellarein
/ 5,6,7,4'-Tetramethoxyflavone
/ Scutellarein 5,6,7,4'-tetramethyl ether
/ 5,6,7-Trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL75349
C072809
9 / 4 / 8 No. 8 No. 15
C00004937 External link 512 Marionol
/ 3',4',5,6,7-Pentamethylquercetagetin
/ Quercetagetin 5,6,7,3',4'-pentamethyl ether
/ 2-(3,4-Dimethoxyphenyl)-3-hydroxy-5,6,7-trimethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00013596 External link 512 Sinensetin
/ Pedalitin permethyl ether
/ 5,6,7,3',4'-Pentamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL226507
C059295
7 / 6 / 7 3 / 0 No. 8 No. 15
C00008277 External link 512 4'-Hydroxy-5,6,7-trimethoxyflavanone
CHEMBL485055
No. 77 No. 14
C00006979 External link 512 4,6'-Dihydroxy-2',3',4'-trimethoxychalcone
CHEMBL2208192
No. 79
C00006989 External link 512 6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone
CHEMBL458376
No. 79

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003841 C00004634 C00013596 1 / 2
O00255 Menin Unclassified protein C00003841 C00004634 C00013596 2 / 5
Q9UBT6 DNA polymerase kappa Enzyme C00004634 C00013596 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00004636 C00013596 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00004649 C00013596 2 / 0
P04792 Heat shock protein beta-1 Unclassified protein C00004634 C00004636 2 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00004634 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00004636 0 / 0
P08183 Multidrug resistance protein 1 drug C00013596 1 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00004643 1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme C00004634 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00003841 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00013596 0 / 0
P15121 Aldose reductase Enzyme C00004634 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003841 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00004636 4 / 4
P04745 Alpha-amylase 1 Enzyme C00004634 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00004634 3 / 1
P45983 Mitogen-activated protein kinase 8 Jnk C00004634 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00004636 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00004634 3 / 3
P02545 Prelamin-A/C Unclassified protein C00004634 11 / 10
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003841 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00004634 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00003841 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00004634 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00004634 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003841 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00004634 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00004634 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00004634 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00004634 1 / 1
P45984 Mitogen-activated protein kinase 9 Jnk C00004634 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00003841 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00003841 1 / 1

3 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00013596
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00013596
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00013596

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989

KEGG DISEASE (32)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)